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Volumn 272, Issue 13, 2005, Pages 3282-3296

Characterization of electrogenic bromosulfophthalein transport in carnation petal microsomes and its inhibition by antibodies against bilitranslocase

Author keywords

Anthocyanin; Bilitranslocase; Bromosulfophthalein; Liver, plant

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ANTHOCYANIN; ANTIBODY; BILIRUBIN; BILITRANSLOCASE; BILIVERDIN; BROMSULFOPHTHALEIN; CARRIER PROTEIN; CYANIDIN 3 GLUCOSIDE; FLUORESCEIN ISOTHIOCYANATE; MEMBRANE PROTEIN; NICOTINIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; UNCLASSIFIED DRUG; VALINOMYCIN;

EID: 22144495427     PISSN: 1742464X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2005.04751.x     Document Type: Article
Times cited : (38)

References (59)
  • 1
    • 0036011081 scopus 로고    scopus 로고
    • Biosynthesis of flavonoids and effects of stress
    • Winkel-Shirley B (2002) Biosynthesis of flavonoids and effects of stress. Curr Opin Plant Biol 5, 218-223.
    • (2002) Curr Opin Plant Biol , vol.5 , pp. 218-223
    • Winkel-Shirley, B.1
  • 2
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer
    • Middleton E Jr, Kandaswami C & Theoharides TC (2000) The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 52, 673-751.
    • (2000) Pharmacol Rev , vol.52 , pp. 673-751
    • Middleton Jr., E.1    Kandaswami, C.2    Theoharides, T.C.3
  • 5
    • 0001136503 scopus 로고
    • Compartmentation of plant phenolic compounds; sites of synthesis and accumulation
    • Hrazdina G & Wagner GJ (1985) Compartmentation of plant phenolic compounds; sites of synthesis and accumulation. Annu Proc Phytochem Soc Eur 25, 119-133.
    • (1985) Annu Proc Phytochem Soc Eur , vol.25 , pp. 119-133
    • Hrazdina, G.1    Wagner, G.J.2
  • 6
    • 0033607282 scopus 로고    scopus 로고
    • Interactions among enzymes of the Arabidopsis flavonoid biosynthetic pathway
    • Burbulis IE & Winkel-Shirley B (1999) Interactions among enzymes of the Arabidopsis flavonoid biosynthetic pathway. Proc Natl Acad Sci USA 96, 12929-12934.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 12929-12934
    • Burbulis, I.E.1    Winkel-Shirley, B.2
  • 7
    • 0344165918 scopus 로고
    • Compartmentation in natural product biosynthesis by multienzyme complexes
    • (Conn EE, ed). Academic Press, New York
    • Stafford HA (1981) Compartmentation in natural product biosynthesis by multienzyme complexes. In The Biochemistry of Plants (Conn EE, ed), pp. 117-137. Academic Press, New York.
    • (1981) The Biochemistry of Plants , pp. 117-137
    • Stafford, H.A.1
  • 8
    • 0037072486 scopus 로고    scopus 로고
    • Transcription factors controlling plant secondary metabolism: What regulates the regulators?
    • Vom Endt D, Kijne JW & Memelink J (2002) Transcription factors controlling plant secondary metabolism: what regulates the regulators? Phytochemistry 61, 107-114.
    • (2002) Phytochemistry , vol.61 , pp. 107-114
    • Vom Endt, D.1    Kijne, J.W.2    Memelink, J.3
  • 9
    • 1842411478 scopus 로고    scopus 로고
    • Metabolic engineering: Prospects for crop improvement through the genetic manipulation of phenylpropanoid biosynthesis and defense responses - A review
    • Dixon RA, Lamb CJ, Masoud S, Sewalt VJ & Paiva NL (1996) Metabolic engineering: prospects for crop improvement through the genetic manipulation of phenylpropanoid biosynthesis and defense responses - a review. Gene 179, 61-71.
