Normothermic and hypothermic models for studying the deleterious effects of hypoxia-reoxygenation on EDHF-mediated relaxation in isolated porcine coronary arteries

Journal of Pharmacological and Toxicological Methods

Volumn 59, Issue 1, 2009, Pages 1-6

  Ziberna, Lovro ^a   Lunder, Mojca ^a,b   Kužner, Jernej ^a   Drevenšek, Gorazd ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

Author keywords

EDHF; Hypothermic hypoxia reoxygenation model; Hypoxia reoxygenation injury; Isolated porcine coronary artery; Normothermic hypoxia reoxygenation model

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; INDOMETACIN; N(G) NITROARGININE; SUBSTANCE P;

ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; DRUG MECHANISM; EXPERIMENTAL MODEL; HYPOTHERMIC HYPOXIA REOXYGENATION MODEL; HYPOXIA; NONHUMAN; NORMOTHERMIC HYPOXIA REOXYGENATION MODEL; PROTEIN FUNCTION; REOXYGENATION; SWINE; VASODILATATION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANIMALS; ANOXIA; BIOLOGICAL FACTORS; CARBON DIOXIDE; CELL HYPOXIA; CORONARY VESSELS; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPOTHERMIA; MODELS, BIOLOGICAL; MUSCLE, SMOOTH, VASCULAR; NEUROTRANSMITTER AGENTS; NITRIC OXIDE SYNTHASE; NITROARGININE; ORGAN CULTURE TECHNIQUES; OXYGEN; REPRODUCIBILITY OF RESULTS; SUBSTANCE P; SUS SCROFA; TEMPERATURE; TIME FACTORS; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASODILATION;

SUS;

EID: 58149457588     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2008.09.003     Document Type: Article

References (30)

