The endothelial plasma membrane transporter bilitranslocase mediates rat aortic vasodilation induced by anthocyanins

Nutrition, Metabolism and Cardiovascular Diseases

Volumn 23, Issue 1, 2013, Pages 68-74

  Ziberna, L ^a   Lunder, M ^a   Tramer, F ^b   Drevensek G ^a   Passamonti, S ^b  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Bilitranslocase; Flavonoids; Membrane transport; Rat aorta; Vasodilation

Indexed keywords

ANTHOCYANIN; ANTIBODY; BILITRANSLOCASE; CYANIDIN 3 O GLUCOSIDE; CYANIDIN 3-O-GLUCOSIDE; GLUCOSIDE; MEMBRANE PROTEIN;

ANIMAL; ARTICLE; CELL MEMBRANE; CHEMISTRY; DRUG EFFECT; FRUIT; IMMUNOLOGY; MALE; PHYSIOLOGY; RAT; THORACIC AORTA; ULTRASTRUCTURE; VACCINIUM MYRTILLUS; VASCULAR ENDOTHELIUM; VASODILATATION; WISTAR RAT;

ANIMALS; ANTHOCYANINS; ANTIBODIES; AORTA, THORACIC; CELL MEMBRANE; ENDOTHELIUM, VASCULAR; FRUIT; GLUCOSIDES; MALE; MEMBRANE PROTEINS; RATS; RATS, WISTAR; VACCINIUM MYRTILLUS; VASODILATION;

RATTUS; RATTUS NORVEGICUS; VACCINIUM MYRTILLUS;

EID: 84872682955     PISSN: 09394753     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.numecd.2011.02.005     Document Type: Article

References (30)

