Comparison of the cytotoxic effect of lapachol, α-lapachone and pentacyclic 1,4-naphthoquinones on human leukemic cells

Investigational New Drugs

Volumn 28, Issue 2, 2010, Pages 139-144

  Salustiano, Eduardo J S ^a   Netto, Chaquip D ^a   Fernandes, Renata F ^a   Da Silva, Alcides J M ^a   Bacelar, Thiago S ^a   Castro, Carolina P ^a   Buarque, Camilla D ^a   Maia, Raquel C ^b   Rumjanek, Vivian M ^a   Costa, Paulo R R ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b INSTITUTO NACIONAL DE CÂNCER   (Brazil)

Author keywords

Lapachone; Lapachol; Leukemia; Multidrug resistance; Naphthoquinones; Oxidative stress

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; ALKYLATING AGENT; ALPHA LAPACHONE; ANTINEOPLASTIC AGENT; LAPACHOL; MITOMYCIN C; PHYTOHEMAGGLUTININ; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CELL PROLIFERATION; CELL STRAIN K 562; CONCENTRATION RESPONSE; CONTROLLED STUDY; DAUDI CELL; DRUG CYTOTOXICITY; DRUG SELECTIVITY; DRUG SENSITIVITY; DRUG STRUCTURE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL; LYMPHOCYTE; PRIORITY JOURNAL; REDUCTION;

CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; LEUKEMIA; LEUKOCYTES, MONONUCLEAR; MITOMYCIN; NAPHTHOQUINONES;

EID: 77951063424     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-009-9231-y     Document Type: Article

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