메뉴 건너뛰기




Volumn 29, Issue 14, 2011, Pages 1876-1884

Novel therapeutics for aggressive non-Hodgkin's lymphoma

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 METHOXYETHOXY) 2 METHYL 3 (2 PYRAZINYLMETHYL)NAPHTHO[2,3 D]IMIDAZOLE 4,9 DIONE; 1 CYCLOPROPYL 3 [3 (5 MORPHOLINOMETHYL 1H BENZIMIDAZOL 2 YL) 1H PYRAZOL 4 YL]UREA; ANTINEOPLASTIC AGENT; AT 7519; AZACITIDINE; AZD 7762; BELINOSTAT; BORTEZOMIB; CARFILZOMIB; CD20 ANTIBODY; CEDIRANIB; DASATINIB; ENZASTAURIN; FOSTAMATINIB; IMATINIB; INIPARIB; LENALIDOMIDE; MOCETINOSTAT; NAVITOCLAX; OBATOCLAX; PANOBINOSTAT; PCI 32765; POMALINOMIDE; ROMIDEPSIN; SORAFENIB; SUNITINIB; TEMSIROLIMUS; UNCLASSIFIED DRUG; UNINDEXED DRUG; VORINOSTAT; XL 228;

EID: 79955802506     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2010.32.7171     Document Type: Review
Times cited : (38)

References (70)
  • 2
    • 52649177173 scopus 로고    scopus 로고
    • Phase II multicenter study of bendamustine plus rituximab in patients with relapsed indolent B-cell and mantle cell non-Hodgkin's lymphoma
    • Robinson KS, Williams ME, van der Jagt RH, et al: Phase II multicenter study of bendamustine plus rituximab in patients with relapsed indolent B-cell and mantle cell non-Hodgkin's lymphoma. J Clin Oncol 26:4473-4479, 2008
    • (2008) J Clin Oncol , vol.26 , pp. 4473-4479
    • Robinson, K.S.1    Williams, M.E.2    Van Der Jagt, R.H.3
  • 4
    • 59249103604 scopus 로고    scopus 로고
    • Novel therapies in peripheral T-cell lymphomas
    • O'Leary HM, Savage KJ: Novel therapies in peripheral T-cell lymphomas. Curr Hematol Malig Rep 3:213-220, 2008
    • (2008) Curr Hematol Malig Rep , vol.3 , pp. 213-220
    • O'Leary, H.M.1    Savage, K.J.2
  • 6
    • 0037142053 scopus 로고    scopus 로고
    • The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma
    • Rosenwald A, Wright G, Chan WC, et al: The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med 346:1937-1947, 2002
    • (2002) N Engl J Med , vol.346 , pp. 1937-1947
    • Rosenwald, A.1    Wright, G.2    Chan, W.C.3
  • 7
    • 57149089307 scopus 로고    scopus 로고
    • Stromal gene signatures in large-B-cell lymphomas
    • Lenz G, Wright G, Dave SS, et al: Stromal gene signatures in large-B-cell lymphomas. N Engl J Med 359:2313-2323, 2008
    • (2008) N Engl J Med , vol.359 , pp. 2313-2323
    • Lenz, G.1    Wright, G.2    Dave, S.S.3
  • 8
    • 0036392058 scopus 로고    scopus 로고
    • Role of genetic and epigenetic changes in Burkitt lymphoma
    • Lindström MS, Wiman KG: Role of genetic and epigenetic changes in Burkitt lymphoma. Semin Cancer Biol 12:381-387, 2002
    • (2002) Semin Cancer Biol , vol.12 , pp. 381-387
    • Lindström, M.S.1    Wiman, K.G.2
  • 10
    • 27244434794 scopus 로고    scopus 로고
    • Pathogenesis of mantle-cell lymphoma: All oncogenic roads lead to dysregulation of cell cycle and DNA damage response pathways
    • DOI 10.1200/JCO.2005.05.019
    • Fernàndez V, Hartmann E, Ott G, et al: Pathogenesis of mantle-cell lymphoma: All oncogenic roads lead to dysregulation of cell cycle and DNA damage response pathways. J Clin Oncol 23:6364-6369, 2005 (Pubitemid 46218848)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.26 , pp. 6364-6369
    • Fernandez, V.1    Hartmann, E.2    Ott, G.3    Campo, E.4    Rosenwald, A.5
