Mecamylamine elicits withdrawal-like signs in rats following a single dose of nicotine

Psychopharmacology

Volumn 225, Issue 2, 2013, Pages 291-302

  Harris, Andrew C ^a,b   Manbeck, Katherine E ^a,c   Schmidt, Clare E ^a,c   Shelley, David ^a  

^a MINNEAPOLIS MEDICAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Acute dependence; Intracranial self stimulation; Mecamylamine; Nicotine; Somatic signs; Withdrawal

Indexed keywords

MECAMYLAMINE; NICOTINE;

ACCURACY; ACUTE DRUG ADMINISTRATION; ADVERSE OUTCOME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DEPTH STIMULATION; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EXPOSURE; DRUG POTENCY; EXPERIMENTAL MODEL; LATENT PERIOD; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SELF STIMULATION; SYNDROME DELINEATION; WITHDRAWAL SYNDROME;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; INJECTIONS, SUBCUTANEOUS; MALE; MECAMYLAMINE; NICOTINE; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; RATS; RATS, WISTAR; SELF STIMULATION; SUBSTANCE WITHDRAWAL SYNDROME; TOBACCO USE DISORDER;

EID: 84872350604     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-012-2814-x     Document Type: Article

References (87)

1. Abreu-Villaca Y, Seidler FJ, Qiao D, Tate CA, Cousins MM, Thillai I, Slotkin TA (2003) Short-term adolescent nicotine exposure has immediate and persistent effects on cholinergic systems: critical periods, patterns of exposure, dose thresholds. Neuropsychopharmacology 28:1935-1949
2. Adams JU, Holtzman SG (1990) Pharmacologic characterization of the sensitization to the rate-decreasing effects of naltrexone induced by acute opioid pretreatment in rats. J Pharmacol Exp Ther 253:483-489
3. Alkondon M, Albuquerque EX (2005) Nicotinic receptor subtypes in rat hippocampal slices are differentially sensitive to desensitization and early in vivo functional up-regulation by nicotine and to block by bupropion. J Pharmacol Exp Ther 313:740-750
4. Bacher I, Wu B, Shytle DR, George TP (2009) Mecamylamine - a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders. Expert Opin Pharmacother 10:2709-2721
5. Baker TB, Piper ME, McCarthy DE, Majeskie MR, Fiore MC (2004) Addiction motivation reformulated: an affective processing model of negative reinforcement. Psychol Rev 111:33-51
6. Balfour DJ (1990) A comparison of the effects of nicotine and (+)-amphetamine on rat behaviour in an unsignalled Sidman avoidance schedule. J Pharm Pharmacol 42:257-260
7. Benowitz NL (2008) Neurobiology of nicotine addiction: implications for smoking cessation treatment. Am J Med 121:S3-S10
8. Bronson ME (1994) Chlordiazepoxide, but not bretazenil, produces acute dependence, as evidenced by disruptions in schedule-controlled behavior. Pharmacol Biochem Behav 48:397-401
9. Bruijnzeel AW, Zislis G, Wilson C, Gold MS (2007) Antagonism of CRF receptors prevents the deficit in brain reward function associated with precipitated nicotine withdrawal in rats. Neuropsychopharmacology 32:955-963
10. Bruijnzeel AW, Bishnoi M, van Tuijl IA, Keijzers KF, Yavarovich KR, Pasek TM, Ford J, Alexander JC, Yamada H (2010) Effects of prazosin, clonidine, and propranolol on the elevations in brain reward thresholds and somatic signs associated with nicotine withdrawal in rats. Psychopharmacology (Berl) 212:485-499
11. Bruijnzeel AW, Ford J, Rogers JA, Scheick S, Ji Y, Bishnoi M, Alexander JC (2012) Blockade of CRF1 receptors in the central nucleus of the amygdala attenuates the dysphoria associated with nicotine withdrawal in rats. Pharmacol Biochem Behav 101:62-68
