Neuroprotective effects of luteolin against apoptosis induced by 6-hydroxydopamine on rat pheochromocytoma PC12 cells

Pharmaceutical Biology

Volumn 51, Issue 2, 2013, Pages 190-196

  Guo, De Jian ^a,b   Li, Fan ^a   Yu, Peter Hoi Fu ^a,b   Chan, Shun Wan ^a,b  

^a State Key Laboratory of Chinese Medicine and Molecular Pharmacology   (China)

^b HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

Bax; Bcl 2; Flavonoid; Neurodegenerative; P53; Parkinson's disease

Indexed keywords

LUTEOLIN; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CELL NUCLEUS; CELL PROTECTION; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY TEST; DOWN REGULATION; DRUG EFFECT; DRUG RESEARCH; FLOW CYTOMETRY; GENE OVEREXPRESSION; GENETIC MARKER; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PHEOCHROMOCYTOMA CELL; PROTO ONCOGENE; RAT; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL SHAPE; CELL SURVIVAL; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; LUTEOLIN; NEURONS; NEUROPROTECTIVE AGENTS; OXIDOPAMINE; PC12 CELLS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEIN P53;

RATTUS;

EID: 84872482758     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2012.716852     Document Type: Article

References (41)

1. Blum D, Wu Y, Nissou MF, Arnaud S, Alim-Louis-Benabid, Verna JM. (1997). p53 and Bax activation in 6-hydroxydopamine-induced apoptosis in PC12 cells. Brain Res, 751, 139-142 (Pubitemid 27122145)
2. Chen TR. (1977). In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. Exp Cell Res, 104, 255-262 (Pubitemid 8047559)
3. Chen CY, Peng WH, Tsai KD, Hsu SL. (2007). Luteolin suppresses inflammation-associated gene expression by blocking NF-kappaB and AP-1 activation pathway in mouse alveolar macrophages. Life Sci, 81, 1602-1614
4. Cheng EH, Wei MC, Weiler S, Flavell RA, Mak TW, Lindsten T, Korsmeyer SJ. (2001). BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell, 8, 705-711 (Pubitemid 32946946)
5. Cheng AC, Huang TC, Lai CS, Pan MH. (2005). Induction of apoptosis by luteolin through cleavage of Bcl-2 family in human leukemia HL-60 cells. Eur J Pharmacol, 509, 1-10
6. Cheng B, Yang X, Hou Z, Lin X, Meng H, Li Z, Liu S. (2007). d-beta- Hydroxybutyrate inhibits the apoptosis of PC12 cells induced by 6-OHDA in relation to up-regulating the ratio of Bcl-2/Bax mRNA. Auton Neurosci, 134, 38-44 (Pubitemid 46900909)
7. Choi J, Sullards MC, Olzmann JA, Rees HD, Weintraub ST, Bostwick DE, Gearing M, Levey AI, Chin LS, Li L. (2006). Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases. J Biol Chem, 281, 10816-10824 (Pubitemid 43855504)
8. Cohen G, Heikkila RE. (1974). The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents. J Biol Chem, 249, 2447-2452
9. Dajas F, Rivera F, Blasina F, Arredondo F, Echeverry C, Lafon L, Morquio A, Heizen H. (2003). Cell culture protection and in vivo neuroprotective capacity of flavonoids. Neurotox Res, 5, 425-432
10. Fiskum G, Starkov A, Polster BM, Chinopoulos C. (2003). Mitochondrial mechanisms of neural cell death and neuroprotective interventions in Parkinson's disease. Ann N Y Acad Sci, 991, 111-119 (Pubitemid 36793807)
11. Galati G, Moridani MY, Chan TS, O'Brien PJ. (2001). Peroxidative metabolism of apigenin and naringenin versus luteolin and quercetin: Glutathione oxidation and conjugation. Free Radic Biol Med, 30, 370-382 (Pubitemid 32155536)
12. Gorman AM, McGowan A, O'Neill C, Cotter T. (1996). Oxidative stress and apoptosis in neurodegeneration. J Neurol Sci, 139 Suppl, 45-52
13. Hartley A, Stone JM, Heron C, Cooper JM, Schapira AH. (1994). Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: Relevance to Parkinson's disease. J Neurochem, 63, 1987-1990 (Pubitemid 24326248)
14. Hou JG, Cohen G, Mytilineou C. (1997). Basic fibroblast growth factor stimulation of glial cells protects dopamine neurons from 6-hydroxydopamine toxicity: Involvement of the glutathione system. J Neurochem, 69, 76-83 (Pubitemid 27274158)
15. Kang SS, Lee JY, Choi YK, Kim GS, Han BH. (2004). Neuroprotective effects of flavones on hydrogen peroxide-induced apoptosis in SH-SY5Y neuroblostoma cells. Bioorg Med Chem Lett, 14, 2261-2264 (Pubitemid 38481402)
16. Kaplan DR, Miller FD. (2000). Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol, 10, 381-391 (Pubitemid 30389307)
17. Kienzl E, Puchinger L, Jellinger K, Linert W, Stachelberger H, Jameson RF. (1995). The role of transition metals in the pathogenesis of Parkinson's disease. J Neurol Sci, 134 Suppl, 69-78