  • 12
    • 30344470789 scopus 로고    scopus 로고
    • Transcript profiling in peripheral T-cell lymphoma, not otherwise specified, and diffuse large B-cell lymphoma identifies distinct tumor profile signatures
    • Mahadevan D, Spier C, Della Croce K, et al: Transcript profiling in peripheral T-cell lymphoma, not otherwise specified, and diffuse large B-cell lymphoma identifies distinct tumor profile signatures. Mol Cancer Ther 4:1867-1879, 2005
    • (2005) Mol Cancer Ther , vol.4 , pp. 1867-1879
    • Mahadevan, D.1    Spier, C.2    Della Croce, K.3
  • 14
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA: The hallmarks of cancer. Cell 100:57-70, 2000 (Pubitemid 30046295)
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 15
    • 44449147036 scopus 로고    scopus 로고
    • Tumor Cell Metabolism: Cancer's Achilles' Heel
    • DOI 10.1016/j.ccr.2008.05.005, PII S1535610808001608
    • Kroemer G, Pouyssegur J: Tumor cell metabolism: Cancer's Achilles' heel. Cancer Cell 13:472-482, 2008 (Pubitemid 351766797)
    • (2008) Cancer Cell , vol.13 , Issue.6 , pp. 472-482
    • Kroemer, G.1    Pouyssegur, J.2
  • 16
    • 61449182121 scopus 로고    scopus 로고
    • Principles of cancer therapy: Oncogene and non-oncogene addiction
    • Luo J, Solimini NL, Elledge SJ: Principles of cancer therapy: Oncogene and non-oncogene addiction. Cell 136:823-837, 2009
    • (2009) Cell , vol.136 , pp. 823-837
    • Luo, J.1    Solimini, N.L.2    Elledge, S.J.3
  • 17
    • 34248141223 scopus 로고    scopus 로고
    • Tumor-stroma interactions in pancreatic ductal adenocarcinoma
    • DOI 10.1158/1535-7163.MCT-06-0686
    • Mahadevan D, Von Hoff DD: Tumor-stroma interactions in pancreatic ductal adenocarcinoma. Mol Cancer Ther 6:1186-1197, 2007 (Pubitemid 46711982)
    • (2007) Molecular Cancer Therapeutics , vol.6 , Issue.4 , pp. 1186-1197
    • Mahadevan, D.1    Von Hoff, D.D.2
  • 19
    • 77951002653 scopus 로고    scopus 로고
    • Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia
    • Friedberg JW, Sharman J, Sweetenham J, et al: Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. Blood 115:2578-2585, 2010
    • (2010) Blood , vol.115 , pp. 2578-2585
    • Friedberg, J.W.1    Sharman, J.2    Sweetenham, J.3
  • 20
    • 78649797979 scopus 로고    scopus 로고
    • Effect of Btk inhibitor PCI-32765 monotherapy on responses in patients with relapsed aggressive NHL: Evidence of antitumor activity from a phase I study
    • suppl; abstr 8012
    • Advani R, Sharman JP, Smith SM, et al: Effect of Btk inhibitor PCI-32765 monotherapy on responses in patients with relapsed aggressive NHL: Evidence of antitumor activity from a phase I study. J Clin Oncol 28:15s, 2010 (suppl; abstr 8012)
    • (2010) J Clin Oncol , vol.28
    • Advani, R.1    Sharman, J.P.2    Smith, S.M.3
  • 23
    • 50049106221 scopus 로고    scopus 로고
    • Molecular inhibition of mTOR with temsirolimus (TORISEL, CCI-779) is a promising strategy in relapsed NHL: The University of Chicago phase II consortium
    • abstr 2483
    • Smith SM, Pro B, Smith S, et al: Molecular inhibition of mTOR with temsirolimus (TORISEL, CCI-779) is a promising strategy in relapsed NHL: The University of Chicago phase II consortium. Blood 108:703a, 2006 (abstr 2483)
    • (2006) Blood , vol.108
