The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 3, 2013, Pages 766-778

  Matin, Azadeh ^a   Doddareddy, Munikumar Reddy ^a   Gavande, Navnath ^a   Nammi, Srinivas ^b   Groundwater, Paul W ^a   Roubin, Rebecca H ^a   Hibbs, David E ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF WESTERN SYDNEY   (Australia)

Author keywords

Metabolic syndrome; Pan PPAR agonist; Peroxisome proliferator activated receptor; PPAR ; PPAR ; PPAR ; Type II diabetes mellitus

Indexed keywords

3' METHOXY 7 HYDROXYISOFLAVONE; 3',4' DIHYDROXYFLAVONE; 3',4' METHYLENEDIOXY 7 (TETRAHYDROPYRAN 2 YLOXY)ISOFLAVONE; 3',5' DIMETHOXY 7 HYDROXYISOFLAVONE; 4' FLUORO 7 HYDROXYISOFLAVONE; 4' METHOXY 7 HYDROXYISOFLAVONE; 4',6 DIHYDROXYFLAVONE; 4',6,7 TRIHYDROXYISOFLAVONE; 5,4' DIHYDROXYFLAVONE; 7 METHOXYBAPTIGENIN; 7,2' DIHYDROXYFLAVONE; 7,3' DIHYDROXYFLAVONE; 7,4' DIHYDROXYFLAVONE; ACACETIN; APIGENIN; BAPTIGENIN; BEZAFIBRATE; CHRYSIN; CHRYSOERIOL; DAIDZEIN; DIOSMETIN; HESPERETIN; ISOFLAVONE DERIVATIVE; KAEMPFEROL; NARINGENIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPUTER MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; EMBRYO; EVENING DOSAGE; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TRANSACTIVATION;

CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HEK293 CELLS; HUMANS; ISOFLAVONES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84872362407     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.11.040     Document Type: Article

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