12. Cheeta S, Irvine EE, Kenny PJ, File SE (2001) The dorsal raphe nucleus is a crucial structure mediating nicotine's anxiolytic effects and the development of tolerance and withdrawal responses. Psychopharmacology (Berl) 155:78-85
13. Corrigall WA, Herling S, Coen KM (1989) Evidence for a behavioral deficit during withdrawal from chronic nicotine treatment. Pharmacol Biochem Behav 33:559-562
14. Cryan JF, Bruijnzeel AW, Skjei KL, Markou A (2003) Bupropion enhances brain reward function and reverses the affective and somatic aspects of nicotine withdrawal in the rat. Psychopharmacology (Berl) 168:347-358
15. Dani JA, Heinemann S (1996) Molecular and cellular aspects of nicotine abuse. Neuron 16:905-908
16. Dar R, Frenk H (2010) Can one puff really make an adolescent addicted to nicotine? A critical review of the literature. Harm Reduct J 7:28
17. Difranza JR (2010) Thwarting science by protecting the received wisdom on tobacco addiction from the scientific method. Harm Reduct J 7:26
18. DiFranza JR, Wellman RJ (2005) A sensitization-homeostasis model of nicotine craving, withdrawal, and tolerance: integrating the clinical and basic science literature. Nicotine Tob Res 7:9-26
19. DiFranza JR, Wellman RJ (2007) Sensitization to nicotine: how the animal literature might inform future human research. Nicotine Tob Res 9:9-20
20. DiFranza JR, Rigotti NA, McNeill AD, Ockene JK, Savageau JA, St Cyr D, Coleman M (2000) Initial symptoms of nicotine dependence in adolescents. Tob Control 9:313-319
21. DiFranza JR, Savageau JA, Fletcher K, Ockene JK, Rigotti NA, McNeill AD, Coleman M, Wood C (2002) Measuring the loss of autonomy over nicotine use in adolescents: the DANDY (Development and Assessment of Nicotine Dependence in Youths) study. Arch Pediatr Adolesc Med 156:397-403
22. DiFranza JR, Savageau JA, Fletcher K, O'Loughlin J, Pbert L, Ockene JK, McNeill AD, Hazelton J, Friedman K, Dussault G, Wood C, Wellman RJ (2007) Symptoms of tobacco dependence after brief intermittent use: the Development and Assessment of Nicotine Dependence in Youth-2 study. Arch Pediatr Adolesc Med 161:704-710
23. Doubeni CA, Reed G, Difranza JR (2010) Early course of nicotine dependence in adolescent smokers. Pediatrics 125:1127-1133
24. Easterling KW, Holtzman SG (1997) Intracranial self-stimulation in rats: sensitization to an opioid antagonist following acute or chronic treatment with mu opioid agonists. J Pharmacol Exp Ther 281:188-199
25. Engelmann JM, Radke AK, Gewirtz JC (2009) Potentiated startle as a measure of the negative affective consequences of repeated exposure to nicotine in rats. Psychopharmacology (Berl) 207:13-25
26. Epping-Jordan MP, Watkins SS, Koob GF, Markou A (1998) Dramatic decreases in brain reward function during nicotine withdrawal. Nature 393:76-79
27. Fenster CP, Whitworth TL, Sheffield EB, Quick MW, Lester RA (1999) Upregulation of surface alpha4beta2 nicotinic receptors is initiated by receptor desensitization after chronic exposure to nicotine. J Neurosci 19:4804-4814
28. Ghosheh O, Dwoskin LP, Li WK, Crooks PA (1999) Residence times and half-lives of nicotine metabolites in rat brain after acute peripheral administration of [2′-(14)C]nicotine. Drug Metab Dispos 27:1448-1455
29. Govind AP, Vezina P, Green WN (2009) Nicotine-induced upregulation of nicotinic receptors: underlying mechanisms and relevance to nicotine addiction. Biochem Pharmacol 78:756-765
