메뉴 건너뛰기




Volumn , Issue , 2011, Pages 265-283

Bioanalysis of Therapeutic Oligonucleotides Using Hybridization-Based Immunoassay Techniques

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84872465454     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/b10714-13     Document Type: Chapter
Times cited : (1)

References (64)
  • 1
    • 1542269161 scopus 로고    scopus 로고
    • Progress in antisense technology
    • Crooke, S. T. 2004. Progress in antisense technology. Annual Review of Medicine 55: 61-95.
    • (2004) Annual Review of Medicine , vol.55 , pp. 61-95
    • Crooke, S.T.1
  • 2
    • 55049111537 scopus 로고    scopus 로고
    • Design and development of antisense drugs
    • Malik, R., and I. Roy. 2008. Design and development of antisense drugs. Expert Opinion on Drug Discovery 3(10): 1189-1207.
    • (2008) Expert Opinion on Drug Discovery , vol.3 , Issue.10 , pp. 1189-1207
    • Malik, R.1    Roy, I.2
  • 3
    • 39049156763 scopus 로고    scopus 로고
    • Applying small RNA mol-ecules to the directed treatment of human diseases: Realizing the potential
    • Pappas, T. C., A. G. Bader, B. F. Andruss, D. Brown, and L. P. Ford. 2008. Applying small RNA mol-ecules to the directed treatment of human diseases: realizing the potential. Expert Opinion on Therapeutic Targets 12(1): 115-127.
    • (2008) Expert Opinion on Therapeutic Targets , vol.12 , Issue.1 , pp. 115-127
    • Pappas, T.C.1    Bader, A.G.2    Andruss, B.F.3    Brown, D.4    Ford, L.P.5
  • 4
    • 60149088848 scopus 로고    scopus 로고
    • Origins and mechanisms of miRNAs and siRNAs
    • Carthew, R. W., and E. J. Sontheimer. 2009. Origins and mechanisms of miRNAs and siRNAs. Cell 136(4): 642-655.
    • (2009) Cell , vol.136 , Issue.4 , pp. 642-655
    • Carthew, R.W.1    Sontheimer, E.J.2
  • 5
    • 58749104364 scopus 로고    scopus 로고
    • The promises and pitfalls of RNA-interference-based therapeutics
    • Castanotto, D., and J. J. Rossi. 2009. The promises and pitfalls of RNA-interference-based therapeutics. Nature 457(7228): 426-133.
    • (2009) Nature , vol.457 , Issue.7228 , pp. 133-426
    • Castanotto, D.1    Rossi, J.J.2
  • 6
    • 38649089811 scopus 로고    scopus 로고
    • Clinical application of CpG-, non-CpG- and antisense oligodeoxy-nucleotides as immunomodulators
    • Dorn, A., and S. Kippenberger. 2008. Clinical application of CpG-, non-CpG- and antisense oligodeoxy-nucleotides as immunomodulators. Current Opinion in Molecular Therapeutics 10(1): 10-20.
    • (2008) Current Opinion in Molecular Therapeutics , vol.10 , Issue.1 , pp. 10-20
    • Dorn, A.1    Kippenberger, S.2
  • 9
    • 33748575899 scopus 로고    scopus 로고
    • Treatment of allergic asthma by target-ing transcription factors using nucleic-acid based technologies
    • Sel, S., W. Henke, A. Dietrich, U. Herz, and H. Renz. 2006. Treatment of allergic asthma by target-ing transcription factors using nucleic-acid based technologies. Current Pharmaceutical Design 12(25): 3291-3304.
    • (2006) Current Pharmaceutical Design , vol.12 , Issue.25 , pp. 3291-3304
    • Sel, S.1    Henke, W.2    Dietrich, A.3    Herz, U.4    Renz, H.5
  • 10
    • 0033692912 scopus 로고    scopus 로고
    • Nuclease-resistant synthetic ribozymes: Developing a new class of therapeutics
    • Usman, N., and L. M. Blarr. 2000. Nuclease-resistant synthetic ribozymes: developing a new class of therapeutics. Journal of Clinical Investigation 106(10): 1197-1202.
