Induction of autophagy and senescence by knockdown of ROC1 E3 ubiquitin ligase to suppress the growth of liver cancer cells

Cell Death and Differentiation

Volumn 20, Issue 2, 2013, Pages 235-247

  Yang, D ^a,b   Li, L ^a,c   Liu, H ^d   Wu, L ^b   Luo, Z ^a,b   Li, H ^b   Zheng, S ^c   Gao, H ^a   Chu, Y ^a   Sun, Y ^e   Liu, J ^a,b   Jia, L ^a  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c NORTHEAST AGRICULTURAL UNIVERSITY   (China)

^d SECOND MILITARY MEDICAL UNIVERSITY   (China)

^e UNIVERSITY OF MICHIGAN   (United States)

Author keywords

autophagy; Cullin RING ligase; Deptor; ROC1; senescence

Indexed keywords

CULLIN; MAMMALIAN TARGET OF RAPAMYCIN; P21 ACTIVATED KINASE; PROTEIN DEPTOR; REGULATOR OF CULLIN 1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; CANCER CELL; CANCER INHIBITION; CANCER PROGNOSIS; CANCER SURVIVAL; CELL AGING; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER CANCER; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AUTOPHAGY; CARCINOMA, HEPATOCELLULAR; CARRIER PROTEINS; CELL AGING; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; G2 PHASE CELL CYCLE CHECKPOINTS; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; M PHASE CELL CYCLE CHECKPOINTS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SURVIVAL RATE; TOR SERINE-THREONINE KINASES;

MAMMALIA;

EID: 84872320049     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2012.113     Document Type: Article

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