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Volumn 45, Issue 10, 2004, Pages 1899-1909

Novel fatty acid elongases and their use for the reconstitution of docosahexaenoic acid biosynthesis

Author keywords

Ciona intestinalis; Oncarhynchus mykiss; Ostreococcus tauri; Polyunsaturated fatty acids; Thalassiosira pseudonana; Xenopus laevis

Indexed keywords

DOCOSAHEXAENOIC ACID; ENZYME; FATTY ACID; FATTY ACID ELONGASE; ICOSAPENTAENOIC ACID; UNCLASSIFIED DRUG; ACYLTRANSFERASE; FATTY ACID ELONGASES; UNSATURATED FATTY ACID;

EID: 10044269845     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1194/jlr.M400181-JLR200     Document Type: Article
Times cited : (168)

References (33)
  • 1
    • 0346095554 scopus 로고    scopus 로고
    • Is docosahexaenoic acid (DHA) essential? Lessons from DHA status regulation, our ancient diet, epidemiology and randomized controlled trials
    • Muskiet, F. A., M. R. Fokkema, A. Schaafsma, E. R. Boersma, and M. A. Crawford. 2004. Is docosahexaenoic acid (DHA) essential? Lessons from DHA status regulation, our ancient diet, epidemiology and randomized controlled trials. J. Nutr. 134: 183-186.
    • (2004) J. Nutr. , vol.134 , pp. 183-186
    • Muskiet, F.A.1    Fokkema, M.R.2    Schaafsma, A.3    Boersma, E.R.4    Crawford, M.A.5
  • 2
    • 0035529578 scopus 로고    scopus 로고
    • Transgenic oilseeds as sustainable source of nutritionally relevant C20 and C22 polyunsaturated fatty acids?
    • Abbadi, A., F. Domergue, A. Meyer, K. Riedel, P. Sperling, T. K. Zank, and E. Heinz. 2001. Transgenic oilseeds as sustainable source of nutritionally relevant C20 and C22 polyunsaturated fatty acids? Eur. J. Lipid Sci. Technol. 103: 106-113.
    • (2001) Eur. J. Lipid Sci. Technol. , vol.103 , pp. 106-113
    • Abbadi, A.1    Domergue, F.2    Meyer, A.3    Riedel, K.4    Sperling, P.5    Zank, T.K.6    Heinz, E.7
  • 3
    • 0034686664 scopus 로고    scopus 로고
    • Metabolism of highly unsaturated n-3 and n-6 fatty acids
    • Sprecher, H. 2000. Metabolism of highly unsaturated n-3 and n-6 fatty acids. Biochim. Biophys. Acta. 1486: 219-231.
    • (2000) Biochim. Biophys. Acta , vol.1486 , pp. 219-231
    • Sprecher, H.1
  • 5
    • 0035976311 scopus 로고    scopus 로고
    • Activity of human Δ5 and Δ6 desaturases on multiple n-3 and n-6 polyunsaturated fatty acids
    • de Antueno, R. J., L. C. Knickle, H. Smith, M. L. Elliot, S. J. Allen, S. Nwaka, and M. D. Winther. 2001. Activity of human Δ5 and Δ6 desaturases on multiple n-3 and n-6 polyunsaturated fatty acids. FEBS Lett. 509: 77-80.
    • (2001) FEBS Lett. , vol.509 , pp. 77-80
    • Antueno, R.J.1    Knickle, L.C.2    Smith, H.3    Elliot, M.L.4    Allen, S.J.5    Nwaka, S.6    Winther, M.D.7
  • 6
    • 0037092587 scopus 로고    scopus 로고
    • The same rat Δ6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis
    • D'Andrea, S., H. Guillou, S. Jan, D. Catheline, J-N. Thibault, M. Bouriel, V. Rioux, and P. Legrand. 2002. The same rat Δ6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis. Biochem. J. 364: 49-55.
    • (2002) Biochem. J. , vol.364 , pp. 49-55
    • D'Andrea, S.1    Guillou, H.2    Jan, S.3    Catheline, D.4    Thibault, J.-N.5    Bouriel, M.6    Rioux, V.7    Legrand, P.8
  • 7
    • 0030971170 scopus 로고    scopus 로고
    • Biosynthesis of docosahexaenoic acid in trout hepatocytes proceeds via 24-carbon intermediates