    • (2000) Journal of Clinical Investigation , vol.106 , Issue.10 , pp. 1197-1202
    • Usman, N.1    Blarr, L.M.2
  • 11
    • 34247277243 scopus 로고    scopus 로고
    • DNAzymes as potential therapeutic molecules
    • Isaka, Y. 2007. DNAzymes as potential therapeutic molecules. Current Opinion in Molecular Therapeutics 9(2): 132-136.
    • (2007) Current Opinion in Molecular Therapeutics , vol.9 , Issue.2 , pp. 132-136
    • Isaka, Y.1
  • 12
    • 57349134691 scopus 로고    scopus 로고
    • Chemical modification of siRNAs for in vivo use
    • Behlke, M. A. 2008. Chemical modification of siRNAs for in vivo use. Oligonucleotides 18(4): 305-320.
    • (2008) Oligonucleotides , vol.18 , Issue.4 , pp. 305-320
    • Behlke, M.A.1
  • 13
    • 0037373763 scopus 로고    scopus 로고
    • Structural modifications of antisense oligonucleotides
    • Urban, E., and C. R. Noe. 2003. Structural modifications of antisense oligonucleotides. Farmaco 58: 243-258
    • (2003) Farmaco , vol.58 , pp. 243-258
    • Urban, E.1    Noe, C.R.2
  • 14
    • 41849116686 scopus 로고    scopus 로고
    • Sugar boost: When ribose modifications improve oligonucleotide per-formance
    • Faria, M., and H. Ulrich. 2008. Sugar boost: when ribose modifications improve oligonucleotide per-formance Current Opinion in Molecular Therapeutics 10: 168-175
    • (2008) Current Opinion in Molecular Therapeutics , vol.10 , pp. 168-175
    • Faria, M.1    Ulrich, H.2
  • 15
    • 34247586674 scopus 로고    scopus 로고
    • 2'-Modified oligonucleotides for antisense therapeutics
    • Prakash, T. P., and B. Bhat. 2007. 2'-Modified oligonucleotides for antisense therapeutics. Current Topics in Medicinal Chemistry 7: 641-649
    • (2007) Current Topics in Medicinal Chemistry , vol.7 , pp. 641-649
    • Prakash, T.P.1    Bhat, B.2
  • 17
    • 67650403364 scopus 로고    scopus 로고
    • Controlled delivery of antisense oligonucleo-tides: A brief review of current strategies
    • Zhao, X., F. Pan, C. M. Holt, A. L. Lewis, and J. R. Lu. 2009. Controlled delivery of antisense oligonucleo-tides: a brief review of current strategies Expert Opinion on Drug Delivery 6(7): 673-686
    • (2009) Expert Opinion on Drug Delivery , vol.6 , Issue.7 , pp. 673-686
    • Zhao, X.1    Pan, F.2    Holt, C.M.3    Lewis, A.L.4    Lu, J.R.5
  • 19
  • 20
    • 0031741998 scopus 로고    scopus 로고
    • Use of capillary electrophoresis methods to characterize the pharma-cokinetics of antisense drugs
    • Chen, S H, and J M Gallo 1998 Use of capillary electrophoresis methods to characterize the pharma-cokinetics of antisense drugs Electrophoresis 19: 2861-2869
    • (1998) Electrophoresis , vol.19 , pp. 2861-2869
    • Chen, S.H.1    Gallo, J.M.2
  • 21
    • 0030573018 scopus 로고    scopus 로고
    • Determination of single-stranded oligodeoxynucleotides by capillary gel electrophoresis with laser-induced fluorescence and on column derivatization
    • Reyderman, L., and S. Stavchansky. 1996. Determination of single-stranded oligodeoxynucleotides by capillary gel electrophoresis with laser-induced fluorescence and on column derivatization. Journal of Chromatography A 755(2): 271-280.