    • Smith, S.M.1    Pro, B.2    Smith, S.3
  • 25
    • 49049087320 scopus 로고    scopus 로고
    • Low-dose, single-agent temsirolimus for relapsed mantle cell lymphoma: A phase 2 trial in the North Central Cancer Treatment Group
    • Ansell SM, Inwards DJ, Rowland KM Jr, et al: Low-dose, single-agent temsirolimus for relapsed mantle cell lymphoma: A phase 2 trial in the North Central Cancer Treatment Group. Cancer 113:508-514, 2008
    • (2008) Cancer , vol.113 , pp. 508-514
    • Ansell, S.M.1    Inwards, D.J.2    Rowland Jr., K.M.3
  • 26
    • 68949102180 scopus 로고    scopus 로고
    • Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma
    • Hess G, Herbrecht R, Romaguera J, et al: Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma. J Clin Oncol 27:3822-3829, 2009
    • (2009) J Clin Oncol , vol.27 , pp. 3822-3829
    • Hess, G.1    Herbrecht, R.2    Romaguera, J.3
  • 27
    • 57449107677 scopus 로고    scopus 로고
    • A phase II trial of the oral mTOR inhibitor everolimus (RAD001) in relapsed aggressive non-Hodgkin lymphoma (NHL)
    • abstr 121
    • Reeder CB, Gornet MK, Habermann TM, et al: A phase II trial of the oral mTOR inhibitor everolimus (RAD001) in relapsed aggressive non-Hodgkin lymphoma (NHL). Blood 110, 2007 (abstr 121)
    • (2007) Blood , vol.110
    • Reeder, C.B.1    Gornet, M.K.2    Habermann, T.M.3
  • 28
    • 51449096670 scopus 로고    scopus 로고
    • A phase 2 clinical trial of deforolimus (AP23573, MK- 8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies
    • Rizzieri DA, Feldman E, Dipersio JF, et al: A phase 2 clinical trial of deforolimus (AP23573, MK- 8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies. Clin Cancer Res 14:2756-2762, 2008
    • (2008) Clin Cancer Res , vol.14 , pp. 2756-2762
    • Rizzieri, D.A.1    Feldman, E.2    Dipersio, J.F.3
  • 31
    • 69549107343 scopus 로고    scopus 로고
    • Phase 2 study of vorinostat (suberoylanilide hydroxamic acid) relapse or refractory indolent non-Hodgkin's lymphoma: A California Cancer Consortium study
    • abstr 1564
    • Kirshbaum M, Popplewell L, Nademance A, et al: Phase 2 study of vorinostat (suberoylanilide hydroxamic acid) relapse or refractory indolent non-Hodgkin's lymphoma: A California Cancer Consortium study. Blood 112, 2008 (abstr 1564)
    • (2008) Blood , vol.112
    • Kirshbaum, M.1    Popplewell, L.2    Nademance, A.3
  • 32
    • 45249105006 scopus 로고    scopus 로고
    • Treatment of relapsed or refractory lymphoma with an oral isotype-selective histone deacetylase inhibitor MGCD0103: Interim results from a phase II study
    • abstr 2571
    • Younes A, Wedgewood A, McLaughlin P, et al: Treatment of relapsed or refractory lymphoma with an oral isotype-selective histone deacetylase inhibitor MGCD0103: Interim results from a phase II study. Blood 110, 2007 (abstr 2571)
    • (2007) Blood , vol.110
    • Younes, A.1    Wedgewood, A.2    McLaughlin, P.3
  • 33
    • 79955804606 scopus 로고    scopus 로고
    • Phase I study of ABT-263, a Bcl-2 family inhibitor, in relapsed or refractory lymphoid malignancies
    • abstr 2108
    • Wilson WH, O'Connor O, Czuczman MS, et al: Phase I study of ABT-263, a Bcl-2 family inhibitor, in relapsed or refractory lymphoid malignancies. Blood 112, 2008 (abstr 2108)
    • (2008) Blood , vol.112
