Conditional Deletion of the Pten Gene in the Mouse Prostate Induces Prostatic Intraepithelial Neoplasms at Early Ages but a Slow Progression to Prostate Tumors

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Kwak, Mi Kyung ^a   Johnson, Daniel T ^a   Zhu, Chunfang ^a   Lee, Suk Hyung ^a   Ye, Ding Wei ^b   Luong, Richard ^a   Sun, Zijie ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; CRE RECOMBINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER REGRESSION; CARCINOGENESIS; CASTRATION; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; EPIGENETICS; GENE; GENE DELETION; GENE EXPRESSION; GENE INACTIVATION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; LOXP SITE; MALE; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; ODD SKIPPED RELATED 1 GENE; PENETRANCE; PROSTATE ADENOCARCINOMA; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PTEN GENE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

AGE OF ONSET; ALLELES; ANIMALS; CASTRATION; CELL TRANSFORMATION, NEOPLASTIC; DISEASE PROGRESSION; FOUNDER EFFECT; GENE DELETION; GENE EXPRESSION; INTEGRASES; MALE; MICE; MICE, TRANSGENIC; NEOPLASM INVASIVENESS; PROSTATE; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROSTATIC NEOPLASMS; PTEN PHOSPHOHYDROLASE; RECEPTORS, ANDROGEN;

MUS;

EID: 84872192006     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0053476     Document Type: Article

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