The FRB domain of mTOR: NMR solution structure and inhibitor design

Biochemistry

Volumn 45, Issue 34, 2006, Pages 10294-10302

  Leone, Marilisa ^a   Crowell, Kevin J ^a   Chen, Jinhua ^a   Jung, Dawoon ^a   Chiang, Gary G ^a   Sareth, Sina ^a   Abraham, Robert T ^a,b   Pellecchia, Maurizio ^a  

^a BURNHAM INSTITUTE   (United States)

^b WYETH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CATALYST ACTIVITY; CELLS; ENZYME INHIBITION; GROWTH KINETICS; NUCLEAR MAGNETIC RESONANCE;

CELL GROWTH; LIGANDS; MAMMALIAN TARGET OF RAPAMYCIN (MTOR); SIGNALING PATHWAYS;

PROTEINS;

ADENOSINE TRIPHOSPHATE; FK 506 BINDING PROTEIN; FK 506 BINDING PROTEIN 12; GLUTATHIONE TRANSFERASE; LIGAND; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHORUS 32; RAPAMYCIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL GROWTH; DISSOCIATION CONSTANT; DRUG DESIGN; ENZYME ACTIVITY; ENZYME ASSAY; GROWTH REGULATION; IMMUNOPRECIPITATION; ISOTOPE LABELING; MOLECULAR MODEL; NITROGEN NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN PURIFICATION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS;

ANIMALS; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; LIGANDS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; SIROLIMUS;

MAMMALIA;

EID: 33748653784     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi060976+     Document Type: Article

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