Intracranial self-stimulation in rats: Sensitization to an opioid antagonist following acute or chronic treatment with mu opioid agonists

Journal of Pharmacology and Experimental Therapeutics

Volumn 281, Issue 1, 1997, Pages 188-199

  Easterling, Keith W ^a   Holtzman, Stephen G ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMPHETAMINE; FENTANYL; LEVORPHANOL; METHADONE; MORPHINE; MU OPIATE RECEPTOR AGONIST; NALTREXONE; OPIATE ANTAGONIST; PENTOBARBITAL; PETHIDINE; SPIRADOLINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DEPENDENCE; DRUG POTENCY; ELECTROSTIMULATION; MALE; NONHUMAN; OPIATE ADDICTION; PRIORITY JOURNAL; RAT; REINFORCEMENT; SELF STIMULATION; SUBCUTANEOUS DRUG ADMINISTRATION; WITHDRAWAL SYNDROME;

ANIMALS; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; MALE; MORPHINE; NALTREXONE; NARCOTIC ANTAGONISTS; OPIOID-RELATED DISORDERS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, MU; SELF STIMULATION;

EID: 0030958025     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. ADAMS, J. U. AND HOLTZMAN, S. G.: Pharmacologic characterization of the sensitization to the rate-decreasing effects of naltrexone-induced by acute opioid pretreatment in rats. J. Pharmacol. Exp. Ther. 253: 483-489, 1990.
2. ADAMS, J. U. AND HULTZMAN, S. G.: Naltrexone-sensitizing effects of centrally administered morphine and opioid peptides. Eur. J. Pharmacol. 193: 67-73, 1991.
3. BALSTER, R. L.: Behavioral studies of tolerance and dependence. In Behavioral Pharmacology: The Current Status, ed. by L. S. Seiden and R. L. Balster, pp. 403-418. Alan R. Liss, Inc., New York. 1985.
4. BICKEL, W. K., STITZER, M. L., LIEBSON, I. A. AND BIGELOW, G. E.: Acute physical dependence in man: Effects of naloxone after brief morphine exposure J. Pharmacol. Exp. Ther. 244: 126-132, 1988.
5. BOZARTH, M. A. AND WISE, R. A.: Anatomically distinct opiate receptor fields mediate reward and physical dependence. Science 224: 516-517, 1984
6. DYKSTRA, L. A.: Development of enhanced sensitivity to naloxone. Life Sci 33: 2079-2089, 1983.
7. EASTERLING, K. W. AND HOLTZMAN, S. G.: Parametric changes in response equilibrium during an intracranial self stimulation (ICSS) task: Can reward value be assessed independently of absolute threshold? Neurosci. Biobehav. Rev. 21: 55-65, 1997.
8. EISENBERG, R. M.: Further studies on the acute dependence produced by morphine in opiate naive rats. Life Sci. 31: 1531-1540, 1982.
9. ESPOSITO, R. AND KORNETSKY, C.: Morphine lowering self-stimulation thresholds: Lack of tolerance with long-term administration. Science 194: 189-191, 1977.
10. GELLERT, V. F. AND HOLTZMAN, S. G.: Discriminative stimulus effects of naltrexone in the morphine-dependent rat. J. Pharmacol. Exp. Ther. 211: 596-605, 1979.
11. GELLERT, V. F. AND SPARSER, S. B.: A comparison of the effects of naloxone upon body weight loss and suppression of fixed-ratio operant behavior in morphine-dependent rats. J. Pharmacol. Exp. Ther. 198: 44-54, 1977.
12. GLICH, S. D., WEAVER, L. M. AND MEIBACH, R. C.: Asymmetrical effects of morphine and naloxone on reward mechanisms, Psychopharmacology 78: 219-224, 1982.
13. GOLDBERG, S. R., MORSE, W. H. AND GOLDBERG, D. M.: Acute and chronic effects of naltrexone and naloxone on schedule-controlled behavior of squirrel monkeys and pigeons. J. Pharmacol. Exp. Ther. 216: 500-509, 1981.
14. HERLING, S., SOLOMON, R. E. AND WOODS, J. H.: Discriminative stimulus effects of dextrorphan in pigeons. J. Pharmacol. Exp. Ther. 227: 723-731, 1983.
15. HIGGINS, G. A. AND SELLERS, E. M.: Antagonist-precipitated opioid withdrawal in rats: Evidence for dissociations between physical and motivational signs. Pharmacol. Biochem. Behav. 48: 1-8, 1994.
16. HOLTZMAN, S. G. AND VILLARREAL, J. E.: Operant behavior in the morphine-dependent rhesus monkey. J. Pharmacol. Exp. Ther. 184: 528-541, 1973.
17. JAFFE, J. H.: Drug addiction and drug abuse. In Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed., ed. by A. Goodman, T. W. Rall, A. S. Nies and P. Taylor, pp. 552-573, Pergamon Press, New York, 1990.
18. KANOF, P. D., HANDELSMAN, L., ARONSON, M. J., NESS, R., COCHRANE, K. J. AND RUBINSTEIN, K. J.: Clinical characteristics of naloxone-precipitated with-drawal in human opioid-dependent subjects. J. Pharmacol. Exp. Ther. 260: 355-363, 1992.