    • (1996) Gene , vol.179 , pp. 61-71
    • Dixon, R.A.1    Lamb, C.J.2    Masoud, S.3    Sewalt, V.J.4    Paiva, N.L.5
  • 10
    • 0029909552 scopus 로고    scopus 로고
    • Different energization mechanisms drive the vacuolar uptake of a flavonoid glucoside and a herbicide glucoside
    • Klein M, Weissenbock G, Dufaud A, Gaillard C, Kreuz K & Martinoia E (1996) Different energization mechanisms drive the vacuolar uptake of a flavonoid glucoside and a herbicide glucoside. J Biol Chem 271, 29666-29671.
    • (1996) J Biol Chem , vol.271 , pp. 29666-29671
    • Klein, M.1    Weissenbock, G.2    Dufaud, A.3    Gaillard, C.4    Kreuz, K.5    Martinoia, E.6
  • 11
    • 0035781089 scopus 로고    scopus 로고
    • Tonoplast transporters: Organization and function
    • Maeshima M (2001) Tonoplast transporters: organization and function. Annu Rev Plant Physiol Plant Mol Biol 52, 469-197.
    • (2001) Annu Rev Plant Physiol Plant Mol Biol , vol.52 , pp. 469-1197
    • Maeshima, M.1
  • 12
    • 0035037365 scopus 로고    scopus 로고
    • The transparent TESTA12 gene of Arabidopsis encodes a multidrug secondary transporter-like protein required for flavonoid sequestration in vacuoles of the seed coat endothelium
    • Debeaujon I, Peeters AJ, Leon-Kloosterziel KM & Koornneef M (2001) The transparent TESTA12 gene of Arabidopsis encodes a multidrug secondary transporter-like protein required for flavonoid sequestration in vacuoles of the seed coat endothelium. Plant Cell 13, 853-871.
    • (2001) Plant Cell , vol.13 , pp. 853-871
    • Debeaujon, I.1    Peeters, A.J.2    Leon-Kloosterziel, K.M.3    Koornneef, M.4
  • 14
    • 0001791972 scopus 로고
    • The uptake of acylated anthocyanin into isolated vacuoles from a cell suspension culture of Daucus carota
    • Hopp W & Seitz HU (1987) The uptake of acylated anthocyanin into isolated vacuoles from a cell suspension culture of Daucus carota. Planta 170, 74-85.
    • (1987) Planta , vol.170 , pp. 74-85
    • Hopp, W.1    Seitz, H.U.2
  • 15
    • 0020575878 scopus 로고
    • Conformational changes of apigenin 7-O-(6-O-malonylglucoside), a vacuolar pigment from parsley, with solvent composition and proton concentration
    • Matern U, Heller W & Himmelspach K (1983) Conformational changes of apigenin 7-O-(6-O-malonylglucoside), a vacuolar pigment from parsley, with solvent composition and proton concentration. Eur J Biochem 133, 439-448.
    • (1983) Eur J Biochem , vol.133 , pp. 439-448
    • Matern, U.1    Heller, W.2    Himmelspach, K.3
  • 17
    • 0033047445 scopus 로고    scopus 로고
    • MRP subfamily ABC transporters from plants and yeast
    • Rea PA (1999) MRP subfamily ABC transporters from plants and yeast. J Exp Bot 50, 895-913.
    • (1999) J Exp Bot , vol.50 , pp. 895-913
    • Rea, P.A.1
  • 18
    • 0000571968 scopus 로고    scopus 로고
    • Vacuolar transport of secondary metabolites and xenobiotics
    • (Robinson D & Rogers J, eds). Sheffield Academic Press, Sheffield, UK
    • Martinoia E, Klein M, Gessler M, Sánchez-Fernández R & Rea PA (2001) Vacuolar transport of secondary metabolites and xenobiotics. In Vacuolar Compartments (Robinson D & Rogers J, eds), pp. 221-253. Sheffield Academic Press, Sheffield, UK.
    • (2001) Vacuolar Compartments , pp. 221-253
    • Martinoia, E.1    Klein, M.2    Gessler, M.3    Sánchez-Fernández, R.4    Rea, P.A.5
  • 19
    • 3142741194 scopus 로고    scopus 로고
    • A multidrug resistance-associated protein involved in anthocyanin transport in Zea mays
    • Goodman CD, Casati P & Walbot V (2004) A multidrug resistance-associated protein involved in anthocyanin transport in Zea mays. Plant Cell 16, 1812-1826.
