Ergometry induces systemic oxidative stress in healthy human subjects

Tohoku Journal of Experimental Medicine

Volumn 221, Issue 1, 2010, Pages 43-48

  Antoncic Svetina, Maja ^a   Sentija, Davor ^b   Cipak, Ana ^c   Milicic, Davor ^d   Meinitzer, Andreas ^e   Tatzber, Franz ^f   Andrisic, Luka ^c   Zelzer, Sieglinde ^e   Zarkovic, Neven ^a  

^a Institute of Cardiovascular Prevention and Rehabilitation Zagreb   (Croatia)

^b UNIVERSITY OF ZAGREB   (Croatia)

^c RUDER BO KOVI INSTITUTE   (Croatia)

^d KBC Zagreb   (Croatia)

^e MEDICAL UNIVERSITY OF GRAZ   (Austria)

^f UNIVERSITY OF APPLIED SCIENCES TECHNIKUM WIEN   (Austria)

Author keywords

Antioxidants; Ergometry; Hydroxyl radical; Oxidative homeostasis; Serum peroxides

Indexed keywords

2,3 DIHYDROXYBENZOIC ACID; ANTIOXIDANT; FREE RADICAL; HYDROXYL RADICAL; PEROXIDE; SALICYLIC ACID; URIC ACID;

ADULT; ANAEROBIC THRESHOLD; ARTICLE; BLOOD SAMPLING; BREATHING RATE; CONTROLLED STUDY; ERGOMETRY; EXERCISE; HEART RATE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; OXIDATIVE STRESS; PHYSICAL PERFORMANCE; PREMEDICATION; RUNNING; TREADMILL; VOLUNTEER; WALKING;

ANTIOXIDANTS; EXERCISE; EXERCISE TEST; EXERCISE TOLERANCE; HUMANS; HYDROXYL RADICAL; MALE; OXIDATIVE STRESS; PEROXIDES; PHYSICAL EXERTION; RESPIRATORY FUNCTION TESTS; SALICYLIC ACID; YOUNG ADULT;

EID: 77951756901     PISSN: 00408727     EISSN: 13493329     Source Type: Journal    
DOI: 10.1620/tjem.221.43     Document Type: Article

References (34)

