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Volumn 96, Issue 5, 2012, Pages 552-561

Diffuse large B cell lymphoma: Molecular targeted therapy

Author keywords

BCR signaling; Diffuse large B cell lymphoma; DLBCL; NF jB; STAT3

Indexed keywords

[4 [4 [(2,3 DIHYDRO 1H INDEN 1 YL)AMINO] 7H PYRROLO[2,3 D]PYRIMIDIN 7 YL] 2 HYDROXYCYCLOPENTYLMETHYL] SULFAMATE; ALISERTIB; B LYMPHOCYTE RECEPTOR; BETA INTERFERON; BORTEZOMIB; CYCLOPHOSPHAMIDE; DOXORUBICIN; ENZASTAURIN; FOSTAMATINIB; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; I KAPPA B KINASE GAMMA; IBRUTINIB; IDELALISIB; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 4; LENALIDOMIDE; MAMMALIAN TARGET OF RAPAMYCIN; MYELOID DIFFERENTIATION FACTOR 88; PANOBINOSTAT; PREDNISONE; PROTEIN BCL 2; RITUXIMAB; RUXOLITINIB; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR REL; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR RELB; UNINDEXED DRUG; VINCRISTINE;

EID: 84872178600     PISSN: 09255710     EISSN: 18653774     Source Type: Journal    
DOI: 10.1007/s12185-012-1198-3     Document Type: Article
Times cited : (20)

References (96)
  • 3
    • 0027394689 scopus 로고
    • Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma
    • Fisher RI, Gaynor ER, Dahlberg S, Oken MM, Grogan TM, Mize EM, et al. Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma. N Engl J Med. 1993;328(14):1002-6.
    • (1993) N Engl J Med , vol.328 , Issue.14 , pp. 1002-1006
    • Fisher, R.I.1    Gaynor, E.R.2    Dahlberg, S.3    Oken, M.M.4    Grogan, T.M.5    Mize, E.M.6
  • 4
    • 3042813710 scopus 로고    scopus 로고
    • Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of young patients with good-prognosis (normal LDH) aggressive lymphomas: Results of the NHL-B1 trial of the DSHNHL
    • Pfreundschuh M, Trumper L, Kloess M, Schmits R, Feller AC, Rudolph C, et al. Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of young patients with good-prognosis (normal LDH) aggressive lymphomas: results of the NHL-B1 trial of the DSHNHL. Blood. 2004;104(3):626-33.
    • (2004) Blood , vol.104 , Issue.3 , pp. 626-633
    • Pfreundschuh, M.1    Trumper, L.2    Kloess, M.3    Schmits, R.4    Feller, A.C.5    Rudolph, C.6
  • 5
    • 0037089314 scopus 로고    scopus 로고
    • Dose-adjusted EPOCH chemotherapy for untreated large B cell lymphomas: A pharmacodynamic approach with high efficacy
    • Wilson WH, Grossbard ML, Pittaluga S, Cole D, Pearson D, Drbohlav N, et al. Dose-adjusted EPOCH chemotherapy for untreated large B cell lymphomas: a pharmacodynamic approach with high efficacy. Blood. 2002;99(8):2685-93.
    • (2002) Blood , vol.99 , Issue.8 , pp. 2685-2693
    • Wilson, W.H.1    Grossbard, M.L.2    Pittaluga, S.3    Cole, D.4    Pearson, D.5    Drbohlav, N.6
  • 6
    • 0037165261 scopus 로고    scopus 로고
    • CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B cell lymphoma
    • Coiffier B, Lepage E, Briere J, Herbrecht R, Tilly H, Bouabdallah R, et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B cell lymphoma. N Engl J Med. 2002;346(4):235-42.
    • (2002) N Engl J Med , vol.346 , Issue.4 , pp. 235-242
    • Coiffier, B.1    Lepage, E.2    Briere, J.3    Herbrecht, R.4    Tilly, H.5    Bouabdallah, R.6
  • 7
    • 77957200763 scopus 로고    scopus 로고
    • Long-term outcome of patients in the LNH- 98.5 trial the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: A study
    • Groupe d'Etudes des Lymphomes de l'Adulte
    • Coiffier B, Thieblemont C, Van Den Neste E, Lepeu G, Plantier I, Castaigne S, et al. Long-term outcome of patients in the LNH- 98.5 trial, the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: a study by the Groupe d'Etudes des Lymphomes de l'Adulte. Blood. 2010; 116(12):2040-5.
    • (2010) Blood , vol.116 , Issue.12 , pp. 2040-2045
    • Coiffier, B.1    Thieblemont, C.2    Van Den Neste, E.3    Lepeu, G.4    Plantier, I.5    Castaigne, S.6
  • 8
    • 33646004738 scopus 로고    scopus 로고
    • CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large-B cell lymphoma: A randomised controlled trial
    • MabThera International Trial (MInT) Group
    • Pfreundschuh M, Trumper L, Osterborg A, Pettengell R, Trneny M, Imrie K, et al. CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large-B cell lymphoma: a randomised controlled trial by the MabThera International Trial (MInT) Group. Lancet Oncol. 2006;7(5):379-91.
    • (2006) Lancet Oncol , vol.7 , Issue.5 , pp. 379-391
    • Pfreundschuh, M.1    Trumper, L.2    Osterborg, A.3    Pettengell, R.4    Trneny, M.5    Imrie, K.6
  • 9
    • 80053384016 scopus 로고    scopus 로고
    • CHOP-like chemotherapy with or without rituximab in young patients with good-prognosis diffuse large-B cell lymphoma: 6-year results of an open-label randomised study
    • MabThera International Trial (MInT) Group
    • Pfreundschuh M, Kuhnt E, Trumper L, Osterborg A, Trneny M, Shepherd L, et al. CHOP-like chemotherapy with or without rituximab in young patients with good-prognosis diffuse large-B cell lymphoma: 6-year results of an open-label randomised study of the MabThera International Trial (MInT) Group. Lancet Oncol. 2011;12(11):1013-22.
    • (2011) Lancet Oncol , vol.12 , Issue.11 , pp. 1013-1022
    • Pfreundschuh, M.1    Kuhnt, E.2    Trumper, L.3    Osterborg, A.4    Trneny, M.5    Shepherd, L.6
  • 10
    • 84864297051 scopus 로고    scopus 로고
    • Impact of rituximab on treatment outcomes of patients with diffuse large B cell lymphoma: A population-based analysis
    • Lee L, Crump M, Khor S, Hoch JS, Luo J, Bremner K, et al. Impact of rituximab on treatment outcomes of patients with diffuse large B cell lymphoma: a population-based analysis. Br J Haematol. 2012;158(4):481-8.