    • (1996) Journal of Chromatography A , vol.755 , Issue.2 , pp. 271-280
    • Reyderman, L.1    Stavchansky, S.2
  • 22
    • 18444396632 scopus 로고    scopus 로고
    • Analysis of nucleic acid constituents by on-line capillary electrophoresis-mass spectrometry
    • Willems, A V, D L Deforce, C H Van Peteghem, and J F Van Bocxlaer 2005 Analysis of nucleic acid constituents by on-line capillary electrophoresis-mass spectrometry Electrophoresis 26(7-8): 1221-1253.
    • (2005) Electrophoresis , vol.26 , Issue.7-8 , pp. 1221-1253
    • Willems, A.V.1    Deforce, D.L.2    Van Peteghem, C.H.3    Van Bocxlaer, J.F.4
  • 24
    • 0030963933 scopus 로고    scopus 로고
    • Determination of antisense phophorothio-ate oligonucloetides and catabolites in biological fluids and tissue extracts using anion-exchange high-performance liquid chromatography and capillary gel electrophoresis
    • Chen, S. H., M. Qian, J. M. Brennan, and J. M. Gallo. 1997. Determination of antisense phophorothio-ate oligonucloetides and catabolites in biological fluids and tissue extracts using anion-exchange high-performance liquid chromatography and capillary gel electrophoresis. Journal of Chromatography B: Biomedical Sciences and Applications 692(1): 43-51
    • (1997) Journal of Chromatography B: Biomedical Sciences and Applications , vol.692 , Issue.1 , pp. 43-51
    • Chen, S.H.1    Qian, M.2    Brennan, J.M.3    Gallo, J.M.4
  • 25
    • 0036279927 scopus 로고    scopus 로고
    • Bioavailability and efficacy of 2. antisense morpholino oligomers targeted to c-myc and cytochrome P-450 3A2 following oral administration in rats
    • Arora, V., D. C. Knapp, M. T. Reddy, D. D. Weller, and P. L. Iversen. 2003. Bioavailability and efficacy of 2. antisense morpholino oligomers targeted to c-myc and cytochrome P-450 3A2 following oral administration in rats. Journal of Pharmaceutical Sciences 91(4): 1009-1018.
    • (2003) Journal of Pharmaceutical Sciences , vol.91 , Issue.4 , pp. 1009-1018
    • Arora, V.1    Knapp, D.C.2    Reddy, M.T.3    Weller, D.D.4    Iversen, P.L.5
  • 26
    • 0035545158 scopus 로고    scopus 로고
    • Analysis of nucleic acids by on-line liquid chromatography-mass spectrometry
    • Huber, C G, and H Oberacher 2001 Analysis of nucleic acids by on-line liquid chromatography-mass spectrometry. Mass Spectrometry Reviews 20(5): 310-343.
    • (2001) Mass Spectrometry Reviews , vol.20 , Issue.5 , pp. 310-343
    • Huber, C.G.1    Oberacher, H.2
  • 27
    • 34250013402 scopus 로고    scopus 로고
    • Application of LC-MS for quantitative analysis and metabolite identification of therapeutic oligonucleotides
    • Lin, Z J, W Li, and G Dai 2007 Application of LC-MS for quantitative analysis and metabolite identification of therapeutic oligonucleotides. Journal of Pharmaceutical and Biomedical Analysis 44(2): 330-341
    • (2007) Journal of Pharmaceutical and Biomedical Analysis , vol.44 , Issue.2 , pp. 330-341
    • Lin, J.Z.1    Li, W.2    Dai, G.3
  • 28
    • 34248166118 scopus 로고    scopus 로고
    • Strategies for bioanalysis of an oligonucleotide class macromolecule from rat plasma using liquid chromatography-tandem mass spec-trometry
    • Zhang, G., J. Lin, K. Srinivasan, O. Kavetskaia, and J. N. Duncan. 2007. Strategies for bioanalysis of an oligonucleotide class macromolecule from rat plasma using liquid chromatography-tandem mass spec-trometry. Analytical Chemistry 79(9): 3416-3424.
