Passive immunization against nicotine attenuates somatic nicotine withdrawal syndrome in the rat

Nicotine and Tobacco Research

Volumn 12, Issue 4, 2010, Pages 438-444

  Malin, David H ^a   Moon, William D ^a   Goyarzu, Pilar ^a   Magallanes, Nancy ^a   Blair, Michelle B ^a   Alexander, Melodee R ^a   McDavid, Lauren ^a   Spurgeon, Jason L ^a   Ennifar, Sofiane ^b   Fattom, Ali ^b  

^a UNIVERSITY OF HOUSTON CLEAR LAKE   (United States)

^b Nabi Biopharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; MECAMYLAMINE; NICOTINE TARTRATE; NICOTINE VACCINE; NICOTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; MALE; NONHUMAN; PASSIVE IMMUNIZATION; PRIORITY JOURNAL; RAT; SMOKING CESSATION; SYMPTOMATOLOGY; WITHDRAWAL SYNDROME; ANIMAL; IMMUNOLOGY; METHODOLOGY; SPRAGUE DAWLEY RAT; TOBACCO DEPENDENCE;

ANIMALS; IMMUNIZATION, PASSIVE; MALE; NICOTINE; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANCE WITHDRAWAL SYNDROME; TOBACCO USE DISORDER;

EID: 77953921419     PISSN: 14622203     EISSN: 1469994X     Source Type: Journal    
DOI: 10.1093/ntr/ntq021     Document Type: Article

References (27)

