-
1
-
-
33644785694
-
The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines
-
Alao JP, Gamble SC, Stavropoulou AV, Pomeranz KM, Lam EW, Coombes RC, and Vigushin DM (2006) The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines. Mol Cancer 5:7.
-
(2006)
Mol Cancer
, vol.5
-
-
Alao, J.P.1
Gamble, S.C.2
Stavropoulou, A.V.3
Pomeranz, K.M.4
Lam, E.W.5
Coombes, R.C.6
Vigushin, D.M.7
-
2
-
-
77949875831
-
Novel targeted therapeutics for metastatic castration-resistant prostate cancer
-
Antonarakis ES, Carducci MA, and Eisenberger MA (2010) Novel targeted therapeutics for metastatic castration-resistant prostate cancer. Cancer Lett 291:1-13.
-
(2010)
Cancer Lett
, vol.291
-
-
Antonarakis, E.S.1
Carducci, M.A.2
Eisenberger, M.A.3
-
3
-
-
73849101809
-
Key factors in mTOR regulation
-
Bai X and Jiang Y (2010) Key factors in mTOR regulation. Cell Mol Life Sci 67: 239-253.
-
(2010)
Cell Mol Life Sci
, vol.67
-
-
Bai, X.1
Jiang, Y.2
-
4
-
-
0038179160
-
Structural analysis of pentacyclic triterpenes from the gum resin of Boswellia serrata by NMR spec-troscopy
-
Belsner K, Büchele B, Werz U, Syrovets T, and Simmet T (2003) Structural analysis of pentacyclic triterpenes from the gum resin of Boswellia serrata by NMR spec-troscopy. Magn Reson Chem 41:115-122.
-
(2003)
Magn Reson Chem
, vol.41
-
-
Belsner, K.1
Büchele, B.2
Werz, U.3
Syrovets, T.4
Simmet, T.5
-
5
-
-
57349100323
-
Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells
-
Bianchini A, Loiarro M, Bielli P, Busà R, Paronetto MP, Loreni F, Geremia R, and Sette C (2008) Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells. Carcinogenesis 29: 2279-2288.
-
(2008)
Carcinogenesis
, vol.29
-
-
Bianchini, A.1
Loiarro, M.2
Bielli, P.3
Busà, R.4
Paronetto, M.P.5
Loreni, F.6
Geremia, R.7
Sette, C.8
-
6
-
-
78349290007
-
Morphoproteomic confirmation of a constitutively activated mTOR pathway in high grade prostatic intraepithelial neoplasia and prostate cancer
-
Brown RE, Zotalis G, Zhang PL, and Zhao B (2008) Morphoproteomic confirmation of a constitutively activated mTOR pathway in high grade prostatic intraepithelial neoplasia and prostate cancer. Int J Clin Exp Pathol 1:333-342.
-
(2008)
Int J Clin Exp Pathol
, vol.1
-
-
Brown, R.E.1
Zotalis, G.2
Zhang, P.L.3
Zhao, B.4
-
7
-
-
0141649214
-
Analysis of 12 different pentacyclic triterpenic acids from frankincense in human plasma by high-performance liquid chromatography and photodiode array detection
-
Büchele B and Simmet T (2003) Analysis of 12 different pentacyclic triterpenic acids from frankincense in human plasma by high-performance liquid chromatography and photodiode array detection. J Chromatogr B Analyt Technol Biomed Life Sci 795:355-362.
-
(2003)
J Chromatogr B Analyt Technol Biomed Life Sci
, vol.795
-
-
Büchele, B.1
Simmet, T.2
-
9
-
-
0038339003
-
Phospholipase D confers rapamycin resistance in human breast cancer cells
-
Chen Y, Zheng Y, and Foster DA (2003) Phospholipase D confers rapamycin resistance in human breast cancer cells. Oncogene 22:3937-3942.
-
(2003)
Oncogene
, vol.22
-
-
Chen, Y.1
Zheng, Y.2
Foster, D.A.3
-
10
-
-
38549108133
-
Antiinflammatory and antiatherogenic effects of the NF-kappaB inhibitor acetyl-11-keto-β-boswellic acid in LPS-challenged ApoE-/-mice
-
Cuaz-Pérolin C, Billiet L, Baugé E, Copin C, Scott-Algara D, Genze F, Büchele B, Syrovets T, Simmet T, and Rouis M (2008) Antiinflammatory and antiatherogenic effects of the NF-kappaB inhibitor acetyl-11-keto-β-boswellic acid in LPS-challenged ApoE-/-mice. Arterioscler Thromb Vasc Biol 28:272-277.
