Neuroprotective effect of baicalein on hydrogen peroxide-mediated oxidative stress and mitochondrial dysfunction in PC12 cells

Journal of Molecular Neuroscience

Volumn 40, Issue 3, 2010, Pages 311-320

  Zhang, Shehua ^a   Ye, Junli ^a   Dong, Guoxiong ^a  

^a QINGDAO UNIVERSITY   (China)

Author keywords

Apoptosis; Baicalein; H2O2; Oxidative stress; PC12 cells; ROS

Indexed keywords

BAICALEIN; CYTOCHROME C; DNA FRAGMENT; HYDROGEN PEROXIDE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL STRAIN; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; IN VITRO STUDY; LIPID PEROXIDATION; MITOCHONDRIAL MEMBRANE POTENTIAL; NEUROPROTECTION; OXIDATIVE STRESS; PROTEIN EXPRESSION; SCUTELLARIA BAICALENSIS; UPREGULATION;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FLAVANONES; HYDROGEN PEROXIDE; LIPID PEROXIDATION; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MOLECULAR STRUCTURE; OXIDANTS; OXIDATIVE STRESS; PC12 CELLS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; REACTIVE OXYGEN SPECIES;

SCUTELLARIA BAICALENSIS;

EID: 77950189444     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-009-9285-5     Document Type: Article

References (49)

