Garlic-derived S-allylmercaptocysteine is a hepato-protective agent in non-alcoholic fatty liver disease in vivo animal model

European Journal of Nutrition

Volumn 52, Issue 1, 2013, Pages 179-191

  Xiao, Jia ^a   Ching, Yick Pang ^a   Liong, Emily C ^a   Nanji, Amin A ^b   Fung, Man Lung ^a   Tipoe, George L ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Fibrosis; Inflammation; NAFLD; Oxidative stress; S allylmercaptocysteine

Indexed keywords

CYCLOOXYGENASE 2; CYTOCHROME P450; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 8; LIVER PROTECTIVE AGENT; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 2; S ALLYLMERCAPTOCYSTEINE; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BLOOD SAMPLING; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; EUTHANASIA; FEMALE; HISTOLOGY; LIPID DIET; LIPOGENESIS; LIPOLYSIS; LIVER; LIVER PROTECTION; MARKER GENE; NONALCOHOLIC FATTY LIVER; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ANIMALS; BLOTTING, WESTERN; CYSTEINE; CYTOCHROME P-450 CYP2E1; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FATTY LIVER; FEMALE; GARLIC; INFLAMMATION; LIPOGENESIS; LIVER; MAP KINASE SIGNALING SYSTEM; NF-KAPPA B; OXIDATIVE STRESS; PHOSPHORYLATION; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; TRANSCRIPTION FACTOR AP-1;

ALLIUM SATIVUM; ANIMALIA; RATTUS;

EID: 84872674658     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-012-0301-0     Document Type: Article

References (39)

