Synthesis and characterization of DNA minor groove binding alkylating agents

Chemical Research in Toxicology

Volumn 26, Issue 1, 2013, Pages 156-168

  Iyer, Prema ^a   Srinivasan, Ajay ^a   Singh, Sreelekha K ^a   Mascara, Gerard P ^a   Zayitova, Sevara ^a   Sidone, Brian ^a   Fouquerel, Elise ^b   Svilar, David ^b,c   Sobol, Robert W ^a,b,c   Bobola, Michael S ^d   Silber, John R ^d   Gold, Barry ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLADENINE; 7 METHYLGUANINE; ALKYLATING AGENT; DIPEPTIDE; DNA; DNA GLYCOSYLTRANSFERASE; METHYL 3 [1 METHYL 5 [1 METHYL 5 (PROPYLCARBAMOYL) 1H PYRROL 3 YLCARBAMOYL] 1H PYRROL 3 YLAMINO] 3 OXOPROPANE 1 SULFONATE; PYRROLE DERIVATIVE; SULFONIC ACID DERIVATIVE; TIOPRONIN; TRIPEPTIDE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; CYTOTOXICITY; DNA BINDING; DNA METHYLATION; DNA REPLICATION; DRUG SYNTHESIS; ESCHERICHIA COLI; GLIOMA CELL; HUMAN; HUMAN CELL; NONHUMAN;

ADENINE; ALKYLATING AGENTS; ANIMALS; CATTLE; CELL LINE, TUMOR; CELL SURVIVAL; DNA; DNA BREAKS, DOUBLE-STRANDED; DNA GLYCOSYLASES; DNA METHYLATION; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HUMANS; PEPTIDES; POLY(ADP-RIBOSE) POLYMERASES; THERMODYNAMICS;

BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 84872528205     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx300437x     Document Type: Article

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