Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 3, 2013, Pages 693-702

  Batie, Shane ^a   Lee, Jamie H ^a   Jama, Rabia A ^a   Browder, Drew O ^a   Montano, Luis A ^a   Huynh, Chanh C ^a   Marcus, Lisa M ^a   Tsosie, Dorian G ^a   Mohammed, Zeynab ^a   Trang, Vu ^a   Marshall, Pamela A ^a   Jurutka, Peter W ^a   Wagner, Carl E ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

Author keywords

Curcumin; Resveratrol; Retinoid X receptor; Rexinoid; Vitamin D receptor

Indexed keywords

1,7 BIS(2 FLUORO 4 HYDROXYPHENYL) 5 HYDROXYHEPT 4 EN 3 ONE; 1,7 BIS(2 FLUORO 4 HYDROXYPHENYL) 5 HYDROXYHEPTA 1,4,6 TRIEN 3 ONE; 1,7 BIS(3 BROMO 4 HYDROXY 5 METHOXYPHENYL) 5 HYDROXYHEPTA 1,4,6 TRIEN 3 ONE; 1,7 BIS(3 BROMO 4 HYDROXYPHENYL) 5 HYDROXYHEPTA 1,4,6 TRIEN 3 ONE; 1,7 BIS(3 CHLORO 4 HYDROXY 5 METHOXYPHENYL) 5 HYDROXYHEPTA 1,4,6 TRIEN 3 ONE; 1,7 BIS(3 CHLORO 4 HYDROXYPHENYL) 5 HYDROXYHEPTA 1,4,6 TRIEN 3 ONE; 1,7 BIS(3 FLUORO 4 HYDROXY 5 METHOXYPHENYL) 5 HYDROXYHEPT 4 EN 3 ONE; 1,7 BIS(3 FLUORO 4 HYDROXY 5 METHOXYPHENYL) 5 HYDROXYHEPTA 1,4,6 TRIEN 3 ONE; 5 HYDROXY 1,7 BIS(4 HYDROXY 3 IODO 5 METHOXYPHENYL)HEPTA 1,4,6 TRIEN 3 ONE; 5 HYDROXY 1,7 BIS(4 HYDROXY 3 METHOXYPHENYL)HEPT 4 EN 3 ONE; ANTINEOPLASTIC AGENT; CALCITRIOL; CELL NUCLEUS RECEPTOR; CURCUMIN; GLUCOCORTICOID; LUCIFERASE; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR; STEROID RECEPTOR COACTIVATOR 1; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ARTICLE; CANCER INHIBITION; CELL STRAIN HCT116; COLON CANCER; DIMERIZATION; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HALOGENATION; HORMONE RESPONSIVE ELEMENT; HUMAN; HUMAN CELL; NONHUMAN; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; TRANSCRIPTION INITIATION;

CURCUMIN; HCT116 CELLS; HUMANS; MOLECULAR STRUCTURE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

CURCUMA LONGA; MAMMALIA;

EID: 84872354757     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.11.033     Document Type: Article

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