    • (2007) Analytical Chemistry , vol.79 , Issue.9 , pp. 3416-3424
    • Zhang, G.1    Lin, J.2    Srinivasan, K.3    Kavetskaia, O.4    Duncan, J.N.5
  • 30
    • 52649089280 scopus 로고    scopus 로고
    • Recent progress in oligonucleotide therapeutics: Antisense to aptamers
    • Leaman, D W 2008 Recent progress in oligonucleotide therapeutics: antisense to aptamers Expert Opinion on Drug Discovery 3(9): 997-1009
    • (2008) Expert Opinion on Drug Discovery , vol.3 , Issue.9 , pp. 997-1009
    • Leaman, D.W.1
  • 31
    • 10744225153 scopus 로고    scopus 로고
    • Asymmetry in the assembly of the RNAi enzyme complex
    • Schwarz, D. Z., G. Hutvagner, T. Du, Z. Xu, N. Aronin, and P. D. Zamore. 2003. Asymmetry in the assembly of the RNAi enzyme complex Cell 115(2): 199-208
    • (2003) Cell , vol.115 , Issue.2 , pp. 199-208
    • Schwarz, D.Z.1    Hutvagner, G.2    Du, T.3    Xu, Z.4    Aronin, N.5    Zamore, P.D.6
  • 32
    • 0025288944 scopus 로고
    • Avidin and streptavidin
    • Green, N. M. 1990. Avidin and streptavidin. Methods in Enzymology 184: 51-67.
    • (1990) Methods in Enzymology , vol.184 , pp. 51-67
    • Green, N.M.1
  • 33
    • 25444513733 scopus 로고    scopus 로고
    • Enhanced sensitivity and precision in an enzyme-linked immunosorbent assay with fluorogenic substrates compared with commonly used chromogenic substrates
    • Meng, Y, K High, J Antonello, M W Washabaugh, and Q Zhao Enhanced sensitivity and precision in an enzyme-linked immunosorbent assay with fluorogenic substrates compared with commonly used chromogenic substrates. Analytical Biochemistry 345: 227-236.
    • Analytical Biochemistry , vol.345 , pp. 227-236
    • Meng, Y.1    High, K.2    Antonello, J.3    Washabaugh, M.W.4    Zhao, Q.5
  • 35
    • 0035113736 scopus 로고    scopus 로고
    • Locked nucleic acid (LNA): Fine-tuning the recognition of DNA and RNA
    • Braasch, D. A., and D. R. Corey. 2001. Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA Chemistry and Biology 8(1): 1-7
    • (2001) Chemistry and Biology , vol.8 , Issue.1 , pp. 1-7
    • Braasch, D.A.1    Corey, D.R.2
  • 36
  • 37
    • 3042626704 scopus 로고    scopus 로고
    • Dilution protocols for detection of hook effects/prozone phenomenon
    • Butch, A W 2000 Dilution protocols for detection of hook effects/prozone phenomenon Clinical Chemistry 46(10): 1719-1720.
    • (2000) Clinical Chemistry , vol.46 , Issue.10 , pp. 1719-1720
    • Butch, A.W.1
  • 38
    • 0036570927 scopus 로고    scopus 로고
    • Development of an ultra-sensitive noncompetitive hybridization-ligation enzyme-linked immunosorbent assay for the determination of phosphorothioate oligodeoxynucleotide in plasma
    • Yu, R Z, B Baker, A Chappell, R S Geary, E Cheung, and A A Levin 2002 Development of an ultra-sensitive noncompetitive hybridization-ligation enzyme-linked immunosorbent assay for the determination of phosphorothioate oligodeoxynucleotide in plasma. Analytical Biochemistry 301(1): 19-25.
    • (2002) Analytical Biochemistry , vol.301 , Issue.1 , pp. 19-25
    • Yu, R.Z.1    Baker, B.2    Chappell, A.3    Geary, R.S.4    Cheung, E.5    Levin, A.A.6
  • 40
    • 0026175462 scopus 로고
    • Substrate specificity and kinetics of degra-dation of antisense oligonucleotides by a 3 '-exonuclease in plasma
    • Eder, P. S., R. J. Devine, J. M. Dagle, and J. A. Walder. 1991. Substrate specificity and kinetics of degra-dation of antisense oligonucleotides by a 3 '-exonuclease in plasma. Antisense Research and Development 1(2): 141-151.