18. Ko WG, Kang TH, Lee SJ, Kim YC, Lee BH. (2002). Effects of luteolin on the inhibition of proliferation and induction of apoptosis in human myeloid leukaemia cells. Phytother Res, 16, 295-298 (Pubitemid 34534964)
19. Lee HJ, Wang CJ, Kuo HC, Chou FP, Jean LF, Tseng TH. (2005). Induction apoptosis of luteolin in human hepatoma HepG2 cells involving mitochondria translocation of Bax/Bak and activation of JNK. Toxicol Appl Pharmacol, 203, 124-131
20. Li WY, Chan SW, Guo DJ, Chung MK, Leung TY, Yu PH. (2009). Water extract of Rheum officinale Baill. induces apoptosis in human lung adenocarcinoma A549 and human breast cancer MCF-7 cell lines. J Ethnopharmacol, 124, 251-256
21. Liu W, Rong Y, Baudry M, Schreiber SS. (1999). Status epilepticus induces p53 sequence-specific DNA binding in mature rat brain. Brain Res Mol Brain Res, 63, 248-253 (Pubitemid 29036975)
22. López-Lázaro M. (2009). Distribution and biological activities of the flavonoid luteolin. Mini Rev Med Chem, 9, 31-59
23. Mandir AS, Simbulan-Rosenthal CM, Poitras MF, Lumpkin JR, Dawson VL, Smulson ME, Dawson TM. (2002). A novel in vivo posttranslational modification of p53 by PARP-1 in MPTP-induced parkinsonism. J Neurochem, 83, 186-192
24. Michels G, Wätjen W, Niering P, Steffan B, Thi QH, Chovolou Y, Kampkötter A, Bast A, Proksch P, Kahl R. (2005). Pro-apoptotic effects of the flavonoid luteolin in rat H4IIE cells. Toxicology, 206, 337-348 (Pubitemid 39601019)
25. Miller FD, Pozniak CD, Walsh GS. (2000). Neuronal life and death: An essential role for the p53 family. Cell Death Differ, 7, 880-888
26. Mosmann T. (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods, 65, 55-63 (Pubitemid 14203433)
27. Ochu EE, Rothwell NJ, Waters CM. (1998). Caspases mediate 6-hydroxydopamine-induced apoptosis but not necrosis in PC12 cells. J Neurochem, 70, 2637-2640 (Pubitemid 28252392)
28. Ohyagi Y, Asahara H, Chui DH, Tsuruta Y, Sakae N, Miyoshi K, Yamada T, Kikuchi H, Taniwaki T, Murai H, Ikezoe K, Furuya H, Kawarabayashi T, Shoji M, Checler F, Iwaki T, Makifuchi T, Takeda K, Kira J, Tabira T. (2005). Intracellular Abeta42 activates p53 promoter: A pathway to neurodegeneration in Alzheimer's disease. FASEB J, 19, 255-257 (Pubitemid 40189273)
29. Oltvai ZN, Milliman CL, Korsmeyer SJ. (1993). Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell, 74, 609-619 (Pubitemid 23259742)
30. Pastorino JG, Chen ST, Tafani M, Snyder JW, Farber JL. (1998). The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition. J Biol Chem, 273, 7770-7775 (Pubitemid 28152810)
31. Perumal AS, Gopal VB, Tordzro WK, Cooper TB, Cadet JL. (1992
32. Vitamin E attenuates the toxic effects of 6-hydroxydopamine on free radical scavenging systems in rat brain. Brain Res Bull, 29, 699-701
33. Reed JC. (1997). Double identity for proteins of the Bcl-2 family. Nature, 387, 773-776 (Pubitemid 27270895)
34. Spencer JP. (2008). Food for thought: The role of dietary flavonoids in enhancing human memory, learning and neuro-cognitive performance. Proc Nutr Soc, 67, 238-252 (Pubitemid 351543406)
35. Walkinshaw G, Waters CM. (1994). Neurotoxin-induced cell death in neuronal PC12 cells is mediated by induction of apoptosis. Neuroscience, 63, 975-987 (Pubitemid 24366149)
36. Wang X, Chen S, Ma G, Ye M, Lu G. (2005). Involvement of proinflammatory factors, apoptosis, caspase-3 activation and Ca2+ disturbance in microglia activation-mediated dopaminergic cell degeneration. Mech Ageing Dev, 126, 1241-1254 (Pubitemid 41572241)
37. Wruck CJ, Claussen M, Fuhrmann G, Römer L, Schulz A, Pufe T, Waetzig V, Peipp M, Herdegen T, Götz ME. (2007). Luteolin protects rat PC12 and C6 cells against MPP+ induced toxicity via an ERK dependent Keap1-Nrf2-ARE pathway. J Neural Transm Suppl, 72, 57-67
38. Wu Y, Blum D, Nissou MF, Benabid AL, Verna JM. (1996). Unlike MPP+, apoptosis induced by 6-OHDA in PC12 cells is independent of mitochondrial inhibition. Neurosci Lett, 221, 69-71 (Pubitemid 27038965)
39. Wu HH, Thomas JA, Momand J. (2000). p53 protein oxidation in cultured cells in response to pyrrolidine dithiocarbamate: A novel method for relating the amount of p53 oxidation in vivo to the regulation of p53-responsive genes. Biochem J, 351, 87-93
40. Xu R, Liu J, Chen X, Xu F, Xie Q, Yu H, Guo Q, Zhou X, Jin Y. (2001
41. Ribozyme-mediated inhibition of caspase-3 activity reduces apoptosis induced by 6-hydroxydopamine in PC12 cells. Brain Res, 899, 10-19