Quercetin supplementation: Insight into the potentially harmful outcomes of neurodegenerative prevention

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 385, Issue 12, 2012, Pages 1185-1197

  Jembrek, Maja Jazvinšćak ^a   Gašparović, Ana Čipak ^a   Vuković, Lidija ^a   Vlainić, Josipa ^a   Žarković, Neven ^a   Oršolić, Nada ^b  

^a RUDER BO KOVI INSTITUTE   (Croatia)

^b UNIVERSITY OF ZAGREB   (Croatia)

Author keywords

Antioxidant supplementation; Bcl 2; Glutathione depletion; P19 neurons; P53 and c fos expression; Quercetin

Indexed keywords

4 HYDROXYNONENAL; CASPASE 3; CASPASE 7; DICHLORODIHYDROFLUORESCEIN DIACETATE; GLUTATHIONE; LACTATE DEHYDROGENASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN C FOS; PROTEIN P53; QUERCETIN; REACTIVE OXYGEN METABOLITE; RNA; TATA BINDING PROTEIN;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL STRUCTURE; CELL SURVIVAL; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG EFFICACY; DRUG SAFETY; EMBRYO; GENE EXPRESSION; INTRACELLULAR SIGNALING; LIPID PEROXIDATION; MOUSE; NERVE CELL; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUPPLEMENTATION; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; L-LACTATE DEHYDROGENASE; LIPID PEROXIDATION; MICE; NEURODEGENERATIVE DISEASES; NEURONS; NEUROPROTECTIVE AGENTS; QUERCETIN; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; TIME FACTORS;

EID: 84872273663     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-012-0799-y     Document Type: Article

References (50)