    • (2012) Br J Haematol , vol.158 , Issue.4 , pp. 481-488
    • Lee, L.1    Crump, M.2    Khor, S.3    Hoch, J.S.4    Luo, J.5    Bremner, K.6
  • 11
    • 45749152667 scopus 로고    scopus 로고
    • Phase II study of dose-adjusted EPOCH and rituximab in untreated diffuse large B cell lymphoma with analysis of germinal center and post-germinal center biomarkers
    • Wilson WH, Dunleavy K, Pittaluga S, Hegde U, Grant N, Steinberg SM, et al. Phase II study of dose-adjusted EPOCH and rituximab in untreated diffuse large B cell lymphoma with analysis of germinal center and post-germinal center biomarkers. J Clin Oncol. 2008;26(16):2717-24.
    • (2008) J Clin Oncol , vol.26 , Issue.16 , pp. 2717-2724
    • Wilson, W.H.1    Dunleavy, K.2    Pittaluga, S.3    Hegde, U.4    Grant, N.5    Steinberg, S.M.6
  • 12
    • 84860573088 scopus 로고    scopus 로고
    • A Cancer and Leukemia Group B multi-center study of DA-EPOCH-rituximab in untreated diffuse large B cell lymphoma with analysis of outcome by molecular subtype
    • Wilson WH, Jung SH, Porcu P, Hurd D, Johnson J, Martin SE, et al. A Cancer and Leukemia Group B multi-center study of DA-EPOCH-rituximab in untreated diffuse large B cell lymphoma with analysis of outcome by molecular subtype. Haematologica. 2011;97(5):758-65.
    • (2011) Haematologica , vol.97 , Issue.5 , pp. 758-765
    • Wilson, W.H.1    Jung, S.H.2    Porcu, P.3    Hurd, D.4    Johnson, J.5    Martin, S.E.6
  • 13
    • 53749093794 scopus 로고    scopus 로고
    • Addition of rituximab to standard chemotherapy improves the survival of both the germinal center B cell-like and non-germinal center B cell-like subtypes of diffuse large B cell lymphoma
    • Fu K, Weisenburger DD, Choi WWL, Perry KD, Smith LM, Shi X, et al. Addition of rituximab to standard chemotherapy improves the survival of both the germinal center B cell-like and non-germinal center B cell-like subtypes of diffuse large B cell lymphoma. J Clin Oncol. 2008;26(28):4587-94.
    • (2008) J Clin Oncol , vol.26 , Issue.28 , pp. 4587-4594
    • Fu, K.1    Weisenburger, D.D.2    Choi, W.W.L.3    Perry, K.D.4    Smith, L.M.5    Shi, X.6
  • 14
    • 0027444652 scopus 로고
    • A predictive model for aggressive non-Hodgkin's lymphoma
    • The International Non-Hodgkin's Lymphoma Prognostic Factors project
    • A predictive model for aggressive non-Hodgkin's lymphoma. The International Non-Hodgkin's Lymphoma Prognostic Factors project. N Engl J Med. 1993;329(14):987-94.
    • (1993) N Engl J Med , vol.329 , Issue.14 , pp. 987-994
  • 15
    • 0034598746 scopus 로고    scopus 로고
    • Distinct types of diffuse large B cell lymphoma identified by gene expression profiling
    • Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, Rosenwald A, et al. Distinct types of diffuse large B cell lymphoma identified by gene expression profiling. Nature. 2000; 403(6769):503-11.
    • (2000) Nature , vol.403 , Issue.6769 , pp. 503-511
    • Alizadeh, A.A.1    Eisen, M.B.2    Davis, R.E.3    Ma, C.4    Lossos, I.S.5    Rosenwald, A.6
  • 16
    • 0037142053 scopus 로고    scopus 로고
    • The use of molecular profiling to predict survival after chemotherapy for diffuse large-B cell lymphoma
    • Rosenwald A, Wright G, Chan WC, Connors JM, Campo E, Fisher RI, et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B cell lymphoma. N Engl J Med. 2002;346(25):1937-47.
    • (2002) N Engl J Med , vol.346 , Issue.25 , pp. 1937-1947
    • Rosenwald, A.1    Wright, G.2    Chan, W.C.3    Connors, J.M.4    Campo, E.5    Fisher, R.I.6
  • 17
    • 0141672946 scopus 로고    scopus 로고
    • Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma
    • Rosenwald A, Wright G, Leroy K, Yu X, Gaulard P, Gascoyne RD, et al. Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma. J Exp Med. 2003;198(6):851-62.
    • (2003) J Exp Med , vol.198 , Issue.6 , pp. 851-862
    • Rosenwald, A.1    Wright, G.2    Leroy, K.3    Yu, X.4    Gaulard, P.5    Gascoyne, R.D.6
  • 18
    • 0043192901 scopus 로고    scopus 로고
    • A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma
    • Wright G, Tan B, Rosenwald A, Hurt EH, Wiestner A, Staudt LM. A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma. Proc Natl Acad Sci USA. 2003;100(17):9991-6.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.17 , pp. 9991-9996
    • Wright, G.1    Tan, B.2    Rosenwald, A.3    Hurt, E.H.4    Wiestner, A.5    Staudt, L.M.6
  • 19
    • 51649111684 scopus 로고    scopus 로고
    • Molecular subtypes of diffuse large B cell lymphoma arise by distinct genetic pathways
    • Lenz G, Wright GW, Emre NCT, Kohlhammer H, Dave SS, Davis RE, et al. Molecular subtypes of diffuse large B cell lymphoma arise by distinct genetic pathways. Proc Nat Acad Sci. 2008;105(36):13520-5.
    • (2008) Proc Nat Acad Sci , vol.105 , Issue.36 , pp. 13520-13525
    • Lenz, G.1    Wright, G.W.2    Nct, E.3    Kohlhammer, H.4    Dave, S.S.5    Davis, R.E.6
  • 20
    • 84856646807 scopus 로고    scopus 로고
    • Untreated primary mediastinal B cell (PMBL) and mediastinal grey zone (MGZL) lymphomas: Comparison of biological features and clinical outcome following DA-EPOCH-R without radiation
    • (Abstract 150)
    • Dunleavy K, Pittaluga S, Shovlin M, Grant N, Grant C, Chen C, et al. Untreated primary mediastinal B cell (PMBL) and mediastinal grey zone (MGZL) lymphomas: comparison of biological features and clinical outcome following DA-EPOCH-R without radiation. Annals Oncol. 2011;22 (supplement 4):(Abstract 150).
