Differential residual effects of zaleplon and zopiclone on actual driving: A comparison with a low dose of alcohol

Sleep

Volumn 25, Issue 2, 2002, Pages 224-231

  Vermeeren, Annemiek ^a   Riedel, Wim J ^a   Van Boxtel, Martin P J ^a   Darwish, Mona ^a   Paty, Isabelle ^a   Patat, Alain ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Alcohol; Car driving; Memory; Psychomotor performance; Zaleplon; Zopiclone

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; CYTOCHROME P450 3A4; PLACEBO; ZALEPLON; ZOPICLONE;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; ATTENTION; CLINICAL TRIAL; COGNITIVE DEFECT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE TIME EFFECT RELATION; DOUBLE BLIND PROCEDURE; DRIVING ABILITY; DROWSINESS; DRUG METABOLISM; DRUG SAFETY; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MEMORY; MOOD; NORMAL HUMAN; PRIORITY JOURNAL; PSYCHOMOTOR PERFORMANCE; SEDATION; SINGLE BLIND PROCEDURE; TASK PERFORMANCE;

ACETAMIDES; ADULT; AUTOMOBILE DRIVING; CROSS-OVER STUDIES; DISORDERS OF EXCESSIVE SOMNOLENCE; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; ETHANOL; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; MALE; PIPERAZINES; PSYCHOMOTOR DISORDERS; PYRIMIDINES; SINGLE-BLIND METHOD;

EID: 0037086988     PISSN: 01618105     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Association of road-traffic accidents with benzodiazepine use
2. Benzodiazepine-related traffic accidents in young and elderly drivers
3. Zaleplon: A review of its use in the treatment of insomnia
4. A placebo-controlled evaluation of single, escalating doses of CL 284,846, a non-benzodiazepine hypnotic
5. Comparative kinetics and dynamics of zaleplon, zolpidem, and placebo
6. Zaleplon pharmacokinetics and absolute bioavailability
7. CL 284,846, a novel sedative-hypnotic: Evaluation of its metabolites for pharmacological activity in vitro and in vivo
8. Zaleplon displays a selectivity to recombinant GABA(A) receptors different from zolpidem, zopiclone and benzodiazepines
9. The use of the rat elevated plusmaze to discriminate between non-selective and BZ-1 (omega 1) selective, benzodiazepine receptor ligands
10. Limited anxiolytic-like effects of non-benzodiazepine hypnotics in rodents
11. Comparison of the pharmacological profiles of the hypnotic drugs, zaleplon and zolpidem
12. Sleep latency is shortened during 4 weeks of treatment with zaleplon, a novel nonbenzodiazepine hypnotic
13. A five week, polysomnographic assessment of zaleplon 10 mg for the treatment of primary insomnia
14. Residual effects of evening and middle-of-the-night administration of zaleplon 10 and 20 mg on memory and actual driving performance
15. A comparison of the residual effects of zaleplon and zolpidem following administration 5 to 2 h before awakening
16. Comparison of the effects of zaleplon, zolpidem, and triazolam on memory, learning, and psychomotor performance
17. Mechanisms of drug-induced driving impairment: A dimensional approach
18. Diazepam impairs lateral position control in highway driving
19. Effects of mefloquine alone and with alcohol on psychomotor and driving performance
20. A "critical" tracking task for manual control research
21. Laboratory studies of the effects of alcohol on some variables related to driving
22. The use of analogue scales in rating subjective feelings
23. Zopiclone. An update of its pharmacology, clinical efficacy and tolerability in the treatment of insomnia
24. The relationship between drivers' blood alcohol concentration (BAC) and actual driving performance during high speed travel
25. Pharmacological studies on zopiclone
26. Zopiclone produces effects on human performance similar to flurazepam, lormetazepam and triazolam
27. Effects of hypnotics on memory
28. A double-blind study to establish the residual effects of zopiclone on performance in healthy volunteers
29. Effects of flurazepam and zopiclone on the performance of chronic insomniac patients: A study of ethanol-drug interaction
30. Residu effecten op de actuele rijprestatie: Zopiclone versus flunitrazepam en nitrazepam
31. Zopiclone's residual effects on psychomotor and information processing skills involved in complex tasks such as car driving: A critical review
32. Low blood alcohol concentrations and driving impairment. A review of experimental studies and international legislation
33. Alcohol and vigilance performance: A review
34. Electrophysiological indices of acute effects of ethanol on involuntary attention shifting
35. The effects of alcohol on the cognitive function of males and females and on skills relating to car driving
36. The effects of single doses of CL284,846, lorazepam, and placebo on psychomotor and memory function in normal male volunteers
37. Residual sequelae of zopiclone