β-Ionone attenuates LPS-induced pro-inflammatory mediators such as NO, PGE2 and TNF-α in BV2 microglial cells via suppression of the NF-κB and MAPK pathway

Toxicology in Vitro

Volumn 27, Issue 2, 2013, Pages 782-787

  Kang, Chang Hee ^a   Jayasooriya, Rajapaksha Gendara Prasad Tharanga ^a   Choi, Yung Hyun ^b   Moon, Sung Kwon ^c   Kim, Wun Jae ^d   Kim, Gi Young ^a  

^a Jeju National University   (South Korea)

^b Dong Eui University   (South Korea)

^c Chungju National University   (South Korea)

^d Chungbuk National University College of Medicine   (South Korea)

Author keywords

Ionone; Akt; Nitric oxide; Nuclear factor B; Prostaglandin E2; Tumor necrosis factor

Indexed keywords

ACETYLCYSTEINE; BETA IONONE; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; PROSTAGLANDIN E2; PROTEIN KINASE B; PROTEIN P50; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL NUCLEUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; COX 2 GENE; CYTOKINE RELEASE; DNA BINDING; ENZYME PHOSPHORYLATION; INOS GENE; MICROGLIA; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TUMOR NECROSIS FACTOR ALPHA GENE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CYCLOOXYGENASE 2; DINOPROSTONE; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MICE; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NORISOPRENOIDS; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84872421822     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2012.12.012     Document Type: Article

References (36)

