Synthesis and potent antitumor activity of new arylamino derivatives of nor-β-lapachone and nor-α-lapachone

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 22, 2007, Pages 7035-7041

  da Silva Júnior, Eufrânio N ^a   de Souza, Maria Cecília B V ^a   Pinto, Antônio V ^b   Pinto, Maria do Carmo F R ^b   Goulart, Marilia O F ^c   Barros, Francisco W A ^d   Pessoa, Claudia ^d   Costa Lotufo, Letícia V ^d   Montenegro, Raquel C ^d   de Moraes, Manoel O ^d   Ferreira, Vitor F ^a  

^a FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c FEDERAL UNIVERSITY OF ALAGOAS   (Brazil)

^d FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

Cancer; Cytotoxicity; Dihydrofuranonaphthoquinones; Lapachones

Indexed keywords

2,2 DIMETHYL 3 (4 NITROPHENYLAMINO) 2,3 DIHYDRONAPHTHO[1,2 B]FURAN 4,5 DIONE; 2,2 DIMETHYL 3 PHENYLAMINO 2,3 DIHYDRONAPHTHO[2,3 B]FURAN 4,9 DIONE; 3 (2,5 DIMETHYLPHENYLAMINO) 2,2 DIMETHYL 2,3 DIHYDRONAPHTHO[1,2 B]FURAN 4,5 DIONE; 3 (4 BROMOPHENYLAMINO) 2,2 DIMETHYL 2,3 DIHYDRONAPHTHO[1,2 B]FURAN 4,5 DIONE; 3 (4 CHLOROPHENYLAMINO) 2,2 DIMETHYL 2,3 DIHYDRONAPHTHO[1,2 B]FURAN 4,5 DIONE; 3 (4 FLUOROPHENYLAMINO) 2,2 DIMETHYL 2,3 DIHYDRONAPHTHO[1,2 B]FURAN 4,5 DIONE; ANTINEOPLASTIC AGENT; DOXORUBICIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL; CELL STRAIN L 929; CENTRAL NERVOUS SYSTEM; COLON CANCER; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; FIBROBLAST; HEMOLYSIS; IC 50; LEUKEMIA CELL; MELANOMA CELL; NONHUMAN; PROSTATE CANCER;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL MEMBRANE; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICE; MOLECULAR STRUCTURE; NAPHTHOQUINONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

MURINAE;

EID: 34548851156     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.07.043     Document Type: Article

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