    • (2004) Plant Cell , vol.16 , pp. 1812-1826
    • Goodman, C.D.1    Casati, P.2    Walbot, V.3
  • 20
    • 0036851184 scopus 로고    scopus 로고
    • Alternate energy-dependent pathways for the vacuolar uptake of glucose and glutathione conjugates
    • Bartholomew DM, Van Dyk DE, Lau SM, O'Keefe DP, Rea PA & Viitanen PV (2002) Alternate energy-dependent pathways for the vacuolar uptake of glucose and glutathione conjugates. Plant Physiol 130, 1562-1572.
    • (2002) Plant Physiol , vol.130 , pp. 1562-1572
    • Bartholomew, D.M.1    Van Dyk, D.E.2    Lau, S.M.3    O'Keefe, D.P.4    Rea, P.A.5    Viitanen, P.V.6
  • 21
    • 0032125377 scopus 로고    scopus 로고
    • Functional complementation of anthocyanin sequestration in the vacuole by widely divergent glutathione S-transferases
    • Alfenito MR, Souer E, Goodman CD, Buell R, Mol J, Koes R & Walbot V (1998) Functional complementation of anthocyanin sequestration in the vacuole by widely divergent glutathione S-transferases. Plant Cell 10, 1135-1149.
    • (1998) Plant Cell , vol.10 , pp. 1135-1149
    • Alfenito, M.R.1    Souer, E.2    Goodman, C.D.3    Buell, R.4    Mol, J.5    Koes, R.6    Walbot, V.7
  • 22
    • 0345874786 scopus 로고    scopus 로고
    • TRANSPARENT TESTA 19 is involved in the accumulation of both anthocyanins and proanthocyanidins in Arabidopsis
    • Kitamura S, Shikazono N & Tanaka A (2004) TRANSPARENT TESTA 19 is involved in the accumulation of both anthocyanins and proanthocyanidins in Arabidopsis. Plant J 37, 104-114.
    • (2004) Plant J , vol.37 , pp. 104-114
    • Kitamura, S.1    Shikazono, N.2    Tanaka, A.3
  • 23
    • 0033845760 scopus 로고    scopus 로고
    • AN9, a petunia glutathione S-transferase required for anthocyanin sequestration, is a flavonoid-binding protein
    • Mueller LA, Goodman CD, Silady RA & Walbot V (2000) AN9, a petunia glutathione S-transferase required for anthocyanin sequestration, is a flavonoid-binding protein. Plant Physiol 123, 1561-1570.
    • (2000) Plant Physiol , vol.123 , pp. 1561-1570
    • Mueller, L.A.1    Goodman, C.D.2    Silady, R.A.3    Walbot, V.4
  • 24
    • 4644298103 scopus 로고    scopus 로고
    • The challenges of moving chemicals within and out of cells: Insights into the transport of plant natural products
    • Grotewold E (2004) The challenges of moving chemicals within and out of cells: insights into the transport of plant natural products. Planta 219, 906-909.
    • (2004) Planta , vol.219 , pp. 906-909
    • Grotewold, E.1
  • 25
    • 0343603660 scopus 로고    scopus 로고
    • A functional-phylogenetic classification system for transmembrane solute transporters
    • Saier MH Jr (2000) A functional-phylogenetic classification system for transmembrane solute transporters. Microbiol Mol Biol Rev 64, 354-411.
    • (2000) Microbiol Mol Biol Rev , vol.64 , pp. 354-411
    • Saier Jr., M.H.1
  • 26
    • 0024804335 scopus 로고
    • Isolation of bilitranslocase, the anion transporter from liver plasma membrane for bilirubin and other organic anions
    • Sottocasa GL, Lunazzi GC & Tiribelli C (1989) Isolation of bilitranslocase, the anion transporter from liver plasma membrane for bilirubin and other organic anions. Methods Enzymol 174, 50-57.
    • (1989) Methods Enzymol , vol.174 , pp. 50-57
    • Sottocasa, G.L.1    Lunazzi, G.C.2    Tiribelli, C.3
  • 27
    • 0025319731 scopus 로고
    • Reconstitution of sulfobromophthalein transport in erythrocyte membranes induced by bilitranslocase
    • Miccio M, Lunazzi GC, Gazzin B & Sottocasa GL (1990) Reconstitution of sulfobromophthalein transport in erythrocyte membranes induced by bilitranslocase. Biochim Biophys Acta 1023, 140-142.
