Lack of a relation between vitamin and mineral antioxidants and bone mineral density: Results from the Women's Health Initiative

American Journal of Clinical Nutrition

Volumn 82, Issue 3, 2005, Pages 581-588

  Wolf, Randi L ^a   Cauley, Jane A ^b   Pettinger, Mary ^c   Jackson, Rebecca ^d   Lacroix, Andrea ^c   Leboff, Meryl S ^e   Lewis, Cora E ^f   Nevitt, Michael C ^g   Simon, Joel A ^g,h   Stone, Katie L ^g   Wactawski Wende, Jean ⁱ  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

^d OHIO STATE UNIVERSITY   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f University of Alabama at Birmingham   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h VETERANS AFFAIRS MEDICAL CENTER   (United States)

ⁱ UNIVERSITY AT BUFFALO   (United States)

Author keywords

Antioxidants; Bone mineral density; Diet; Osteoporosis; Serum; Women's health initiative

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; CAROTENOID; MINERAL; RETINOL; SELENIUM; TOCOPHEROL; VITAMIN;

ADULT; AGED; ARTICLE; BONE DENSITY; DEMOGRAPHY; DIET SUPPLEMENTATION; FEMALE; HUMAN; HUMAN EXPERIMENT; OSTEOPOROSIS; QUESTIONNAIRE; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CROSS-SECTIONAL STUDY; DIET; DRUG EFFECT; HIP; HISTOLOGY; HORMONE SUBSTITUTION; LONGITUDINAL STUDY; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; PHYSIOLOGY; RADIOGRAPHY; RANDOMIZED CONTROLLED TRIAL; SPINE;

AGED; ANTIOXIDANTS; ASCORBIC ACID; BONE DENSITY; CROSS-SECTIONAL STUDIES; DIET; DIETARY SUPPLEMENTS; FEMALE; HIP; HORMONE REPLACEMENT THERAPY; HUMANS; LONGITUDINAL STUDIES; MIDDLE AGED; MINERALS; QUESTIONNAIRES; RANDOMIZED CONTROLLED TRIALS; SPINE; VITAMINS;

EID: 27244437111     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn.82.3.581     Document Type: Article

References (48)

1. NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. Osteoporosis prevention, diagnosis, and therapy. JAMA 2001;285:785-95.
2. National Osteoporosis Foundation Report 2002. Internet: http://www.nog.org/osteoporosis/diseasefacts.htm (accessed 24 August 2004).
3. Heaney RP. Calcium, dairy products and osteoporosis. J Am Coll Nutr 2000;19:83-99S.
4. Dawson-Hughes B, Dallal GE, Krall EA, Sadowski L, Sahyoun N, Tannenbaum S. A controlled trial of the effect of calcium supplementation on bone mineral density in postmenopausal women. N Engl J Med 1990;323:878-83.
5. Chapuy MC, Arlot ME, Duboeuf F, et al. Vitamin D3 and calcium to prevent hip fractures in elderly women. N Engl J Med 1992;327:1637-42.
6. Reid IR, Ames RW, Evans MC, Gamble GD, Sharpe SJ. Effect of calcium supplementation on bone loss in postmenopausal women. N Engl J Med 1993;328:460-4.
7. Johnston CC Jr, Miller JZ, Slemenda CW, et al. Calcium supplementation and increases in bone mineral density in children. N Engl J Med 1992;327:82-7.
8. Lloyd T, Andon MB, Rollings N, et al. Calcium supplementation and bone mineral density in adolescent girls. JAMA 1993;270:841-4.
9. Chevalley T, Rizzoli R, Nydegger V, et al. Effects of calcium supplements on femoral bone mineral density and vertebral fracture rate in vitamin D-replete elderly patients. Osteoporos Int 1994;4:256-2.
10. Recker RR, Hinders S, Davies KM, et al. Correcting calcium nutritional deficiency prevents spine fractures in elderly women. J Bone Miner Res 1996;11:1961-6.
11. Dawson-Hughes B, Harris SS, Krall EA, Dallal GE. Effects of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 1997;337:670-6.
12. Reid IR, Ames RW, Evans MC, Sharpe SJ, Gamble GD. Determinants of the rate of bone loss in normal postmenopausal women. J Clin Endocrinol Metab 1994;79:950-4.
13. Aloia JF, Vaswani A, Yeh JK, Ross PL, Flaster E, Dilmanian FA. Calcium supplementation with and without hormone replacement therapy to prevent post-menopausal bone loss. Ann Intern Med 1994;120:97-103.
14. Riggs BL, Melton LJ, eds. Osteoporosis: etiology, diagnosis, and management. New York, NY: Raven Press, 1988.
15. Shikany JM, Patterson RE, Agurs-Collins T, Anderson G. Antioxidant supplement use in Women's Health Initiative participants. Prev Med 2003;36:379-87.
16. Hall SL, Greendale GA. The relation of dietary vitamin C intake to bone mineral density: results from the PEPI Study. Calcif Tissue Int 1998;63:183-9.
17. Melhus H, Michaelsson K, Holmberg L, Wolk A, Ljunghall S. Smoking, antioxidant vitamins, and the risk of hip fractures. J Bone Miner Res 1999;14:129-35.
18. Leveille SG, La Croix AZ, Koepsell TD, Beresford SA, VanBelle G, Buchner DM. Dietary vitamin C and bone mineral density in postmenopausal women in Washington State, USA. J Epidemiol Community Health 1997;51:479-85.
19. The Women's Health Initiative Study Group. Design of the Women's Health Initiative clinical trial and observational study. Control Clin Trials 1998;19:61-109.
20. Ainsworth BE, Haskell WL, Whitt MC, et al. Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 2000;32(9 suppl):S498-504.
21. Simon JA, Hudes ES. Relation of ascorbic acid to bone mineral density and self-reported fractures among US adults. Am J Epidemiol 2001;154:427-33.
22. Feskanich D, Willett W, Stampfter MJ, Colditz GA. Milk, dietary calcium, and bone fractures in women: a 12-year prospective study. Am J Public Health 1997;87:992-7.
23. Melhus H, Michaelsson K, Kindmark A, et al. Excessive dietary intake of vitamin A is associated with reduced bone mineral density and increased risk for hip fracture. Ann Intern Med 1998;129:770-8.
24. Ensrud KE, Palermo L, Black DM, et al. Hip and calcaneal bone loss increase with advancing age: longitudinal results from the study of osteoporotic fractures. J Bone Miner Res 1995;10:1778-87.
25. Jordan P, Brubucher D, Moser U, Stahelin HB, Gey KF. Vitamin E and vitamin A concentrations in plasma adjusted for cholesterol and triglycerides by multiple regression. Clin Chem 1995;41:924-7.
26. Anderson GL, Manson J, Wallace R, et al. Implementation of the Women's Health Initiative study design. Ann Epidemiol 2003;13(9 suppl): S5-17.
27. Kanis JA, Melton LJ III, Christiansen C, Johnston CC, Khaltaev N. The diagnosis of osteoporosis. J Bone Miner Res 1994;9:1137-41.
28. Diplock AT. Antioxidant nutrients and disease prevention: an overview. Am J Clin Nutri 1991;53(1 suppl):189-93S.
29. Garrett IR, Boyce BF, Oreffo RO, Bonewald L, Poser J, Mundy GR. Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest 1990;85:632-639.
30. Roughead ZK, Kunkel ME. Effect of diet on bone matrix constituents. J Am Coll Nutr 1991;10:242-6.
31. Franceschi RT. The role of ascorbic acid in mesenchymal differentiation. Nutr Rev 1992;50:65-70.
32. Freudenheim JL, Johnson NE, Smith EL. Relationships between usual nutrient intake and bone-mineral content of women 35-65 years of age: longitudinal and cross-sectional analysis. Am J Clin Nutr 1986;44:863-76.
33. Wang MC, Luz Villa ML, Marcus R, Kelsey JL. Associations of vitamin C, calcium, and protein with bone mass in postmenopausal Mexican American women. Osteoporos Int 1997;7:533-8.
34. Maggio D, Barabani M, Pierandrei M, et al. Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study. J Clin Endocrinol Metab 2003;88:1523-7.
35. Weininger J, King JC. Effect of oral contraceptive agents on ascorbic acid metabolism in the rhesus monkey. Am J Clin Nutr 1982;35:1408-16.
36. Kalesh DG, Mallikarjuneswara VR, Clemetson CAB. Effect of estrogen containing contraceptives on platelet and plasma ascorbic acid concentrations. Contraception 1971;4:183-92.
37. Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277 (letter).
38. Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9.
39. McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6.
40. Saroja N, Mallikarjuneswara VR, Clemetson CAB. Effect of estrogens on ascorbic acid in the plasma and blood vessels of guinea pigs. Contraception 1971;3:269-77.
41. Manolagas SC, Jilka RL. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 1995;332:305-11.
42. Xu H, Watkins BA, Seifert MF. Vitamin E stimulates trabecular bone formation and alters epiphyseal cartilage morphometry. Calcif Tissu Int 1995;57:293-300.
43. Binkley N, Krueger D. Hypervitaminosis A and bone. Nutr Rev 2000;58:138-44.
44. Feskanich D, Singh V, Willett WC, Colditz GA. Vitamin A intake and hip fractures among postmenopausal women. JAMA 2002;287:47-54.
45. Michaelsson K, Lithell H, Vessby B, Melhus H. Serum retinol levels and the risk of fracture. N Engl J Med 2003;348:287-94.
46. Promislow JH, Goodman-Gruen D, Slymen DJ, Barrett-Conner E. Retinol intake and bone mineral density in the elderly: the Rancho Bernardo Study. J Bone Miner Res 2002;17:1349-58.
47. Opotowsky AR, Bilezikian JP; NHANES I follow-up study. Serum vitamin A concentration and the risk of hip fracture among women 50 to 74 years old in the United States: a prospective analysis of NHANES I follow-up study. Am J Med 2004;117:169-74.
48. Willett W. Nutritional epidemiology. 2nd ed. New York, NY: Oxford University Press, 1998.