    • (2011) Annals Oncol , vol.22 , Issue.SUPPL. 4
    • Dunleavy, K.1    Pittaluga, S.2    Shovlin, M.3    Grant, N.4    Grant, C.5    Chen, C.6
  • 22
    • 0035905313 scopus 로고    scopus 로고
    • Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells
    • Davis RE, Brown KD, Siebenlist U, Staudt LM. Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells. J Exp Med. 2001;194(12):1861-74.
    • (2001) J Exp Med , vol.194 , Issue.12 , pp. 1861-1874
    • Davis, R.E.1    Brown, K.D.2    Siebenlist, U.3    Staudt, L.M.4
  • 23
    • 84863337695 scopus 로고    scopus 로고
    • Pathogenetic importance and therapeutic implications of NF-kappaB in lymphoid malignancies
    • Lim KH, Yang Y, Staudt LM. Pathogenetic importance and therapeutic implications of NF-kappaB in lymphoid malignancies. Immunol Rev. 2012;246(1):359-78.
    • (2012) Immunol Rev , vol.246 , Issue.1 , pp. 359-378
    • Lim, K.H.1    Yang, Y.2    Staudt, L.M.3
  • 24
    • 73849145729 scopus 로고    scopus 로고
    • Chronic active B cell-receptor signalling in diffuse large B cell lymphoma
    • Davis RE, Ngo VN, Lenz G, Tolar P, Young RM, Romesser PB, et al. Chronic active B cell-receptor signalling in diffuse large B cell lymphoma. Nature. 2010;463(7277):88-92.
    • (2010) Nature , vol.463 , Issue.7277 , pp. 88-92
    • Davis, R.E.1    Ngo, V.N.2    Lenz, G.3    Tolar, P.4    Young, R.M.5    Romesser, P.B.6
  • 25
    • 41149136296 scopus 로고    scopus 로고
    • Oncogenic CARD11 mutations in human diffuse large B cell lymphoma
    • Lenz G, Davis RE, Ngo VN, Lam L, George TC, Wright GW, et al. Oncogenic CARD11 mutations in human diffuse large B cell lymphoma. Science. 2008;319(5870):1676-9.
    • (2008) Science , vol.319 , Issue.5870 , pp. 1676-1679
    • Lenz, G.1    Davis, R.E.2    Ngo, V.N.3    Lam, L.4    George, T.C.5    Wright, G.W.6
  • 26
    • 79551686422 scopus 로고    scopus 로고
    • Oncogenically active MYD88 mutations in human lymphoma
    • Ngo VN, Young RM, Schmitz R, Jhavar S, Xiao W, Lim KH, et al. Oncogenically active MYD88 mutations in human lymphoma. Nature. 2011;470(7332):115-9.
    • (2011) Nature , vol.470 , Issue.7332 , pp. 115-119
    • Ngo, V.N.1    Young, R.M.2    Schmitz, R.3    Jhavar, S.4    Xiao, W.5    Lim, K.H.6
  • 27
    • 38949165127 scopus 로고    scopus 로고
    • Constitutively activated STAT3 promotes cell proliferation and survival in the activated B cell subtype of diffuse large B cell lymphomas
    • Ding BB, Yu JJ, Yu RY, Mendez LM, Shaknovich R, Zhang Y, et al. Constitutively activated STAT3 promotes cell proliferation and survival in the activated B cell subtype of diffuse large B cell lymphomas. Blood. 2008;111(3):1515-23.
    • (2008) Blood , vol.111 , Issue.3 , pp. 1515-1523
    • Ding, B.B.1    Yu, J.J.2    Yu, R.Y.3    Mendez, L.M.4    Shaknovich, R.5    Zhang, Y.6
  • 28
    • 43549097394 scopus 로고    scopus 로고
    • Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-{kappa}B pathways in subtypes of diffuse large B cell lymphoma
    • Lam LT, Wright G, Davis RE, Lenz G, Farinha P, Dang L, et al. Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-{kappa}B pathways in subtypes of diffuse large B cell lymphoma. Blood. 2008;111(7): 3701-13.
    • (2008) Blood , vol.111 , Issue.7 , pp. 3701-3713
    • Lam, L.T.1    Wright, G.2    Davis, R.E.3    Lenz, G.4    Farinha, P.5    Dang, L.6
  • 29
    • 79955485953 scopus 로고    scopus 로고
    • STAT3 inhibition is a therapeutic strategy for ABClike diffuse large B cell lymphoma
    • Scuto A, Kujawski M, Kowolik C, Krymskaya L, Wang L, Weiss LM, et al. STAT3 inhibition is a therapeutic strategy for ABClike diffuse large B cell lymphoma. Cancer Res. 2011;71(9): 3182-8.
    • (2011) Cancer Res , vol.71 , Issue.9 , pp. 3182-3188
    • Scuto, A.1    Kujawski, M.2    Kowolik, C.3    Krymskaya, L.4    Wang, L.5    Weiss, L.M.6
  • 30
    • 66649112854 scopus 로고    scopus 로고
    • Frequent inactivation of A20 in B cell lymphomas
    • Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi K, et al. Frequent inactivation of A20 in B cell lymphomas. Nature. 2009;459(7247):712-6.
    • (2009) Nature , vol.459 , Issue.7247 , pp. 712-716
    • Kato, M.1    Sanada, M.2    Kato, I.3    Sato, Y.4    Takita, J.5    Takeuchi, K.6
  • 31
    • 84859200452 scopus 로고    scopus 로고
    • Aggressive B cell lymphomas: A review of new and old entities in the WHO classification
    • Jaffe ES, Pittaluga S. Aggressive B cell lymphomas: a review of new and old entities in the WHO classification. Hematol Am Soc Hematol Educ Program. 2011;2011:506-14.
    • (2011) Hematol Am Soc Hematol Educ Program , vol.2011 , pp. 506-514
    • Jaffe, E.S.1    Pittaluga, S.2
  • 32
    • 84867051939 scopus 로고    scopus 로고
    • Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics
    • Schmitz R, Young RM, Ceribelli M, Jhavar S, Xiao W, Zhang M, et al. Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. Nature. 2012.
    • (2012) Nature
    • Schmitz, R.1    Young, R.M.2    Ceribelli, M.3    Jhavar, S.4    Xiao, W.5    Zhang, M.6
  • 33
    • 77649230092 scopus 로고    scopus 로고
    • B cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B cell lymphoma
    • Snuderl M, Kolman OK, Chen YB, Hsu JJ, Ackerman AM, Dal Cin P, et al. B cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B cell lymphoma. Am J Surg Pathol. 2010;34(3):327-40.