    • Wilson, W.H.1    O'Connor, O.2    Czuczman, M.S.3
  • 34
    • 77955102504 scopus 로고    scopus 로고
    • Phase I dose finding studies of obatoclax (GX15-070), a small molecule pan-BCL-2 family antagonist, in patients with advanced solid tumors or lymphoma
    • Hwang JJ, Kuruvilla J, Mendelson D, et al: Phase I dose finding studies of obatoclax (GX15-070), a small molecule pan-BCL-2 family antagonist, in patients with advanced solid tumors or lymphoma. Clin Cancer Res 16:4038-4045, 2010
    • (2010) Clin Cancer Res , vol.16 , pp. 4038-4045
    • Hwang, J.J.1    Kuruvilla, J.2    Mendelson, D.3
  • 35
    • 55949118445 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of YM155, a small-molecule inhibitor of survivin
    • Tolcher AW, Mita A, Lewis LD, et al: Phase I and pharmacokinetic study of YM155, a small-molecule inhibitor of survivin. J Clin Oncol 26:5198-5203, 2008
    • (2008) J Clin Oncol , vol.26 , pp. 5198-5203
    • Tolcher, A.W.1    Mita, A.2    Lewis, L.D.3
  • 36
    • 54449095901 scopus 로고    scopus 로고
    • Lenalidomide monotherapy in relapsed or refractory aggressive non-Hodgkin's lymphoma
    • Wiernik PH, Lossos IS, Tuscano JM, et al: Lenalidomide monotherapy in relapsed or refractory aggressive non-Hodgkin's lymphoma. J Clin Oncol 26:4952-4957, 2008
    • (2008) J Clin Oncol , vol.26 , pp. 4952-4957
    • Wiernik, P.H.1    Lossos, I.S.2    Tuscano, J.M.3
  • 37
    • 67650892772 scopus 로고    scopus 로고
    • Confirmation of the efficacy and safety of lenalidomide oral monotherapy in patients with relapsed or refractory diffuse large B-cell lymphoma: Results of an international study (NHL-003)
    • abstr 268
    • Czuczman MS, Vose JM, Zinzani PL, et al: Confirmation of the efficacy and safety of lenalidomide oral monotherapy in patients with relapsed or refractory diffuse large B-cell lymphoma: Results of an international study (NHL-003). Blood 112, 2008 (abstr 268)
    • (2008) Blood , vol.112
    • Czuczman, M.S.1    Vose, J.M.2    Zinzani, P.L.3
  • 38
    • 67649669059 scopus 로고    scopus 로고
    • Confirmation of the efficacy and safety of lenalidomide oral monotherapy in patients with relapsed or refractory mantle-cell lymphoma: Results of an international study (NHL-003)
    • abstr 262
    • Zinzani PL, Witzig TE, Vose JM, et al: Confirmation of the efficacy and safety of lenalidomide oral monotherapy in patients with relapsed or refractory mantle-cell lymphoma: Results of an international study (NHL-003). Blood 112, 2008 (abstr 262)
    • (2008) Blood , vol.112
    • Zinzani, P.L.1    Witzig, T.E.2    Vose, J.M.3
  • 39
    • 64149112784 scopus 로고    scopus 로고
    • Lenalidomide oral monotherapy produces a high response rate in patients with relapsed or refractory mantle cell lymphoma
    • Habermann TM, Lossos IS, Justice G, et al: Lenalidomide oral monotherapy produces a high response rate in patients with relapsed or refractory mantle cell lymphoma. Br J Haematol 145:344-349, 2009
    • (2009) Br J Haematol , vol.145 , pp. 344-349
    • Habermann, T.M.1    Lossos, I.S.2    Justice, G.3
  • 40
    • 61649094981 scopus 로고    scopus 로고
    • Bortezomib in patients with relapsed or refractory mantle cell lymphoma: Updated time-to-event analyses of the multicenter phase 2 PINNACLE study
