Introducing Amylo-Glo, a novel fluorescent amyloid specific histochemical tracer especially suited for multiple labeling and large scale quantification studies

Journal of Neuroscience Methods

Volumn 209, Issue 1, 2012, Pages 120-126

  Schmued, Larry ^a   Raymick, James ^b   Tolleson, William ^a   Sarkar, Sumit ^a   Zhang, Yi Hong ^a   Bell Cohn, Ashlee ^c  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b Toxicologic Pathology Associates   (United States)

^c UNIVERSITY OF ARKANSAS   (United States)

Author keywords

A beta; Alzheimer's disease; Amylo Glo; Amyloid plaques; Fluorescent dye; Histology; Multiple labeling

Indexed keywords

AMYLO GLO; AMYLOID; AMYLOID BETA PROTEIN[1-40]; CONGO RED; THIOFLAVINE; TRACER; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CHEMICAL STRUCTURE; CONTRAST ENHANCEMENT; FLUORESCENCE HISTOCHEMISTRY; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; MOUSE; NISSL STAINING; NONHUMAN; PRIORITY JOURNAL; SPECTROFLUOROMETRY; SPECTROSCOPY; TISSUE SECTION;

ANIMALS; BRAIN; FLUORESCENT ANTIBODY TECHNIQUE; FLUORESCENT DYES; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; PLAQUE, AMYLOID;

EID: 84863438720     PISSN: 01650270     EISSN: 1872678X     Source Type: Journal    
DOI: 10.1016/j.jneumeth.2012.05.019     Document Type: Article

References (10)

1. Alzheimer A. English translataion. Alzheimer Dis Assoc Disord 1987, 1:7-8.
2. Borchelt D.R., Ratovitski T., van Lare J., Lee M.K., Gonzales V., Jenkins N.A., et al. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 1997, 19:939-945.
3. Crystal A.S., Giasson B.I., Crowe A., Kung M.P., Zhuang Z.P., Trojanowski J.Q., et al. A comparison of amyloid fibrillogenesis using the novel fluorescent compound K114. J Neurochem 2003, 86:1359-1368.
4. Neurodegeneration: the molecular pathology of dementia & movement disorder 2003, pp. 47-65. 2nd ed. D. Dickson, R.O. Weller (Eds.).
5. Glenner G.G. Amyloid deposits and amyloidosis: the beta-fibrilloses (second of two parts). N Engl J Med 1980, 302:1333-1343.
6. Guntern R., Bouras C., Hof P.R., Vallet P.G. An improved thioflavine S method for staining neurofibrillary tangles and senile plaques in Alzheimer's disease. Experientia 1992, 48:8-10.
7. LeVine H. Mechanism of A beta(1-40) fibril-induced fluorescence of (trans,trans)-1-bromo-2,5-bis(4-hydroxystyryl)benzene (K114). Biochemistry 2005, 44:15937-15943.
8. Puchtler H., Sweat F. Congo red as a stain for fluorescence microscopy of amyloid. J Histochem Cytochem 1965, 13:693-694.
9. Skovronsky D.M., Zhang B., Kung M.P., Kung H.F., Trojanowski J.Q., Lee V.M. In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 2000, 97:7609-7614.
10. Zhuang Z.P., Kung M.P., Hou C., Skovronsky D.M., Gur T.L., Plossl K., et al. Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates. J Med Chem 2001, 44:1905-1914.