    • (2010) Am J Surg Pathol , vol.34 , Issue.3 , pp. 327-340
    • Snuderl, M.1    Kolman, O.K.2    Chen, Y.B.3    Hsu, J.J.4    Ackerman, A.M.5    Dal Cin, P.6
  • 35
    • 70349575802 scopus 로고    scopus 로고
    • Lymphomas with concurrent BCL2 and MYC translocations: The critical factors associated with survival
    • Johnson NA, Savage KJ, Ludkovski O, Ben-Neriah S, Woods R, Steidl C, et al. Lymphomas with concurrent BCL2 and MYC translocations: the critical factors associated with survival. Blood. 2009;114(11):2273-9.
    • (2009) Blood , vol.114 , Issue.11 , pp. 2273-2279
    • Johnson, N.A.1    Savage, K.J.2    Ludkovski, O.3    Ben-Neriah, S.4    Woods, R.5    Steidl, C.6
  • 36
    • 80054045437 scopus 로고    scopus 로고
    • BCL2 and MYC dual-hit lymphoma/leukemia
    • Tomita N. BCL2 and MYC dual-hit lymphoma/leukemia. J Clin Exp Hematop. 2011;51(1):7-12.
    • (2011) J Clin Exp Hematop , vol.51 , Issue.1 , pp. 7-12
    • Tomita, N.1
  • 37
    • 77953030981 scopus 로고    scopus 로고
    • Altered subcellular localization of c-Myc protein identifies aggressive B cell lymphomas harboring a c-MYC translocation
    • Ruzinova MB, Caron T, Rodig SJ. Altered subcellular localization of c-Myc protein identifies aggressive B cell lymphomas harboring a c-MYC translocation. Am J Surg Pathol. 2010;34(6): 882-91.
    • (2010) Am J Surg Pathol , vol.34 , Issue.6 , pp. 882-891
    • Ruzinova, M.B.1    Caron, T.2    Rodig, S.J.3
  • 38
    • 84867060272 scopus 로고    scopus 로고
    • Immunohistochemical double-hit score is a strong predictor of outcome in patients with diffuse large B cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone
    • Green TM, Young KH, Visco C, Xu-Monette ZY, Orazi A, Go RS, et al. Immunohistochemical double-hit score is a strong predictor of outcome in patients with diffuse large B cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone. J Clin Oncol. 2012;30(28): 3460-7.
    • (2012) J Clin Oncol , vol.30 , Issue.28 , pp. 3460-3467
    • Green, T.M.1    Young, K.H.2    Visco, C.3    Xu-Monette, Z.Y.4    Orazi, A.5    Go, R.S.6
  • 39
    • 84867088456 scopus 로고    scopus 로고
    • Concurrent expression of MYC and BCL2 in diffuse large b cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone
    • Johnson NA, Slack GW, Savage KJ, Connors JM, Ben-Neriah S, Rogic S, et al. Concurrent Expression of MYC and BCL2 in Diffuse Large B Cell Lymphoma Treated With Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone. J Clin Oncol. 2012;30(28):3452-9.
    • (2012) J Clin Oncol , vol.30 , Issue.28 , pp. 3452-3459
    • Johnson, N.A.1    Slack, G.W.2    Savage, K.J.3    Connors, J.M.4    Ben-Neriah, S.5    Rogic, S.6
  • 40
    • 84861211721 scopus 로고    scopus 로고
    • MYC? diffuse large B-cell lymphoma is not salvaged by classical R-ICE or R-DHAP followed by BEAM plus autologous stem cell transplantation
    • Cuccuini W, Briere J, Mounier N, Voelker HU, Rosenwald A, Sundstrom C, et al. MYC? diffuse large B-cell lymphoma is not salvaged by classical R-ICE or R-DHAP followed by BEAM plus autologous stem cell transplantation. Blood. 2012;119(20): 4619-24.
    • (2012) Blood , vol.119 , Issue.20 , pp. 4619-4624
    • Cuccuini, W.1    Briere, J.2    Mounier, N.3    Voelker, H.U.4    Rosenwald, A.5    Sundstrom, C.6
  • 41
    • 19944428834 scopus 로고    scopus 로고
    • Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B cell lymphoma defined by gene expression profiling
    • Lam LT, Davis RE, Pierce J, Hepperle M, Xu Y, Hottelet M, et al. Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B cell lymphoma defined by gene expression profiling. Clin Cancer Res. 2005;11(1):28-40.
    • (2005) Clin Cancer Res , vol.11 , Issue.1 , pp. 28-40
    • Lam, L.T.1    Davis, R.E.2    Pierce, J.3    Hepperle, M.4    Xu, Y.5    Hottelet, M.6
  • 42
    • 20044396543 scopus 로고    scopus 로고
    • Study of proteasome inhibitor bortezomib in relapsed or refractory B cell non-Hodgkin's lymphoma
    • Goy A, Phase II. Study of proteasome inhibitor bortezomib in relapsed or refractory B cell non-Hodgkin's lymphoma. J Clin Oncol. 2005;23(4):667-75.
    • (2005) J Clin Oncol , vol.23 , Issue.4 , pp. 667-675
    • Goy, A.1    Phase, I.I.2
  • 43
    • 33750625445 scopus 로고    scopus 로고
    • Multicenter phase II study of bortezomib in patients with relapsed or refractory mantle cell lymphoma
    • Fisher RI, Bernstein SH, Kahl BS, Djulbegovic B, Robertson MJ, de Vos S, et al. Multicenter phase II study of bortezomib in patients with relapsed or refractory mantle cell lymphoma. J Clin Oncol. 2006;24(30):4867-74.
    • (2006) J Clin Oncol , vol.24 , Issue.30 , pp. 4867-4874
    • Fisher, R.I.1    Bernstein, S.H.2    Kahl, B.S.3    Djulbegovic, B.4    Robertson, M.J.5    De Vos, S.6
  • 44
    • 34047257880 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib acts independently of p53 and induces cell death via apoptosis and mitotic catastrophe in B cell lymphoma cell lines
    • Strauss SJ, Higginbottom K, Juliger S, Maharaj L, Allen P, Schenkein D, et al. The proteasome inhibitor bortezomib acts independently of p53 and induces cell death via apoptosis and mitotic catastrophe in B cell lymphoma cell lines. Cancer Res. 2007;67(6):2783-90.
    • (2007) Cancer Res , vol.67 , Issue.6 , pp. 2783-2790
    • Strauss, S.J.1    Higginbottom, K.2    Juliger, S.3    Maharaj, L.4    Allen, P.5    Schenkein, D.6
  • 45
    • 79955802506 scopus 로고    scopus 로고
    • Novel therapeutics for aggressive non- Hodgkin's lymphoma
    • Mahadevan D, Fisher RI. Novel therapeutics for aggressive non- Hodgkin's lymphoma. J Clin Oncol. 2011;29(14):1876-84.