1. Dohadwala M.M., Vita J.A. Grapes and cardiovascular disease. J Nutr 2009, 139:1788S-1793S.
2. Hooper L., Kroon P., Rimm E., Cohn J., Harvey I., Le Cornu K., et al. Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. Am J Clin Nutr 2008, 88:38-50.
3. Bell D., Gochenaur K. Direct vasoactive and vasoprotective properties of anthocyanin-rich extracts. J Appl Physiol 2006, 100:1164-1170.
4. Andriambeloson E., Magnier C., Haan-Archipoff G., Lobstein A., Anton R., Beretz A., et al. Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta. J Nutr 1998, 128:2324-2333.
5. Ndiaye M., Chataigneau M., Lobysheva I., Chataigneau T., Schini-Kerth V.B. Red wine polyphenol-induced, endothelium-dependent NO-mediated relaxation is due to the redox-sensitive PI3-kinase/Akt-dependent phosphorylation of endothelial NO-synthase in the isolated porcine coronary artery. FASEB J 2005, 19:455-457.
6. Madeira S.V.F., Auger C., Anselm E., Chataigneau M., Chataigneau T., Soares de Moura R., et al. eNOS activation induced by a polyphenol-rich grape skin extract in porcine coronary arteries. J Vasc Res 2009, 46:406-416.
7. Dobson P.D., Kell D.B. Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?. Nat Rev Drug Discov 2008, 7:205-220.
8. Passamonti S., Terdoslavich M., Franca R., Vanzo A., Tramer F., Braidot E., et al. Bioavailability of flavonoids: a review of their membrane transport and the function of bilitranslocase in animal and plant organisms. Curr Drug Metab 2009, 10:369-394.
9. Maestro A., Terdoslavich M., Vanzo A., Kuku A., Tramer F., Nicolin V., et al. Expression of bilitranslocase in the vascular endothelium and its function as a flavonoid transporter. Cardiovasc Res 2010, 85:175-183.
10. Battiston L., Passamonti S., Macagno A., Sottocasa G.L. The bilirubin-binding motif of bilitranslocase and its relation to conserved motifs in ancient biliproteins. Biochem Biophys Res Commun 1998, 247:687-692.
11. Passamonti S., Cocolo A., Braidot E., Petrussa E., Peresson C., Medic N., et al. Characterization of electrogenic bromosulfophthalein transport in carnation petal microsomes and its inhibition by antibodies against bilitranslocase. FEBS J 2005, 272:3282-3296.
12. Ziberna L., Lunder M., Kuzner J., Drevensek G. Normothermic and hypothermic models for studying the deleterious effects of hypoxia-reoxygenation on EDHF-mediated relaxation in isolated porcine coronary arteries. J Pharmacol Toxicol Methods 2009, 59:1-6.
13. Passamonti S., Vanzo A., Vrhovsek U., Terdoslavich M., Cocolo A., Decorti G., et al. Hepatic uptake of grape anthocyanins and the role of bilitranslocase. Food Res Int 2005, 38:953-960.
14. Passamonti S., Battiston L., Sottocasa G.L. Arylsulfonylation of bilitranslocase in plasma membranes from rat liver enables to discriminate between natural and artificial substrates. Biochim Biophys Acta 1997, 1323:130-136.
15. Passamonti S., Terdoslavich M., Margon A., Cocolo A., Medic N., Micali F., et al. Uptake of bilirubin into HepG2 cells assayed by thermal lens spectroscopy. Function of bilitranslocase. FEBS J 2005, 272:5522-5535.
16. Passamonti S., Vrhovsek U., Mattivi F. The interaction of anthocyanins with bilitranslocase. Biochem Biophys Res Commun 2002, 296:631-636.
17. Burns J., Gardner P.T., O'Neil J., Crawford S., Morecroft I., McPhail D.B., et al. Relationship among antioxidant activity, vasodilation capacity, and phenolic content of red wines. J Agric Food Chem 2000, 48:220-230.
18. Marczylo T.H., Cooke D., Brown K., Steward W.P., Gescher A.J. Pharmacokinetics and metabolism of the putative cancer chemopreventive agent cyanidin-3-glucoside in mice. Cancer Chemother Pharmacol 2009, 64:1261-1268.
19. Galvano F., La Fauci L., Vitaglione P., Fogliano V., Vanella L., Felgines C. Bioavailability, antioxidant and biological properties of the natural free-radical scavengers cyanidin and related glycosides. Ann Ist Super Sanita 2007, 43:382-393.
20. Hashimoto M., Kim S., Eto M., Iijima K., Ako J., Yoshizumi M., et al. Effect of acute intake of red wine on flow-mediated vasodilatation of the brachial artery. Am J Cardiol 2001, 88:1457-1460. A9.
21. Heinonen M. Antioxidant activity and antimicrobial effect of berry phenolics-a Finnish perspective. Mol Nutr Food Res 2007, 51:684-691.
22. Kähkönen M.P., Hopia A.I., Heinonen M. Berry phenolics and their antioxidant activity. J Agric Food Chem 2001, 49:4076-4082.
23. Xu J., Ikeda K., Yamori Y. Cyanidin-3-glucoside regulates phosphorylation of endothelial nitric oxide synthase. FEBS Lett 2004, 574:176-180.
24. Ndiaye M., Chataigneau T., Andriantsitohaina R., Stoclet J.-C., Schini-Kerth V.B. Red wine polyphenols cause endothelium-dependent EDHF-mediated relaxations in porcine coronary arteries via a redox-sensitive mechanism. Biochem Biophys Res Commun 2003, 310:371-377.
25. Ullrich V., Bachschmid M. Superoxide as a messenger of endothelial function. Biochem Biophys Res Commun 2000, 278:1-8.
26. Cunningham P., Afzal-Ahmed I., Naftalin R. Docking studies show that D-glucose and quercetin slide through the transporter GLUT1. J Biol Chem 2006, 281:5797-5803.
27. Walle T., Walle U. The beta-D-glucoside and sodium-dependent glucose transporter 1 (SGLT1)-inhibitor phloridzin is transported by both SGLT1 and multidrug resistance-associated proteins 1/2. Drug Metab Dispos 2003, 31:1288-1291.
28. Mandery K., Bujok K., Schmidt I., Keiser M., Siegmund W., Bettina B., et al. Influence of the flavonoids apigenin, kaempferol and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1. Biochem Pharmacol 2010.
29. Wang X., Wolkoff A., Morris M. Flavonoids as a novel class of human organic anion-transporting polypeptide OATP1B1 (OATP-C) modulators. Drug Metab Dispos 2005, 33:1666-1672.
30. Dreiseitel A., Oosterhuis B., Vukman K.V., Schreier P., Oehme A., Locher S., et al. Berry anthocyanins and anthocyanidins exhibit distinct affinities for the efflux transporters BCRP and MDR1. Br J Pharmacol 2009, 158:1942-1950.