    • Buzzi, M., R. J. Henderson, and J. R. Sargent. 1997. Biosynthesis of docosahexaenoic acid in trout hepatocytes proceeds via 24-carbon intermediates. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 116: 263-267.
    • (1997) Comp. Biochem. Physiol. B Biochem. Mol. Biol. , vol.116 , pp. 263-267
    • Buzzi, M.1    Henderson, R.J.2    Sargent, J.R.3
  • 8
    • 0037116606 scopus 로고    scopus 로고
    • 9 polyunsaturated fatty acid-specific elongating activity from the docosahexaenoic acid (DHA)-producing microalga, Isochrysis galbana
    • 9 polyunsaturated fatty acid-specific elongating activity from the docosahexaenoic acid (DHA)-producing microalga, Isochrysis galbana. FEBS Lett. 510: 159-165.
    • (2002) FEBS Lett. , vol.510 , pp. 159-165
    • Qi, B.1    Beaudoin, F.2    Fraser, T.3    Stobart, A.K.4    Napier, J.A.5    Lazarus, C.M.6
  • 9
    • 0041315728 scopus 로고    scopus 로고
    • Acyl carriers used as substrates by the desaturases and elongases involved in very long-chain polyunsaturated fatty acids biosynthesis reconstituted in yeast
    • Domergue, F., A. Abbadi, C. Ott, T. K. Zank, U. Zähringer, and E. Heinz. 2003. Acyl carriers used as substrates by the desaturases and elongases involved in very long-chain polyunsaturated fatty acids biosynthesis reconstituted in yeast. J. Biol. Chem. 278: 35115-35126.
    • (2003) J. Biol. Chem. , vol.278 , pp. 35115-35126
    • Domergue, F.1    Abbadi, A.2    Ott, C.3    Zank, T.K.4    Zähringer, U.5    Heinz, E.6
  • 10
    • 0035943661 scopus 로고    scopus 로고
    • Identification of a Δ4 fatty acid desaturase from Thraustochytrium sp. involved in the biosynthesis of docosahexanoic acid by heterologous expression in Saccharomyces cerevisiae and Brassica juncea
    • Qiu, X., H. Hong, and S. L. Mackenzie. 2001. Identification of a Δ4 fatty acid desaturase from Thraustochytrium sp. involved in the biosynthesis of docosahexanoic acid by heterologous expression in Saccharomyces cerevisiae and Brassica juncea. J. Biol. Chem. 276: 31561-31566.
    • (2001) J. Biol. Chem. , vol.276 , pp. 31561-31566
    • Qiu, X.1    Hong, H.2    Mackenzie, S.L.3
  • 11
    • 0042026506 scopus 로고    scopus 로고
    • Biosynthesis of docosahexaenoic acid in Euglena gracilis: Biochemical and molecular evidence for the involvement of a Δ4-fatty acyl group desaturase
    • Meyer, A., P. Cirpus, C. Ott, R. Schlecker, U. Zähringer, and E. Heinz. 2003. Biosynthesis of docosahexaenoic acid in Euglena gracilis: biochemical and molecular evidence for the involvement of a Δ4-fatty acyl group desaturase. Biochemistry. 42: 9779-9788.
    • (2003) Biochemistry , vol.42 , pp. 9779-9788
    • Meyer, A.1    Cirpus, P.2    Ott, C.3    Schlecker, R.4    Zähringer, U.5    Heinz, E.6
  • 12
    • 0142231412 scopus 로고    scopus 로고
    • Identification of a very long chain polyunsaturated fatty acid Δ4-desaturase from the microalga Pavlova lutheri
    • Tonon, T., D. Harvey, T. R. Larson, and I. A. Graham. 2003. Identification of a very long chain polyunsaturated fatty acid Δ4-desaturase from the microalga Pavlova lutheri. FEBS Lett. 553: 440-444.
    • (2003) FEBS Lett. , vol.553 , pp. 440-444
    • Tonon, T.1    Harvey, D.2    Larson, T.R.3    Graham, I.A.4
  • 13
    • 0036678764 scopus 로고    scopus 로고
    • Cloning and functional characterisation of an enzyme involved in the elongation of Δ6-polyunsaturated fatty acids from the moss Physcomitrella patens
