Capsaicin modulates pulmonary antioxidant defense system during benzo(a)pyrene-induced lung cancer in Swiss albino mice

Phytotherapy Research

Volumn 22, Issue 4, 2008, Pages 529-533

  Anandakumar, P ^a   Kamaraj, S ^a   Jagan, S ^a   Ramakrishnan, G ^a   Vinodhkumar, R ^a   Devaki, T ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Antioxidants; Benzo(a)pyrene; Capsaicin; Lipid peroxidation; Oxidative stress

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; BENZO[A]PYRENE; CAPSAICIN; CATALASE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; RETINOL; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FEEDING; LIPID OXIDATION; LUNG CANCER; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; SWISS WEBSTER MOUSE;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BENZO(A)PYRENE; CAPSAICIN; CATALASE; GLUCOSEPHOSPHATE DEHYDROGENASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; LIPID PEROXIDATION; LUNG; LUNG NEOPLASMS; MALE; MICE; OXIDATIVE STRESS; SUPEROXIDE DISMUTASE; VITAMIN A; VITAMIN E;

CAPSICUM ANNUUM VAR. ANNUUM; MUS;

EID: 42949147662     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2393     Document Type: Article

References (41)

1. Balaji Raghavendran HR, Sathivel A, Devaki T. 2005. Protective effect of Sargassum polycystum (Brown Alga) against acetaminophen induced lipid peroxidation in rats. Phytother Res 19: 113-115.
2. Balansky D, Bernstein RE. 1963. The purification and properties of glucose-6-phosphate dehydrogenase from human erythrocytes. Biochim Biophys Acta 67: 313-315.
3. 3 prevents DNA damage and restores antioxidant enzymes in rat hepatocarcinogenesis induced by diethylnitrosamine and promoted by phenobarbitol. World J Gastroenterol 10: 1268-1275.
4. Bayfield RF, Cole ER. 1980. Colorimetric estimation of vitamin A with trichloroacetic acid. Methods Enzymol 67: 189-195.
5. Beutler E. 1982. Active transport of glutathione disulfide from erythrocytes. In Functions of Glutathione-Biochemical, Physiological, Toxicological and Clinical Aspects, Larson A, Orrenius S, Holmgren A, Mannerwik B (eds). Raven Press: New York, 65.
6. Britton JA, Westhoff C, Howe G. 2000. Diet and benign ovarian tumors. Cancer Causes Control 11: 389-401.
7. Buzby GP, Mullen JH, Stein TP, Rosato EF. 1980. Host-tumor interactions and nutrient supply. Cancer 45: 2940-2947.
8. Church DF, Pryor WA. 1985. Free radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect 64: 111-126.
9. Cugell DW, Kamp DW. 2004. Asbestos and the pleuro. Chest 125: 1103-1117.
10. Desai ID. 1984. Vitamin E analysis methods for animal tissues. Methods Enzymol 105: 138-143.
11. Devasagayam TPA. 1986. Lipid peroxidation in rat uterus. Biochim Biophys Acta 876: 507-514.
12. Feng Q, Kumagai T, Torii Y, Nakamura Y, Osawa T, Uchida K. 2001. Anticarcinogenic antioxidants as inhibitors against intracellular oxidative stress. Free Radic Res 35: 779-788.
13. Fridovich I. 1975. SOD. Ann Res Biochem 44: 147-159.
14. Frie B, England L, Ames BN. 1981. Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci 4: 6377-6381.
15. Habig WH, Pabst MJ, Jacob WB. 1974. Glutathione-S-transferase. The first enzymatic step in mercapturic acid formation. J Biol Chem 249: 7130-7139.
16. Harris CC, Sun T. 1984. Multifactorial etiology of human liver cancer. Carcinogenesis 5: 697-701.
17. Kempiah P, Srinivasan K. 2004. Influence of dietary curcumin, capsaicin and garlic on the antioxidant state of red blood cells and the liver in high-fat-fed rats. Ann Nutr Metab 48: 314-320.
18. Kogure K, Goto S, Nishimura M et al. 2002. Mechanism of potent antiperoxidative effect of capsaicin. Biochim Biophys Acta 1573: 84-92.
19. Komburst DJ, Mavis RD. 1980. Relative susceptibility of microsomes from lung, heart, liver, kidney, brain and testes to lipid peroxidation, correlation with vitamin E contents. Lipids 15: 315-322.