-
(2008)
Arterioscler Thromb Vasc Biol
, vol.28
-
-
Cuaz-Pérolin, C.1
Billiet, L.2
Baugé, E.3
Copin, C.4
Scott-Algara, D.5
Genze, F.6
Büchele, B.7
Syrovets, T.8
Simmet, T.9
Rouis, M.10
-
11
-
-
79955676741
-
Cinnamic acid derivatives as anticancer agents - A review
-
De P, Baltas M, and Bedos-Belval F (2011) Cinnamic acid derivatives as anticancer agents - a review. Curr Med Chem 18:1672-1703.
-
(2011)
Curr Med Chem
, vol.18
-
-
De, P.1
Baltas, M.2
Bedos-Belval, F.3
-
12
-
-
77951231349
-
MTOR and cancer: Many loops in one pathway
-
Efeyan A and Sabatini DM (2010) mTOR and cancer: many loops in one pathway. Curr Opin Cell Biol 22:169-176.
-
(2010)
Curr Opin Cell Biol
, vol.22
-
-
Efeyan, A.1
Sabatini, D.M.2
-
13
-
-
77149153396
-
Tirucallic acids are novel pleckstrin homology domain-dependent Akt inhibitors inducing apoptosis in prostate cancer cells
-
Estrada AC, Syrovets T, Pitterle K, Lunov O, Büchele B, Schimana-Pfeifer J, Schmidt T, Morad SA, and Simmet T (2010) Tirucallic acids are novel pleckstrin homology domain-dependent Akt inhibitors inducing apoptosis in prostate cancer cells. Mol Pharmacol 77:378-387.
-
(2010)
Mol Pharmacol
, vol.77
-
-
Estrada, A.C.1
Syrovets, T.2
Pitterle, K.3
Lunov, O.4
Büchele, B.5
Schimana-Pfeifer, J.6
Schmidt, T.7
Morad, S.A.8
Simmet, T.9
-
14
-
-
77956275419
-
EIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression
-
Furic L, Rong L, Larsson O, Koumakpayi IH, Yoshida K, Brueschke A, Petroulakis E, Robichaud N, Pollak M, and Gaboury LA et al. (2010) eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression. Proc Natl Acad Sci USA 107:14134-14139.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
-
-
Furic, L.1
Rong, L.2
Larsson, O.3
Koumakpayi, I.H.4
Yoshida, K.5
Brueschke, A.6
Petroulakis, E.7
Robichaud, N.8
Pollak, M.9
Gaboury, L.A.10
-
15
-
-
65949111747
-
EIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival
-
Graff JR, Konicek BW, Lynch RL, Dumstorf CA, Dowless MS, McNulty AM, Parsons SH, Brail LH, Colligan BM, and Koop JW et al. (2009) eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival. Cancer Res 69:3866-3873.
-
(2009)
Cancer Res
, vol.69
-
-
Graff, J.R.1
Konicek, B.W.2
Lynch, R.L.3
Dumstorf, C.A.4
Dowless, M.S.5
McNulty, A.M.6
Parsons, S.H.7
Brail, L.H.8
Colligan, B.M.9
Koop, J.W.10
-
16
-
-
58649114084
-
MTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice
-
Guertin DA, Stevens DM, Saitoh M, Kinkel S, Crosby K, Sheen JH, Mullholland DJ, Magnuson MA, Wu H, and Sabatini DM (2009) mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell 15: 148-159.
-
(2009)
Cancer Cell
, vol.15
-
-
Guertin, D.A.1
Stevens, D.M.2
Saitoh, M.3
Kinkel, S.4
Crosby, K.5
Sheen, J.H.6
Mullholland, D.J.7
Magnuson, M.A.8
Wu, H.9
Sabatini, D.M.10
-
17
-
-
79953882401
-
Phosphatidic acid binds and stimulates Arabidopsis sphingosine kinases
-
Guo L, Mishra G, Taylor K, and Wang X (2011) Phosphatidic acid binds and stimulates Arabidopsis sphingosine kinases. J Biol Chem 286:13336-13345.