1. Ates, O., Azizi, S., Alp, H.H., Kiziltunc, A., Beydemir, S., Cinici, E., Kocer, I. & Baykal, O. (2009) Decreased serum paraoxonase 1 activity and increased serum homocysteine and malondialde-hyde levels in age-related macular degeneration. Tohoku J. Exp. Med., 217, 17-22.
2. Bejma, J. & Ji, L.L. (1999) Aging and acute exercise enhance free radical generation in rat skeletal muscle. J. Appl. Physiol., 87, 465-470.
3. Bloomer, R.J. (2008) Effect of exercise on oxidative stress biomarkers. Adv. Clin. Chem., 46, 1-50.
4. Borovic, S., Meinitzer, A., Loncaric, I., Sabolovic, S., Wildburger, R., Tillian, M., Martinac, P., Stipancic, I. & Zarkovic, N. (2000) Monitoring influence of surgical stress on formation of hydroxyl radicals in tumor bearing rats by measuring salicylic acid metabolites. Electron. J. Int. Fed. Clin. Chem. Lab. Med., 12, 1-4.
5. Braughler, J.M. & Hall, E.D. (1989) Central nervous system trauma and stroke: I. Biochemical considerations for oxygen radical formation and lipid peroxidation. Free Radic. Biol. Med., 6, 289-301.
6. Cindric, M., Cipak, A., Mrakovcic, L., Zarkovic, K., Borovic, S., Wildburger, R. & Zarkovic, N. (2009) Homeostasis, stress and aging. Turk. Klin. Tip. Bilim Der., 29, s3-s5.
7. Esterbauer, H., Schaur, R.J. & Zollner, H. (1991) Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde, and related aldehydes. Free Radic. Biol. Med., 11, 81-128.
8. Gomez-Cabrera, M.C., Domenech, E., Ji, L.L. & Vina, J. (2006) Exercise as an antioxidant: it up-regulates important enzymes for cell adaptations to exercise. Sci. Sports, 21, 85-89.
9. Gomez-Cabrera, M.C., Domenech, E. & Vina, J. (2008) Moderate exercise is an antioxidant: Upregulation of antioxidant genes by training. Free Radic. Biol. Med., 44, 126-131.
10. Hall, E.D. & Braughler, J.M. (1989) Central nervous system trauma and stroke: II. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation. Free Radic. Biol. Med., 6, 303-313.
11. Halliwell, B. (1996) Antioxidants in human health and disease. Annu. Rev. Nutr., 16, 33-50.
12. Hellsten-Westing, Y. (1993) Immunohistochemical localization of xanthine oxidase in human cardiac and skeletal muscle. Histochemistry, 100, 215-222.
13. Isik, A., Koca, S.S., Ustundag, B. & Selek, S. (2007) Decreased total antioxidant response and increased oxidative stress in Behcet's disease. Tohoku J. Exp. Med., 212, 133-141.
14. Jamieson, D.J. (1998) Oxidative responses of the yeast Saccharomyces cerevisiae. Yeast, 14, 1511-1527.
15. Ji, L.L., Radak, Z. & Goto, S. (2008) Hormesis and exercise: How the cell copes with oxidative stress. Am. J. Pharmacol. Toxicol., 3, 44-58.
16. Khoschsorur, G.A., Winklhofer-Roob, B.M., Rabl, H., Auer, Th., Peng, Z. & Schaur, R.J. (2000) Evaluation of a sensitive HPLC method for the determination of malondialdehyde, and application of the method to different biological materials. Chromatographia, 52, 181-184.
17. Liu, L., Leech, J.A., Urch, R.B. & Silverman, F.S. (1997) In vivo salicylate hydroxylation: a potential biomarker for assessing acute ozone exposure and effects in humans. Am. J. Respir. Crit. Care Med., 156, 1405-1412.
18. Liu, M.L., Bergholm, R., Makimattila, S., Lahdenpera, S., Valkonen, M., Hilden, H., Yki-Jarvinen, H. & Taskinen, M.R. (1999) A marathon run increases the susceptibility of LDL to oxidation in vitro and modifies plasma antioxidants. Am. J. Physiol., 276, E1083-E1091.
19. Mamiya, T., Katsuoka, F., Hirayama, A., Nakajima, O., Kobayashi, A., Maher, J.M., Matsui, H., Hyodo, I., Yamamoto, M. & Hosoya, T. (2008) Hepatocyte-specific deletion of heme oxygenase-1 disrupts redox homeostasis in basal and oxidative environments. Tohoku J. Exp. Med., 216, 331-339.
20. Mastaloudis, A., Leonard, S.W. & Traber, M.G. (2001) Oxidative stress in athletes during extreme endurance exercise. Free Radic. Biol. Med., 31, 911-922.
21. McCabe, D.R., Maher, T.J. & Acworth, I.N. (1997) Improved method for the estimation of hydroxyl free radical levels in vivo based on liquid chromatography with electrochemical detection. J. Chromatogr. B Biomed. Sci. Appl., 691, 23-32.
22. Meyer, T., Lucia, A., Earnest, C.P. & Kindermann, W. (2005) A conceptual framework for performance diagnosis and training prescription from submaximal gas exchange parameters - theory and application. Int. J. Sports Med., 26, S38-48.
23. Nikolic-Heitzler, V., Rabuzin, F., Tatzber, F., Vrkic, N., Bulj, N., Borovic, S., Wonisch, W., Sunko, B.M. & Zarkovic, N. (2006) Persistent oxidative stress after myocardial infarction treated by percutaneous coronary intervention. Tohoku J. Exp. Med., 210, 247-255.
24. Parise, G., Phillips, S.M., Kaczor, J.J. & Tarnopolsky, M.A. (2005) Antioxidant enzyme activity is up-regulated after unilateral resistance exercise training in older adults. Free Radic. Biol. Med., 39, 289-295.
25. Schippinger, G., Fankhauser, F., Abuja, P.M., Winklhofer-Roob, B.M., Nadlinger, K., Halwachs-Baumann, G. & Wonisch, W. (2009) Competitive and seasonal oxidative stress in elite alpine ski racers. Scand. J. Med. Sci. Sports, 19, 206-212.
26. Svacinová, H., Nováková, M., Placheta, Z., Kohzuki, M., Nagasaka, M., Minami, N., Dobšák, P. & Siegelová, J. (2008) Benefit of combined cardiac rehabilitation on exercise capacity and cardiovascular parameters in patients with type 2 diabetes. Tohoku J. Exp. Med., 215, 103-111.
27. Tasoulis, M.K., Livaditi, O., Stamatakos, M., Stefanaki, C., Paneris, P., Prigouris, P., Flevari, A., Goutas, N., Vlachodimitropoulos, D., Villiotou, V. & Douzinas, E.E. (2009) High concentrations of reactive oxygen species in the BAL fluid are correlated with lung injury in rabbits after hemorrhagic shock and resuscitation. Tohoku J Exp Med., 219, 193-199.
28. Tatzber, F., Griebenow, S., Wonisch, W. & Winkler, R. (2003) Dual method for the determination of peroxidase activity and total peroxides-iodide leads to a significant increase of peroxidase activity in human sera. Anal. Biochem., 316, 147-153.
29. Urso, M.L. & Clarkson, PM. (2003) Oxidative stress, exercise, and antioxidant supplementation. Toxicology, 189, 41-54.
30. Vina, J., Gomez-Cabrera, M.C., Lloret, A., Marquez, R., Minana, J.B., Pallardo, F.V. & Sastre, J. (2000) Free radicals in exhaustive physical exercise: mechanism of production, and protection by antioxidants. IUBMB Life, 50, 271-277.
31. Wildburger, R., Mrakovcic, L., Stroser, M., Andrisic, L., Borovic Sunjic, S., Zarkovic, K. & Zarkovic, N. (2009) Lipid Peroxidation and Age-Associated Diseases-Cause or Consequence? Turk. Klin. Tip. Bilim Der., 29, 189-193.
32. Wonisch, W., Uhl, K., Schimetta, W. & Rabl, H. (2005) Pre-operative delivery of a vitamin cocktail diminished oxidative stress after vascular surgery in PAD patients-a pilot investigation. Biofactors, 24, 299-303.
33. Zarkovic, N. (2003) 4-Hydroxynonenal as a bioactive marker of pathopysiological processes. Mol. Aspects Med., 24, 281-291.
34. Zarkovic, N. (2009) Protein-aldehydic adducts as biomarkers of oxidative stress, lipid peroxidation and oxidative homeostasis. Free Radic. Res., 43, 33.