    • (1991) Antisense Research and Development , vol.1 , Issue.2 , pp. 141-151
    • Eder, P.S.1    Devine, R.J.2    Dagle, J.M.3    Walder, J.A.4
  • 41
    • 34247526364 scopus 로고    scopus 로고
    • Nucleotide pyrophos-phatase/phosphodiesterase 1 is responsible for degradation of antisense phosphorothioate oligonucleo-tides
    • Wojcik, M., M. Cieslak, W. J. Stec, J. W. Goding, and M. Koziolkiewicz. 2007. Nucleotide pyrophos-phatase/phosphodiesterase 1 is responsible for degradation of antisense phosphorothioate oligonucleo-tides Oligonucleotides 17(1): 134-145
    • (2007) Oligonucleotides , vol.17 , Issue.1 , pp. 134-145
    • Wojcik, M.1    Cieslak, M.2    Stec, W.J.3    Goding, J.W.4    Koziolkiewicz, M.5
  • 43
    • 0037109211 scopus 로고    scopus 로고
    • ‘Immunomers’-novel 3'-3'- linked CpG oligodeoxyribonucleotides as potent immunomodulatory agents
    • Yu, D., E. R. Kandimalla, L. Bhagat, J. Y. Tang, Y. Cong, J. Tang, and S. Agrawal. 2002. ‘Immunomers’-novel 3'-3'- linked CpG oligodeoxyribonucleotides as potent immunomodulatory agents Nucleic Acids Research 30(20): 4460-4469
    • (2002) Nucleic Acids Research , vol.30 , Issue.20 , pp. 4460-4469
    • Yu, D.1    Kandimalla, E.R.2    Bhagat, L.3    Tang, J.Y.4    Cong, Y.5    Tang, J.6    Agrawal, S.7
  • 44
    • 0023651476 scopus 로고
    • Nicks 3' or 5' to AP sites or to mis-paired bases, and one-nucleotide gaps can be sealed by T4 DNA ligase
    • Goffin, C., V. Bailly, and W. G. Verly. 1987. Nicks 3' or 5' to AP sites or to mis-paired bases, and one-nucleotide gaps can be sealed by T4 DNA ligase. Nucleic Acids Research 15(21): 8755-8771.
    • (1987) Nucleic Acids Research , vol.15 , Issue.21 , pp. 8755-8771
    • Goffin, C.1    Bailly, V.2    Verly, W.G.3
  • 45
    • 0042121058 scopus 로고    scopus 로고
    • OligoDesign: Optimal design of LNA (locked nucleic acid) oligonucleotide capture probes for gene expression profiling
    • Tolstrup, N., P. S. Neilson, J. G. Kolberg, A. M. Frankel, H. Vissing, and S. Kauppinen. 2003. OligoDesign: optimal design of LNA (locked nucleic acid) oligonucleotide capture probes for gene expression profiling Nucleic Acids Research 31(13): 3758-3762
    • (2003) Nucleic Acids Research , vol.31 , Issue.13 , pp. 3758-3762
    • Tolstrup, N.1    Neilson, P.S.2    Kolberg, J.G.3    Frankel, A.M.4    Vissing, H.5    Kauppinen, S.6
  • 47
    • 0037264483 scopus 로고    scopus 로고
    • Single-strand-specific nucleases
    • Desai, N. A., and V. Shankar. 2003. Single-strand-specific nucleases. FEMS Microbiology Reviews 26(5): 457-491
    • (2003) FEMS Microbiology Reviews , vol.26 , Issue.5 , pp. 457-491
    • Desai, N.A.1    Shankar, V.2
  • 48
    • 1642591341 scopus 로고
    • Biochemical method for mapping mutational alterations in DNA with S1 nuclease: The location of deletions and temperature-sensitive mutations in simian virus 40
    • Shenk, T E, C Rhodes, P W J Rigby, and P Berg 1975 Biochemical method for mapping mutational alterations in DNA with S1 nuclease: the location of deletions and temperature-sensitive mutations in simian virus 40 Proceedings on the National Academy of Sciences 72(3): 989-993
    • (1975) Proceedings on the National Academy of Sciences , vol.72 , Issue.3 , pp. 989-993
    • Shenk, T.E.1    Rhodes, C.2    Rigby, P.W.J.3    Berg, P.4
  • 49
    • 33745329502 scopus 로고    scopus 로고
    • A specific picomolar hybridization-based ELISA assay for the determination of phosphorothioate oligonucleotides in plasma and cellular matrices
    • Wei, X., G. Dai, G. Marcucci, Z. Liu, D. Hoyt, W. Blum, and K. K. Chan. 2006. A specific picomolar hybridization-based ELISA assay for the determination of phosphorothioate oligonucleotides in plasma and cellular matrices. Pharmaceutical Research 23(6): 1251-1264.