1. Falck-Ytter Y, Younossi ZM, Marchesini G, McCullough AJ (2001) Clinical features and natural history of nonalcoholic steatosis syndromes. Semin Liver Dis 21:17-26 (Pubitemid 32240483)
2. Loguercio C, De Simone T, D'Auria MV, de Sio I, Federico A, Tuccillo C, Abbatecola AM, Del Vecchio Blanco C, Agostinacchio E, Benedetti A, Svegliati-Baroni G, Budillon G, Cimino L, Chiaramonte M, Saltarelli P, Fraioli F, Fargion S, Fracanzani AL, Floreani A, Blasone L, Grieco A, Miele L, Rappaccini G, Gasbarrini G, Loria P, Carulli N, Marchesini G, Bianchi G, Matarazzo M, Mecenate F, Persico M, De Marino F, Portincasa P, Palmieri V, Palasciano G, Spadaro A, Ajello A, Smedile A, Bugianesi E, Visconti M, Salvio A, Varriale M, Vecchione R, Terracciano LM, Guido M (2004) Non-alcoholic fatty liver disease: a multicentre clinical study by the Italian Association for the Study of the Liver. Digest Liver Dis 36:398-405 (Pubitemid 41122210)
3. Bataller R, Brenner DA (2005) Liver fibrosis. J Clin Invest 115:209-218. doi: 10.1172/jci24282 (Pubitemid 40385459)
4. Polyzos SA, Kountouras J, Zavos C (2009) Nonalcoholic fatty liver disease: the pathogenetic roles of insulin resistance and adipocytokines. Curr Mol Med 9:299-314
5. Ban JO, Yuk DY, Woo KS, Kim TM, Lee US, Jeong HS, Kim DJ, Chung YB, Hwang BY, Oh KW, Hong JT (2007) Inhibition of cell growth and induction of apoptosis via inactivation of NF-kappaB by a sulfurcompound isolated from garlic in human colon cancer cells. J Pharmacol Sci 104:374-383 (Pubitemid 47381270)
6. Lee Y (2008) Induction of apoptosis by S-allylmercapto-l-cysteine, a biotransformed garlic derivative, on a human gastric cancer cell line. Int J Mol Med 21:765-770
7. Xiao D, Pinto JT, Soh JW, Deguchi A, Gundersen GG, Palazzo AF, Yoon JT, Shirin H, Weinstein IB (2003) Induction of apoptosis by the garlic-derived compound S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH(2)-terminal kinase 1 activation. Cancer Res 63:6825-6837 (Pubitemid 37322965)
8. Pedraza-Chaverri J, Barrera D, Maldonado PD, Chirino YI, Macias-Ruvalcaba NA, Medina-Campos ON, Castro L, Salcedo MI, Hernandez-Pando R (2004) S-allylmercaptocysteine scavenges hydroxyl radical and singlet oxygen in vitro and attenuates gentamicin-induced oxidative and nitrosative stress and renal damage in vivo. BMC Clin Pharmacol 4:5. doi: 10.1186/1472-6904-4-5 (Pubitemid 38751349)
9. Sumioka I, Matsura T, Yamada K (2001) Therapeutic effect of S-allylmercaptocysteine on acetaminophen-induced liver injury in mice. Eur J Pharmacol 433:177-185 (Pubitemid 34045178)
10. Nakagawat S, Kasuga S, Matsuura H (1989) Prevention of liver damage by aged garlic extract and its components in mice. Phytother Res 3:50-53. doi: 10.1002/ptr.2650030203 (Pubitemid 19195462)
11. XIao J, Liong EC, Ling MT, Ching YP, Fung ML, Tipoe GL (2011) S-allylmercaptocysteine reduces carbon tetrachloride induced hepatic oxidative stress and necroinflammmation via nuclear factor kappa B-dependent pathways in mice. Eur J Nutr. doi: 10.1007/s00394-011-0217-0
12. Tipoe GL, Ho CT, Liong EC, Leung TM, Lau TY, Fung ML, Nanji AA (2009) Voluntary oral feeding of rats not requiring a very high fat diet is a clinically relevant animal model of non-alcoholic fatty liver disease (NAFLD). Histol Histopathol 24:1161-1169
13. Tipoe GL, Liong EC, Leung TM, Nanji AA (2008) A voluntary oral-feeding rat model for pathological alcoholic liver injury. Methods Mol Biol 447:11-31. doi: 10.1007/978-1-59745-242-7-2
14. Sumioka I, Matsura T, Kasuga S, Itakura Y, Yamada K (1998) Mechanisms of protection by S-allylmercaptocysteine against acetaminophen-induced liver injury in mice. Jpn J Pharmacol 78:199-207 (Pubitemid 28508409)
15. Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, Ferrell LD, Liu YC, Torbenson MS, Unalp-Arida A, Yeh M, McCullough AJ, Sanyal AJ, Nonalcoholic Steatohepatitis Clinical Research Network (2005) Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41:1313-1321 (Pubitemid 40770284)
16. Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, Kubista M, Mueller R, Nolan T, Pfaffl MW, Shipley GL, Vandesompele J, Wittwer CT (2009) The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem 55:611-622. doi: 10.1373/clinchem.2008.112797
17. Jiang J, Torok N (2008) Nonalcoholic steatohepatitis and the metabolic syndrome. Metab Syndr Relat Disord 6:1-7. doi: 10.1089/met.2007.0026 (Pubitemid 351363913)
18. Mussig K, Haring HU (2010) Insulin signal transduction in normal cells and its role in carcinogenesis. Exp Clin Endocrinol Diabetes 118:356-359. doi: 10.1055/s-0029-1243603
