Behavioral manifestations of the nicotine abstinence syndrome in the rat: peripheral versus central mechanisms

Psychopharmacology

Volumn 129, Issue 4, 1997, Pages 348-356

  Hildebrand, B E ^a   Nomikos, G G ^a   Bondjers, C ^a   Nisell, M ^a   Svensson, T H ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Chlorisondamine; Locomotor activity; Mecamylamine; Nicotine dependence; Nicotine withdrawal; Tetramethylammonium

Indexed keywords

CHLORISONDAMINE; MECAMYLAMINE; NICOTINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; TETRAMETHYLAMMONIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG INFUSION; DRUG WITHDRAWAL; LICKING; LOCOMOTION; MALE; NONHUMAN; OSMOTIC MINIPUMP; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; PTOSIS; RAT; RATING SCALE; SUBCUTANEOUS DRUG ADMINISTRATION; WITHDRAWAL SYNDROME; YAWNING;

ANIMALS; BEHAVIOR, ANIMAL; MALE; NICOTINE; RATS; RATS, WISTAR; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 0031057228     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050200     Document Type: Article

References (28)

1. Benwell MEM, Balfour DJK (1992) The effects of acute and repeated nicotine treatment on nucleus accumbens dopamine and locomotor activity. Br J Pharmacol 105:849-856
2. Benwell MEM, Balfour DJK, Birrell CE (1995) Desensitization of the nicotine-induced mesolimbic dopamine responses during constant infusion with nicotine. Br J Pharmacol 114:454-460
3. Clarke PBS (1984) Chronic central nicotinic blockade after a single administration of the bisquaternary ganglion-blocking drug chlorisondamine. Br J Pharmacol 83:527-535
4. Clarke PBS (1987) Nicotine and smoking: a perspective from animal studies. Psychopharmacology 92:135-143
5. Clarke PBS (1991) Nicotinic receptor blockade therapy and smoking cessation. Br J Addict 86:501-505
6. Clarke PBS, Kumar R (1983a) The effects of nicotine on locomotor activity in non-tolerant and tolerant rats. Br J Pharmacol 78:329-337
7. Clarke PBS, Kumar R (1983b) Characterisation of the locomotor stimulant action of nicotine in tolerant rats. Br J Pharmacol 80:587-594
8. Corrigall WA, Herling S, Coen KM (1989) Evidence for a behavioral deficit during withdrawal from chronic nicotine treatment. Pharmacol Biochem Behav 33:559-562
9. El-Bizri H, Clarke PBS (1994) Regulation of nicotinic receptors in rat brain following quasi-irreversible nicotinic blockade by chlorisondamine and chronic treatment with nicotine. Br J Pharmacol 113:917-925
10. Engberg G, Hajos M (1994) Nicotine-induced activation of locus coeruleus neurons an analysis of peripheral versus central induction. Naunyn-Schmiedeberg's Arch Pharmacol 349:443-446
11. Gianutsos G, Drawbaugh RB, Hynes MD, Lal H (1974) Behavioral evidence for dopaminergic supersensitivity after chronic haloperidol. Life Sci 14:887-898
12. Gianutsos G, Drawbaugh R, Hynes m, Lal H (1975) The narcotic withdrawal syndrome in the rat. In: Ehrenpreis S, Neidle A (eds) Methods in narcotic research. Dekker, New York, pp 293-309
13. Grant KA, Valverius P, Hudspith M, Tabakoff B (1990) Ethanol withdrawal seizures and the NMDA receptor complex. Eur J Pharmacol 176:289-296
14. Hajos M, Engberg G (1988) Role of primary sensory neurons in the central effects of nicotine. Psychopharmacology 94:468-470
15. Levin ED, Morgan MM, Galvez C, Ellison GD (1987) Chronic nicotine and withdrawal effects on body weight and food and water consumption in female rats. Physiol Behav 39:441-444
16. Majchrowicz E (1975) Induction of physical dependence upon ethanol and the associated behavioral changes in rats. Psychopharmacologia 43:245-254
17. Malin DH, Murray JB, Crucian GP, Schweitzer FC, Cook RE, Skolnick MH (1988) Auricular micro-electrostimulation: naloxone reversible attenuation of opiate abstinence syndrome. Biol Psychiatry 24:886-890
18. Malin DH, Lake JR, Newlin-Maultsby P, Roberts LK, Lanier JG, Carter VA, Cunningham JS, Wilson OB (1992) Rodent model of nicotine abstinence syndrome. Pharmacol Biochem Behav 43:119-184
19. Malin DH, Lake JR, Carter VA, Cunningham JS, Wilson OB (1993) Naloxone precipitates nicotine abstinence syndrome in the rat. Psychopharmacology 112:339-342
20. Malin DH, Lake JR, Carter VA, Cunningham JS, Hebert KM, Payne MC, Conrad D, Wilson OB (1994) The nicotinic antagonist mecamylamine precipitates nicotine abstinence syndrome in the rat. Psychopharmacology 115[1 2]:180-184
21. Martin WR, Wikler A, Eades CG, Pescor FT (1963) Tolerance to and physical dependence on morphine in rats. Psychopharmacologia 4:247-260
22. Nisell M, Nomikos GG, Hertel P, Panagis G, Svensson TH (1996) Condition-independent sensitization of locomotor stimulation and mesocortical dopamine release following chronic nicotine treatment in the rat. Synapse 22[4]:369-381
23. Shiftman SM, Jarvik ME (1976) Smoking withdrawal symptoms in two weeks of abstinence. Psychopharmacology 50:35-39
24. Svensson TH (1987) Peripheral, autonomic regulation of locus coeruleus noradrenergic neurons in brain: putative implications in psychiatry and psychopharmacology. Psychopharmacology 92:1-7
25. Taylor P (1980) Ganglionic stimulating and blocking agents. In: Gilman AG, Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics (6th edn). MacMillan, New York, pp 211-219
26. Tung CS, Ugedo L, Grenhoff J, Engberg G, Svensson TH (1989) Peripheral induction of burst firing in locus coeruleus neurons by nicotine mediated via excitatory amino acids. Synapse 4:313-318
27. US Department of Health and Human Services (1988) The health consequences of smoking: Nicotine addiction. A report of the Surgeon General. DHHS Publication (CDC) 88 8406. US Government Printing Office, Washington, DC
28. Valentino RJ, Aston-Jones GS (1995) Physiological and anatomical determinants of locus coeruleus discharge. In: Bloom FE, Kupfer DJ (eds) Psychopharmacology: the fourth generation of progress. Raven Press, New York, pp 373-385