    • (2006) Pharmaceutical Research , vol.23 , Issue.6 , pp. 1251-1264
    • Wei, X.1    Dai, G.2    Marcucci, G.3    Liu, Z.4    Hoyt, D.5    Blum, W.6    Chan, K.K.7
  • 50
    • 22044438502 scopus 로고    scopus 로고
    • Quantitation of oligonucleotides in human plasma with a novel hybridization assay offers greatly enhanced sensitivity over capillary gel electrophoresis
    • Efler, S. M., L. Zhang, B. O. Noll, E. Uhlmann, and H. L. Davis. 2005. Quantitation of oligonucleotides in human plasma with a novel hybridization assay offers greatly enhanced sensitivity over capillary gel electrophoresis. Oligonucleotides 15: 119-131.
    • (2005) Oligonucleotides , vol.15 , pp. 119-131
    • Efler, S.M.1    Zhang, L.2    Noll, B.O.3    Uhlmann, E.4    Davis, H.L.5
  • 51
    • 0042121058 scopus 로고    scopus 로고
    • OligoDesign: Optimal design of LNA (locked nucleic acid) oligonucleotide capture probes for gene expression profiling
    • Tolstrup, N, P S Neilson, J G Kolberg, A M Frankel, H Vissing, and S Kauppinen 2003 OligoDesign: optimal design of LNA (locked nucleic acid) oligonucleotide capture probes for gene expression profiling Nucleic Acids Research 31(13): 3758-3762
    • (2003) Nucleic Acids Research , vol.31 , Issue.13 , pp. 3758-3762
    • Tolstrup, N.1    Neilson, P.S.2    Kolberg, J.G.3    Frankel, A.M.4    Vissing, H.5    Kauppinen, S.6
  • 52
    • 0030863191 scopus 로고    scopus 로고
    • A competitive enzyme hybridiza-tion assay for plasma determination of phosphodiester and phosphorothioate antisense oligonucleotides
    • Deverre, J. R., V. Boutet, E. Ezan, J. Grassi, and J. M. Grognet. 1997. A competitive enzyme hybridiza-tion assay for plasma determination of phosphodiester and phosphorothioate antisense oligonucleotides Nucleic Acids Research 25(18): 3584-3589.
    • (1997) Nucleic Acids Research , vol.25 , Issue.18 , pp. 3584-3589
    • Deverre, J.R.1    Boutet, V.2    Ezan, E.3    Grassi, J.4    Grognet, J.M.5
  • 53
    • 22144466240 scopus 로고    scopus 로고
    • The five-parameter logistic: A characterization and comparison with the four-parameter logistic
    • Gottschalk, P. G., and J. R. Dunn. 2005. The five-parameter logistic: A characterization and comparison with the four-parameter logistic Analytical Biochemistry 343: 54-65
    • (2005) Analytical Biochemistry , vol.343 , pp. 54-65
    • Gottschalk, P.G.1    Dunn, J.R.2
  • 55
    • 0002264403 scopus 로고
    • The renal regulation of acid base balance in man I The nature of the mechanism for acidifying the urine
    • Pitts, R. F., W. D. Lotspeich, W. A. Schiess, J. L. Ayer, and P. Miner. 1948. The renal regulation of acid base balance in man I The nature of the mechanism for acidifying the urine Journal of Clinical Investigation 27(1): 48-56.
