Amentoflavone induces cell-cycle arrest and apoptosis in MCF-7 human breast cancer cells via mitochondria-dependent pathway

In Vivo

Volumn 26, Issue 6, 2012, Pages 963-970

  Pei, Jen Sheng ^a   Liu, Chia Chi ^b,f   Hsu, Yuan Nian ^a   Lin, Li Ling ^b   Wang, Shou Cheng ^b,e   Chung, Jing Gung ^b,c   Bau, Da Tian ^b,c,d   Lin, Song Shei ^b  

^a TAOYUAN GENERAL HOSPITAL   (Taiwan)

^b CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e TAICHUNG ARMED FORCES GENERAL HOSPITAL   (Taiwan)

^f TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Amentoflavone; Apoptosis; Breast cancer; Cell cycle arrest; MCF 7 cancer cells; Mitochondria

Indexed keywords

AMENTOFLAVONE; CALCIUM; CASPASE 3; CYTOCHROME C; PROTEIN BCL 2; PROTEIN BID; PROTEIN P53; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CALCIUM CELL LEVEL; CELL CYCLE ARREST; CELL DEATH; CELL STRAIN MCF 7; CELL VIABILITY; CHROMATIN CONDENSATION; CONTROLLED STUDY; DNA DAMAGE; DNA FRAGMENTATION; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; UPREGULATION;