    • (2011) J Clin Oncol , vol.29 , Issue.14 , pp. 1876-1884
    • Mahadevan, D.1    Fisher, R.I.2
  • 46
    • 67650398258 scopus 로고    scopus 로고
    • Differential efficacy of bortezomib plus chemotherapy within molecular subtypes of diffuse large B cell lymphoma
    • Dunleavy K, Pittaluga S, Czuczman MS, Dave SS, Wright G, Grant N, et al. Differential efficacy of bortezomib plus chemotherapy within molecular subtypes of diffuse large B cell lymphoma. Blood. 2009;113(24):6069-76.
    • (2009) Blood , vol.113 , Issue.24 , pp. 6069-6076
    • Dunleavy, K.1    Pittaluga, S.2    Czuczman, M.S.3    Dave, S.S.4    Wright, G.5    Grant, N.6
  • 47
    • 79952154013 scopus 로고    scopus 로고
    • Bortezomib plus CHOP-rituximab for previously untreated diffuse large B cell lymphoma and mantle cell lymphoma
    • Ruan J, Martin P, Furman RR, Lee SM, Cheung K, Vose JM, et al. Bortezomib plus CHOP-rituximab for previously untreated diffuse large B cell lymphoma and mantle cell lymphoma. J Clin Oncol. 2011;29(6):690-7.
    • (2011) J Clin Oncol , vol.29 , Issue.6 , pp. 690-697
    • Ruan, J.1    Martin, P.2    Furman, R.R.3    Lee, S.M.4    Cheung, K.5    Vose, J.M.6
  • 48
    • 41149168649 scopus 로고    scopus 로고
    • Lenalidomide for the treatment of B cell malignancies
    • Chanan-Khan AA, Cheson BD. Lenalidomide for the treatment of B cell malignancies. J Clin Oncol. 2008;26(9):1544-52.
    • (2008) J Clin Oncol , vol.26 , Issue.9 , pp. 1544-1552
    • Chanan-Khan, A.A.1    Cheson, B.D.2
  • 49
    • 80053502780 scopus 로고    scopus 로고
    • Higher response to lenalidomide in relapsed/ refractory diffuse large B cell lymphoma in nongerminal center B cell-like than in germinal center B cell-like phenotype
    • Hernandez-Ilizaliturri FJ, Deeb G, Zinzani PL, Pileri SA, Malik F, Macon WR, et al. Higher response to lenalidomide in relapsed/ refractory diffuse large B cell lymphoma in nongerminal center B cell-like than in germinal center B cell-like phenotype. Cancer. 2011;117(22):5058-66.
    • (2011) Cancer , vol.117 , Issue.22 , pp. 5058-5066
    • Hernandez-Ilizaliturri, F.J.1    Deeb, G.2    Zinzani, P.L.3    Pileri, S.A.4    Malik, F.5    MacOn, W.R.6
  • 50
    • 84862152044 scopus 로고    scopus 로고
    • Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma
    • Yang Y, Shaffer AL 3rd, Emre NC, Ceribelli M, Zhang M, Wright G, et al. Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma. Cancer Cell. 2012;21(6): 723-37.
    • (2012) Cancer Cell , vol.21 , Issue.6 , pp. 723-737
    • Yang, Y.1    Shaffer Iii, A.L.2    Emre, N.C.3    Ceribelli, M.4    Zhang, M.5    Wright, G.6
  • 51
    • 80855156719 scopus 로고    scopus 로고
    • Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide
    • Zhu YX, Braggio E, Shi CX, Bruins LA, Schmidt JE, Van Wier S, et al. Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide. Blood. 2011;118(18):4771-9.
    • (2011) Blood , vol.118 , Issue.18 , pp. 4771-4779
    • Zhu, Y.X.1    Braggio, E.2    Shi, C.X.3    Bruins, L.A.4    Schmidt, J.E.5    Van Wier, S.6
  • 52
    • 64749098830 scopus 로고    scopus 로고
    • An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
    • Soucy TA, Smith PG, Milhollen MA, Berger AJ, Gavin JM, Adhikari S, et al. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature. 2009;458(7239):732-6.
    • (2009) Nature , vol.458 , Issue.7239 , pp. 732-736
    • Soucy, T.A.1    Smith, P.G.2    Milhollen, M.A.3    Berger, A.J.4    Gavin, J.M.5    Adhikari, S.6
  • 53
    • 77956578834 scopus 로고    scopus 로고
    • MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B cell lymphoma models: Rationale for treatment of NF-{kappa}B-dependent lymphoma
    • Milhollen MA, Traore T, Adams-Duffy J, Thomas MP, Berger AJ, Dang L, et al. MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma. Blood. 2010;116(9):1515-23.
    • (2010) Blood , vol.116 , Issue.9 , pp. 1515-1523
    • Milhollen, M.A.1    Traore, T.2    Adams-Duffy, J.3    Thomas, M.P.4    Berger, A.J.5    Dang, L.6
  • 54
    • 0037204949 scopus 로고    scopus 로고
    • B cell antigen receptor signaling: Roles in cell development and disease
    • Gauld SB. Dal Porto JM, Cambier JC. B cell antigen receptor signaling: roles in cell development and disease. Science. 2002;296(5573):1641-2.
    • (2002) Science , vol.296 , Issue.5573 , pp. 1641-1642
    • Gauld, S.B.1    Dal Porto, J.M.2    Cambier, J.C.3
  • 55
    • 41349110211 scopus 로고    scopus 로고
    • SYK-dependent tonic B cell receptor signaling is a rational treatment target in diffuse large B cell lymphoma
    • Chen L, Monti S, Juszczynski P, Daley J, Chen W, Witzig TE, et al. SYK-dependent tonic B cell receptor signaling is a rational treatment target in diffuse large B cell lymphoma. Blood. 2008;111(4):2230-7.
    • (2008) Blood , vol.111 , Issue.4 , pp. 2230-2237
    • Chen, L.1    Monti, S.2    Juszczynski, P.3    Daley, J.4    Chen, W.5    Witzig, T.E.6
  • 56
    • 77951002653 scopus 로고    scopus 로고
    • Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia
    • Friedberg JW, Sharman J, Sweetenham J, Johnston PB, Vose JM, Lacasce A, et al. Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. Blood. 2010;115(13):2578-85.
    • (2010) Blood , vol.115 , Issue.13 , pp. 2578-2585
    • Friedberg, J.W.1    Sharman, J.2    Sweetenham, J.3    Johnston, P.B.4    Vose, J.M.5    Lacasce, A.6
  • 57
    • 84856877017 scopus 로고    scopus 로고
    • PCI-32765: A novel Bruton's tyrosine kinase inhibitor for the treatment of lymphoid malignancies
    • Winer ES, Ingham RR, Castillo JJ. PCI-32765: a novel Bruton's tyrosine kinase inhibitor for the treatment of lymphoid malignancies. Expert Opin Investig Drugs. 2012;21(3):355-61.