1. Baeuerle P.A., Henkel T. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 1994, 12:147-179.
2. Baldermann S., Kato M., Kurosawa M., Kurobayashi Y., Fujita A., Reischmann P., Watanabe N. Functional characterization of a carotenoid cleavage dioxygenase 1 and its relation to the carotenoid accumulation and volatile emission during the floral development of Osmanthus fragrans Lour. J. Exp. Bot. 2010, 61:2967-2977.
3. Baldwin A.S. The NF-κB and IκB proteins: New discoveries and insights. Annu. Rev. Immunol. 1996, 14:649-683.
4. Bhat N.R., Zhang P., Lee J.C., Hogan E.L. Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-α gene expression in endotoxin-stimulated primary glial cultures. J. Neurosci. 1998, 18:1633-1641.
5. Bogdan C. The multiplex function of nitric oxide in (auto) immunity. J. Exp. Med. 1998, 187:1361-1365.
6. L expression. Chem. Biol. Interact. 2010, 184:359-365.
7. Choi Y., Moon A., Kim Y.C. A pinusolide derivative, 15-methoxypinusolidic acid from Biota orientalis inhibits inducible nitric oxide synthase in microglia cells: implication for a potential anti-inflammatory effect. Int. Immunopharmacol. 2008, 8:548-555.
8. De Nardin E. The role of inflammatory and immunological mediators in periodontitis and cardiovascular disease. Ann. Periodontol. 2001, 6:30-40.
9. Dobrenis K. Microglia in cell culture and in transplantation therapy for central nervous system disease. Methods 1998, 16:320-344.
10. Dubois R.N., Abramson S.B., Crofford L., Gupta R.A., Simon L.S., Van De., Putte L.B., Lipsky P.E. Cyclooxygenase in biology and disease. FASEB J. 1998, 12:1063-1073.
11. Ghosh S., Hayden M.S. New regulators of NF-κB in inflammation. Nat. Rev. Immunol. 2008, 8:837-848.
12. Gonzalez-Scarano F., Baltuch G. Microglia as mediators of inflammatory and degenerative diseases. Annu. Rev. Neurosci. 1999, 22:219-240.
13. Hattori Y., Hattori S., Kasai K. Lipopolysaccharide activates Akt in vascular smooth muscle cells resulting in induction of inducible nitric oxide syntheses through nuclear factor-kappa B activation. Eur. J. Pharmacol. 2003, 481:153-158.
14. Janakiram N.B., Cooma I., Mohammed A., Steele V.E., Rao C.V. β-Ionone inhibits colonic aberrant crypt foci formation in rats, suppresses cell growth, and induces retinoid X receptor-α in human colon cancer cells. Mol. Cancer Ther. 2008, 7:181-190.
15. Kim M.O., Moon D.O., Kang C.H., Kwon T.K., Choi Y.H., Kim G.Y. β-Ionone enhances TRAIL-induced apoptosis in hepatocellular carcinoma cells through Sp1-dependent up regulation of DR5 and down regulation of NF-κB activity. Mol. Cancer Ther. 2010, 9:833-843.
16. Kleinert H., Pautz A., Linker K., Schwarz P.M. Regulation of the expression of inducible nitric oxide syntheses. Eur. J. Pharmacol. 2004, 500:255-266.
17. Lawson L.J., Perry V.H., Dri P., Gordon S. Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience 1990, 39:151-170.
18. Lee A.K., Sung S.H., Kim Y.C., Kim S.G. Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-α and COX-2 expression by sauchinone effects on I-κBα phosphorylation, C/EBP and AP-1 activation. Br. J. Pharmacol. 2003, 139:11-20.
19. Liu B., Hong J.S. Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J. Pharmacol. Exp. Ther. 2003, 304:1-7.
20. Liu J.R., Dong H.W., Sun X.R., Wang Q., Sun W.G., Parry J.W., Liu Q., Han X.H., Sun C.J., Chen B.Q., Yang B.F. Effects of β-ionone on mammary carcinogenesis and antioxidant status in rats treated with DMBA. Nutr. Cancer 2010, 62:58-65.
21. Liu J.R., Sun X.R., Dong H.W., Sun C.H., Sun W.G., Chen B.Q., Song Y.Q., Yang B.F. β-Ionone suppresses mammary carcinogenesis, proliferative activity and induces apoptosis in the mammary gland of the Sprague-Dawley rat. Int. J. Cancer 2008, 122:2689-2698.
22. Lu Y.C., Yeh W.C., Ohashi P.S. LPS/TLR4 signal transduction pathway. Cytokine 2008, 42:145-151.
23. Madrid L.V., Wang C.Y., Guttridge D.C., Schottelius A.J., Baldwin A.S., Mayo M.W. Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-κB. Mol. Cell Biol. 2000, 20:1626-1638.
24. Marks-Konczalik J., Chu S.C., Moss J. Cytokine-mediated transcriptional induction of the human inducible nitric oxide synthase gene requires both activator protein 1 and nuclear factor κB-binding sites. J. Biol. Chem. 1998, 273:22201-22208.
25. McGeer P.L., McGeer E.G. The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res. Brain Res. Rev. 1995, 21:195-218.
26. McGeer P.L., Yasojima K., McGeer E.G. Inflammation in Parkinson's disease. Adv. Neurol. 2001, 86:83-89.
27. Meda L., Cassatella M.A., Szendrei G.I., Otvos L., Baron P., Villalba M., Ferrari D., Rossi F. Activation of microglia cells by β-amyloid protein and interferon-γ. Nature 1995, 374:647-650.
28. Medzhitov R., Horng T. Transcriptional control of the inflammatory response. Nat. Rev. Immunol. 2009, 9:692-703.
29. Moalem G., Tracey D.J. Immune and inflammatory mechanisms in neuropathic pain. Brain Res. Rev. 2006, 51:240-264.
30. Nathan C., Xie Q.W. Nitric oxide synthases: roles, tolls, and controls. Cell 1994, 78:915-918.
31. Perry V.H., Gordon S. Macrophages and microglia in the nervous system. Trends Neurosci. 1988, 11:273-277.
32. Pyo H., Jou I., Hong S., Joe E.H. Mitogen-activated protein kinases activated by lipopolysaccharide and β-amyloid in cultured rat microglia. NeuroReport 1998, 9:871-874.
33. Romero-Sandoval A., Chai N., Nutile-McMenemy N., De Leo J.A. A comparision of spinal Iba 1 and GFAP expression in rodent models of acute and chronic pain. Brain Res. 2008, 1219:116-126.
34. Sun H.Z., Yang T.W., Zang W.J., Wu S.F. Dehydroepiandrosterone-induced proliferation of prostatic epithelial cell is mediated by NF-κB via PI3K/AKT signaling pathway. J. Endocrinol. 2010, 204:311-318.
35. Tien Y.C., Lin J.Y., Lai C.H., Kuo C.H., Lin W.Y., Tsai C.H., Tsai F.J., Cheng Y.C., Peng W.H., Huang C.Y. Carthamus tinctorius L. prevents LPS-induced TNF-α signaling activation and cell apoptosis through JNK1/2-NF-κB pathway inhibition in H9c2 cardiomyoblast cells. J. Ethnopharmacol. 2010, 130:505-513.
36. Togashi H., Sasaki M., Frohman E., Taira E., Ratan R.R., Dawson T.M., Dawson V.L. Neuronal (type I) nitric oxide synthase regulates nuclear factor kappaB activity and immunologic (type II) nitric oxide synthase expression. Proc. Natl. Acad. Sci. USA 1997, 94:2676-2680.