EID: 84872186005     PISSN: 0258851X     EISSN: 17917549     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Bray F, Ren JS, Masuyer E and Ferlay J: Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer doi: 10.1002/ijc.27711, 2012.
2. Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127: 2893-2917, 2010.
3. Ross JA and Kasum CM: Dietary flavonoids: Bioavailability, metabolic effects, and safety. Annu Rev Nutr 22: 19-34, 2002.
4. Beecher GR: Overview of dietary flavonoids: Nomenclature, occurrence and intake. J Nutr 133: 3248S-3254S, 2003.
5. Dajas F, Rivera-Megret F, Blasina F, Arredondo F, Abin-Carriquiry JA, Costa G, Echeverry C, Lafon L, Heizen H, Ferreira M and Morquio A: Neuroprotection by flavonoids. Braz J Med Biol Res 36: 1613-1620, 2003.
6. Mandel S, Weinreb O, Amit T and Youdim MB: Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (-)-epigallocatechin-3- gallate: implications for neurodegenerative diseases. J Neurochem 88: 1555-1569, 2004.
7. Simonyi A, Wang Q, Miller RL, Yusof M, Shelat PB, Sun AY and Sun GY: Polyphenols in cerebral ischemia: Novel targets for neuroprotection. Mol Neurobiol 31: 135-147, 2005.
8. Zhao B: Natural antioxidants for neurodegenerative diseases. Mol Neurobiol 31: 283-293, 2005.
9. Mora A, Paya M, Rios JL and Alcaraz MJ: Structure-activity relationships of polymethoxyflavones and other flavonoids as inhibitors of non-enzymic lipid peroxidation. Biochem Pharmacol 40: 793-797, 1990.
10. Kang DG, Yin MH, Oh H, Lee DH and Lee HS: Vasorelaxation by amentoflavone isolated from Selaginella tamariscina. Planta Med 70: 718-722, 2004.
11. Lin YM, Anderson H, Flavin MT, Pai YH, Mata-Greenwood E, Pengsuparp T, Pezzuto JM, Schinazi RF, Hughes SH and Chen FC: In vitro anti-HIV activity of biflavonoids isolated from Rhussuccedanea and Garcinia multiflora. J Nat Prod 60: 884-888, 1997.
12. Guruvayoorappan C and Kuttan G: Inhibition of tumor-specific angiogenesis by amentoflavone. Biochemistry (Mosc) 73: 209-218, 2008.
13. Ying TH, Yang SF, Tsai SJ, Hsieh SC, Huang YC, Bau DT and Hsieh YH: Fisetin induces apoptosis in human cervical cancer HeLa cells through ERK1/2-mediated activation of caspase-8-/caspase-3-dependent pathway. Arch Toxicol 86: 263-273, 2012.
14. 1 phase arrest via inhibition of cyclin E and provokes apoptosis through endoplasmic reticulum stress and mitochondrion-dependent pathways in human leukemia HL-60 cells. Anticancer Res 32:1671-1679, 2012.
15. 2/ M phase arrest via p53 expression and induces apoptosis through caspase- and mitochondria-dependent signaling pathways in human prostate cancer DU-145 cells. Anticancer Res 31: 1691-1702, 2011.
16. Ho YT, Lu CC, Yang JS, Chiang JH, Li TC, Ip SW, Hsia TC, Liao CL, Lin JG, Wood WG and Chung JG: Berberine induced apoptosis via promoting the expression of caspase-8, -9 and -3, apoptosis-inducing factor and endonuclease G in SCC-4 human tongue squamous carcinoma cancer cells. Anticancer Res 29:4063-4070, 2009.
17. Chang YH, Yang JS, Kuo SC and Chung JG: Induction of mitotic arrest and apoptosis by a novel synthetic quinolone analogue, CWC-8, via intrinsic and extrinsic apoptotic pathways in human osteogenic sarcoma U-2 OS cells. Anticancer Res 29:3139-3148, 2009.
18. Wu PP, Kuo SC, Huang WW, Yang JS, Lai KC, Chen HJ, Lin KL, Chiu YJ, Huang LJ and Chung JG: (-)-Epigallocatechin gallate induced apoptosis in human adrenal cancer NCI-H295 cells through caspase-dependent and caspase-independent pathway. Anticancer Res 29: 1435-1442, 2009.
19. 2+ on rhein-induced apoptosis in A-549 human lung cancer cells. Anticancer Res 29:309-318, 2009.
20. Wang TS, Hsu TY, Chung CH, Wang AS, Bau DT and Jan KY: Arsenite induces oxidative DNA adducts and DNA-protein cross-links in mammalian cells. Free Radic Biol Med 31: 321-330, 2001.
21. Bau DT, Gurr JR and Jan KY: Nitric oxide is involved in arsenite inhibition of pyrimidine dimer excision. Carcinogenesis 22: 709-716, 2001.
22. Li J and Yuan J: Caspases in apoptosis and beyond. Oncogene 27: 6194-6206, 2008.
23. Stegh AH and Peter ME: Apoptosis and caspases. Cardiol Clin 19: 13-29, 2001.
24. Peled M, Shaish A, Greenberger S, Katav A, Hodish I, Ben-Shushan D, Barshack I, Mendel I, Frishman L, Tal R, Bangio L, Breitbart E and Harats D: Antiangiogenic systemic gene therapy combined with doxorubicin administration induced caspase 8 and 9-mediated apoptosis in endothelial cells and an antimetastasis effect. Cancer Gene Ther 15: 535-542, 2008.
25. Nagase M, Shiota T, Tsushima A, Murshedul Alam M, Fukuoka S, Yoshizawa T and Sakato N: Molecular mechanism of satratoxin-induced apoptosis in HL-60 cells: Activation of caspase-8 and caspase-9 is involved in activation of caspase-3. Immunol Lett 84: 23-27, 2002.
26. 2- induced apoptosis in HeLa cells. Cell Physiol Biochem 27: 539-546, 2011.
27. Lee JS, Sul JY, Park JB, Lee MS, Cha EY, Song IS, Kim JR and Chang ES: Fatty acid synthase inhibition by Amentoflavone suppresses HER2/neu (ERBB2) oncogene in SKBR3 human breast cancer cells. Phytother Res, 2012.
28. Lee S, Kim H, Kang JW, Kim JH, Lee DH, Kim MS, Yang Y, Woo ER, Kim YM, Hong J and Yoon DY: The biflavonoid amentoflavone induces apoptosis via suppressing E7 expression, cell cycle arrest at sub-G(1) phase, and mitochondria-emanated intrinsic pathways in human cervical cancer cells. J Med Food 14: 808-816, 2011.
29. Guruvayoorappan C and Kuttan G: Amentoflavone stimulates apoptosis in B16F-10 melanoma cells by regulating bcl-2, p53 as well as caspase-3 genes and regulates the nitric oxide as well as proinflammatory cytokine production in B16F-10 melanoma cells, tumor associated macrophages and peritoneal macrophages. J Exp Ther Oncol 7: 207-218, 2008.