Degradation of zopiclone during storage of spiked and authentic whole blood and matching dried blood spots

International Journal of Legal Medicine

Volumn 127, Issue 1, 2013, Pages 69-76

  Jantos, Ricarda ^a   Vermeeren, Annemiek ^b   Sabljic, Danica ^a   Ramaekers, Johannes G ^b   Skopp, Gisela ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Dried blood spots; LC MS MS; Stability; Whole blood; Zopiclone

Indexed keywords

2 AMINO 5 CHLOROPYRIDINE; 2-AMINO-5-CHLOROPYRIDINE; AZABICYCLO DERIVATIVE; HYPNOTIC SEDATIVE AGENT; PIPERAZINE DERIVATIVE; PYRIDINE DERIVATIVE; ZOPICLONE;

ARTICLE; BLOOD; CHEMISTRY; DRUG STABILITY; FORENSIC TOXICOLOGY; HUMAN; LABORATORY DIAGNOSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

AZABICYCLO COMPOUNDS; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; FORENSIC TOXICOLOGY; HUMANS; HYPNOTICS AND SEDATIVES; MASS SPECTROMETRY; PIPERAZINES; PYRIDINES; SPECIMEN HANDLING;

MLCS; MLOWN;

EID: 84872402174     PISSN: 09379827     EISSN: 14371596     Source Type: Journal    
DOI: 10.1007/s00414-012-0696-4     Document Type: Article

References (45)

