Inhibition of p66ShcA longevity gene rescues podocytes from HIV-1-induced oxidative stress and apoptosis

Journal of Biological Chemistry

Volumn 284, Issue 24, 2009, Pages 16648-16658

  Husain, Mohammad ^a   Meggs, Leonard G ^b   Vashistha, Himanshu ^b   Simoes, Sonia ^b   Griffiths, Kevin O ^b   Kumar, Dileep ^a   Mikulak, Joanna ^a   Mathieson, Peter W ^c   Saleem, Moin A ^c   Del Valle, Luis ^d   Pina Oviedo, Sergio ^d   Wang, Jin Ying ^d   Seshan, Surya V ^e   Malhotra, Ashwani ^b   Reiss, Krzysztof ^d   Singhal, Pravin C ^a  

^a North Shore Long Island Jewish Health System ^*  (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; DNA STRAND BREAK; DOMINANT NEGATIVE; EPITHELIAL CELLS; EXPRESSION VECTORS; HUMAN IMMUNODEFICIENCY VIRUS; IN-VITRO; ISOFORM; NEPHROPATHY; PODOCYTES; REACTIVE OXYGEN SPECIES; REDOX ACTIVITY; SMALL INTERFERING RNA; STRESS RESPONSE REGULATORS; STRESS SIGNALS; WILD TYPES;

NUCLEIC ACIDS; OXYGEN; REDOX REACTIONS; RNA;

CELL DEATH;

PROTEIN SHC; PROTEIN SHC P66; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL IMMORTALIZATION; CELL SURVIVAL; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; EXPRESSION VECTOR; GENE ACTIVATION; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LONGEVITY; MACROPHAGE; OXIDATIVE STRESS; PHENOTYPE; PODOCYTE; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; REDOX STRESS;

ACTIVE TRANSPORT, CELL NUCLEUS; APOPTOSIS; CARRIER PROTEINS; CELL LINE, TRANSFORMED; FORKHEAD TRANSCRIPTION FACTORS; GREEN FLUORESCENT PROTEINS; HIV INFECTIONS; HIV-1; HUMANS; MEMBRANE PROTEINS; OXIDATIVE STRESS; PHENOTYPE; PHOSPHORYLATION; PODOCYTES; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SHC SIGNALING ADAPTOR PROTEINS; THREONINE; TRANSFECTION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 67650236778     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.008482     Document Type: Article

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