Genetic inactivation of the p66 isoform of ShcA is neuroprotective in a murine model of multiple sclerosis

European Journal of Neuroscience

Volumn 35, Issue 3-4, 2012, Pages 562-571

  Su, Kimmy G ^a   Savino, Costanza ^b   Marracci, Gail ^a,c   Chaudhary, Priya ^a   Yu, Xiaolin ^a   Morris, Brooke ^a   Galipeau, Danielle ^a   Giorgio, Marco ^b   Forte, Michael ^a   Bourdette, Dennis ^a,c  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b PORTLAND VA MEDICAL CENTER   (United States)

^c EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

Author keywords

EAE; Mitochondria; Multiple sclerosis; Neurodegeneration; Neuroprotective; P66 isoform of ShcA

Indexed keywords

ISOPROTEIN; PROTEIN P66; PROTEIN SHCA; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ADAPTOR PROTEIN; CD11B ANTIGEN; CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 4; P66 ISOFORM OF SHCA PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AXONAL INJURY; BRAIN MITOCHONDRION; CELL VIABILITY; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE SEVERITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FEMALE; GENE INACTIVATION; HISTOPATHOLOGY; MOUSE; MULTIPLE SCLEROSIS; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; OPTIC NERVE; PARALYSIS; PREDICTION; PRIORITY JOURNAL; SPINAL CORD; WILD TYPE; BRAIN NERVE CELL; CD4+ T LYMPHOCYTE; CELL INFILTRATION; CYTOKINE PRODUCTION; GENE; INFLAMMATION; KNOCKOUT MOUSE; LUMBAR SPINAL CORD; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MICROGLIA; NERVE DEGENERATION; SHCA GENE; THORACIC SPINAL CORD; WHITE MATTER;

ANIMALS; AXONS; CELL PROLIFERATION; CELLS, CULTURED; CEREBRAL CORTEX; CYCLOPHILINS; CYTOKINES; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FREUND'S ADJUVANT; GLYCOPROTEINS; HYDROGEN PEROXIDE; LEUKEMIC INFILTRATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, ELECTRON, TRANSMISSION; NERVE FIBERS, MYELINATED; NEURONS; OPTIC NERVE; PEPTIDE FRAGMENTS; SHC SIGNALING ADAPTOR PROTEINS; SPINAL CORD; T-LYMPHOCYTES;

EID: 84857053087     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2011.07972.x     Document Type: Article

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