1. I Budihardjo H Olive M Lutter X Luo X Wang 1999 Biochemical pathways of caspase activation during apoptosis Annu. Rev. Cell dev. Biol. 15 269 290 10.1146/annurev.cellbio.15.1.269 10611963 1:CAS:528:DC%2BD3cXhtVSnuro%3D (Pubitemid 32250377)
2. DA Butterfield T Koppal B Howard, et al. 1998 Structural and functional changes in proteins induced by free radical-mediated oxidative stress and protective action of the antioxidants N-tert-butyl-alpha-phenylnitrone and vitamin E Ann N Y Acad Sci 854 448 462 10.1111/j.1749-6632.1998.tb09924.x 9928452 1:CAS:528:DyaK1MXjtVehuw%3D%3D (Pubitemid 29022824)
3. S Chen Q Ruan E Bedner A Deptala X Wang TC Hsieh F Traganos Z Darzynkiewicz 2001 Effects of the flavonoid baicalin and its metabolite baicalein on androgen receptor expression, cell cycle progression and apoptosis of prostate cancer cell lines Cell Prolif 34 5 293 304 10.1046/j.0960-7722.2001. 00213.x 11591177 1:CAS:528:DC%2BD3MXotFWms70%3D (Pubitemid 32939476)
4. ZZ Chong F Li K Maiese 2005 Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease Prog Neurobiol 75 207 246 10.1016/j.pneurobio.2005.02.004 15882775 1:CAS:528:DC%2BD2MXktVOntbc%3D (Pubitemid 40693131)
5. Z Gao K Huang X Yang H Xu 1999 Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi Biochim Biophys Acta 1472 643 650 10564778 1:CAS:528:DyaK1MXntlClt70%3D
6. Z Gao K Huang H Xu 2001 Protective effects of flavonoids in the root of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells Pharmacol Res 43 173 178 10.1006/phrs.2000.0761 11243719 1:CAS:528:DC%2BD3MXhsl2jt70%3D (Pubitemid 32601447)
7. Y Gilgun-Sherki Z Rosenbaum E Melamed D Offen 2002 Antioxidant therapy in acute central nervous system injury: current state Pharmacol Rev 54 271 284 10.1124/pr.54.2.271 12037143 1:CAS:528:DC%2BD38XltVOhsr4%3D (Pubitemid 34575717)
8. M Giorgio M Trinei E Migliaccio PG Pelicci 2007 Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals? Nat. Rev., Mol. Cell Biol 8 722 728 10.1038/nrm2240 1:CAS:528:DC%2BD2sXpsVartbw%3D (Pubitemid 47312827)
9. JM Gutteridge B Halliwell 2000 Free radicals and antioxidants in the year 2000. A historical look to the future Ann N Y Acad Sci 899 136 147 10863535 1:CAS:528:DC%2BD3cXks1Shs7s%3D
10. B Halliwell OI Aruoma, et al. 1991 DNA damage by oxygen-derived species. Its mechanism and measurement in mammalian systems FEBS Lett 281 9 19 10.1016/0014-5793(91)80347-6 1849843 1:CAS:528:DyaK3MXisVaisbo%3D
11. C Hetz PA Vitte A Bombrun TK Rostovtseva, et al. 2005 Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia J Biol Chem 280 52 42960 42970 10.1074/jbc.M505843200 16219766 1:CAS:528:DC%2BD2MXhtlCmsb7K (Pubitemid 43049259)
12. WF Hodnick FS Kung WJ Roettger CW Bohmont RS Pardini 1986 Inhibition of mitochondrial respiration and production of toxic oxygen radicals by flavonoids. A structure-activity study Biochem Pharmacol 35 2345 2357 10.1016/0006-2952(86) 90461-2 3729991 1:CAS:528:DyaL28XkvFSrsrc%3D
13. WF Hodnick EB Milosavljevic JH Nelson RS Pardini 1998 Electrochemistry of flavonoids: relationships between redox potentials, inhibition of mitochondrial respiration, and production of oxygen radicals by flavonoids Biochem Pharmacol 37 2607 2611 10.1016/0006-2952(88)90253-5
14. H Ischiropoulos JS Beckman 2003 Oxidative stress and nitration in neurodegeneration: cause, effect, or association? J Clin Invest 111 163 169 12531868 1:CAS:528:DC%2BD3sXlsVGkuw%3D%3D
15. EA Jonas JM Hardwick LK Kaczmarek 2005 Actions of BAX on mitochondrial channel activity and on synaptic transmission Antioxid Redox Signal 7 9-10 1092 1100 10.1089/ars.2005.7.1092 16115013 1:CAS:528:DC%2BD2MXos1eru7Y%3D (Pubitemid 41232505)