30. Harris AC, Gewirtz JC (2004) Elevated startle during withdrawal from acute morphine: a model of opiate withdrawal and anxiety. Psychopharmacology (Berl) 171:140-147
31. Harris AC, Gewirtz JC (2005) Acute opioid dependence: characterizing the early adaptations underlying drug withdrawal. Psychopharmacology (Berl) 178:353-366
32. Harris CM, Emmett-Oglesby MW, Robinson NG, Lal H (1986) Withdrawal from chronic nicotine substitutes partially for the interoceptive stimulus produced by pentylenetetrazol (PTZ). Psychopharmacology (Berl) 90:85-89
33. Harris AC, Hanes SL, Gewirtz JC (2004) Potentiated startle and hyperalgesia during withdrawal from acute morphine: effects of multiple opiate exposures. Psychopharmacology (Berl) 176:266-273
34. Harris AC, Mattson C, Lesage MG, Keyler DE, Pentel PR (2010) Comparison of the behavioral effects of cigarette smoke and pure nicotine in rats. Pharmacol Biochem Behav 96:217-227
35. Harris AC, Pentel PR, Burroughs D, Staley MD, Lesage MG (2011) A lack of association between severity of nicotine withdrawal and individual differences in compensatory nicotine self-administration in rats. Psychopharmacology (Berl) 217:153-166
36. Harrison AA, Gasparini F, Markou A (2002) Nicotine potentiation of brain stimulation reward reversed by DH beta E and SCH 23390, but not by eticlopride, LY 314582 or MPEP in rats. Psychopharmacology (Berl) 160:56-66
37. Hildebrand BE, Nomikos GG, Bondjers C, Nisell M, Svensson TH (1997) Behavioral manifestations of the nicotine abstinence syndrome in the rat: peripheral versus central mechanisms. Psychopharmacology (Berl) 129:348-356
38. Hughes JR (2007) Effects of abstinence from tobacco: etiology, animal models, epidemiology, and significance: a subjective review. Nicotine Tob Res 9:329-339
39. Hughes JR, Shiffman S (2008) Conceptualizations of nicotine dependence: a response to DiFranza. Nicotine Tob Res 10:1811-1812, author reply 1813-4
40. Hulihan-Giblin BA, Lumpkin MD, Kellar KJ (1990) Acute effects of nicotine on prolactin release in the rat: agonist and antagonist effects of a single injection of nicotine. J Pharmacol Exp Ther 252:15-20
41. Huston-Lyons D, Kornetsky C (1992) Effects of nicotine on the threshold for rewarding brain stimulation in rats. Pharmacol Biochem Behav 41:755-759
42. James JR, Villanueva HF, Johnson JH, Arezo S, Rosecrans JA (1994) Evidence that nicotine can acutely desensitize central nicotinic acetylcholinergic receptors. Psychopharmacology (Berl) 114:456-462
43. Kenny PJ, Markou A (2001) Neurobiology of the nicotine withdrawal syndrome. Pharmacol Biochem Behav 70:531-549
44. Keyler DE, Roiko SA, Benlhabib E, Lesage MG, St Peter JV, Stewart S, Fuller S, Le CT, Pentel PR (2005) Monoclonal nicotine-specific antibodies reduce nicotine distribution to brain in rats: Dose- and affinity-response relationships. Drug Metab Disposition 33:1056-1061
45. Koob GF, Le Moal M (2005) Plasticity of reward neurocircuitry and the 'dark side' of drug addiction. Nat Neurosci 8:1442-1444
46. Kornetsky C, Esposito RU (1979) Euphorigenic drugs: effects on the reward pathways of the brain. Fed Proc 38:2473-2476
47. 3H]acetylcholine to nicotinic receptors. Neuropharmacology 24:527-531
48. Littleton J (2001) Receptor regulation as a unitary mechanism for drug tolerance and physical dependence - not quite as simple as it seemed! Addiction 96:87-101
