Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells

Molecular Cancer

Volumn 12, Issue 1, 2013, Pages

  Smith, Charlotte M ^a   Haucke, Volker ^b,c   McCluskey, Adam ^d   Robinson, Phillip J ^a   Chircop, Megan ^a,e  

^a UNIVERSITY OF SYDNEY   (Australia)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^d UNIVERSITY OF NEWCASTLE   (Australia)

^e CHILDREN'S MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

Cancer; Cell death; Clathrin; Metaphase; Pitstop; Spindle assembly checkpoint

Indexed keywords

CLATHRIN; PITSTOP 2; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; M PHASE CELL CYCLE CHECKPOINT; METAPHASE; MITOSIS;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL PROLIFERATION; CELL SURVIVAL; CENTRIOLES; CLATHRIN; HELA CELLS; HUMANS; M PHASE CELL CYCLE CHECKPOINTS; MICE; MICROTUBULES; MITOSIS; MITOTIC SPINDLE APPARATUS; MOLECULAR TARGETED THERAPY; NIH 3T3 CELLS; SULFONAMIDES; THIAZOLIDINES;

EID: 84872268808     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-12-4     Document Type: Article

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