-
(2011)
J Biol Chem
, vol.286
-
-
Guo, L.1
Mishra, G.2
Taylor, K.3
Wang, X.4
-
18
-
-
77049124756
-
Free-solution, label-free proteinprotein interactions characterized by dynamic light scattering
-
Hanlon AD, Larkin MI, and Reddick RM (2010) Free-solution, label-free proteinprotein interactions characterized by dynamic light scattering. Biophys J 98: 297-304.
-
(2010)
Biophys J
, vol.98
-
-
Hanlon, A.D.1
Larkin, M.I.2
Reddick, R.M.3
-
19
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay N and Sonenberg N (2004) Upstream and downstream of mTOR. Genes Dev 18: 1926-1945.
-
(2004)
Genes Dev
, vol.18
-
-
Hay, N.1
Sonenberg, N.2
-
20
-
-
79953038262
-
PTEN loss in the continuum of common cancers, rare syndromes and mouse models
-
Hollander MC, Blumenthal GM, and Dennis PA (2011) PTEN loss in the continuum of common cancers, rare syndromes and mouse models. Nat Rev Cancer 11: 289-301.
-
(2011)
Nat Rev Cancer
, vol.11
-
-
Hollander, M.C.1
Blumenthal, G.M.2
Dennis, P.A.3
-
21
-
-
46149092748
-
Role of mTOR in anticancer drug resistance: Perspectives for improved drug treatment
-
Jiang BH and Liu LZ (2008) Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment. Drug Resist Updat 11:63-76.
-
(2008)
Drug Resist Updat
, vol.11
-
-
Jiang, B.H.1
Liu, L.Z.2
-
22
-
-
33746794674
-
Expression of mTOR signaling pathway markers in prostate cancer progression
-
Kremer CL, Klein RR, Mendelson J, Browne W, Samadzedeh LK, Vanpatten K, Highstrom L, Pestano GA, and Nagle RB (2006) Expression of mTOR signaling pathway markers in prostate cancer progression. Prostate 66:1203-1212.
-
(2006)
Prostate
, vol.66
-
-
Kremer, C.L.1
Klein, R.R.2
Mendelson, J.3
Browne, W.4
Samadzedeh, L.K.5
Vanpatten, K.6
Highstrom, L.7
Pestano, G.A.8
Nagle, R.B.9
-
23
-
-
33748653784
-
The FRB domain of mTOR: Nmr solution structure and inhibitor design
-
Leone M, Crowell KJ, Chen J, Jung D, Chiang GG, Sareth S, Abraham RT, and Pellecchia M (2006) The FRB domain of mTOR: NMR solution structure and inhibitor design. Biochemistry 45:10294-10302.
-
(2006)
Biochemistry
, vol.45
-
-
Leone, M.1
Crowell, K.J.2
Chen, J.3
Jung, D.4
Chiang, G.G.5
Sareth, S.6
Abraham, R.T.7
Pellecchia, M.8
-
24
-
-
77952291860
-
The effect of carboxydextran-coated superparamagnetic iron oxide nanoparticles on c-Jun N-terminal kinase-mediated apoptosis in human macrophages
-
Lunov O, Syrovets T, Büchele B, Jiang X, Röcker C, Tron K, Nienhaus GU, Walther P, Mailänder V, and Landfester K et al. (2010) The effect of carboxydextran-coated superparamagnetic iron oxide nanoparticles on c-Jun N-terminal kinase-mediated apoptosis in human macrophages. Biomaterials 31:5063-5071.
-
(2010)
Biomaterials
, vol.31
-
-
Lunov, O.1
Syrovets, T.2
Büchele, B.3
Jiang, X.4
Röcker, C.5
Tron, K.6
Nienhaus, G.U.7
Walther, P.8
Mailänder, V.9
Landfester, K.10
-
25
-
-
84985520823
-
4-Dialkylaminopyridines as acylation catalysts. 5. Simple method for esterification of carboxylic-acids
-
Neises B and Steglich W (1978) 4-Dialkylaminopyridines as acylation catalysts. 5. Simple method for esterification of carboxylic-acids. Angew Chem Int Ed Engl 17: 522-524.
-
(1978)
Angew Chem Int Ed Engl
, vol.17
-
-
Neises, B.1
Steglich, W.2
-
26
-
-
80055116342
-
Boswellic acid suppresses growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model through modulation of multiple targets
-
Park B, Prasad S, Yadav V, Sung B, and Aggarwal BB (2011) Boswellic acid suppresses growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model through modulation of multiple targets. PLoS ONE 6:e26943.
