Two cases of fatal zopiclone overdose

Journal of Analytical Toxicology

Volumn 20, Issue 2, 1996, Pages 131-133

  Boniface, Peter J ^a   Russell, Sarah G G ^a  

^a MT ALBERT RESEARCH CENTRE   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ZOPICLONE;

ADULT; AGED; ARTICLE; CASE REPORT; DEATH; DRUG BLOOD LEVEL; DRUG LIVER LEVEL; DRUG OVERDOSE; FEMALE; HUMAN;

EID: 0029916857     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/20.2.131     Document Type: Article

References (11)

1. P. Duriez, C. Barthelemy, H. Rives, C. Courjanet, and J. Gregoire. Traitement des troubles du sommeil par le zopiclone. Therapie 34: 317-25 (1979).
2. D. Wheatley, Zopiclone: a non-benzodiazepine hypnotic controlled comparison to temazepam in insomnia. Br. J. Psychiatry 146:312-14 (1985).
3. M. Tanaka, Y. Mizuki, H. Isozaki, and K. Inanaga. Effect of zopiclone on the arousal level of healthy volunteers assessed by the averaged photopalpebral reflex. Eur. J. Clin. Pharmacol. 24: 469-74 (1983).
4. D.J. Pounder and J.I. Davies. Zopiclone poisoning: tissue distribution and potential for postmortem diffusion. Forensic Sci. Int. 65:177-83 (1994).
5. S.T. Tan, P.J. Boniface, I.C. Martin, and S.L. Nolan. Development of a method for the determination of zopiclone in whole blood. J. Chromatogr. Biomed. Appl. 584: 199-206 (1992).
6. S.J. Dickson, W.J. Cleary, A.W. Missen, E.A. Querée, and S.M. Shaw. The relative efficiency of drug extraction procedures for enzyme digested livers. J. Anal. Toxicol. 4: 74-77 (1980).
7. Zopiclone: another carriage on the tranquilliser train. Lancet 335: 507-508 (1990).
8. L.G. Miller, B.W. Leduc, and D.J. Greenblatt. Determination of zopiclone in plasma by liquid chromatography with application to steady-state monitoring. J. Chromatogr. Biomed. Appl. 380: 211-15 (1986).
9. K.L. Goa and R.C. Heel Zopiclone - a review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy as a hypnotic. Drugs 32: 48-65 (1986).
10. New Ethicals Compendium New Zealand Edition. R. Saunders, Ed., Adis Press, Auckland, New Zealand, 1994, p 1206.
11. A.L. Liboux, A. Frydman, and J. Caillot. Simultaneous determination of zopiclone and its two major metabolites (N-oxide and N-desmethyl) in human biological fluids by reversed phase high performance liquid chromatography. J. Chromatogr. 417: 151-58 (1987).