    • (2012) Expert Opin Investig Drugs , vol.21 , Issue.3 , pp. 355-361
    • Winer, E.S.1    Ingham, R.R.2    Castillo, J.J.3
  • 58
    • 77955625479 scopus 로고    scopus 로고
    • The Bruton tyrosine kinase inhibitor PCI-32765 blocks B cell activation and is efficacious in models of autoimmune disease and B cell malignancy
    • Honigberg LA, Smith AM, Sirisawad M, Verner E, Loury D, Chang B, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B cell activation and is efficacious in models of autoimmune disease and B cell malignancy. Proc Natl Acad Sci USA. 2010;107(29):13075-80.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.29 , pp. 13075-13080
    • Honigberg, L.A.1    Smith, A.M.2    Sirisawad, M.3    Verner, E.4    Loury, D.5    Chang, B.6
  • 59
    • 84865973672 scopus 로고    scopus 로고
    • The future of B cell lymphoma therapy: The B cell receptor and its downstream pathways
    • Kenkre VP, Kahl BS. The future of B cell lymphoma therapy: the B cell receptor and its downstream pathways. Curr Hematol Malig Rep. 2012;7(3):216-20.
    • (2012) Curr Hematol Malig Rep , vol.7 , Issue.3 , pp. 216-220
    • Kenkre, V.P.1    Kahl, B.S.2
  • 60
    • 84860478464 scopus 로고    scopus 로고
    • The Bruton's Tyrosine Kinase (Btk) Inhibitor PCI-32765 modulates chronic active bcr signaling and induces tumor regression in relapsed/refractory ABC DLBCL
    • Staudt LM, Dunleavy K, Buggy JJ, Hedrick E, Lucas N, Pittaluga S, et al. The Bruton's Tyrosine Kinase (Btk) Inhibitor PCI-32765 Modulates Chronic Active BCR Signaling and Induces Tumor Regression in Relapsed/Refractory ABC DLBCL. ASH Annual Meeting Abstracts. 2011;118(21):2716.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 2716
    • Staudt, L.M.1    Dunleavy, K.2    Buggy, J.J.3    Hedrick, E.4    Lucas, N.5    Pittaluga, S.6
  • 61
    • 18244409933 scopus 로고    scopus 로고
    • Diffuse large B cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning
    • Shipp MA, Ross KN, Tamayo P, Weng AP, Kutok JL, Aguiar RC, et al. Diffuse large B cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning. Nat Med. 2002;8(1):68-74.
    • (2002) Nat Med , vol.8 , Issue.1 , pp. 68-74
    • Shipp, M.A.1    Ross, K.N.2    Tamayo, P.3    Weng, A.P.4    Kutok, J.L.5    Aguiar, R.C.6
  • 63
    • 34249075706 scopus 로고    scopus 로고
    • Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B cell lymphoma
    • Robertson MJ, Kahl BS, Vose JM, de Vos S, Laughlin M, Flynn PJ, et al. Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B cell lymphoma. J Clin Oncol. 2007;25(13):1741-6.
    • (2007) J Clin Oncol , vol.25 , Issue.13 , pp. 1741-1746
    • Robertson, M.J.1    Kahl, B.S.2    Vose, J.M.3    De Vos, S.4    Laughlin, M.5    Flynn, P.J.6
  • 64
    • 84857640749 scopus 로고    scopus 로고
    • Randomized phase II study of R-CHOP plus enzastaurin versus R-CHOP in the first line treatment of patients with intermediate and high-risk diffuse large B cell lymphoma (DLBCL)-preliminary analysis
    • (Abstract 074)
    • Hainsworth JD, Arrowsmith ER, Mccleod M, Fayad LE, Hamid O, Davis L, et al. Randomized phase II study of R-CHOP plus enzastaurin versus R-CHOP in the first line treatment of patients with intermediate and high-risk diffuse large B cell lymphoma (DLBCL)-preliminary analysis. Annals Oncol. 2011;22(suppl 4):(Abstract 074).
    • (2011) Annals Oncol , vol.22 , Issue.SUPPL. 4
    • Hainsworth, J.D.1    Arrowsmith, E.R.2    McCleod, M.3    Fayad, L.E.4    Hamid, O.5    Davis, L.6
  • 65
    • 78751553221 scopus 로고    scopus 로고
    • CAL-101, a p110 selective phosphatidylinositol- 3-kinase inhibitor for the treatment of B cell malignancies, inhibits PI3K signaling and cellular viability
    • Lannutti BJ, Meadows SA, Herman SEM, Kashishian A, Steiner B, Johnson AJ, et al. CAL-101, a p110 selective phosphatidylinositol- 3-kinase inhibitor for the treatment of B cell malignancies, inhibits PI3K signaling and cellular viability. Blood. 2010;117(2):591-4.
    • (2010) Blood , vol.117 , Issue.2 , pp. 591-594
    • Lannutti, B.J.1    Meadows, S.A.2    Sem, H.3    Kashishian, A.4    Steiner, B.5    Johnson, A.J.6
  • 66
    • 79953655788 scopus 로고    scopus 로고
    • CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase P110D, demonstrates clinical activity and pharmacodynamic effects in patients with relapsed or refractory chronic lymphocytic leukemia
    • Furman RR, Byrd JC, Brown JR, Coutre SE, Benson DM, Jr., Wagner-Johnston ND, et al. CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase P110D, demonstrates clinical activity and pharmacodynamic effects in patients with relapsed or refractory chronic lymphocytic leukemia. ASH Annual Meeting Abstracts. 2010;116(21):55.
    • (2010) ASH Annual Meeting Abstracts , vol.116 , Issue.21 , pp. 55
    • Furman, R.R.1    Byrd, J.C.2    Brown, J.R.3    Coutre, S.E.4    Benson Jr., D.M.5    Wagner-Johnston, N.D.6
  • 68
    • 33847351136 scopus 로고    scopus 로고
    • The JAK-STAT signaling pathway: Input and output integration
    • Murray PJ. The JAK-STAT signaling pathway: input and output integration. J Immunol. 2007;178(5):2623-9.
    • (2007) J Immunol , vol.178 , Issue.5 , pp. 2623-2629
    • Murray, P.J.1
  • 69
    • 0034657336 scopus 로고    scopus 로고
    • The role of STATs in transcriptional control and their impact on cellular function
    • Bromberg J, Darnell JE Jr. The role of STATs in transcriptional control and their impact on cellular function. Oncogene. 2000;19(21):2468-73.