19. LORENS, S. A. AND MITCHELL C. L.: Influence of morphine on lateral hypothalamic self-stimulation in the rat. Psychopharmacologia 32: 271-277, 1973.
20. MALDONADO, R., STINUS, L., GOLD, L. H. AND KOOB, G. F.: Role of different brain structures in the expression of the physical morphine withdrawal syndrome. J. Pharmacol. Exp. Ther. 261: 669-677, 1992.
21. MARCUS, R. AND KORNETSKY, C.: Negative and positive intracranial reinforcement thresholds: Effects of morphine. Psychopharmacologia 38: 1-13, 1974.
22. MEYER, D. R. AND SPARBER, S. B.: Evidence of possible opiate dependence during the behavioral depressant action of a single dose of morphine. Life Sci. 73: 1087-1094, 1977.
23. NAKAKI, T., SAITO, M., NAKADATE, T., TOKUNAGA, Y. AND KATO, R.: Acute physical dependence induced by continuous intravenous infusion of morphine or meperidine in the rat. Psychopharmacology 73: 215-218, 1981.
24. RAMABADRAN, K.: Naloxone-precipitated abstinence in mice, rats and gerbils acutely dependent on morphine, Life Sci. 33: 385-388, 1983.
25. SCHAEFER, G. J. AND HOLTZMAN, S. G.: Dose- and time-dependent effects of narcotic analgesics on intracranial self-stimulation in the rat. Psychopharmacology (Berl.) 53: 227-234, 1977.
26. SCHAEFER, G. J. AND MICHAEL, R.: Changes in response rates and reinforcement thresholds for intracranial self-stimulation during morphine withdrawal. Pharmacol. Biochem. Behav. 25: 1263-1269, 1986.
27. SCHINDLER, C. W., GOLDBERG, S. R. AND KATZ, J. L.: Pharmacological specificity of enhanced sensitivity to naltrexone in rats, Psychopharmacology 110: 60-68, 1993.
28. SCHULTEIS, G., MARKOU, A., GOLD, L. H., STINUS, L. AND KOOB, G. F.: Relative sensitivity to naloxone of multiple indices of opiate withdrawal: A quantitative dose-response analysis. J. Pharmacol. Exp. Ther. 271: 1391-1398, 1994.
29. SMITS, S. E.: Quantitaten of physical dependence in mice by naloxone-precipitated jumping after a single dose of morphine. Res. Commun. Chem. Pathol. Pharmacol. 10: 651, 1975.
30. STINUS, L., LE MOAL, M. AND KOOB, G. F.: Nucleus accumbens and amygdala are possible substrates for the aversive stimulus effects of opiate withdrawal. Neuroscience 37: 767-773, 1990.
31. TAKEMORI, A. E., TETSUO, O. AND NISHIYAMA, N.: Alteration of analgesic receptor-antagonist interaction induced by morphine. J. Pharmacol. Exp. Ther. 188: 261-265, 1973.
32. THOMPSON, T. AND SCHUSTER, C. R.: Morphine self-administration, food-reinforced, and avoidance behaviors in rhesus monkeys. Psychopharmacilogia 5: 87-94, 1964.
33. TULUNAY, F. C. AND TAKEMORI, A. E.: The increased efficacy of narcotic antagoniots induced by various narcotic analgesics. J. Pharmacol. Exp. Ther. 190: 395-400, 1974a.
34. TULUNAY, F. C. AND TAKEMORI, A. E.: Further studies on the alteration of analgesic receptor-antagonist interaction induced by morphine. J. Pharmacol. Exp. Ther. 190: 401-407, 1974b.
35. VAN WOLFSWINKEL, L. AND VAN REE, J. M.: Effects of morphine and naloxone on thresholds of ventral tegmental electrical self-stimulation. Naunyn-Schmiedeberg's Arch. Pharmacol. 330: 84-92, 1985.
36. VAN WOLFSWINKEL, L., SEIFER, W. F. AND VAN REE, J. M.: Long-term changes in self-stimulation threshold by repeated morphine and naloxone treatment. Life Sci. 37: 169-176, 1985.
37. VAN VOIGHTLANDKR, P. F., LAHTI, R. A. AND LADENS, J. H.: U-50,488: A selective and structurally novel non-mu (kappa] opioid agonist. J. Pharmacol. Exp. Ther. 224: 7-12, 1983.
38. WEI, E., LOH, H. H. AND WAY, L. E.: Quantitative aspects of precipitated abstinence in morphine-dependent rats. J. Pharmacol. Exp. Ther. 184: 398-403, 1973.
39. WHITE-GBADEBO, D. AND HOLTZMAN, S. G.: Acute sensitization to opioid antagonists. Pharmacol. Biochem. Behav. 47: 559-566, 1994a.
40. WHITE-GBADEBO, D. AND HOLTZMAN, S. G.: Naloxone pretreatment blocks acute morphine-induced sensitization to naltrexone. Psychopharmacology 114: 225-228, 1994b.
41. WISE, R. A. AND BOZARTH, M. A.: A paychomotor stimulant theory of addiction. Psychol. Rev. 94: 469-492, 1987.
42. YOUNG, A. M.: Effects of acute morphine pretreatment on the rate-decreasing and antagonist activity of naloxone. Psychopharmacology 88: 201-208, 1986.