1. Akhtar RS, Ness JM, Roth KA (2004) Bcl-2 family regulation of neuronal development and neurodegeneration. Biochim Biophys Acta 1644:189-203
2. Antoncic-Svetina M, Sentija D, Cipak A, Milicic D, Meinitzer A, Tatzber F, Andrisic L, Zelzer S, Zarkovic N (2010) Ergometry induces systemic oxidative stress in healthy human subjects. Tohoku J Exp Med 221:43-48
3. Arredondo F, Echeverry C, Abin-Carriquiry JA, Blasina F, Antúnez K, Jones DP, Go Y-M, Liang Y-L, Dajas F (2010) After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult. Free Radic Biol Med 49:738-747
4. Bischoff SC (2008) Quercetin: potentials in the prevention and therapy of disease. Curr Opin Clin Nutr Metab Care 11:733-740
5. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C (2007) Mortality in randomized trials of antioxidant supplements for primary and secondary prevention. Systematic review and metaanalysis. JAMA 297:842-857
6. Boots AW, Kubben N, Haenen GRMM, Bast A (2003) Oxidized quercetin reacts with thiols rather than with ascorbate: implication for quercetin supplementation. Biochem Biophys Res Commun 308:560-565
7. Boots AW, Li H, Schins RPF, Duffin R, Heemskerk JWM, Bast A, Haenen GRMM (2007) The quercetin paradox. Toxicol Appl Pharmacol 222:89-96
8. Boots AW, Haenen GRMM, Bast A (2008) Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol 585:325-337
9. Choi EJ, Kim G-H (2010) Quercetin accumulation by chronic administration causes the caspase-3 activation in liver and brain of mice. Biofactors 36:216-221
10. Choi EJ, Lee BH, Lee K, Chee K-M (2005) Long-term combined administration of quercetin and daidzein inhibits quercetininduced suppression of glutathione antioxidant defenses. Food Chem Toxicol 43:793-798
11. Čipak Gašparović A, Lovaković T, Žarković N (2010) Oxidative stress and antioxidants: biological response modifiers of oxidative homeostasis in cancer. Period Biol 4:433-439
12. Darley-Usmar VM, Severn A, O'Leary VJ, Rogers M (1991) Treatment of macrophages with oxidized low-density lipoprotein increases their intracellular glutathione content. Biochem J 278:429-434
13. de Boer VCJ, Dihal AA, van der Woude H, Arts ICW, Wolffram S, Alink GM, Rietjens IMCM, Keijer J, Hollman PCH (2005) Tissue distribution of quercetin in rats and pigs. J Nutr 135:1718-1725
14. de Martins RP, de Braga HC, da Silva AP, Dalmarco JB, de Bem AF, dos Santos AR, Dafre AL, Pizzolatti MG, Latini A, Aschner M, Farina M (2009) Synergistic neurotoxicity induced by methylmercury and quercetin in mice. Food Chem Toxicol 47:645-649
15. Dianzani MU (2003) 4-Hydroxynonenal from pathology to physiology. Mol Asp Med 24:263-272
16. Emerit J, Edeas M, Bricaire F (2004) Neurodegenerative diseases and oxidative stress. Biomed Pharmacother 58:39-46
17. Estus S, Zaks W, Freeman R, Gruda M, Bravo R, Johnson E (1994) Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. J Cell Biol 127:1717-1727
18. Filipe P, Haigle J, Silva JN, Freitas J, Fernandes A, Mazière J-C, Mazière C, Santus R, Morlière P (2004) Anti- and pro-oxidant effects of quercetin in copper-induced low density lipoprotein oxidation. Quercetin as an effective antioxidant against prooxidant effects of urate. Eur J Biochem 271:1991-1999
19. Geng Y, Walls KC, Ghosh AP, Akhtar RS, Klocke BJ, Roth KA (2010) Cytoplasmic p53 and activated Bax regulate p53-dependent, transcription- independent neural precursor cell apoptosis. J Histochem Cytochem 58:265-275
20. Guéraud F, Atalay M, Bresgen N, Cipak A, Eckl PM, Huc L, Jouanin I, Siems W, Uchida K (2010) Chemistry and biochemistry of lipid peroxidation products. Free Radic Res 44:1098-1124
21. Ham J, Towers E, Gilley J, Terzano S, Randall R (2005) BH3-only proteins: key regulators of neuronal apoptosis. Cell Death Differ 12:1015-1020
22. Ishisaka A, Ichikawa S, Sakakibara H, Piskula MK, Nakamura T, Kato Y, Ito M, Miyamoto K, Tsuji A, Kawai Y, Terao J (2011) Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats. Free Radic Biol Med 51:1329-1336
23. Jakubowicz-Gil J, Rzeski W, Zdzisinska B, Dobrowolski P, Gawron A (2008) Cell death and neuronal arborization upon quercetin treatment in rat neurons. Acta Neurobiol Exp 68:139-146
24. Jazvinscak Jembrek M, Vuković L, Puhović J, Erhardt J, Oršolić N (2012) Neuroprotective effect of quercetin against hydrogen peroxide-induced oxidative injury in P19 neurons. J Mol Neurosci 47:286-299