49. Liu J, Schulteis G (2004) Brain reward deficits accompany naloxone-precipitated withdrawal from acute opioid dependence. Pharmacol Biochem Behav 79:101-108
50. Malin DH, Goyarzu P (2009) Rodent models of nicotine withdrawal syndrome. Handb Exp Pharmacol 192:401-434
51. Malin DH, Lake JR, Newlin-Maultsby P, Roberts LK, Lanier JG, Carter VA, Cunningham JS, Wilson OB (1992) Rodent model of nicotine abstinence syndrome. Pharmacol Biochem Behav 43:779-784
52. Malin DH, Lake JR, Carter VA, Cunningham JS, Hebert KM, Conrad DL, Wilson OB (1994) The nicotinic antagonist mecamylamine precipitates nicotine abstinence syndrome in the rat. Psychopharmacology (Berl) 115:180-184
53. Malin DH, Moon WD, Goyarzu P, Magallanes N, Blair MB, Alexander MR, McDavid L, Spurgeon JL, Ennifar S, Fattom A (2010) Passive immunization against nicotine attenuates somatic nicotine withdrawal syndrome in the rat. Nicotine Tob Res 12:438-444
54. Markou A (2008) Review. Neurobiology of nicotine dependence. Philos Trans R Soc Lond Biol Sci 363:3159-3168
55. Markou A, Koob GF (1992) Construct validity of a self-stimulation threshold paradigm: effects of reward and performance manipulations. Physiol Behav 51:111-119
56. Markou A, Paterson NE (2001) The nicotinic antagonist methyllycaconitine has differential effects on nicotine self-administration and nicotine withdrawal in the rat. Nicotine Tob Res 3:361-373
57. Marks MJ, Burch JB, Collins AC (1983) Effects of chronic nicotine infusion on tolerance development and nicotinic receptors. J Pharmacol Exp Ther 226:817-825
58. 3H]epibatidine binding in response to repeated nicotine administration in rats. Psychopharmacology (Berl) 150:1-8
59. Morrison CF (1974) Effects of nicotine and its withdrawal on the performance of rats on signalled and unsignalled avoidance schedules. Psychopharmacologia (Berl) 38:25-35
60. Nguyen HN, Rasmussen BA, Perry DC (2004) Binding and functional activity of nicotinic cholinergic receptors in selected rat brain regions are increased following long-term but not short-term nicotine treatment. J Neurochem 90:40-49
61. O'Dell LE, Bruijnzeel AW, Smith RT, Parsons LH, Merves ML, Goldberger BA, Richardson HN, Koob GF, Markou A (2006) Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction. Psychopharmacology (Berl) 186:612-619
62. O'Dell LE, Torres OV, Natividad LA, Tejeda HA (2007) Adolescent nicotine exposure produces less affective measures of withdrawal relative to adult nicotine exposure in male rats. Neurotoxicol Teratol 29:17-22
63. O'Loughlin J, DiFranza J, Tyndale RF, Meshefedjian G, McMillan-Davey E, Clarke PB, Hanley J, Paradis G (2003) Nicotine-dependence symptoms are associated with smoking frequency in adolescents. American journal of preventive medicine 25:219-225
64. Ochoa EL, Li L, McNamee MG (1990) Desensitization of central cholinergic mechanisms and neuroadaptation to nicotine. Mol Neurobiol 4:251-287
65. Paterson NE, Balfour DJ, Markou A (2008) Chronic bupropion differentially alters the reinforcing, reward-enhancing and conditioned motivational properties of nicotine in rats. Nicotine Tob Res 10:995-1008
66. Perkins KA, Lerman C, Coddington SB, Jetton C, Karelitz JL, Scott JA, Wilson AS (2008) Initial nicotine sensitivity in humans as a function of impulsivity. Psychopharmacology (Berl) 200:529-544
67. Pomerleau OF (1995) Individual differences in sensitivity to nicotine: implications for genetic research on nicotine dependence. Behav Genet 25:161-177
