Functional characterization of the chicken fatty acid elongases

Journal of Nutrition

Volumn 143, Issue 1, 2013, Pages 12-16

  Gregory, Melissa K ^a   Geier, Mark S ^b   Gibson, Robert A ^c   James, Michael J ^a  

^a ROYAL ADELAIDE HOSPITAL   (Australia)

^b SOUTH AUSTRALIAN RESEARCH AND DEVELOPMENT INSTITUTE   (Australia)

^c UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DOCOSAHEXAENOIC ACID; ELOVE5 PROTEIN; ELOVL2 PROTEIN; ENZYME; ICOSAPENTAENOIC ACID; POLYUNSATURATED FATTY ACID; UNCLASSIFIED DRUG;

ARTICLE; ENERGY; ENZYME ACTIVITY; ENZYME ANALYSIS; LIVER; MALE; NONHUMAN; PROTEIN EXPRESSION; SEQUENCE ANALYSIS;

ACETYLTRANSFERASES; ALPHA-LINOLENIC ACID; ANIMALS; ANIMALS, INBRED STRAINS; AVIAN PROTEINS; CHICKENS; DIETARY FATS, UNSATURATED; FATTY ACIDS, MONOUNSATURATED; FATTY ACIDS, OMEGA-3; GENE EXPRESSION REGULATION, ENZYMOLOGIC; ISOENZYMES; LIVER; MALE; OSMOLAR CONCENTRATION; PHOSPHOLIPIDS; RANDOM ALLOCATION; RECOMBINANT PROTEINS; RNA, MESSENGER; SOUTH AUSTRALIA; SUBSTRATE SPECIFICITY;

ANIMALIA; GALLUS GALLUS; RATTUS;

EID: 84872183544     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.112.170290     Document Type: Article

References (25)