16. RA Kirkland JL Franklin 2003 Bax, reactive oxygen, and cytochrome c release in neuronal apoptosis Antioxid Redox Signal 5 5 589 596 10.1089/152308603770310257 14580315 1:CAS:528:DC%2BD3sXosVersb0%3D
17. C Le Bel H Ischiropoulos SC Bondy 1992 Evaluation of the probe 2, 7-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress Chem Res Toxicol 5 227 231 10.1021/tx00026a012
18. A Lebeau F Esclaire W Rostène D Pélaprat 2001 Baicalein protects cortical neurons from beta-amyloid (25-35) induced toxicity NeuroReport 12 10 2199 2202 10.1097/00001756-200107200-00031 11447334 1:CAS:528: DC%2BD3MXls1emsro%3D
19. YS Lee EJ Kwon DQ Jin SH Park YS Kang K Huh JA Kim 2002 Redox status-dependent regulation of cyclooxygenases mediates the capsaicin-induced apoptosis in human neuroblastoma cells J. Environ. Pathol. Toxicol. 21 2 113 120 1:CAS:528:DC%2BD38XlsVWqu7g%3D
20. CC Lin DE Shieh 1996 The anti-inflammatory activity of Scutellaria rivularis extracts and its active components, baicalin, baicalein and wogonin Am J Chin Med 24 1 31 36 10.1142/S0192415X96000050 8739179 1:STN:280: DyaK28zisl2gsw%3D%3D
21. X Liu XZ Zhu 1999 Roles of P53, c-Myc, Bcl-2, Bax and caspase in glutamate-induced neuronal apoptosis and the possible neuroprotective mechanism of basic fibroblast growth factor Mol Brain Res 70 201 206
22. T Lindsten WX Zong CB Thompson 2005 Defining the role of the Bcl-2 family of proteins in the nervous system Neuroscientist 11 1 10 15 10.1177/1073858404269267 15632274 1:CAS:528:DC%2BD2MXht1ylsrk%3D (Pubitemid 40223086)
23. 2 in vitro FEBS J 276 870 881 10.1111/j.1742-4658.2008.06831.x 19143845 1:CAS:528:DC%2BD1MXhs1Kitbg%3D
24. JL Martindale NJ Holbrook 2002 Cellular response to oxidative stress: signaling for suicide and survival J Cell Physiol 192 1 15 10.1002/jcp.10119 12115731 1:CAS:528:DC%2BD38XksVGmurc%3D (Pubitemid 34587382)
25. M Mihara M Uchiama 1978 Determination of malonaldheyde precursor in tissues by thiobarbituric acid test Anal Biochem 86 271 278 10.1016/0003- 2697(78)90342-1 655387 1:STN:280:DyaE1c7osFSjsQ%3D%3D
26. YH Miura I Tomita T Watanabe T Hirayama S Fukui 1998 Active oxygens generation by flavonoids Biol Pharm Bull 21 93 96 9514598 1:CAS:528: DyaK1cXhtlGgsL0%3D
27. M Naoi W Maruyama M Shamoto-Nagai H Yi Y Akao M Tanaka 2005 Oxidative stress in mitochondria: decision to survival and death of neurons in neurodegenerative disorders Mol Neurobiol 31 1-3 81 93 10.1385/MN:31:1-3:081 15953813 1:CAS:528:DC%2BD2MXmtFKltbw%3D
28. M Okouchi O Ekshyyan M Maracine TY Aw 2007 Neuronal apoptosis in neurodegeneration Antioxid Redox Signal 9 1059 1096 10.1089/ars.2007.1511 17571960 1:CAS:528:DC%2BD2sXot1Wktrc%3D (Pubitemid 47080820)
29. EK Perry AT Pickering WW Wang PJ Houghton NS Perry 1999 Medicinal plants and Alzheimer's disease: from ethnobotany to phytotherapy J Pharm Pharmacol 51 5 527 534 10.1211/0022357991772808 10411211 1:CAS:528:DyaK1MXksVKhtLc%3D (Pubitemid 29319777)
30. PX Petit SA Susin N Zamzami B Mignotte G Kroemer 1996 Mitochondria and programmed cell death: back to the future FEBS Lett 396 1 7 13 10.1016/0014-5793(96)00988-X 8906857 1:CAS:528:DyaK28Xms1eit7g%3D (Pubitemid 26360271)
31. BM Polster G Fiskum 2004 Mitochondrial mechanisms of neural cell apoptosis J Neurochem 90 6 1281 1289 10.1111/j.1471-4159.2004.02572.x 15341512 1:CAS:528:DC%2BD2cXnvVGqs7s%3D (Pubitemid 39223632)
32. AV Rao B Balachandran 2002 Role of oxidative stress and antioxidants in neurodegenerative diseases Nutr. Neurosci. 5 291 309 10.1080/1028415021000033767 12385592 1:CAS:528:DC%2BD38XosFehtb0%3D (Pubitemid 35174629)