1. Adams, M.L., & Cicero, T.J. (1998). Nitric oxide mediates mecamylamineand naloxone-precipitated nicotine withdrawal. European Journal of Pharmacology, 345, R1-R2.
2. Carboni, E., Bortone, L., Giua, C., & Di Chiara, G. (2000). Dissociation of physical abstinence signs from changes in extracellular dopamine in the nucleus accumbens and in the pre-frontal cortex of nicotine dependent rats. Drug Alcohol Dependency, 58, 93-102.
3. Carrera, M.R., Ashley, J.A., Hoffman, T.Z., Isomura, S., Wirsching, P., Koob, G.F., et al. (2004). Investigations using immunizations to attenuate the psychoactive effects of nicotine. Bioorganic Medicinal Chemistry, 12, 563-570.
4. Cerny, E.H., Levy, R., Mauel, J., Mpandi, M., Mutter, M., Henzelin-Nkubana, C., et al. (2002). Preclinical development of a vaccine 'against smoking'. Onkologie, 25, 406-411.
5. Cornuz, J., Zwahlen, S., Jungi, W.F., Osterwalder, J., Klingler, K., van Melle, G., et al. (2008). A vaccine against nicotine for smoking cessation: A randomized controlled trial. PLoS ONE, 3, e2547.
6. Cushman, M., & Castagnoli, N., Jr. (1972). The synthesis of trans-3'-methylnicotine. Journal of Organic Chemistry, 37, 1268-1271.
7. de Villiers, S.H., Lindblom, N., Kalayanov, G., Gordon, S., Malmerfelt, A., Johansson, A.M., et al. (2002). Active immunization against nicotine suppresses nicotine-induced dopamine release in the rat nucleus accumbens shell. Respiration, 69, 247-253.
8. Epping-Jordan, M.P., Watkins, S.S., Koob, G.F., & Markou, A. (1998). Dramatic decreases in brain reward function during nicotine withdrawal. Nature, 393, 76-79.
9. Goyarzu, P., Moon, W.D., Magallanes, N., Lonakadi, V., & Malin, D.H. (2005). An environmental variable strongly modulates mecamylamine-precipitated nicotine abstinence syndrome. 1027.15 Neuroscience Abstracts 2005, Society for Neuroscience, 119.
10. Hatsukami, D.K., Rennard, S., Jorenby, D., Fiore, M., Koopmeiners, J., de Vos, A., et al. (2005). Safety and immunogenicity of a nicotine conjugate vaccine in current vaccine in current smokers. Clinical Pharmacological Therapies, 78, 456-467.
11. Hieda, Y., Keyler, D.E., VanDeVoort, J.T., Niedbala, R.S., Raphael, D.E., Ross, C.A., et al. (1999). Immunization of rats reduces nicotine distribution to brain. Psychopharmacology, 143, 150-157.
12. Hildebrand, B.E., Nomikos, G.G., Bondjers, C., Nissel, M., & Svensson, T.H. (1997). Behavioral manifestations of the nioctine abstinence syndrome in the rat: peripheral versus central mechanisms. Psychopharmacology, 129, 348-356.
13. Keyler, D.E., Hieda, Y., St Peter, J., & Pentel, P.R. (1999). Altered disposition of repeated nicotine doses in rats immunized against nicotine. Nicotine & Tobacco Research, 1, 241-249.
14. LeSage, M.G., Keyler, D.E., Hieda, Y., Collins, G., Burroughs, D., Le, C., et al. (2006). Effects of a nicotine conjugate vaccine on the acquisition and maintenance of nicotine self-administration in rats. Psychopharmacology, 184, 409-416.
15. Lindblom, N., de Villiers, S.H., Kalayanov, G., Gordon, S., Johansson, A.M., & Svensson, T.H. (2002). Active immunization against nicotine prevents reinstatement of nicotine-seeking behavior in rats. Respiration, 69, 254-260.
16. Lindblom, N., de Villiers, S.H., Semenova, S., Kalayanov, G., Gordon, S., Schilstrom, B., et al. (2005). Active immunization against nicotine blocks the reward facilitating effects of nicotine and partially prevents nicotine withdrawal in the rat as measured by dopamine output in the nucleus accumbens, brain reward thresholds and somatic signs. Naunyn Schmiedebergs Archives of Pharmacology, 37, 182-194.
17. Malin, D.H. (2001). Nicotine dependence studies with a laboratory model. Pharmacology, Biochemistry, and Behavior, 70, 551-559.
18. Malin, D.H., & Goyarzu, P. (2009). Rodent models of nicotine withdrawal syndrome. In J.E. Henningfield, E.D. London & S. Pogun (Eds.), Handbook of experimental pharmacology 192: Nicotine psychopharmacology (pp. 401-434). New York: Springer.
19. Malin, D.H., Alvarado, C.L., Woodhouse, K.S., Karp, H., Urdiales, E., Lay, D., et al. (2002). Passive immunization against nicotine attenuates nicotine discrimination. Life Sciences, 70, 2793-2798.
20. Malin, D.H., Lake, J.R., Carter, V.A., Cunningham, J.S., Hebert, K.M., Conrad, D.L., et al. (1994). The nicotinic antagonist mecamylamine precipitates nicotine abstinence syndrome in the rat. Psychopharmacology, 115, 180-184.
21. Malin, D.H., Lake, J.R., Lin, A., Saldaña, M., Balch, L., Irvin, M.L., et al. (2001). Passive immunization against nicotine prevents nicotine alleviation of nicotine abstinence syndrome. Pharmacology, Biochemistry, and Behavior, 68, 87-92.
22. Malin, D.H., Lake, J.R., Newlin-Maultsby, P., Roberts, L.K., Lanier, J.G., Carter, V.A., et al. (1992). Rodent model of nicotine abstinence syndrome. Pharmacology, Biochemistry, and Behavior, 43, 779-784.
23. Maurer, P., Jennings, G.T., Willers, J., Rohner, F., Lindmean, Y., Roubicek, K., et al. (2005). A Therapeutic vaccine for nicotine dependence: Preclinical efficacy, and phase I safety and immunogenicity. European Journal of Immunology, 35, 2031-2040.
24. Pentel, P.R., Dufek, M.B., Roiko, S.A., Lesage, M.G., & Keyler, D.E. (2006). Differential effects of passive immunization with nicotine-specific antibodies on the acute and chronic distribution of nicotine to brain in rats. Journal of Pharmacology and Experimental Therapeutics, 317, 660-666.
25. Pentel, P.R., Malin, D.H., Ennifar, S., Heida, Y., Keyler, D.E., Lake, J.R., et al. (2000). A nicotine conjugate vaccine reduces nicotine distribution to brain and attenuates its behavioral and cardiovascular effects in rats. Pharmacology, Biochemistry, and Behavior, 65, 191-198.
26. Suzuki, T., Ise, Y., Tsuda, M., Maeda, J., & Misawa, M. (1996). Mecamylamine-precipitated nicotine-withdrawal aversion in rats. European Journal of Pharmacology, 314, 281-284.
27. Wagena, E.J., de Vos, A., Horwith, G., & van Schayck, C.P. (2008). The immunogenicity and safety of a nicotine vaccine in smokers and nonsmokers: Results of a randomized, placebo-controlled phase 1/2 trial. Nicotine & Tobacco Research, 10, 213-218.