Cytotoxicity of lapachol, β-lapachone and related synthetic 1,4-naphthoquinones against oesophageal cancer cells

European Journal of Medicinal Chemistry

Volumn 62, Issue , 2013, Pages 98-110

  Sunassee, Suthananda N ^a,e   Veale, Clinton G L ^a   Shunmoogam Gounden, Nelusha ^b   Osoniyi, Omalaja ^b   Hendricks, Denver T ^b   Caira, Mino R ^b   De La Mare, Jo Anne ^a   Edkins, Adrienne L ^a   Pinto, Antônio V ^c   Da Silva Júnior, Eufrânio N ^d   Davies Coleman, Michael T ^a  

^a RHODES UNIVERSITY   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^d FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^e FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

Author keywords

Cytotoxicity; Naphthoquinones; Oesophageal cancer cell line WHCO1; SAR

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 2 (1' HYDROXY 1' FURAMYLMETHYL) 1,4 NAPHTHOQUINONE; 2 (1' HYDROXY 1' NAPHTHYLMETHYL) 1,4 NAPHTHOQUINONE; 2 (1' HYDROXY 3' PHENYLPROPYL) 1,4 NAPHTHOQUINONE; 2 [1' HYDROXY 1' (4' CHLOROPHENYL)METHYL] 1,4 NAPHTHOQUINONE; 2 [1' HYDROXY 1' (4' FLUOROPHENYL)METHYL] 1,4 NAPHTHOQUINONE; 2 [1' HYDROXY 1' (5' CHLORO 3' METHYLPHENYL)METHYL] 1,4 NAPHTHOQUINONE; 2 [1' HYDROXY 1' (5' CHLOROPHENYL)METHYL] 1,4 NAPHTHOQUINONE; 2 [1' HYDROXY 1' (5' FLUOROPHENYL)METHYL] 1,4 NAPHTHOQUINONE; BETA LAPACHONE; CISPLATIN; DOXORUBICIN; LAPACHOL; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN C JUN; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; ESOPHAGUS CANCER; FIBROBLAST; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; PROTEIN CLEAVAGE; PROTON NUCLEAR MAGNETIC RESONANCE; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; ESOPHAGEAL NEOPLASMS; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NAPHTHOQUINONES; NIH 3T3 CELLS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84872683746     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.12.048     Document Type: Article

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