    • Zank, T. K., U. Zähringer, C. Beckmann, G. Pohnert, W. Boland, H. Holtorf, R. Reski, J. Lerchl, and E. Heinz. 2002. Cloning and functional characterisation of an enzyme involved in the elongation of Δ6- polyunsaturated fatty acids from the moss Physcomitrella patens. Plant J. 31: 255-268.
    • (2002) Plant J. , vol.31 , pp. 255-268
    • Zank, T.K.1    Zähringer, U.2    Beckmann, C.3    Pohnert, G.4    Boland, W.5    Holtorf, H.6    Reski, R.7    Lerchl, J.8    Heinz, E.9
  • 17
    • 0029774363 scopus 로고    scopus 로고
    • Isolation and characterization of a gene affecting fatty acid elongation in Saccharomyces cerevisiae
    • Toke, D. A., and C. E. Martin. 1996. Isolation and characterization of a gene affecting fatty acid elongation in Saccharomyces cerevisiae. J. Biol. Chem. 271: 18413-18422.
    • (1996) J. Biol. Chem. , vol.271 , pp. 18413-18422
    • Toke, A.D.1    Martin, C.E.2
  • 18
    • 0030878240 scopus 로고    scopus 로고
    • ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation
    • Oh, C-S., D. A. Toke, S. Mandala, and C. E. Martin. 1997. ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation. J. Biol. Chem. 272: 17376-17384.
    • (1997) J. Biol. Chem. , vol.272 , pp. 17376-17384
    • Oh, C.-S.1    Toke, D.A.2    Mandala, S.3    Martin, C.E.4
  • 19
    • 0031809489 scopus 로고    scopus 로고
    • Can adults adequately convert α-linolenic acid (18:3n-3) to eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3)?
    • Gerster, H. 1998. Can adults adequately convert α-linolenic acid (18:3n-3) to eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3)? Int. J. Vit. Nutr. Res. 68: 159-173.
    • (1998) Int. J. Vit. Nutr. Res. , vol.68 , pp. 159-173
    • Gerster, H.1
  • 24
    • 0024440559 scopus 로고
    • Galactose as a gratuitous inducer of GAL gene expression in yeasts growing on glucose
    • Hovland, P., J. Flick, M. Johnston, and R. A. Sclafani. 1989. Galactose as a gratuitous inducer of GAL gene expression in yeasts growing on glucose. Gene. 83: 57-64.
    • (1989) Gene , vol.83 , pp. 57-64
    • Hovland, P.1    Flick, J.2    Johnston, M.3    Sclafani, R.A.4
  • 26
    • 0036040288 scopus 로고    scopus 로고
    • Cloning and functional characterization of Phaeodactylum tricornutum front-end desaturases involved in eicosapentaenoic acid biosynthesis
    • Domergue, F., J. Lerchl, U. Zähringer, and E. Heinz. 2002. Cloning and functional characterization of Phaeodactylum tricornutum front-end desaturases involved in eicosapentaenoic acid biosynthesis. Eur. J. Biochem. 269: 4105-4113.
    • (2002) Eur. J. Biochem. , vol.269 , pp. 4105-4113
    • Domergue, F.1    Lerchl, J.2    Zähringer, U.3    Heinz, E.4
  • 30
    • 0037274642 scopus 로고    scopus 로고
    • Suppression of the ELO-2 FA elongation activity results in alterations of the fatty acid composition and multiple physiological defects, including abnormal ultradian rhythms, in Caenorhabditis elegans
    • Kniazeva, M., M. Sieber, S. McCauley, K. Zhang, J. L. Watts, and M. Han. 2003. Suppression of the ELO-2 FA elongation activity results in alterations of the fatty acid composition and multiple physiological defects, including abnormal ultradian rhythms, in Caenorhabditis elegans. Genetics. 163: 159-169.
    • (2003) Genetics , vol.163 , pp. 159-169
    • Kniazeva, M.1    Sieber, M.2    McCauley, S.3    Zhang, K.4    Watts, J.L.5    Han, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.