20. Kosower NS, Kosower EM. 1976. The glutathione-glutathione disulphide system. In Free Radicals in Biology, Pryor WA (ed.). Academic Press: New York, 57-84.
21. Marklund S, Marklund G. 1974. Involvement of superoxide anion radical in the autooxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47: 469-474.
22. Mikhail F, Denissenko K, Annie P, Moon-Shong T, Gerd PP. 1996. Preferential formation of benzo(a)pyrene adducts at lung cancer mutational hot spots in p53. Science 274: 430-432.
23. Modly CE, Das M, Don PS, Marcelo CS, Mukhtar H, Bickers DR. 1986. Capsaicin as an in vitro inhibitor of benzo(a)pyrene metabolism and its DNA binding in human and murine keratinocytes. Drug Metab Dispos 14: 413-416.
24. Moron MS, Despierre JW, Minnervik B. 1979. Levels of glutathione, glutathione reductase and glutathione-S-transferase activities in rat lung and liver. Biochim Biophys Acta 582: 67-78.
25. Omaye AT, Turnbull JD, Sauberdich HE. 1979. Selected method for determination of ascorbic acid in animal cells, tissues and fluids. Methods Enzymol 62: 1-11.
26. Ozen T, Korkmaz H. 2003. Modulatory effect of Urtica dioica L (Urticaceae) leaf extract on biotransformation of enzyme systems, antioxidant enzymes, LDH and lipid peroxidation in mice. Phytomedicine 10: 405-415.
27. Ramakrishnan G, Balaji Raghavendran HR, Vinodhkumar R, Devaki T. 2006. Suppression of N-nitrosodiethylamine induced hepatocarcinogenesis by Silymarin in rats. Chem Biol Interact 161: 104-114.
28. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hajeman DG, Hoekstra WG. 1973. Selenium - biochemical role as a component of glutathione purification and assay. Science 179: 588-590.
29. Selvendiran K, Prince Vijeya Singh J, Sakthisekaran D. 2006. In vivo effect of piperine on serum and tissue glycoprotein levels in benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice. Pulm Pharmacol Ther 19: 107-111.
30. Selvendiran K, Sakthisekaran D. 2004. Chemopreventive effect of piperine on modulating lipid peroxidation and membrane bound enzymes in benzo(a)pyrene induced lung carcinogenesis. Biomed Pharmacother 58: 264-267.
31. Serbecic N, Ehmann AK, Beutelspacher SC. 2005. Reduction of lipid peroxidation and apoptosis in corneal endothelial cells by vitamin A. Ophthalmologe 6: 607-613.
32. Shimeda Y, Hirotani Y, Akimoto Y et al. 2005. Protective effects of capsaicin against cisplastin-induced nephrotoxicity. Biol Pharm Bull 28: 1635-1638.
33. Sikkim H, Muke B. 2000. Lipid peroxidation and antioxidant enzymes in the blood of rats treated with benzo(a)pyrene. Chem Biol Interact 127: 139-150.
34. Sinha AK. 1972. Colorimetric assay of catalase. Anal Biochem 47: 389-394.
35. Sumathi R, Baskaran G, Varalakshmi P. 1996. Relationship between glutathione and DL-alpha lipoic acid against cadmium induced hepatotoxicity. Jpn J Med Sci Biol 49: 39-48.
36. Sun Y. 1990. Free radicals, antioxidant enzymes and carcinogenesis. Free Radic Biol Med 8: 583-599.
37. Surh YJ, Lee RC, Park KK, Mayne ST, Liem A, Miller JA. 1995. Chemopreventive effects of capsaicin and diallyl sulfide against mutagenesis or tumorigenesis by vinyl carbamate and N-nitrosodimethylamine. Carcinogenesis 16: 2467-2471.
38. Teel RW. 1991. Effects of capsaicin on rat liver S9-mediated metabolism and DNA binding of aflatoxin. Nutr Cancer 15: 27-32.
39. Thirunavukkarasu C, Princevijeyasingh J, Selvendiran K, Sakthisekaran D. 2002. Chemopreventive efficacy of selenium against DEN-induced hepatoma in albino rats. Cell Biochem Funct 19: 265-271.
40. Vijayalakshmi T, Muthulakshmi V, Sachnanandam P. 1997. Salubrious effect of Semecarpus anacardium against lipid peroxidative changes in adjuvant arthritis-studied in rats. Mol Cell Biochem 175: 65-69.
41. Zhang Z, Hamilton SM, Stewart C, Strother A, Teel RW. 1993. Inhibition of liver microsomal cytochrome P-450 activity and metabolism of the tobacco-specific nitrosamine NNK by capsaicin and ellagic acid. Anticancer Res 13: 2341-2346.