    • (1990) Biochim Biophys Acta , vol.1023 , pp. 140-142
    • Miccio, M.1    Lunazzi, G.C.2    Gazzin, B.3    Sottocasa, G.L.4
  • 29
    • 18144387251 scopus 로고    scopus 로고
    • Immunolocalisation of bilitranslocase in mucosecretory and parietal cells of the rat gastric mucosa
    • Nicolin V, Grill V, Micali F, Narducci P & Passamonti S (2005) Immunolocalisation of bilitranslocase in mucosecretory and parietal cells of the rat gastric mucosa. J Mol Histol 36, 45-50.
    • (2005) J Mol Histol , vol.36 , pp. 45-50
    • Nicolin, V.1    Grill, V.2    Micali, F.3    Narducci, P.4    Passamonti, S.5
  • 31
    • 0038018460 scopus 로고    scopus 로고
    • The stomach as a site for anthocyanins absorption from food
    • Passamonti S, Vrhovsek U, Vanzo A & Mattivi F (2003) The stomach as a site for anthocyanins absorption from food. FEBS Lett 544, 210-213.
    • (2003) FEBS Lett , vol.544 , pp. 210-213
    • Passamonti, S.1    Vrhovsek, U.2    Vanzo, A.3    Mattivi, F.4
  • 32
    • 0001448624 scopus 로고
    • Acceleration of membrane senescence in cut carnation flowers by treatment with ethylene
    • Thompson JE, Mayak S, Shinitzky M & Halevy AH (1982) Acceleration of membrane senescence in cut carnation flowers by treatment with ethylene. Plant Physiol 69, 859-863.
    • (1982) Plant Physiol , vol.69 , pp. 859-863
    • Thompson, J.E.1    Mayak, S.2    Shinitzky, M.3    Halevy, A.H.4
  • 33
    • 0000587140 scopus 로고
    • Free radical production, catalase and superoxide dismutase activities and membrane integrity during senescence of petals of cut carnations (Dianthus caryophyllus)
    • Droillard MJ, Paulin A & Massot JC (1987) Free radical production, catalase and superoxide dismutase activities and membrane integrity during senescence of petals of cut carnations (Dianthus caryophyllus). Physiologia Plantarum 71, 197-202.
    • (1987) Physiologia Plantarum , vol.71 , pp. 197-202
    • Droillard, M.J.1    Paulin, A.2    Massot, J.C.3
  • 34
    • 0023777589 scopus 로고
    • The quinoid structure is the molecular requirement for recognition of phthaleins by the organic anion carrier at the sinusoidal plasma membrane level in the liver
    • Passamonti S & Sottocasa GL (1988) The quinoid structure is the molecular requirement for recognition of phthaleins by the organic anion carrier at the sinusoidal plasma membrane level in the liver. Biochim Biophys Acta 943, 119-125.
    • (1988) Biochim Biophys Acta , vol.943 , pp. 119-125
    • Passamonti, S.1    Sottocasa, G.L.2
  • 35
    • 0024580791 scopus 로고
    • Bilitranslocase is the protein responsible for the electrogenic movement of sulfobromophthalein in plasma membrane vesicles from rat liver: Immunochemical evidence using mono- and poly-clonal antibodies
    • Miccio M, Baldini G, Basso V, Gazzin B, Lunazzi GC, Tiribelli C & Sottocasa GL (1989) Bilitranslocase is the protein responsible for the electrogenic movement of sulfobromophthalein in plasma membrane vesicles from rat liver: immunochemical evidence using mono- and poly-clonal antibodies. Biochim Biophys Acta 981, 115-120.
    • (1989) Biochim Biophys Acta , vol.981 , pp. 115-120
    • Miccio, M.1    Baldini, G.2    Basso, V.3    Gazzin, B.4    Lunazzi, G.C.5    Tiribelli, C.6    Sottocasa, G.L.7
  • 36
    • 0032054945 scopus 로고    scopus 로고
    • Bilitranslocase can exist in two metastable forms with different affinities for the substrates - Evidence from cysteine and arginine modification
    • Passamonti S, Battiston L & Sottocasa GL (1998) Bilitranslocase can exist in two metastable forms with different affinities for the substrates - evidence from cysteine and arginine modification. Eur J Biochem 253, 84-90.