1. Gustavsen I, Al-Sammurraie M, Mørland J, Bramness JG (2009) Impairment related to blood drug concentrations of zopiclone and zolpidem compared to alcohol in apprehended drivers. Accid Anal Prev 41:462-466
2. Bocca ML, Le Doze F, Etard O, Pottier M, L'Hoste J, Denise P (1999) Residual effects of zolpidem 10 mg and zopiclone 7.5 mg versus flunitrazepam 1 mg and placebo on driving performance and ocular saccades. Psychopharmacology 143:373-379
3. Leufkens TR, Lund JS, Vermeeren A (2009) Highway driving performance and cognitive functioning the morning after bedtime and middle-of-the-night use of gaboxadol, zopiclone and zolpidem. J Sleep Res 18:387-396
4. Vermeeren A, Danjou PE, O'Hanlon JF (1998) Residual effects of evening and middle-of-the-night administration of zaleplon 10 and 20 mg on memory and actual driving performance. Hum Psychopharmacol Clin Exp 13:S98-S107
5. Vermeeren A, Riedel WJ, van Boxtel MPJ, Darwish M, Paty I, Patat A (2002) Differential residual effects of zaleplon and zopiclone on actual driving: a comparison with a low dose of alcohol. Sleep 25:224-231
6. Bramness JG, Arnestad M, Karinen R, Hilberg T (2001) Fatal overdose of zopiclone in an elderly woman with bronchogenic carcinoma. J Forensic Sci 46:1247-1249
7. Aranko K, Henriksson M, Hublin C, Seppäläinen AM (1991) Misuse of zopiclone and convulsions during withdrawal. Pharmacopsychiat 24:138-140
8. Boniface PJ, Russell SGG (1996) Two cases of fatal zopiclone overdose. J Anal Toxicol 20:131-133
9. Jones AW, Holmgren A, Kugelberg FC (2007) Concentrations of scheduled prescription drugs in blood of impaired drivers: considerations for interpreting the results. Ther Drug Monit 29:248-260
10. Kratzsch C, Peters FT, Kraemer T, Weber AA, Maurer HH (2003) Screening, library-assisted identification and validated quantification of fifteen neuroleptics and their metabolites in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization. J Mass Spectrom 38:283-295
11. Mannaert E, Tytgat J, Daenens P (1997) Detection of 2-amino-5- chloropyridine in urine as a parameter of zopiclone (Imovane) intake using HPLC with diode array detection. J Anal Toxicol 21:208-212
12. Holmgren P, Druid H, Holmgren A, Ahlner J (2004) Stability of drugs in stored postmortem femoral blood and vitreous humor. J Forensic Sci 49:820-825
13. Nilsson GH, Kugelberg FC, Kronstrand R, Ahlner J (2010) Stability tests of zopiclone in whole blood. Forensic Sci Int 200:130-135
14. Galloway JH, Marsh JD, Newton CM, Forrest ARW (1999) A method for the rapid detection of the zopiclone degradation product 2-amino-5-chloropyridine. Sci Justice 39:253-256
15. Fernandez C, Gimenez F, Mayrargue J, Thullier A, Farinotti R (1995) Degradation and racemization of zopiclone enantiomers in plasma and partially aqueous solutions. Chirality 7:267-271
16. Swamy PV, Sushma P, Chirag G, Prasad K, Alu MY, Raju SA (2008) Parenteral formulation of zopiclone. Indian J Pharm Sci 70:99-102
17. Lageron M, Fleury MB (1989) Acid catalyzed hydrolysis of a series of zopiclone analogues. J Pharm Sci 78:627-631
18. Skopp G, Pötsch L (2001) Nachweis von Cocain in Blutspots. Arch Kriminol 207:81-88
19. Garcia Boy R, Henseler J, Mattern R, Skopp G (2008) Determination of morphine and 6-acetylmorphine in blood with use of dried blood spots. Ther Drug Monit 30:733-739
20. Guthrie R, Susi A (1963) A simple phenylalanine method for detecting phenylketonuria in large populations of human infants. Pediatrics 32:338-343
21. Chace DH, Kalas TA, Naylor EW (2003) Use of tandem mass spectrometry for multianalyte screening of dried blood spot specimens from newborns. Clin Chem 49:1797-1817
22. Skopp G (2004) Preanalytic aspects in postmortem toxicology. Forensic Sci Int 142:75-100
23. Jantos R, Veldstra JL, Mattern R, Brookhuis KA, Skopp G (2011) Analysis of 3,4-methylenedioxymetamphetamine: whole blood versus dried blood spots. J Anal Toxicol 35:269-273
24. Jantos R, Skopp G (2011) Comparison of drug analysis in whole blood and dried blood spots. Toxichem Krimtech 35:268-275
25. Ingels AM, Lambert WE, Stove CP (2010) Determination of gamma-hydroxybutyric acid in dried blood spots using a simple GC-MS method with direct "on spot" derivatization. Anal Bioanal Chem 398:2173-2182
26. Alfazil AA, Anderson RA (2008) Stability of benzodiazepines and cocaine in blood spots stored on filter paper. J Anal Toxicol 32:511-515
27. Peters FT (2007) Stability of analytes in biosamples - an important issue in clinical and forensic toxicology. Anal Bioanal Chem 388:1505-1519
28. Peters FT, Hartung M, Herbold M, Schmitt G, Daldrup T, Mußhoff F (2009) Anhang B zur Richtlinie der GTFCh zur Qualitätssicherung bei forensisch-toxikologischen Untersuchungen. Anforderungen an die Validierung von Analysenmethoden Toxichem Krimtech 76:185-208
29. Food and Drug Administration (2001) FDA guidance for industry: bioanalytical method validation. US Department of Health and Human Services, Center for Drug Evaluation and Research
30. Matuszewski BK, Constanzer ML, Chavez-Eng CM (2003) Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal Chem 75:3019-3030
31. Bansal S, DeStefano A (2007) Key elements of bioanalytical method validation for small molecules. AAPS J 9:E109-E114
32. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (2005) ICH harmonised tripartite guideline: validation of analytical procedures: text and methodology Q2 (R1). International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use
33. Nowatzke W, Woolf E (2007) Best practices during bioanalytical method validation for the characterization of assay reagents and the evaluation of analyte stability in assay standards, quality controls, and study samples. AAPS J 9:E117-E122
34. J Falbe and M Regitz (1989) (eds) Römpp Chemie Lexikon. Thieme, Stuttgart
35. Nilsson G (2010) Stability of zopiclone in whole blood - studies from a forensic perspective. Department of Medical and Health Sciences, Universität Linköping
36. Nilsson GH, Kugelberg FC, Ahlner J, Kronstrand R (2011) Influence of pre-analytical conditions on the interpretation of zopiclone concentrations in whole blood. Forensic Sci Int 207:35-39
37. Fernandez C, Gimenez F, Thuillier A, Farinotti R (1999) Stereoselective binding of zopiclone to human plasma proteins. Chirality 11:129-132
38. Goa KL, Heel RC (1986) Zopiclone: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy as an hypnotic. Drugs 32:48-65
39. Skopp G, Poetsch L, Koenig I, Mattern R (1998) A preliminary study on the stability of benzodiazepines in blood and plasma stored at 4 C. Int J Legal Med 111:1-5
40. Jantos R, Schumacher M, Skopp G (2011) Comparison of opioid analysis in whole blood and dried blood spots. Poster at SOFT TIAFT Meeting, San Francisco
41. Faller A, Richter B, Kluge M, Koenig P, Seitz HK, Thierauf A, Gnann H, Winkler M, Mattern R, Skopp G (2011) LC-MS/MS analysis of phosphatidylethanol in dried blood spot versus conventional blood specimens. Anal Bioanal Chem 401:1163-1166
42. Bland JM, Altman DG (1999) Measuring agreement in method comparison studies. Stat Methods Med Res 8:135-160
43. Miller LG, Leduc BW, Greenblatt DJ (1986) Determination of zopiclone in plasma by liquid chromatography with application to steady-state monitoring. J Chromatogr 380:211-215
44. Stamm D (1982) A new concept for quality control of clinical laboratory investigations in the light of clinical requirements and based on reference method values. J Clin Chem Clin Biochem 20:817-824
45. Chen J, Hsieh Y (2005) Stabilizing drug molecules in biological samples. Ther Drug Monit 27:617-624