    • Goy A, Bernstein SH, Kahl BS, et al: Bortezomib in patients with relapsed or refractory mantle cell lymphoma: Updated time-to-event analyses of the multicenter phase 2 PINNACLE study. Ann Oncol 20:520-525, 2009
    • (2009) Ann Oncol , vol.20 , pp. 520-525
    • Goy, A.1    Bernstein, S.H.2    Kahl, B.S.3
  • 42
    • 38149008164 scopus 로고    scopus 로고
    • A phase 1 study of SNS-032 (formerly BMS-387032), a potent inhibitor of cyclin-dependent kinases 2, 7 and 9 administered as a single oral dose and weekly infusion in patients with metastatic refractory solid tumors
    • Heath EI, Bible K, Martell RE, et al: A phase 1 study of SNS-032 (formerly BMS-387032), a potent inhibitor of cyclin-dependent kinases 2, 7 and 9 administered as a single oral dose and weekly infusion in patients with metastatic refractory solid tumors. Invest New Drugs 26:59-65, 2008
    • (2008) Invest New Drugs , vol.26 , pp. 59-65
    • Heath, E.I.1    Bible, K.2    Martell, R.E.3
  • 43
    • 73849145729 scopus 로고    scopus 로고
    • Chronic active B-cell-receptor signaling in diffuse large B-cell lymphoma
    • Davis RE, Ngo VN, Lenz G, et al: Chronic active B-cell-receptor signaling in diffuse large B-cell lymphoma. Nature 463:88-92, 2010
    • (2010) Nature , vol.463 , pp. 88-92
    • Davis, R.E.1    Ngo, V.N.2    Lenz, G.3
  • 44
    • 34848833908 scopus 로고    scopus 로고
    • Enzastaurin
    • DOI 10.1097/CCO.0b013e3282f10a00, PII 0000162220071100000009
    • Ma S, Rosen ST: Enzastaurin. Curr Opin Oncol 19:590-595, 2007 (Pubitemid 47508866)
    • (2007) Current Opinion in Oncology , vol.19 , Issue.6 , pp. 590-595
    • Ma, S.1    Rosen, S.T.2
  • 47
    • 68949154548 scopus 로고    scopus 로고
    • The future of small molecule inhibitors in lymphoma
    • Gerecitano J: The future of small molecule inhibitors in lymphoma. Curr Oncol Rep 11:378-385, 2009
    • (2009) Curr Oncol Rep , vol.11 , pp. 378-385
    • Gerecitano, J.1
  • 48
    • 70350637486 scopus 로고    scopus 로고
    • Emerging therapies for B-cell non-Hodgkin lymphoma
    • Briones J: Emerging therapies for B-cell non-Hodgkin lymphoma. Expert Rev Anticancer Ther 9:1305-1316, 2009
    • (2009) Expert Rev Anticancer Ther , vol.9 , pp. 1305-1316
    • Briones, J.1
  • 49
    • 77956114814 scopus 로고    scopus 로고
    • Prognostic factors in follicular lymphoma
    • Relander T, Johnson NA, Farinha P, et al: Prognostic factors in follicular lymphoma. J Clin Oncol 28:2902-2913, 2010
    • (2010) J Clin Oncol , vol.28 , pp. 2902-2913
    • Relander, T.1    Johnson, N.A.2    Farinha, P.3
  • 50
    • 40849143771 scopus 로고    scopus 로고
    • A phase I trial of the pan Bcl-2 family inhibitor obatoclax mesylate (GX15-070) in combination with bortezomib in patients with relapsed/refractory mantle cell lymphoma
    • abstr 2569
    • Goy A, Ford P, Feldman T, et al: A phase I trial of the pan Bcl-2 family inhibitor obatoclax mesylate (GX15-070) in combination with bortezomib in patients with relapsed/refractory mantle cell lymphoma. Blood 110, 2007 (abstr 2569)
    • (2007) Blood , vol.110
    • Goy, A.1    Ford, P.2    Feldman, T.3
  • 52
    • 41149168649 scopus 로고    scopus 로고
    • Lenalidomide for the treatment of B-cell malignancies
