The severity of cortical Alzheimer's type changes is positively correlated with increased amyloid-β levels: Resolubilization of amyloid-β with transition metal ion chelators

Journal of Alzheimer's Disease

Volumn 3, Issue 2, 2001, Pages 209-219

  Fonte, Justin ^a   Miklossy, Judith ^b   Atwood, Craig ^c   Martins, Ralph ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY INSTITUTE OF PATHOLOGY   (Switzerland)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; METAL ION; N,N,N',N' TETRAKIS(2 PYRIDYLMETHYL)ETHYLENEDIAMINE; THIOCTIC ACID;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CHELATION; CONTROLLED STUDY; DISEASE SEVERITY; HUMAN; HUMAN CELL; MOUSE; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; SENILE PLAQUE;

EID: 0034987999     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2001-3206     Document Type: Article

References (49)

1. Protection by the heavy metal chelator N,N,N',N'-tetrakis (2-pyridylmethyl)ethylenediamine (TPEN) against the lethal action of botulinum neurotoxin A and B
2. Consensus report of the Working Group on: "Molecular and Biochemical Markers of Alzheimer's Disease", The Ronald and Nancy Reagan Institute of the Alzheimer's Association and the National Institute on Aging Working Group
3. Dramatic aggregation of Alzheimer Aβ by Cu(ll) is induced by conditions representing physiological acidosis
4. Alzheimer's beta-amyloid peptide: Affinity for metal chelates
5. Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ 1-42/1-40 ratio in vitro and in vivo
6. Staging of Alzheimer-related cortical destruction
7. Rapid induction of Alzheimer Aβ amyloid formation by zinc
8. Modulation of Aβ adhesiveness and secretase site cleavage by zinc
9. Aqueous dissolution of Alzheimer's disease Aβ amyoild deposits by biometal depletion
10. Mutant pre-senilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
11. Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: The CERAD experience. Part XV
12. Cole Microglial response to amyloid plaques in APPSW transgenic mice
13. Cerebral cortex pathology in aging and Alzheimer's disease: A quantitative survey of large hospital-based geriatric and psychiatric cohorts
14. Alzheimer's disease: Initial report of the purification and characterization of .a novel cerebrovascular amyloid protein
15. The effect of DL-β-Lipoic Acid on heavy-metal intoxication in mice and dogs
16. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presinilin 1 transgenes
17. Zinc-induced Alzheimer's Aβ 1-40 aggregation is mediated by conformational factors
18. Secretory cleavage site of Alzheimer amyloid precursor protein is heterogeneous in Down syndrome brain
19. Diagnosis of Alzheimer's disease
20. Synaptic pathology of Alzheimer's disease
21. Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: Implications for initial events in amyloid plaque formation
22. Arango The E280A presenilin Alzhemier mutation produces increased Aβ 42 deposition and severe cerebellar pathology
23. Intra-cellular accmmulation of detergent-soluble amyloidogenic Aβ fragment of Alzheimier's disease precursor protein in the hippocampus of aged transgenic mice
24. Copper, iron. and zinc in Alzheimer's disease senile plaques
25. Amyloid plaque core protein in Alzheimer disease and Down syndrome
26. Neuritic pathology and dementia in Alzheimer's disease
27. Soluble pool of Aβ Amyloid as a determinant of severity of neurodegeneration in Alzheimer's Disease
28. Curly fibre and tangle-like structures in the ependyma and the choroid plexus - A pathogenetic relationship with the cortical Alzheimer-type changes?
29. Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease
30. Making the diagnosis of Alzheimer's disease. A primer for practicing pathologists
31. Tanzi Differential effects of apolipoprotein E isoforms on metal-induced aggregation of Aβ using physiological concentrations
32. Distribution of reducible 4-hydroxynonenal adduct immunoreactivity in Alzheimer disease is associated with APOE genotype
33. Correlation between elevated levels of amyloid b-peptide in the brain and cognitive decline
34. Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging
35. Neuroprotection by the metabolic anfioxidant β-lipoic acid
36. Antioxidant properties and clinical applications of alpha-lipoic acid and dihydrolipoic acid
37. Alpha lipoic acid protects against reperfusion injury following cerebral ischemia in rats
38. β-Lipoic acid supplementation prevents symptoms of vitamin E deficiency
39. Apolipoprotein E-epsilon4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease
40. β-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: Implications for the pathology of Alzheimer disease
41. Morphological and biochemical analysis of amyloid plaque core proteins purified from Alzheimer disease brain tissue
42. Tricine-sodium dodecyl sulfate-poluacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa
43. Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: Implications for Alzheimer. disease
44. Binding of human apolipoprotein E to synthetic amyloid beta peptide: Isoform-specific effects and implications for late-onset Alzheimer disease
45. Frequency of the apolipoprotein E epsilon 2 allele is diminished in sporadic Alzheimer disease
46. Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mulant presenilins
47. Alzheimer amyloid-beta peptide forms denaturant-resistant complex with type epsilon 3 but not type epsilon 4 isoform of native apolipoprotein