1. Cheung D.W., Chen G., MacKay M.J., and Burnette E. Regulation of vascular tone by endothelium-derived hyperpolarizing factor. Clinical and Experimental Pharmacology and Physiology 26 (1999) 172-175
2. Cohen R.A., and Vanhoutte P.M. Endothelium-dependent hyperpolarization. Beyond nitric oxide and cyclic GMP. Circulation 92 (1995) 3337-3349
3. Dae M.W., Gao D.W., Sessler D.I., Chair K., and Stillson C.A. Effect of endovascular cooling on myocardial temperature, infarct size, and cardiac output in human-sized pigs. American Journal of Physiology 282 (2002) H1584-1591
4. Dauber I.M., Lesnefsky E.J., VanBenthuysen K.M., Weil J.V., and Horwitz L.D. Reactive oxygen metabolite scavengers decrease functional coronary microvascular injury due to ischemia-reperfusion. The American Journal of Physiology 260 (1991) H42-49
5. Dong Y.Y., Wu M., Yim A.P., and He G.W. Effect of hypoxia-reoxygenation on endothelial function in porcine cardiac microveins. The Annals of Thoracic Surgery 81 (2006) 1708-1714
6. Garg S., Hofstra L., Reutelingsperger C., and Narula J. Apoptosis as a therapeutic target in acutely ischemic myocardium. Current Opinion in Cardiology 18 (2003) 372-377
7. Globus M.Y., Busto R., Lin B., Schnippering H., and Ginsberg M.D. Detection of free radical activity during transient global ischemia and recirculation: effects of intraischemic brain temperature modulation. Journal of Neurochemistry 65 (1995) 1250-1256
8. Gross G.J., O'Rourke S.T., Pelc L.R., and Warltier D.C. Myocardial and endothelial dysfunction after multiple, brief coronary occlusions: role of oxygen radicals. The American Journal of Physiology 263 (1992) H1703-1709
9. Hashimoto M., Ishida Y., Naruse I., and Paul R.J. Prolonged cold storage abolishes endothelium-dependent relaxing responses to A23187 and substance P in porcine coronary arteries. Journal of Vascular Research 29 (1992) 64-70
10. Hashimoto M., Close L.A., Ishida Y., and Paul R.J. Dependence of endothelium-mediated relaxation on oxygen and metabolism in porcine coronary arteries. The American journal of physiology 265 (1993) H299-306
11. Herrera G.M., and Walker B.R. Involvement of L-type calcium channels in hypoxic relaxation of vascular smooth muscle. Journal of Vascular Research 35 (1998) 265-273
12. Hill C.E., Phillips J.K., and Sandow S.L. Heterogeneous control of blood flow amongst different vascular beds. Medicinal Research Reviews 21 (2001) 1-60
13. Kaeffer N., Richard V., Francois A., Lallemand F., Henry J.P., and Thuillez C. Preconditioning prevents chronic reperfusion-induced coronary endothelial dysfunction in rats. The American Journal of Physiology 271 (1996) H842-849
14. Komori K., and Vanhoutte P.M. Endothelium-derived hyperpolarizing factor. Blood Vessels 27 (1990) 238-245
15. Kuzner J., Drevensek G., Gersak B., and Budihna M. Hypoxic and pharmacological preconditioning preserves vasomotor response of porcine coronary artery. Polish Journal of Pharmacology 56 (2004) 789-797
16. Laude K., Beauchamp P., Thuillez C., and Richard V. Endothelial protective effects of preconditioning. Cardiovascular Research 55 (2002) 466-473
17. Laude K., Thuillez C., and Richard V. Coronary endothelial dysfunction after ischemia-reperfusion: mechanisms and possibilities for protection. Therapie 56 (2001) 589-593
18. Matsumoto T., Miyamori K., Kobayashi T., and Kamata K. Specific impairment of endothelium-derived hyperpolarizing factor-type relaxation in mesenteric arteries from streptozotocin-induced diabetic mice. Vascular Pharmacology 44 (2006) 450-460
19. Ren Z., Yang Q., Floten H.S., Furnary A.P., Yim A.P., and He G.W. ATP-sensitive potassium channel openers may mimic the effects of hypoxic preconditioning on the coronary artery. The Annals of Thoracic Surgery 71 (2001) 642-647
20. Richard V., Kaeffer N., Tron C., and Thuillez C. Ischemic preconditioning protects against coronary endothelial dysfunction induced by ischemia and reperfusion. Circulation 89 (1994) 1254-1261
21. Saikumar P., Dong Z., Weinberg J.M., and Venkatachalam M.A. Mechanisms of cell death in hypoxia/reoxygenation injury. Oncogene 17 (1998) 3341-3349
22. Selemidis S., and Cocks T. Smooth muscle mediates circumferential conduction of hyperpolarization and relaxation to focal endothelial cell activation in large coronary arteries. Naunyn-Schmiedeberg's Archives of Pharmacology 375 (2007) 85-94
23. Shimizu S., and Paul R.J. Hypoxia and alkalinization inhibit endothelium-derived nitric oxide but not endothelium-derived hyperpolarizing factor responses in porcine coronary artery. The Journal of Pharmacology and Experimental Therapeutics 291 (1999) 335-344
24. Shimokawa H., Yasutake H., Fujii K., Owada M.K., Nakaike R., Fukumoto Y., et al. The importance of the hyperpolarizing mechanism increases as the vessel size decreases in endothelium-dependent relaxations in rat mesenteric circulation. Journal of Cardiovascular Pharmacology 28 (1996) 703-711
25. Thorne G.D., Shimizu S., and Paul R.J. Hypoxic vasodilation in porcine coronary artery is preferentially inhibited by organ culture. American Journal of Physiology. Cell Physiology 281 (2001) C24-32
26. Tousoulis D., Davies G.J., Tentolouris C., Crake T., Lefroy D.C., and Toutouzas P. Effects of inhibition of nitric oxide synthesis in patients with coronary artery disease and stable angina. European Heart Journal 18 (1997) 608-613
27. Tsao P.S., Aoki N., Lefer D.J., Johnson III G., and Lefer A.M. Time course of endothelial dysfunction and myocardial injury during myocardial ischemia and reperfusion in the cat. Circulation 82 (1990) 1402-1412
28. Uluoglu C., and Zengil H. Comparison of different de-endothelization procedures in the isolated rat thoracic aorta: a short communication. Research Communications in Molecular Pathology and Pharmacology 113-114 (2003) 289-297
29. VanBenthuysen K.M., McMurtry I.F., and Horwitz L.D. Reperfusion after acute coronary occlusion in dogs impairs endothelium-dependent relaxation to acetylcholine and augments contractile reactivity in vitro. The Journal of Clinical Investigation 79 (1987) 265-274
30. Vedernikov Y.P., Graser T., and Li D.S. Hypoxic and posthypoxic responses in isolated coronary arteries and veins: role of endothelium. Biomedica Biochimica Acta 49 (1990) 1177-1184