    • Chanan-Khan AA, Cheson BD: Lenalidomide for the treatment of B-cell malignancies. J Clin Oncol 26:1544-1552, 2008
    • (2008) J Clin Oncol , vol.26 , pp. 1544-1552
    • Chanan-Khan, A.A.1    Cheson, B.D.2
  • 53
    • 34548539145 scopus 로고    scopus 로고
    • A phase I/II study of lenalidomide (Len) in combination with rituximab (R) in relapsed/refractory mantle cell lymphoma (MCL) with early evidence of efficacy
    • suppl; abstr 8030
    • Wang M, Fayad L, Hagemeister F, et al: A phase I/II study of lenalidomide (Len) in combination with rituximab (R) in relapsed/refractory mantle cell lymphoma (MCL) with early evidence of efficacy. J Clin Oncol 25:448s, 2007 (suppl; abstr 8030)
    • (2007) J Clin Oncol , vol.25
    • Wang, M.1    Fayad, L.2    Hagemeister, F.3
  • 54
    • 2342667387 scopus 로고    scopus 로고
    • The development of proteasome inhibitors as anticancer drugs
    • Adams J: The development of proteasome inhibitors as anticancer drugs. Cancer Cell 5:417-421, 2004
    • (2004) Cancer Cell , vol.5 , pp. 417-421
    • Adams, J.1
  • 56
    • 66649127621 scopus 로고    scopus 로고
    • Mutations of multiple genes cause deregulation of NFkappaB in diffuse large B-cell lymphoma
    • Compagno M, Lim WK, Grunn A, et al: Mutations of multiple genes cause deregulation of NFkappaB in diffuse large B-cell lymphoma. Nature 459:717-721, 2009
    • (2009) Nature , vol.459 , pp. 717-721
    • Compagno, M.1    Lim, W.K.2    Grunn, A.3
  • 57
    • 70349300630 scopus 로고    scopus 로고
    • Efficacy and toxicity of 2 schedules of frontline rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone plus bortezomib in patients with B-cell lymphoma: A randomized phase 2 trial from the French Adult Lymphoma Study Group (GELA)
    • Ribrag V, Gisselbrecht C, Haioun C, et al: Efficacy and toxicity of 2 schedules of frontline rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone plus bortezomib in patients with B-cell lymphoma: A randomized phase 2 trial from the French Adult Lymphoma Study Group (GELA). Cancer 115:4540-4546, 2009
    • (2009) Cancer , vol.115 , pp. 4540-4546
    • Ribrag, V.1    Gisselbrecht, C.2    Haioun, C.3
  • 58
    • 35348925627 scopus 로고    scopus 로고
    • CHOP-R + bortezomib as initial therapy for diffuse large B-cell lymphoma (DLBCL)
    • suppl; abstr 8031
    • Leonard JP, Furman RR, Cheung YK, et al: CHOP-R + bortezomib as initial therapy for diffuse large B-cell lymphoma (DLBCL). J Clin Oncol 25:448s, 2007 (suppl; abstr 8031)
    • (2007) J Clin Oncol , vol.25
    • Leonard, J.P.1    Furman, R.R.2    Cheung, Y.K.3
  • 59
    • 16844374736 scopus 로고    scopus 로고
    • Phase I/II study of bortezomib alone and bortezomib with dose-adjusted EPOCH chemotherapy in relapsed or refractory aggressive B-cell lymphoma
    • abstr 1385
    • Dunleavy K, Janik J, Gea-Banacloche J, et al: Phase I/II study of bortezomib alone and bortezomib with dose-adjusted EPOCH chemotherapy in relapsed or refractory aggressive B-cell lymphoma. Blood 104:389a, 2004 (abstr 1385)
    • (2004) Blood , vol.104
    • Dunleavy, K.1    Janik, J.2    Gea-Banacloche, J.3
  • 60
    • 58149332686 scopus 로고    scopus 로고
    • Translating an antagonist of chemokine receptor CXCR4: From bench to bedside
    • Wong D, Korz W: Translating an antagonist of chemokine receptor CXCR4: From bench to bedside. Clin Cancer Res 14:7975-7980, 2008
