GABAA receptor-mediated acceleration of aging-associated memory decline in APP/PS1 mice and its pharmacological treatment by picrotoxin

PLoS ONE

Volumn 3, Issue 8, 2008, Pages

  Yoshiike, Yuji ^a   Kimura, Tetsuya ^a   Yamashita, Shunji ^a   Furudate, Hiroyuki ^b   Mizoroki, Tatsuya ^a   Murayama, Miyuki ^a   Takashima, Akihiko ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b SAITAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; BICUCULLINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; PICROTOXIN; POSTSYNAPTIC DENSITY PROTEIN 95; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; AMYLOID PRECURSOR PROTEIN; PRESENILIN 1;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; COGNITION; CONTROLLED STUDY; DRUG MECHANISM; HIPPOCAMPUS POTENTIAL; HOMEOSTASIS; LONG TERM POTENTIATION; MALE; MEMORY DISORDER; MENTAL PERFORMANCE; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; RECEPTOR BINDING; RECEPTOR UPREGULATION; TRANSGENIC MOUSE; TREATMENT DURATION; ANIMAL; COGNITIVE DEFECT; DRUG EFFECT; GENETICS; HUMAN; LEARNING; MAZE TEST; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

MUS; MUS MUSCULUS; RODENTIA;

AGING; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; COGNITION DISORDERS; GABA ANTAGONISTS; HUMANS; LEARNING; LONG-TERM POTENTIATION; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; PICROTOXIN; PRESENILIN-1; RECEPTORS, GABA-A;

EID: 51849145128     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0003029     Document Type: Article

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