Effects of orally administered capsaicin, the principal component of capsicum fruits, on the in vitro metabolism of the tobacco-specific nitrosamine NNK in hamster lung and liver microsomes

Anticancer Research

Volumn 17, Issue 2 A, 1997, Pages 1093-1098

  Zhang, Zhuo ^a   Huynh, Huong ^a   Teel, Robert W ^a  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Capsaicin; Carcinogenesis; Chemoprevention; NNK

Indexed keywords

CAPSAICIN; KETOL; NITROSAMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG EFFECT; HYDROXYLATION; LIVER CARCINOGENESIS; LIVER METABOLISM; LIVER MICROSOME; LUNG ALVEOLUS CELL; LUNG CANCER; LUNG CARCINOGENESIS; MALE; METHYLATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SYRIAN HAMSTER;

ADMINISTRATION, ORAL; ANIMALS; CAPSAICIN; CARCINOGENS; CRICETINAE; GUINEA PIGS; LUNG; MALE; MESOCRICETUS; MICROSOMES, LIVER; NITROSAMINES;

EID: 0030896073     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Burton HR, Childs GH, Anderson RA and Fleming PD: Changes in chemical composition of Burley tobacco during senescence and curing. 3. Tobacco-specific nitrosamines. J Agric Food Chem 37: 426-430, 1989.
2. Hecht SS and Hoffmann D: Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke. Carcinogenesis 9: 875-884, 1988.
3. Hecht SS and Hoffmann D: The relevance of tobacco-specific nitrosamines to human cancer. Cancer Surveys 8: 273-294, 1989.
4. Crespi CL, Penman BW, Gclboin HV and Gonzalez FJ: A tobacco smoke derived nitrosamine. 4-(methylnitrosamino)-1-(3-pyridyl)-l-butanone, is activated by multiple human cytochrome P-450s including polymorphic human cytochrome P-450 2D6. Carcinogenesis 12: 1197-1201, 1991.
5. Murphy SE, Palomino A, Hecht SS and Hoffmann D: Dose-response study of DNA and hemoglobin adduct formation by 4-(methylnitrosamino)-l-(3-pyridyl)-1-butanone in F344 rats. Cancer Res 50: 5446-5452, 1990.
6. Hirayama T: Lung cancer in Japan: effects of nutrition and passive smoking. In Lung Cancer: causes and prevention. M Mizell and P Correa (eds). Verlag Chemie International, Deerfield Beach, FL. pp 175-195, 1984.
7. Yang CS, Brady JF and Hong J-Y: Dietary effects on cytochrome P-450, xenobiotic metabolism and toxicity. FASEB J 6: 737-744, 1992.
8. Ames BN: Dietary carcinogens and anticarcinogens. Science 227: 1256-1264, 1981.
9. Monsereenusorn Y, Kongsamut S and Pezalla P: Capsaicin. A literature survey, CR Toxicol 90: 321-339, 1982.
10. Surh Y-J and Lee SS: Capsaicin, a double-edged sword: toxicity, metabolism and chemopreventive potential. Life Sci 56: 1845-1855, 1995.
11. Miller MS, Brendel K, Burks TF and Sipes IG: Interaction of capsaicinoids with drug-metabolizing systems. Biochem Pharmacol 52: 547-551, 1983.
12. Hamid MR, Bachmann E and Metwally SA: Interaction of capsacin with mixedfunction oxidases ex vivo and in vitro studies. J Drug Res (Egypt) 16: 29-36, 1985.
13. Modly CE, Das M, Don PSC, Marcelo C, Mukhtar H and Bickers DR: Capsaicin as an in vitro inhibitor of benzo[a]pyrene metabolism and its DNA binding in human and murine keratinocytes. Drug Metab Dispos 14: 413-417, 1986.
14. Teel RW: Effects of capsaicin on rat liver S-9 mediated metabolism and DNA-binding of aflatoxin. Nutr Cancer 75: 27-32, 1991.
15. Teel RW: Effects of phytochemicals on the mutagenicity of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone (NNK) in Salmonella typhimurium strain TA1535. Phytother Res 7: 248-251, 1993.
16. Lijinsky W and Andrews AW: The superiority of hamster liver fraction for activating nitrosamines to mutagens in Salmonella typhimurium. Mutat Res 111: 135-144, 1983.
17. Hecht SS, Young R and Chen CB: Metabolism in the F344 rat of 4-(methylmtrosamino)-1-(3-pyridyl)-1-butanone. a tobacco-specific carcinogen. Cancer Res 40: 4144-4150, 1980.
18. Hecht SS, Lin D and Chen CB: Comprehensive analysis of urinary metabolites of N-nitrosonornicotine. Carcinogenesis 2: 833-838, 1981.
19. Govindarajan VS and Sathyanarayana MN: Capsicum -production, technology, chemistry and quality. Part V. Impact on physiology, pharmacology, nutrition and metabolism: structure, pungency, pain and desensitization sequences. Food Sci Nutr 29: 435-474, 1991.
20. Maron DM and Ames BN: Revised methods for the Salmonella mutagenicity test." Mutat Res 113: 173-215, 1983.
21. Lowry OH, Rosenbrough NJ, Farr AI and Randall RJ: Protein measurement with the folin phenol reagent. J Biol Chem 192: 265-275, 1951.
22. Smith TJ, Guo Z, Thomas PE, Chung F-L, Morse MA, Elkind K and Yang CS: Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mouse lung microsomes and its inhibition by isothiocyanates. Cancer Res 50: 6817-6822, 1990.
23. Peterson LA, Mathew R and Hecht SS: Quantitation of microsomal α-hydroxylation of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Carcinogenesis 12: 2069-2072, 1991.
24. 6-Methylguanine is a critical determinant of 4(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenesis in A/J mouse lung. Cancer Res 51: 5557-5564, 1991.
25. 6-methylguanine. Cancer Res 55: 2780-2785, 1993.
26. Smith TJ, Guo Z, Hong J-Y, Ning S, Thomas PE and Yang CS: Kinetics and enzyme involvement in the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-l-butanone (NNK) in microsomes of rat lung and nasal mucosa. Carcinogensis 13: 1409-1414, 1992.