    • (1948) Journal of Clinical Investigation , vol.27 , Issue.1 , pp. 48-56
    • Pitts, R.F.1    Lotspeich, W.D.2    Schiess, W.A.3    Ayer, J.L.4    Miner, P.5
  • 56
    • 39549117983 scopus 로고    scopus 로고
    • Delivery vehicles for small interfering RNA in vivo
    • De Fougerolles, A. R. 2008. Delivery vehicles for small interfering RNA in vivo. Human Gene Therapy 19: 125-132.
    • (2008) Human Gene Therapy , vol.19 , pp. 125-132
    • De Fougerolles, A.R.1
  • 57
    • 59349116903 scopus 로고    scopus 로고
    • Knocking down barriers: Advances in siRNA delivery
    • Whitehead, K A, R Langer, and D G Anderson 2009 Knocking down barriers: advances in siRNA delivery Nature Reviews 8: 129-138
    • (2009) Nature Reviews , vol.8 , pp. 129-138
    • Whitehead, K.A.1    Langer, R.2    Anderson, D.G.3
  • 59
    • 0003484310 scopus 로고    scopus 로고
    • U S Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Veterinary Medicine (CVM). 2001. Guidance for Industry: Bioanalytical Method Validation
    • (2001) Guidance for Industry: Bioanalytical Method Validation
  • 60
    • 34249277443 scopus 로고    scopus 로고
    • Key elements of bioanalytical method validation for macromolecules
    • Kelley, M., and B. DeSilva. 2007. Key elements of bioanalytical method validation for macromolecules. AAPS Journal 9(2): E156-E163.
    • (2007) AAPS Journal , vol.9 , Issue.2 , pp. E156-E163
    • Kelley, M.1    DeSilva, B.2
  • 61
    • 38849144763 scopus 로고    scopus 로고
    • Confirmatory reanalysis of incurred bioanalytical samples
    • Rocci, M. L., Jr., V. Devanarayan, D. B. Haughley, and P. Jardieu. 2007. Confirmatory reanalysis of incurred bioanalytical samples AAPS Journal 9(3): E336-E343
    • (2007) AAPS Journal , vol.9 , Issue.3 , pp. E336-E343
    • Rocci, M.L.1    Devanarayan, V.2    Haughley, D.B.3    Jardieu, P.4
  • 62
    • 85137940521 scopus 로고    scopus 로고
    • A parent-specific hybridization assay for quan-tifying therapeutic oligonucleotides and siRNA in biological samples Poster
    • Los Angeles, California, Nov. 8-12 (Patent Pending No. US 61/258, 046)
    • Tremblay, G. A., P. R. Oldfield, and A. J. Bartlett. 2009. A parent-specific hybridization assay for quan-tifying therapeutic oligonucleotides and siRNA in biological samples Poster. Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists (AAPS), Los Angeles, California, Nov. 8-12 (Patent Pending No. US 61/258, 046).
    • (2009) Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists (AAPS)
    • Tremblay, G.A.1    Oldfield, P.R.2    Bartlett, A.J.3
  • 63
    • 33745787972 scopus 로고    scopus 로고
    • Multiplexed and Microparticle-based Analyses: Quantitative Tools for the Large-Scale Analysis of Biological Systems
    • Nolan, J. P., and F. Mandy. 2006. Multiplexed and Microparticle-based Analyses: Quantitative Tools for the Large-Scale Analysis of Biological Systems. Cytometry 69(5): 318-325.
    • (2006) Cytometry , vol.69 , Issue.5 , pp. 318-325
    • Nolan, J.P.1    Mandy, F.2
  • 64
    • 35549010108 scopus 로고    scopus 로고
    • Comparison of an electrochemiluminescence assay in plate format over a colorimetric ELISA, for the detection of ricin B chain (RCA-B)
    • Gugliermo-Viret, V, and P Thullier 2007 Comparison of an electrochemiluminescence assay in plate format over a colorimetric ELISA, for the detection of ricin B chain (RCA-B). Journal of Immunological Methods 328: 70-78
    • (2007) Journal of Immunological Methods , vol.328 , pp. 70-78
    • Gugliermo-Viret, V.1    Thullier, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.