33. JC Reed 1997 Bcl-2 family proteins: regulators of apoptosis and chemoresistance in hematologic malignancies Semin Hematol 34 9 19 9408956 1:CAS:528:DyaK2sXotV2gtbo%3D
34. SG Rhee 1999 Redox signaling: hydrogen peroxide as intracellular messenger Exp. Mol. Med. 31 53 59 10410302 1:CAS:528:DyaK1MXksFegurw%3D
35. SW Ryter HP Kim A Hoetzel JW Park K Nakahira X Wang AM Choi 2007 Mechanisms of cell death in oxidative stress Antioxid Redox Signal 9 1 49 89 10.1089/ars.2007.9.49 17115887 1:CAS:528:DC%2BD28Xht1Wqur3L
36. ZH Shao TL Vanden Hoek Y Qin LB Becker PT Schumacker CQ Li, et al. 2002 Baicalein attenuates oxidant stress in cardiomyocytes Am J Physiol Heart Circ Physiol 282 H999 H1006 11834498 1:CAS:528:DC%2BD38Xit1Ghu7w%3D
37. DE Shieh LT Liu CC Lin 2000 Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin Anticancer Res 20 5A 2861 2865 11062694 1:CAS:528:DC%2BD3cXnvVequro%3D
38. L Soane G Fiskum 2005 Inhibition of mitochondrial neural cell death pathways by protein transduction of Bcl-2 family proteins J Bioenerg Biomembr 37 3 179 190 10.1007/s10863-005-6590-8 16167175 1:CAS:528:DC%2BD2MXhtVWiu7%2FM (Pubitemid 41420473)
39. JP Spencer A Jenner OI Aruoma, et al. 1994 Intense oxidative DNA damage promoted by L-dopa and its metabolites. Implications for neurodegenerative disease FEBS Lett 353 3 246 250 10.1016/0014-5793(94)01056-0 7957867 1:CAS:528:DyaK2MXitlWqtLk%3D (Pubitemid 24327007)
40. XM Sun SB Bratton M Butterworth M MacFarlane GM Cohen 2002 Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein J Biol Chem 277 11345 11351 10.1074/jbc.M109893200 11801595 1:CAS:528:DC%2BD38Xis1KgsLo%3D
41. WG Telford LE King PJ Fraker 1991 Evaluation of glucocorticoid-induced DNA fragmentation in mouse thymocytes by flow cytometry Cell Prolif 24 5 447 459 10.1111/j.1365-2184.1991.tb01173.x 1657218 1:CAS:528:DyaK38XpvFGhsw%3D%3D
42. VJ Thannickal BL Fanburg 2000 Reactive oxygen species in cell signaling Am. J. Physiol., Lung Cell. Mol. Physiol 279 L1005 L1028 1:CAS:528: DC%2BD3cXptFSksbg%3D
43. G Waris H Ahsan 2006 Reactive oxygen species: role in the development of cancer and various chronic conditions J. Carcinog. 5 14 10.1186/1477-3163-5-14 16689993 1:CAS:528:DC%2BD28XlvVait7c%3D (Pubitemid 43919215)
44. JA Wu AS Attele L Zhang CS Yuan 2001 Anti-HIV activity of medicinal herbs: usage and potential development Am J Chin Med 29 1 69 81 10.1142/S0192415X01000083 11321482 1:STN:280:DC%2BD3Mris1Gjsg%3D%3D
45. KA Youdim JP Spencer H Schroeter C Rice-Evans 2002 Dietary flavonoids as potential neuroprotectants Biol. Chem. 383 503 519 10.1515/BC.2002.052 12033439 1:CAS:528:DC%2BD38XksVajt7g%3D (Pubitemid 34506287)
46. Y Zhang B Zhao 2003 Green tea polyphenols enhance sodium nitroprusside- induced neurotoxicity in human neuroblastoma SH-SY5Y cells J Neurochem 86 5 1189 1200 12911627 1:CAS:528:DC%2BD3sXmvFaitL0%3D
47. Y Zhang VL Dawson TM Dawson 2000a Oxidative stress and genetics in the pathogenesis of Parkinson's disease Neurobiol. Dis. 7 240 250 10.1006/nbdi.2000.0319 1:CAS:528:DC%2BD3cXmtVGntbk%3D
48. YW Zhang I Morita L Zhang G Shao XS Yao S Murota 2000 Screening of anti-hypoxia/reoxygenation agents by an in vitro model. Part 2: inhibition of tyrosine kinase activation prevented hypoxia/reoxygenation-induced injury in endothelial gap junctional intercellular communication Planta Med 66 2 119 23 10.1055/s-2000-11126 10763583 1:CAS:528:DC%2BD3cXivVaqtrk%3D (Pubitemid 30164351)
49. B Zhao 2009 Natural antioxidants protect neurons in Alzheimer's disease and Parkinson's disease Neurochem Res 34 4 630 638 10.1007/s11064-008-9900-9 19125328 1:CAS:528:DC%2BD1MXhtlWjsA%3D%3D