    • (2000) Oncogene , vol.19 , Issue.21 , pp. 2468-2473
    • Bromberg, J.1    Darnell Jr., J.E.2
  • 70
    • 28644445445 scopus 로고    scopus 로고
    • Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
    • Kortylewski M, Kujawski M, Wang T, Wei S, Zhang S, Pilon-Thomas S, et al. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med. 2005;11(12):1314-21.
    • (2005) Nat Med , vol.11 , Issue.12 , pp. 1314-1321
    • Kortylewski, M.1    Kujawski, M.2    Wang, T.3    Wei, S.4    Zhang, S.5    Pilon-Thomas, S.6
  • 71
    • 80755140046 scopus 로고    scopus 로고
    • SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies
    • Hart S, Goh KC, Novotny-Diermayr V, Hu CY, Hentze H, Tan YC, et al. SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies. Leukemia. 2011;25(11):1751-9.
    • (2011) Leukemia , vol.25 , Issue.11 , pp. 1751-1759
    • Hart, S.1    Goh, K.C.2    Novotny-Diermayr, V.3    Hu, C.Y.4    Hentze, H.5    Tan, Y.C.6
  • 72
    • 84861780038 scopus 로고    scopus 로고
    • Ruxolitinib: The first FDA approved therapy for the treatment of myelofibrosis
    • Mascarenhas J, Hoffman R. Ruxolitinib: the first FDA approved therapy for the treatment of myelofibrosis. Clin Cancer Res. 2012;18(11):3008-14.
    • (2012) Clin Cancer Res , vol.18 , Issue.11 , pp. 3008-3014
    • Mascarenhas, J.1    Hoffman, R.2
  • 73
  • 75
    • 78649982367 scopus 로고    scopus 로고
    • STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors
    • Lee H, Deng J, Kujawski M, Yang C, Liu Y, Herrmann A, et al. STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors. Nat Med. 2010;16(12):1421-8.
    • (2010) Nat Med , vol.16 , Issue.12 , pp. 1421-1428
    • Lee, H.1    Deng, J.2    Kujawski, M.3    Yang, C.4    Liu, Y.5    Herrmann, A.6
  • 76
    • 84865159639 scopus 로고    scopus 로고
    • S1PR1 is an effective target to block STAT3 signaling in activated B cell like diffuse large B cell lymphoma
    • Liu Y, Deng J, Wang L, Lee H, Armstrong B, Scuto A, et al. S1PR1 is an effective target to block STAT3 signaling in activated B cell like diffuse large B cell lymphoma. Blood. 2012;120(7):1458-65.
    • (2012) Blood , vol.120 , Issue.7 , pp. 1458-1465
    • Liu, Y.1    Deng, J.2    Wang, L.3    Lee, H.4    Armstrong, B.5    Scuto, A.6
  • 77
    • 3142721913 scopus 로고    scopus 로고
    • Requirement of histone deacetylase activity for signaling by STAT1
    • Klampfer L, Huang J, Swaby LA, Augenlicht L. Requirement of histone deacetylase activity for signaling by STAT1. J Biol Chem. 2004;279(29):30358-68.
    • (2004) J Biol Chem , vol.279 , Issue.29 , pp. 30358-30368
    • Klampfer, L.1    Huang, J.2    Swaby, L.A.3    Augenlicht, L.4
  • 78
    • 84862019471 scopus 로고    scopus 로고
    • Regulation of STAT3 by histone deacetylase-3 in diffuse large B cell lymphoma: Implications for therapy
    • Gupta M, Han JJ, Stenson M, Wellik L, Witzig TE. Regulation of STAT3 by histone deacetylase-3 in diffuse large B cell lymphoma: implications for therapy. Leukemia. 2011;26(6):1356-64.
    • (2011) Leukemia , vol.26 , Issue.6 , pp. 1356-1364
    • Gupta, M.1    Han, J.J.2    Stenson, M.3    Wellik, L.4    Witzig, T.E.5
  • 79
    • 0030901289 scopus 로고    scopus 로고
    • Control of inflammation, cytokine expression, and germinal center formation by BCL-6
    • Dent AL, Shaffer AL, Yu X, Allman D, Staudt LM. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science. 1997;276(5312):589-92.
    • (1997) Science , vol.276 , Issue.5312 , pp. 589-592
    • Dent, A.L.1    Shaffer, A.L.2    Yu, X.3    Allman, D.4    Staudt, L.M.5
  • 80
    • 11144277489 scopus 로고    scopus 로고
    • Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B cell lymphoma cells
    • Polo JM, Dell'Oso T, Ranuncolo SM, Cerchietti L, Beck D, Da Silva GF, et al. Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B cell lymphoma cells. Nat Med. 2004;10(12):1329-35.
    • (2004) Nat Med , vol.10 , Issue.12 , pp. 1329-1335
    • Polo, J.M.1    Dell'Oso, T.2    Ranuncolo, S.M.3    Cerchietti, L.4    Beck, D.5    Da Silva, G.F.6
  • 81
    • 10344247666 scopus 로고    scopus 로고
    • The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells
    • Phan RT, Dalla-Favera R. The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells. Nature. 2004; 432(7017):635-9.
    • (2004) Nature , vol.432 , Issue.7017 , pp. 635-639
    • Phan, R.T.1    Dalla-Favera, R.2
  • 82
    • 13144259651 scopus 로고    scopus 로고
    • BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci
    • Pasqualucci L, Migliazza A, Fracchiolla N, William C, Neri A, Baldini L, et al. BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. Proc Natl Acad Sci USA. 1998;95(20):11816-21.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.20 , pp. 11816-11821
    • Pasqualucci, L.1    Migliazza, A.2    Fracchiolla, N.3    William, C.4    Neri, A.5    Baldini, L.6
  • 83
    • 0037217921 scopus 로고    scopus 로고
    • Clinical impact of the differentiation profile assessed by immunophenotyping in patients with diffuse large B cell lymphoma
    • Colomo L, Lopez-Guillermo A, Perales M, Rives S, Martinez A, Bosch F, et al. Clinical impact of the differentiation profile assessed by immunophenotyping in patients with diffuse large B cell lymphoma. Blood. 2003;101(1):78-84.
    • (2003) Blood , vol.101 , Issue.1 , pp. 78-84
    • Colomo, L.1    Lopez-Guillermo, A.2    Perales, M.3    Rives, S.4    Martinez, A.5    Bosch, F.6
  • 85
    • 77954752069 scopus 로고    scopus 로고
    • Rearrangement of MYC is associated with poor prognosis in patients with diffuse large B cell lymphoma treated in the era of rituximab
    • Barrans S, Crouch S, Smith A, Turner K, Owen R, Patmore R, et al. Rearrangement of MYC is associated with poor prognosis in patients with diffuse large B cell lymphoma treated in the era of rituximab. J Clin Oncol. 2010;28(20):3360-5.