-
(2011)
PLoS ONE
, vol.6
-
-
Park, B.1
Prasad, S.2
Yadav, V.3
Sung, B.4
Aggarwal, B.B.5
-
27
-
-
70249141572
-
A quantitative fluorescence study of protein monolayer formation on colloidal nanoparticles
-
Röcker C, Pötzl M, Zhang F, Parak WJ, and Nienhaus GU (2009) A quantitative fluorescence study of protein monolayer formation on colloidal nanoparticles. Nat Nanotechnol 4:577-580.
-
(2009)
Nat Nanotechnol
, vol.4
-
-
Röcker, C.1
Pötzl, M.2
Zhang, F.3
Parak, W.J.4
Nienhaus, G.U.5
-
28
-
-
0035971180
-
The TOR kinases link nutrient sensing to cell growth
-
Rohde J, Heitman J, and Cardenas ME (2001) The TOR kinases link nutrient sensing to cell growth. J Biol Chem 276:9583-9586.
-
(2001)
J Biol Chem
, vol.276
-
-
Rohde, J.1
Heitman, J.2
Cardenas, M.E.3
-
29
-
-
0036479313
-
Phos-phorylation of eukaryotic initiation factor 4E markedly reduces its affinity for capped mRNA
-
Scheper GC, van Kollenburg B, Hu J, Luo Y, Goss DJ, and Proud CG (2002) Phos-phorylation of eukaryotic initiation factor 4E markedly reduces its affinity for capped mRNA. J Biol Chem 277:3303-3309.
-
(2002)
J Biol Chem
, vol.277
-
-
Scheper, G.C.1
Van Kollenburg, B.2
Hu, J.3
Luo, Y.4
Goss, D.J.5
Proud, C.G.6
-
30
-
-
0035992276
-
The tumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma
-
Shen Z, Wen XF, Lan F, Shen ZZ, and Shao ZM (2002) The tumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma. Clin Cancer Res 8: 2085-2090.
-
(2002)
Clin Cancer Res
, vol.8
-
-
Shen, Z.1
Wen, X.F.2
Lan, F.3
Shen, Z.Z.4
Shao, Z.M.5
-
31
-
-
0037376168
-
Cyclin D1 serves as a cell cycle regulatory switch in actively proliferating cells
-
Stacey DW (2003) Cyclin D1 serves as a cell cycle regulatory switch in actively proliferating cells. Curr Opin Cell Biol 15:158-163.
-
(2003)
Curr Opin Cell Biol
, vol.15
-
-
Stacey, D.W.1
-
32
-
-
10844262511
-
Acetylboswellic acids inhibit lipopolysaccharide-mediated TNF - A induction in monocytes by direct interaction with IkappaB kinases
-
Syrovets T, Büchele B, Krauss C, Laumonnier Y, and Simmet T (2005a) Acetylboswellic acids inhibit lipopolysaccharide-mediated TNF - a induction in monocytes by direct interaction with IkappaB kinases. J Immunol 174:498-506.
-
(2005)
J Immunol
, vol.174
-
-
Syrovets, T.1
Büchele, B.2
Krauss, C.3
Laumonnier, Y.4
Simmet, T.5
-
33
-
-
14044268207
-
Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo
-
Syrovets T, Gschwend JE, Büchele B, Laumonnier Y, Zugmaier W, Genze F, and Simmet T (2005b) Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo. J Biol Chem 280:6170-6180.
-
(2005)
J Biol Chem
, vol.280
-
-
Syrovets, T.1
Gschwend, J.E.2
Büchele, B.3
Laumonnier, Y.4
Zugmaier, W.5
Genze, F.6
Simmet, T.7
-
34
-
-
33744826819
-
MolDock: A new technique for high-accuracy molecular docking
-
Thomsen R and Christensen MH (2006) MolDock: a new technique for high-accuracy molecular docking. J Med Chem 49:3315-3321.
-
(2006)
J Med Chem
, vol.49
-
-
Thomsen, R.1
Christensen, M.H.2
-
35
-
-
62849111751
-
Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: Competition with rapamycin
-
Toschi A, Lee E, Xu L, Garcia A, Gadir N, and Foster DA (2009) Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin. Mol Cell Biol 29:1411-1420.
