Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke

Journal of Neuroscience

Volumn 31, Issue 24, 2011, Pages 8894-8904

  Akpan, Nsikan ^a   Serrano Saiz, Esther ^a   Zacharia, Brad E ^a   Otten, Marc L ^a   Ducruet, Andrew F ^a   Snipas, Scott J ^b   Liu, Wen ^a   Velloza, Jennifer ^a   Cohen, Greg ^a   Sosunov, Sergeyi A ^a   Frey, William H ^c   Salvesen, Guy S ^a   Connolly Jr , E Sander ^a   Troy, Carol M ^a  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

^b BURNHAM INSTITUTE   (United States)

^c REGIONS HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 6; CASPASE 9; CASPASE 9 INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; IN VIVO STUDY; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; STROKE;

ADMINISTRATION, INTRANASAL; ALDEHYDES; ANIMALS; BRAIN INFARCTION; CASPASE 6; CASPASE 9; CYSTEINE PROTEINASE INHIBITORS; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; HIPPOCAMPUS; HUMANS; INFARCTION, MIDDLE CEREBRAL ARTERY; INHIBITOR OF APOPTOSIS PROTEINS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; NERVOUS SYSTEM DISEASES; NEURONS; PTEN PHOSPHOHYDROLASE; RATS; RATS, WISTAR; TIME FACTORS;

EID: 79959314865     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0698-11.2011     Document Type: Article

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