1. Huang YS, Smith RS, Redden PR, Cantrill RC, Horrobin DF. Modification of liver fatty acid metabolism in mice by n-3 and n-6 delta 6- desaturase substrates and products. Biochim Biophys Acta. 1991;1082: 319-27.
2. James MJ, Ursin VM, Cleland LG. Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids. Am J Clin Nutr. 2003;77:1140-5.
3. Yamazaki K, Fujikawa M, Hamazaki T, Yano S, Shono T. Comparison of the conversion rates of alpha-linolenic acid (18:3(n - 3)) and stearidonic acid (18:4(n - 3)) to longer polyunsaturated fatty acids in rats. Biochim Biophys Acta. 1992;1123:18-26.
4. Inagaki K, Aki T, Fukuda Y, Kawamoto S, Shigeta S, Ono K, Suzuki O. Identification and expression of a rat fatty acid elongase involved in the biosynthesis of C18 fatty acids. Biosci Biotechnol Biochem. 2002;66: 613-21.
5. Leonard AE, Bobik EG, Dorado J, Kroeger PE, Chuang LT, Thurmond JM, Parker-Barnes JM, Das T, Huang YS, Mukerji P. Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids. Biochem J. 2000;350:765-70.
6. Gregory MK, Gibson RA, Cook-Johnson RJ, Cleland LG, James MJ. Elongase reactions as control points in long-chain polyunsaturated fatty acid synthesis. PLoS ONE. 2011;6:e29662.
7. Leonard AE, Kelder B, Bobik EG, Chuang LT, Lewis CJ, Kopchick JJ, Mukerji P, Huang YS. Identification and expression of mammalian long-chain PUFA elongation enzymes. Lipids. 2002;37:733-40.
8. Betti M, Perez TI, Zuidhof MJ, Renema RA. Omega-3-enriched broiler meat: 3. Fatty acid distribution between triacylglycerol and phospholipid classes. Poult Sci. 2009;88:1740-54.
9. Kartikasari LR, Hughes RJ, Geier MS, Makrides M, Gibson RA. Dietary alpha-linolenic acid enhances omega-3 long chain polyunsaturated fatty acids levels in chicken tissues. Prostaglandins Leukot Essent Fatty Acids. 2012;87:103-9.
10. López-Ferrer S, Baucells MD, Barroeta AC, Galobart J, Grashorn MA. n-3 enrichment of chicken meat. 2. Use of precursors of longchain polyunsaturated fatty acids: linseed oil. Poult Sci. 2001;80: 753-61.
11. Zelenka J, Schneiderova D, Mrkvicova E, Dolezal P. The effect of dietary linseed oils with different fatty acid pattern on the content of fatty acids in chicken meat. Vet Med. 2008;53:77-85.
12. Fébel H, Mezes M, Palfy T, Herman A, Gundel J, Lugasi A, Balogh K, Kocsis I, Blazovics A. Effect of dietary fatty acid pattern on growth, body fat composition and antioxidant parameters in broilers. J Anim Physiol Anim Nutr (Berl). 2008;92:369-76.
13. Gibbs RA, Rymer C, Givens DI. Postgraduate symposium: long-chain n-3 PUFA: intakes in the UK and the potential of a chicken meat prototype to increase them. Proc Nutr Soc. 2010;69:144-55.
14. Gregory MK, See VH, Gibson RA, Schuller KA. Cloning and functional characterisation of a fatty acyl elongase from southern bluefin tuna (Thunnus maccoyii). Comp Biochem Physiol B Biochem Mol Biol. 2010;155:178-85.
15. Ajuyah AO, Hardin RT, Sim JS. Effect of dietary full-fat flax seed with and without antioxidant on the fatty acid composition of major lipid classes of chicken meats. Poult Sci. 1993;72:125-36.
16. Fraeye I, Bruneel C, Lemahieu C, Buyse J, Muylaert K, Foubert I. Dietary enrichment of eggs with omega-3 fatty acids: a review. Food Res Int. 2012;48:961-9.
17. Tu WC, Cook-Johnson RJ, James MJ, Muhlhausler BS, Gibson RA. Omega-3 long chain fatty acid synthesis is regulated more by substrate levels than gene expression. Prostaglandins Leukot Essent Fatty Acids. 2010;83:61-8.
18. Agaba M, Tocher DR, Dickson CA, Dick JR, Teale AJ. Zebrafish cDNA encoding multifunctional fatty acid elongase involved in production of eicosapentaenoic (20:5n-3) and docosahexaenoic (22:6n-3) acids. Mar Biotechnol (NY). 2004;6:251-61.
19. Agaba MK, Tocher DR, Zheng X, Dickson CA, Dick JR, Teale AJ. Cloning and functional characterisation of polyunsaturated fatty acid elongases of marine and freshwater teleost fish. Comp Biochem Physiol B Biochem Mol Biol. 2005;142:342-52.
20. Hastings N, Agaba MK, Tocher DR, Zheng X, Dickson CA, Dick JR, Teale AJ. Molecular cloning and functional characterization of fatty acyl desaturase and elongase cDNAs involved in the production of eicosapentaenoic and docosahexaenoic acids from alpha-linolenic acid in Atlantic salmon (Salmo salar). Mar Biotechnol (NY). 2004;6:463-74.
21. Meyer A, Kirsch H, Domergue F, Abbadi A, Sperling P, Bauer J, Cirpus P, Zank TK, Moreau H, Zahringer U, et al. Novel fatty acid elongases and their use for the reconstitution of docosahexaenoic acid biosynthesis. J Lipid Res. 2004;45:1899-909.
22. Zheng X, Ding Z, Xu Y, Monroig O, Morais S, Tocher DR. Physiological roles of fatty acyl desaturases and elongases in marine fish: characterisation of cDNAs of fatty acyl δ6 desaturase and elovl5 elongase of cobia (Rachycentron canadum). Aquaculture. 2009;290: 122-31.
23. Morais S, Mourente G, Ortega A, Tocher JA, Tocher DR. Expression of fatty acyl desaturase and elongase genes, and evolution of DHA:EPA ratio during development of unfed larvae of Atlantic bluefin tuna (Thunnus thynnus L.). Aquaculture. 2011;313:129-39.
24. Morais S, Monroig O, Zheng X, Leaver MJ, Tocher DR. Highly unsaturated fatty acid synthesis in Atlantic salmon: characterization of ELOVL5- and ELOVL2-like elongases. Mar Biotechnol (NY). 2009; 11:627-39.
25. Whelan J. Dietary stearidonic acid is a long chain (n-3) polyunsaturated fatty acid with potential health benefits. J Nutr. 2009;139:5-10.