Enhanced blood pressure and appetite responses to chronic central melanocortin-3/4 receptor blockade in dietary-induced obesity

Journal of Hypertension

Volumn 28, Issue 7, 2010, Pages 1466-1470

  Dubinion, John H ^a   Da Silva, Alexandre A ^a   Hall, John E ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

hypertension; melanocortin receptors; metabolism; obesity; proopiomelanocortin

Indexed keywords

MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE];

ANIMAL EXPERIMENT; ANIMAL MODEL; APPETITE; ARTICLE; BODY WEIGHT; CALORIC INTAKE; ENERGY EXPENDITURE; HEART RATE; LIPID DIET; MEAN ARTERIAL PRESSURE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT;

EID: 77955671183     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/HJH.0b013e328339f20e     Document Type: Article

References (20)

1. Garrison RJ, Kannel WB, Stokes J, Castelli WP. Incidence and precursors of hypertension in young adults: The Framingham Offspring Study. Prev Med 1987; 16:235-251.
2. Hall JE. The kidney, hypertension, and obesity. Hypertension 2003; 41:625-633.
3. Haynes WG, Sivitz WI, Morgan DA, Walsh SA, Mark AL. Sympathetic and cardiorenal actions of leptin. Hypertension 1997; 30:619-623.
4. Haynes WG, Morgan DA, Walsh SA, Mark AL, Sivitz WI. Receptor-mediated regional sympathetic nerve activation by leptin. J Clin Invest 1997; 100:270-278.
5. Dunbar JC, Hu Y, Lu H. Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats. Diabetes 1997; 46:2040-2043.
6. Shek EW, Brands MW, Hall JE. Chronic leptin infusion increases arterial pressure. Hypertension 1998; 31:409-414.
7. Seeley RJ, Yagaloff KA, Fisher SL, Burn P, Thiele TE, van Dijk G, et al. Melanocortin receptors in leptin effects. Nature 1997; 390:349.
8. Satoh N, Ogawa Y, Katsuura G, Numata Y, Masuzaki H, Yoshimasa Y, Nakao K. Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system. Neurosci Lett 1998; 249:107-110.
9. Haynes WG, Morgon DA, Djalali A, Sivitz WI, Mark AL. Interaction between the melanocortin system and leptin in control of sympathetic nerve traffic. Hypertension 1999; 33:542-547.
10. Rahmouni K, Haynes WG, Morgan DA, Mark AL. Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin. J Neurosci 2003; 23:5998-6004.
11. Mark AL, Correia ML, Rahmouni K, Haynes WG. Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications. J Hypertens 2002; 20:1245-1250. (Pubitemid 34925659)
12. Frederich RC, Hamann A, Anderson S, Lollmann B, Lowell BB, Flier JS. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med 1995; 1:1311-1314.
13. Mantzoros CS, Flier JS. Editorial: leptin as a therapeutic agent: trials and tribulations. J Clin Endocrinol Metab 2000; 85:4000-4002.
14. Tallam LS, da Silva AA, Hall JE. Melanocortin-4 receptor mediates chronic cardiovascular and metabolic actions of leptin. Hypertension 2006; 48:58-64.
15. Silva AA, Kuo JJ, Tallam LS, Liu J, Hall JE. Does obesity induce resistance to the long-term cardiovascular and metabolic actions of melanocortin 3/4 receptor activation? Hypertension 2006; 47:259-264.
16. Kuo JJ, Silva AA, Hall JE. Hypothalamic melanocortin receptors and chronic regulation of arterial pressure and renal function. Hypertension 2003; 41:768-774.
17. Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 1997; 385:165-168. (Pubitemid 27034218)
18. Jé quier E. Leptin signaling, adiposity, and energy balance. Ann N Y Acad Sci 2002; 967:379-388.
19. Greenfield JR, Miller JW, Keogh JM, Henning E, Satterwhite JH, Cameron GS, et al. Modulation of blood pressure by central melanocortinergic pathways. N Engl J Med 2009; 360:44-52.
20. Cone RD. Studies on the physiological functions of the melanocortin system. Endocr Rev 2006; 27:736-749.