68. Pomerleau OF, Collins AC, Shiffman S, Pomerleau CS (1993) Why some people smoke and others do not: new perspectives. J Consult Clin Psychol 61:723-731
69. Robinson SE, James JR, Lapp LN, Vann RE, Gross DF, Philibin SD, Rosecrans JA (2006) Evidence of cellular nicotinic receptor desensitization in rats exhibiting nicotine-induced acute tolerance. Psychopharmacology (Berl) 184:306-313
70. Robinson SE, Vann RE, Britton AF, O'Connell MM, James JR, Rosecrans JA (2007) Cellular nicotinic receptor desensitization correlates with nicotine-induced acute behavioral tolerance in rats. Psychopharmacology (Berl) 192:71-78
71. Roiko SA, Harris AC, LeSage MG, Keyler DE, Pentel PR (2009) Passive immunization with a nicotine-specific monoclonal antibody decreases brain nicotine levels but does not precipitate withdrawal in nicotine-dependent rats. Pharmacol Biochem Behav 93:105-111
72. Rosecrans JA, Wiley JL, Bass CE, Karan LD (1995) Nicotine-induced acute tolerance: studies involving schedule-controlled behavior. Brain Res Bull 37:359-362
73. Schulteis G, Liu J (2006) Brain reward deficits accompany withdrawal (hangover) from acute ethanol in rats. Alcohol 39:21-28
74. Schulteis G, Heyser CJ, Koob GF (1999) Differential expression of response-disruptive and somatic indices of opiate withdrawal during the initiation and development of opiate dependence. Behav Pharmacol 10:235-242
75. Schwartz RD, Kellar KJ (1983) Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo. Science 220:214-216
76. Sharp BM, Beyer HS (1986) Rapid desensitization of the acute stimulatory effects of nicotine on rat plasma adrenocorticotropin and prolactin. J Pharmacol Exp Ther 238:486-491
77. Shytle RD, Penny E, Silver AA, Goldman J, Sanberg PR (2002) Mecamylamine (Inversine): an old antihypertensive with new research directions. J Hum Hypertens 16:453-457
78. Skjei KL, Markou A (2003) Effects of repeated withdrawal episodes, nicotine dose, and duration of nicotine exposure on the severity and duration of nicotine withdrawal in rats. Psychopharmacology (Berl) 168:280-292
79. Spear LP (2000) The adolescent brain and age-related behavioral manifestations. Neurosci Biobehav Rev 24:417-463
80. US Public Health Service (1994) Preventing tobacco use among young people: a report of the Surgeon General. US Government Printing Office, Washington
81. Vann RE, Balster RL, Beardsley PM (2006a) Dose, duration, and pattern of nicotine administration as determinants of behavioral dependence in rats. Psychopharmacology (Berl) 184:482-493
82. Vann RE, James JR, Rosecrans JA, Robinson SE (2006b) Nicotinic receptor inactivation after acute and repeated in vivo nicotine exposures in rats. Brain Res 1086:98-103
83. Wang H, Sun X (2005) Desensitized nicotinic receptors in brain. Brain Res Brain Res Rev 48:420-437
84. Watkins SS, Koob GF, Markou A (2000a) Neural mechanisms underlying nicotine addiction: acute positive reinforcement and withdrawal. Nicotine Tob Res 2:19-37
85. Watkins SS, Stinus L, Koob GF, Markou A (2000b) Reward and somatic changes during precipitated nicotine withdrawal in rats: centrally and peripherally mediated effects. J Pharmacol Exp Ther 292:1053-1064
86. Way EL, Loh HH, Shen FH (1969) Simultaneous quantitative assessment of morphine tolerance and physical dependence. J Pharmacol Exp Ther 167:1-8
87. Wong CL, Bentley CA (1978) Increased antagonist potency of naloxone caused by morphine pretreatment in mice. Eur J Pharmacol 47:415-422