    • (1998) Eur J Biochem , vol.253 , pp. 84-90
    • Passamonti, S.1    Battiston, L.2    Sottocasa, G.L.3
  • 37
    • 0034730853 scopus 로고    scopus 로고
    • Gastric uptake of nicotinic acid by bilitranslocase
    • Passamonti S, Battiston L & Sottocasa GL (2000) Gastric uptake of nicotinic acid by bilitranslocase. FEBS Lett 482, 167-168.
    • (2000) FEBS Lett , vol.482 , pp. 167-168
    • Passamonti, S.1    Battiston, L.2    Sottocasa, G.L.3
  • 38
    • 0023645201 scopus 로고
    • Refined three-dimensional structures of two cyanobacterial C-phycocyanins at 2.1 and 2.5 Å resolution. A common principle of phycobilin-protein interaction
    • Schirmer T, Bode W & Huber R (1987) Refined three-dimensional structures of two cyanobacterial C-phycocyanins at 2.1 and 2.5 Å resolution. A common principle of phycobilin-protein interaction. J Mol Biol 196, 677-695.
    • (1987) J Mol Biol , vol.196 , pp. 677-695
    • Schirmer, T.1    Bode, W.2    Huber, R.3
  • 39
    • 0032577917 scopus 로고    scopus 로고
    • The bilirubin-binding motif of bilitranslocase and its relation to conserved motifs in ancient biliproteins
    • Battiston L, Passamonti S, Macagno A & Sottocasa GL (1998) The bilirubin-binding motif of bilitranslocase and its relation to conserved motifs in ancient biliproteins. Biochem Biophys Res Commun 247, 687-692.
    • (1998) Biochem Biophys Res Commun , vol.247 , pp. 687-692
    • Battiston, L.1    Passamonti, S.2    Macagno, A.3    Sottocasa, G.L.4
  • 40
    • 0013808999 scopus 로고
    • Pyruvate carboxylase. V. Interaction of the enzyme with adenosine triphosphate
    • Scrutton MC & Utter MF (1965) Pyruvate carboxylase. V. Interaction of the enzyme with adenosine triphosphate. J Biol Chem 240, 3714-3723.
    • (1965) J Biol Chem , vol.240 , pp. 3714-3723
    • Scrutton, M.C.1    Utter, M.F.2
  • 41
    • 0028305406 scopus 로고
    • Isolation of highly purified plant plasma membranes and the separation of inside-out and right-side-out vesicles
    • Larsson C, Sommarin M & Widell S (1994) Isolation of highly purified plant plasma membranes and the separation of inside-out and right-side-out vesicles. Methods Enzymol 228, 451-469.
    • (1994) Methods Enzymol , vol.228 , pp. 451-469
    • Larsson, C.1    Sommarin, M.2    Widell, S.3
  • 42
    • 0033863355 scopus 로고    scopus 로고
    • Dietary intake and bioavailability of polyphenols
    • Scalbert A & Williamson G (2000) Dietary intake and bioavailability of polyphenols. J Nutr 130, 2073S-2085S.
    • (2000) J Nutr , vol.130
    • Scalbert, A.1    Williamson, G.2
  • 44
    • 0000611658 scopus 로고
    • Chemical structure of anthocyanins
    • (Markakis P, ed). Academic Press, New York
    • Brouillard R (1982) Chemical structure of anthocyanins. In Anthocyanins as Food Colors (Markakis P, ed), pp. 1-40. Academic Press, New York.
    • (1982) Anthocyanins as Food Colors , pp. 1-40
    • Brouillard, R.1
  • 45
    • 0032718566 scopus 로고    scopus 로고
    • +-pumping ATPases. Regulation and biosynthesis
    • +-pumping ATPases. Regulation and biosynthesis. Plant Cell 11, 677-690.