19. Melo AM, Bittencourt P, Nakutis FS, Silva AP, Cursino J, Santos GA, Ashino NG, Velloso LA, Torsoni AS, Torsoni MA (2011) Solidago chilensis Meyen hydroalcoholic extract reduces JNK/IkappaB pathway activation and ameliorates insulin resistance in diet-induced obesity mice. Exp Biol Med (Maywood). doi: 10.1258/ebm.2011.011105
20. Schattenberg JM, Galle PR (2010) Animal models of non-alcoholic steatohepatitis: of mice and man. Digest Dis 28:247-254
21. Lam TK, Yoshii H, Haber CA, Bogdanovic E, Lam L, Fantus IG, Giacca A (2002) Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-delta. Am J Physiol Endocrinol Metab 283:E682-E691. doi: 10.1152/ajpendo.00038.2002
22. Shulman GI (2000) Cellular mechanisms of insulin resistance. J Clin Invest 106:171-176. doi: 10.1172/jci10583 (Pubitemid 30483118)
23. Nguyen MT, Satoh H, Favelyukis S, Babendure JL, Imamura T, Sbodio JI, Zalevsky J, Dahiyat BI, Chi NW, Olefsky JM (2005) JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. J Biol Chem 280:35361-35371. doi: 10.1074/jbc.M504611200 (Pubitemid 41532725)
24. Ghanim H, Aljada A, Daoud N, Deopurkar R, Chaudhuri A, Dandona P (2007) Role of inflammatory mediators in the suppression of insulin receptor phosphorylation in circulating mononuclear cells of obese subjects. Diabetologia 50:278-285. doi: 10.1007/s00125-006-0508-9
25. Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, Capeau J, Feve B (2006) Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 17:4-12
26. Malaguarnera M, Di Rosa M, Nicoletti F, Malaguarnera L (2009) Molecular mechanisms involved in NAFLD progression. J Mol Med 87:679-695. doi: 10.1007/s00109-009-0464-1
27. Xu ZJ, Fan JG, Ding XD, Qiao L, Wang GL (2010) Characterization of high-fat, diet-induced, non-alcoholic steatohepatitis with fibrosis in rats. Dig Dis Sci 55:931-940. doi: 10.1007/s10620-009-0815-3
28. Leclercq IA, Da Silva Morais A, Schroyen B, Van Hul N, Geerts A (2007) Insulin resistance in hepatocytes and sinusoidal liver cells: mechanisms and consequences. J Hepatol 47:142-156. doi: 10.1016/j.jhep.2007.04.002 (Pubitemid 46830723)
29. Wang XL, Zhang L, Youker K, Zhang MX, Wang J, LeMaire SA, Coselli JS, Shen YH (2006) Free fatty acids inhibit insulin signaling-stimulated endothelial nitric oxide synthase activation through upregulating PTEN or inhibiting Akt kinase. Diabetes 55:2301-2310. doi: 10.2337/db05-1574 (Pubitemid 44743628)
30. Fujishiro M, Gotoh Y, Katagiri H, Sakoda H, Ogihara T, Anai M, Onishi Y, Ono H, Abe M, Shojima N, Fukushima Y, Kikuchi M, Oka Y, Asano T (2003) Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytes. Mol Endocrinol 17:487-497. doi: 10.1210/me.2002-0131 (Pubitemid 36315641)
31. Liu HY, Collins QF, Xiong Y, Moukdar F, Lupo EG Jr, Liu Z, Cao W (2007) Prolonged treatment of primary hepatocytes with oleate induces insulin resistance through p38 mitogen-activated protein kinase. J Biol Chem 282:14205-14212. doi: 10.1074/jbc.M609701200 (Pubitemid 47100474)
32. Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS (2002) A central role for JNK in obesity and insulin resistance. Nature 420:333-336. doi: 10.1038/nature01137 (Pubitemid 35398190)
33. Schattenberg JM, Singh R, Wang Y, Lefkowitch JH, Rigoli RM, Scherer PE, Czaja MJ (2006) JNK1 but not JNK2 promotes the development of steatohepatitis in mice. Hepatology 43:163-172. doi: 10.1002/hep.20999 (Pubitemid 43733603)
34. Svegliati-Baroni G, Candelaresi C, Saccomanno S, Ferretti G, Bachetti T, Marzioni M, De Minicis S, Nobili L, Salzano R, Omenetti A, Pacetti D, Sigmund S, Benedetti A, Casini A (2006) A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury. Am J Pathol 169:846-860 (Pubitemid 44411952)
35. Wang Z, Yao T, Song Z (2010) Extracellular signal-regulated kinases 1/2 suppression aggravates transforming growth factor-beta1 hepatotoxicity: a potential mechanism for liver injury in methionine-choline deficient-diet-fed mice. Exp Biol Med (Maywood) 235:1347-1355. doi: 10.1258/ebm.2010.010160
36. Czaja MJ, Liu H, Wang Y (2003) Oxidant-induced hepatocyte injury from menadione is regulated by ERK and AP-1 signaling. Hepatology 37:1405-1413. doi: 10.1053/jhep.2003.50233 (Pubitemid 36667321)
37. Mebratu Y, Tesfaigzi Y (2009) How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer? Cell Cycle 8:1168-1175
38. Hayden MS, Ghosh S (2004) Signaling to NF-kappaB. Genes Dev 18:2195-2224. doi: 10.1101/gad.1228704 (Pubitemid 39209568)
39. Tanaka S, Haruma K, Yoshihara M, Kajiyama G, Kira K, Amagase H, Chayama K (2006) Aged garlic extract has potential suppressive effect on colorectal adenomas in humans. J Nutr 136:821S-826S (Pubitemid 43363785)