Identification and mechanism of 10-carbon fatty acid as modulating ligand of peroxisome proliferator-activated receptors

Journal of Biological Chemistry

Volumn 287, Issue 1, 2012, Pages 183-195

  Malapaka, Raghu R V ^a   Khoo, SokKean ^a   Zhang, Jifeng ^b   Choi, Jang H ^c   Zhou, X Edward ^a   Xu, Yong ^a   Gong, Yinhan ^d   Li, Jun ^d   Yong, Eu Leong ^d   Chalmers, Michael J ^e   Chang, Lin ^b   Resau, James H ^a   Griffin, Patrick R ^e   Chen, Y Eugene ^b   Xu, H Eric ^a,f  

^a VAN ANDEL RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

^f SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOGENESIS; ANTIDIABETIC DRUG; DECANOIC ACID; DIABETIC MICE; GLYCEMIC INDEX; LIPID METABOLISMS; LIPID PROFILE; LONG CHAINS; MEDIUM CHAIN TRIGLYCERIDES; MEDIUM-CHAIN FATTY ACIDS; MOLECULAR TARGETS; NUCLEAR RECEPTORS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; SIDE EFFECT; THIAZOLIDINEDIONES; WEIGHT GAIN;

CRYSTAL STRUCTURE; CYTOLOGY; DRUG INTERACTIONS; GLUCOSE; LIGANDS; TRANSCRIPTION FACTORS;

UNSATURATED FATTY ACIDS;

CHOLESTEROL; DECANOIC ACID; GLUCOSE; LIPID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; ROSIGLITAZONE; TRIACYLGLYCEROL;

ADIPOGENESIS; ADIPOSE TISSUE; AF 2 HELIX; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL STRAIN 3T3; CELL STRAIN COS7; CHOLESTEROL BLOOD LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SAFETY; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; LIGAND BINDING; LIPID BLOOD LEVEL; LIVER PARENCHYMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR AFFINITY; RECEPTOR UPREGULATION; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN;

AMINO ACID SEQUENCE; ANIMALS; BLOOD GLUCOSE; CERCOPITHECUS AETHIOPS; COS CELLS; DECANOIC ACIDS; DIABETES MELLITUS; DRUG DESIGN; LIGANDS; MALE; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY;

MUS;

EID: 84855286480     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.294785     Document Type: Article

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