25. Jung SH, Kim BJ, Lee EH, Osborne NN (2010) Isoquercitrin is the most effective antioxidant in the plant Thuja orientalis and able to counteract oxidative-induced damage to a transformed cell line (RGC-5 cells). Neurochem Int 57:713-721
26. Kelsey NA, Wilkins HM, Linseman DA (2010) Nutraceutical antioxidants as novel neuroprotective agents. Molecules 15: 7779-7814
27. Kley N, Chung RY, Fay S, Loeffler JP, Seizinger BR (1992) Repression of the basal c-fos promoter by wild-type p53. Nucl Acid Res 20:4083-4087
28. Lavoie S, Chen Y, Dalton TP, Gysin R, Cuénod M, Steullet P, Do KQ (2009) Curcumin, quercetin, and tBHQ modulate glutathione levels in actrocytes and neurons: importance of the glutamate cysteine ligase modifier subunit. J Neurochem 108: 1410-1422
29. Marinić M, Piantanida I, Rusak G, Žinić M (2006) Interactions of quercetin and its lanthane complex with double stranded DNA/RNA and single stranded RNA: spectrophotometric sensing of poly G J Inorg Biochem 100:288-298
30. Martin KR, Appel CL (2010) Polyphenols as dietary supplements: a double-edged sword. Nutr Diet Suppl 2:1-12
31. Mennen LI, Walke R, Bennetau-Pelissero C, Scalbert A (2005) Risks and safety of polyphenol consumption. Am J Clin Nutr 81 (suppl):326S-329S
32. Montenegro MF, Neto-Neves EM, Dias-Junior CA, Ceron CS, Castro MM, Gomes VA, Kanashiro A, Tanus-Santos JE (2010) Quercetin restores plasma nitrite and nitroso species levels in renovascular hypertension. Naunyn-Schmiedeberg's Arch Pharmacol 4: 293-301
33. Noguchi N (2008) Role of oxidative stress in adaptive responses in special reference to atherogenesis. J Clin Biochem Nutr 43: 131-138
34. Oršolić N, Benković V, Lisičić D, Bikić D, Erhardt J, Horvat-Knežević A (2010) Protective effects of propolis and related polyphenolic/flavonoid compounds against toxicity induced by irinotecan. Med Oncol 27:1346-1358
35. Oršolić N, Gajski G, Garaj-Vrhovac V, Bikić D, Prskalo ZŠ, Sirovina D (2011) DNA-protective effects of quercetin or naringenin in alloxan-induced diabetic mice. Eur J Pharmacol 656:110-118
36. Ossola B, Kääriäinen TM, Raasmaja A, Männistö PT (2008) Time-dependent protective and harmful effects of quercetin on 6-OHDA-induced toxicity in neuronal SH-SY5Y cells. Toxicology 250:1-8
37. Ossola B, Kääriäinen TM, Männistö PT (2009) The multiple faces of quercetin in neuroprotection. Expert Opin Drug Saf 8:397-409
38. Pastore A, Federici G, Bertini E, Piemonte F (2003) Analysis of glutathione: implication in redox and detoxification. Clin Chim Acta 333:19-39
39. Pavlica S, Gebhardt R (2010) Protective effects of flavonoids and two metabolites against oxidative stress in neuronal PC12 cells. Life Sci 86:79-86
40. Ristow M, Schmeisser S (2011) Extending life span by increasing oxidative stress. Free Radic Biol Med 51:327-336
41. Ristow M, Zarse K, Oberbach A, Klöting N, Birringer M, Kiehntopf M, Stumvoll M, Kahn CR, Blüher M (2009) Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Natl Acad Sci USA 106:8665-8670
42. Slemmer JE, Shacka JJ, Sweeney MI, Weber JT (2008) Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging. Curr Med Chem 15:404-414
43. Spencer JPE, Rice-Evans C, Williams RJ (2003) Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability. J Biol Chem 278:34783-34793
44. Steckley D, Karajgikar M, Dale LB, Fuerth B, Swan P, Drummond-Main C, Poulter MO, Ferguson SSG, Strasser A, Cregan SP (2007) Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis. J Neurosci 27:12989-12999
45. Tedeschi A, Di Giovanni S (2009) The non-apoptotic role of p53 in neuronal biology: enlightening the dark side of the moon. EMBO Rep 10:576-583
46. Turetsky DM, Huettner JE, Gottlieb DI, Goldberg MP, Choi DW (1993) Glutamate receptor-mediated currents and toxicity in embryonal carcinoma cells. J Neurobiol 24:1157-1169
47. Vargas AJ, Burd R (2010) Hormesis and synergy: pathways and mechanisms of quercetin in cancer prevention and management. Nutr Rev 68:418-428
48. Yelisyeyeva O, Semen K, Zarkovic N, Kaminskyy D, Lutsyk O, Rybalchenko V (2012) Activation of aerobic metabolism by amaranth oil improves heart rate variability both in athletes and patients with type 2 diabetes mellitus. Arch Physiol Biochem 118:1-11
49. Zarkovic N (2003) 4-Hydroxynonenal as a bioactive marker of patho-physiological processes. Mol Asp Med 24:281-291
50. Zhang S, Ye J, Dong G (2010) Neuroprotective effect of baicalein on hydrogen peroxide-mediated oxidative stress and mitochondrial dysfunction in PC12 cells. J Mol Neurosci 40:311-320