    • (2010) J Clin Oncol , vol.28 , Issue.20 , pp. 3360-3365
    • Barrans, S.1    Crouch, S.2    Smith, A.3    Turner, K.4    Owen, R.5    Patmore, R.6
  • 86
    • 70449589073 scopus 로고    scopus 로고
    • MYC gene rearrangements are associated with a poor prognosis in diffuse large B cell lymphoma patients treated with R-CHOP chemotherapy
    • Savage KJ, Johnson NA, Ben-Neriah S, Connors JM, Sehn LH, Farinha P, et al. MYC gene rearrangements are associated with a poor prognosis in diffuse large B cell lymphoma patients treated with R-CHOP chemotherapy. Blood. 2009;114(17):3533-7.
    • (2009) Blood , vol.114 , Issue.17 , pp. 3533-3537
    • Savage, K.J.1    Johnson, N.A.2    Ben-Neriah, S.3    Connors, J.M.4    Sehn, L.H.5    Farinha, P.6
  • 87
    • 84855281681 scopus 로고    scopus 로고
    • MYC+ aggressive B cell lymphomas: Novel therapy of untreated Burkitt lymphoma (BL) and MYC+ diffuse large B cell lymphoma (DLBCL) with DA-EPOCH-R
    • (Abstract 071)
    • Dunleavy K, Pittaluga S, Wayne AS, Shovlin M, Johnson J, Little R, et al. MYC+ aggressive B cell lymphomas: novel therapy of untreated Burkitt lymphoma (BL) and MYC+ diffuse large B cell lymphoma (DLBCL) with DA-EPOCH-R. Annals Oncol 2011;22 (suppl 4):(Abstract 071).
    • (2011) Annals Oncol , vol.22 , Issue.SUPPL. 4
    • Dunleavy, K.1    Pittaluga, S.2    Wayne, A.S.3    Shovlin, M.4    Johnson, J.5    Little, R.6
  • 88
    • 80052955256 scopus 로고    scopus 로고
    • BET bromodomain inhibition as a therapeutic strategy to target c-Myc
    • Delmore JE, Issa GC, Lemieux ME, Rahl PB, Shi J, Jacobs HM, et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell. 2011;146(6):904-17.
    • (2011) Cell , vol.146 , Issue.6 , pp. 904-917
    • Delmore, J.E.1    Issa, G.C.2    Lemieux, M.E.3    Rahl, P.B.4    Shi, J.5    Jacobs, H.M.6
  • 89
    • 84864040412 scopus 로고    scopus 로고
    • Drug response in a genetically engineered mouse model of multiple myeloma is predictive of clinical efficacy
    • Chesi M, Matthews GM, Garbitt VM, Palmer SE, Shortt J, Lefebure M, et al. Drug response in a genetically engineered mouse model of multiple myeloma is predictive of clinical efficacy. Blood. 2012;120(2):376-85.
    • (2012) Blood , vol.120 , Issue.2 , pp. 376-385
    • Chesi, M.1    Matthews, G.M.2    Garbitt, V.M.3    Palmer, S.E.4    Shortt, J.5    Lefebure, M.6
  • 91
    • 0038015849 scopus 로고    scopus 로고
    • Aurora2/BTAK/STK15 is involved in cell cycle checkpoint and cell survival of aggressive non-Hodgkin's lymphoma
    • Hamada M, Yakushijin Y, Ohtsuka M, Kakimoto M, Yasukawa M, Fujita S. Aurora2/BTAK/STK15 is involved in cell cycle checkpoint and cell survival of aggressive non-Hodgkin's lymphoma. Br J Haematol. 2003;121(3):439-47.
    • (2003) Br J Haematol , vol.121 , Issue.3 , pp. 439-447
    • Hamada, M.1    Yakushijin, Y.2    Ohtsuka, M.3    Kakimoto, M.4    Yasukawa, M.5    Fujita, S.6
  • 92
    • 0037586498 scopus 로고    scopus 로고
    • AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol
    • Anand S, Penrhyn-Lowe S, Venkitaraman AR. AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. Cancer Cell. 2003;3(1):51-62.
    • (2003) Cancer Cell , vol.3 , Issue.1 , pp. 51-62
    • Anand, S.1    Penrhyn-Lowe, S.2    Venkitaraman, A.R.3
  • 93
    • 81155151133 scopus 로고    scopus 로고
    • Phase i study of an investigational Aurora A kinase inhibitor MLN8237 in patients with advanced hematologic malignancies
    • Padmanabhan S, Shea TC, Vose JM, Reeder CB, Berdeja JG, McDonagh KT, et al. Phase I study of an investigational Aurora A kinase inhibitor MLN8237 in patients with advanced hematologic malignancies. ASH Annual Meeting Abstracts. 2010; 116(21):2799.
    • (2010) ASH Annual Meeting Abstracts , vol.116 , Issue.21 , pp. 2799
    • Padmanabhan, S.1    Shea, T.C.2    Vose, J.M.3    Reeder, C.B.4    Berdeja, J.G.5    McDonagh, K.T.6
  • 94
    • 84859816148 scopus 로고    scopus 로고
    • Aurora A inhibitor (MLN8237) plus vincristine plus rituximab is synthetic lethal and a potential curative therapy in aggressive B cell non-Hodgkin lymphoma
    • Mahadevan D, Stejskal A, Cooke LS, Manziello A, Morales C, Persky DO, et al. Aurora A inhibitor (MLN8237) plus vincristine plus rituximab is synthetic lethal and a potential curative therapy in aggressive B cell non-Hodgkin lymphoma. Clin Cancer Res. 2012;18(8):2210-9.
    • (2012) Clin Cancer Res , vol.18 , Issue.8 , pp. 2210-2219
    • Mahadevan, D.1    Stejskal, A.2    Cooke, L.S.3    Manziello, A.4    Morales, C.5    Persky, D.O.6
  • 95
    • 77951010885 scopus 로고    scopus 로고
    • Aggressive lymphomas
    • Lenz G, Staudt LM. Aggressive lymphomas. N Engl J Med. 2010;362(15):1417-29.
    • (2010) N Engl J Med , vol.362 , Issue.15 , pp. 1417-1429
    • Lenz, G.1    Staudt, L.M.2
  • 96
    • 79960506526 scopus 로고    scopus 로고
    • Molecular targeted approaches in mantle cell lymphoma
    • Weniger MA, Wiestner A. Molecular targeted approaches in mantle cell lymphoma. Semin Hematol. 2011;48(3):214-26.
    • (2011) Semin Hematol , vol.48 , Issue.3 , pp. 214-226
    • Weniger, M.A.1    Wiestner, A.2


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