    • (1999) Plant Cell , vol.11 , pp. 677-690
    • Sze, H.1    Li, X.2    Palmgren, M.G.3
  • 47
    • 0027375830 scopus 로고
    • Localization of glutathione conjugation activities toward bromosulfophthalein in perfused rat liver. Studies with the multiple indicator dilution technique
    • Zhao Y, Snel CA, Mulder GJ & Pang KS (1993) Localization of glutathione conjugation activities toward bromosulfophthalein in perfused rat liver. Studies with the multiple indicator dilution technique. Drug Metab Dispos 21, 1070-1078.
    • (1993) Drug Metab Dispos , vol.21 , pp. 1070-1078
    • Zhao, Y.1    Snel, C.A.2    Mulder, G.J.3    Pang, K.S.4
  • 50
    • 0023247203 scopus 로고
    • Measurement of sulfobromophthalein uptake in isolated rat hepatocytes by a direct spectrophotometric method
    • Persico M & Sottocasa GL (1987) Measurement of sulfobromophthalein uptake in isolated rat hepatocytes by a direct spectrophotometric method. Biochim Biophys Acta 930, 129-134.
    • (1987) Biochim Biophys Acta , vol.930 , pp. 129-134
    • Persico, M.1    Sottocasa, G.L.2
  • 51
    • 0023686908 scopus 로고
    • Binding of sulfobromophthalein to rat and human ligandins: Characterization of a binding-site peptide
    • Bhargava MM & Dasgupta A (1988) Binding of sulfobromophthalein to rat and human ligandins: characterization of a binding-site peptide. Biochim Biophys Acta 955, 296-300.
    • (1988) Biochim Biophys Acta , vol.955 , pp. 296-300
    • Bhargava, M.M.1    Dasgupta, A.2
  • 52
    • 0020081385 scopus 로고
    • Role of ligandin as a binding protein and as an enzyme in the biliary excretion of sulfobromophthalein
    • Gregus Z & Klaassen CD (1982) Role of ligandin as a binding protein and as an enzyme in the biliary excretion of sulfobromophthalein. J Pharmacol Exp Ther 221, 242-246.
    • (1982) J Pharmacol Exp Ther , vol.221 , pp. 242-246
    • Gregus, Z.1    Klaassen, C.D.2
  • 54
    • 0027999314 scopus 로고
    • Lipoxygenase activity associated to isolated soybean plasma membranes
    • Macri F, Braidot E, Petrussa E & Vianello A (1994) Lipoxygenase activity associated to isolated soybean plasma membranes. Biochim Biophys Acta 1215, 109-114.
    • (1994) Biochim Biophys Acta , vol.1215 , pp. 109-114
    • Macri, F.1    Braidot, E.2    Petrussa, E.3    Vianello, A.4
  • 56
    • 0018123351 scopus 로고
    • Sodium-dependent alanine transport in plasmamembrane vesicles from rat liver
    • van Amelsvoort JM, Sips HJ & van Dam K (1978) Sodium-dependent alanine transport in plasmamembrane vesicles from rat liver. Biochem J 174, 1083-1086.
    • (1978) Biochem J , vol.174 , pp. 1083-1086
    • Van Amelsvoort, J.M.1    Sips, H.J.2    Van Dam, K.3
  • 57
    • 23144433236 scopus 로고    scopus 로고
    • Bilitranslocase: Structural and functional aspects of an organic anion carrier
    • (Pandalai GS, ed). Research Signpost, Kerala, India, Kerala
    • Passamonti S & Sottocasa GL (2002) Bilitranslocase: structural and functional aspects of an organic anion carrier. In Recent Research Developments in Biochemistry (Pandalai GS, ed), pp. 371-391. Research Signpost, Kerala, India, Kerala.
    • (2002) Recent Research Developments in Biochemistry , pp. 371-391
    • Passamonti, S.1    Sottocasa, G.L.2
  • 58
    • 0018396166 scopus 로고
    • Bilirubin. Solubility and interaction with albumin and phospholipid
    • Brodersen R (1979) Bilirubin. Solubility and interaction with albumin and phospholipid. J Biol Chem 254, 2364-2369.
    • (1979) J Biol Chem , vol.254 , pp. 2364-2369
    • Brodersen, R.1


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