Vitamin E attenuates the toxic effects of 6-hydroxydopamine on free radical scavenging systems in rat brain

Brain Research Bulletin

Volumn 29, Issue 5, 1992, Pages 699-701

  Perumal, A S ^a   Gopal, V B ^a   Tordzro, W K ^a   Cooper, T B ^a   Cadet, J L ^a,b  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b NEUROLOGICAL INSTITUTE   (United States)

Author keywords

6 Hydroxydopamine; Free radical; Glutathione; Parkinson's disease; Superoxide dismutase; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; FREE RADICAL; GLUTATHIONE; OXIDOPAMINE; SCAVENGER; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN PROTECTION; BRAIN STEM; BRAIN TOXICITY; CONTROLLED STUDY; CORPUS STRIATUM; FRONTAL CORTEX; HIPPOCAMPUS; INTRAGASTRIC DRUG ADMINISTRATION; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PARKINSON DISEASE; PRIORITY JOURNAL; RAT;

ANIMAL; BRAIN; BRAIN CHEMISTRY; FREE RADICAL SCAVENGERS; GLUTATHIONE; MALE; OXIDOPAMINE; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE; VITAMIN E;

EID: 0026446062     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/0361-9230(92)90142-K     Document Type: Article

References (26)

1. Brain peroxidase and catalase in Parkinson's disease
2. Medical uses of vitamin
3. Effect of 6-hydroxydopamine on brain norepinephrine and dopamine: Evidence for selective degeneration of catecholamine neurons
4. Vitamin E attenuates the toxic effects of intrastriatal injection of 6-OHDA in rats: Behavioral and biochemical evidence
5. Destruction of sympathetic nerve terminals by 6-hydroxydopamine: Protection by 1-phenyl-3-(2-thiaxolyl)-2-thiourea, diethyl dithiocarbomate, methimazole, cysteamine, ethanol and n-butanol
6. The generation of hydrogen peroxide, superoxide radical and hydroxy radical by 6-hydroxydopamine, dialuric acid and related cytotoxic agents
7. Oxyradical toxicity in catecholamine neurons
8. Free-radical-mediated fragmentation of monoamine oxidase in the mitochondrial membrane
9. Fragmentation of extracellular and intracellular polypeptides by free radicals
10. Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease
11. The endogenous toxin hypothesis of the etiology of Parkinson's disease and a pilot trial of high-dosage antioxidants in an attempt to show the progression of the illness
12. Monoamines in human striaturn: Topographic distribution in normals, and in Parkinson's disease and their role in akinesia, rigidity and tremor
13. Assay of glutathione peroxidase
14. Superoxide radical: An endogenous toxicant
15. Enzymatic and non-enzymatic assay of superoxide dismutase
16. Determination of glutathione and glutathione disulfide using glutathione reductase and 1-vinylpyridine
17. The interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide: Inactivation of the enzyme
18. Biochemical neuropathology of Parkinson's disease
19. Regional effects of 6-hydroxydopamine (6-OHDA) on free radical scavenger in rat brain
20. Reduction of brain glutathione by L-buthionine sulfoxime potentiates the dopamine-depleting action of 6-hydroxydopamine in rat striatum
21. Oxyradicals and related species: Their formation, lifetimes and reactions
22. Transition metals, ferritin, glutathione and ascorbic acid in Parkinsonian brains
23. Oxygen effect in the radiolysis of proteins part 2. Bovine serum albumin
24. The effect of water-deprivation on locomotor activity in rats treated with 6-hydroxydopamine
25. Free radical mechanisms in tissue injury