-
(2009)
Mol Cell Biol
, vol.29
-
-
Toschi, A.1
Lee, E.2
Xu, L.3
Garcia, A.4
Gadir, N.5
Foster, D.A.6
-
36
-
-
38549134335
-
Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: Compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR
-
Veverka V, Crabbe T, Bird I, Lennie G, Muskett FW, Taylor RJ, and Carr MD (2008) Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR. Oncogene 27: 585-595.
-
(2008)
Oncogene
, vol.27
-
-
Veverka, V.1
Crabbe, T.2
Bird, I.3
Lennie, G.4
Muskett, F.W.5
Taylor, R.J.6
Carr, M.D.7
-
37
-
-
70449711383
-
Targeting NF-k B with a natural triterpenoid alleviates skin inflammation in a mouse model of psoriasis
-
Wang H, Syrovets T, Kess D, Büchele B, Hainzl H, Lunov O, Weiss JM, Scharffetter-Kochanek K, and Simmet T (2009) Targeting NF-k B with a natural triterpenoid alleviates skin inflammation in a mouse model of psoriasis. J Immunol 183: 4755-4763.
-
(2009)
J Immunol
, vol.183
-
-
Wang, H.1
Syrovets, T.2
Kess, D.3
Büchele, B.4
Hainzl, H.5
Lunov, O.6
Weiss, J.M.7
Scharffetter-Kochanek, K.8
Simmet, T.9
-
38
-
-
35648962915
-
Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation
-
Wang X, Yue P, Chan CB, Ye K, Ueda T, Watanabe-Fukunaga R, Fukunaga R, Fu H, Khuri FR, and Sun SY (2007) Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation. Mol Cell Biol 27:7405-7413.
-
(2007)
Mol Cell Biol
, vol.27
-
-
Wang, X.1
Yue, P.2
Chan, C.B.3
Ye, K.4
Ueda, T.5
Watanabe-Fukunaga, R.6
Fukunaga, R.7
Fu, H.8
Khuri, F.R.9
Sun, S.Y.10
-
39
-
-
84857505779
-
Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers
-
Yadav VR, Prasad S, Sung B, Gelovani JG, Guha S, Krishnan S, and Aggarwal BB (2012) Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers. Int J Cancer 130:2176-2184.
-
(2012)
Int J Cancer
, vol.130
-
-
Yadav, V.R.1
Prasad, S.2
Sung, B.3
Gelovani, J.G.4
Guha, S.5
Krishnan, S.6
Aggarwal, B.B.7
-
40
-
-
80051917141
-
Phosphatidic acid activates mammalian target of rapamycin complex 1 (mTORC1) kinase by displacing FK506 binding protein 38 (FKBP38) and exerting an allosteric effect
-
Yoon MS, Sun Y, Arauz E, Jiang Y, and Chen J (2011) Phosphatidic acid activates mammalian target of rapamycin complex 1 (mTORC1) kinase by displacing FK506 binding protein 38 (FKBP38) and exerting an allosteric effect. J Biol Chem 286: 29568-29574.
-
(2011)
J Biol Chem
, vol.286
-
-
Yoon, M.S.1
Sun, Y.2
Arauz, E.3
Jiang, Y.4
Chen, J.5
-
41
-
-
33847394119
-
PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR
-
Zhang H, Bajraszewski N, Wu E, Wang H, Moseman AP, Dabora SL, Griffin JD, and Kwiatkowski DJ (2007) PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR. J Clin Invest 117:730-738.
-
(2007)
J Clin Invest
, vol.117
-
-
Zhang, H.1
Bajraszewski, N.2
Wu, E.3
Wang, H.4
Moseman, A.P.5
Dabora, S.L.6
Griffin, J.D.7
Kwiatkowski, D.J.8
-
42
-
-
1242272929
-
PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells
-
Zhao H, Dupont J, Yakar S, Karas M, and LeRoith D (2004) PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells. Oncogene 23:786-794.
-
(2004)
Oncogene
, vol.23
-
-
Zhao, H.1
Dupont, J.2
Yakar, S.3
Karas, M.4
LeRoith, D.5
-
43
-
-
78650510609
-
MTOR: From growth signal integration to cancer, diabetes and ageing
-
Zoncu R, Efeyan A, and Sabatini DM (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12:21-35.
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
|