    • (2008) Clin Cancer Res , vol.14 , pp. 7975-7980
    • Wong, D.1    Korz, W.2
  • 61
    • 64249173226 scopus 로고    scopus 로고
    • The AMD3100 story: The path to the discovery of a stem cell mobilizer (Mozobil)
    • De Clercq E: The AMD3100 story: The path to the discovery of a stem cell mobilizer (Mozobil). Biochem Pharmacol 77:1655-1664, 2009
    • (2009) Biochem Pharmacol , vol.77 , pp. 1655-1664
    • De Clercq, E.1
  • 62
    • 67649592154 scopus 로고    scopus 로고
    • CXCR4 chemokine receptor antagonists: Perspectives in SCLC
    • Burger JA, Stewart DJ: CXCR4 chemokine receptor antagonists: Perspectives in SCLC. Expert Opin Investig Drugs 18:481-490, 2009
    • (2009) Expert Opin Investig Drugs , vol.18 , pp. 481-490
    • Burger, J.A.1    Stewart, D.J.2
  • 63
    • 70349310325 scopus 로고    scopus 로고
    • Phase II-I-II study of two different doses and schedules of pralatrexate, a high-affinity substrate for the reduced folate carrier, in patients with relapsed or refractory lymphoma reveals marked activity in T-cell malignancies
    • O'Connor OA, Horwitz S, Hamlin P, et al: Phase II-I-II study of two different doses and schedules of pralatrexate, a high-affinity substrate for the reduced folate carrier, in patients with relapsed or refractory lymphoma reveals marked activity in T-cell malignancies. J Clin Oncol 27:4357-4364, 2009
    • (2009) J Clin Oncol , vol.27 , pp. 4357-4364
    • O'Connor, O.A.1    Horwitz, S.2    Hamlin, P.3
  • 64
    • 67449130517 scopus 로고    scopus 로고
    • Results of a phase 2 NCI multicenter study of romidepsin in patients with relapsed peripheral T-cell lymphoma (PTCL)
    • abstr 1567
    • Piekarz R, Wright J, Frye R, et al: Results of a phase 2 NCI multicenter study of romidepsin in patients with relapsed peripheral T-cell lymphoma (PTCL). Blood 112, 2008 (abstr 1567)
    • (2008) Blood , vol.112
    • Piekarz, R.1    Wright, J.2    Frye, R.3
  • 65
    • 77957566161 scopus 로고    scopus 로고
    • Interim report of a phase 2 clinical trial of lenalidomide for T-cell non-Hodgkin lymphoma
    • Dueck G, Chua N, Prasad A, et al: Interim report of a phase 2 clinical trial of lenalidomide for T-cell non-Hodgkin lymphoma. Cancer 116:4541-4548, 2010
    • (2010) Cancer , vol.116 , pp. 4541-4548
    • Dueck, G.1    Chua, N.2    Prasad, A.3
  • 66
    • 77950616726 scopus 로고    scopus 로고
    • Novel Agents in Development for Peripheral T-Cell Lymphoma
    • suppl 1
    • O'Connor OA: Novel Agents in Development for Peripheral T-Cell Lymphoma. Semin Hematol 47:S11-S14, 2010 (suppl 1)
    • (2010) Semin Hematol , vol.47
    • O'Connor, O.A.1
  • 67
    • 77950486830 scopus 로고    scopus 로고
    • A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo
    • Cerchietti LC, Ghetu AF, Zhu X, et al: A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo. Cancer Cell 17:400-411, 2010
    • (2010) Cancer Cell , vol.17 , pp. 400-411
    • Cerchietti, L.C.1    Ghetu, A.F.2    Zhu, X.3
  • 68
    • 64749098830 scopus 로고    scopus 로고
    • An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
    • Soucy TA, Smith PG, Milhollen MA, et al: An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature 458:732-736, 2009
    • (2009) Nature , vol.458 , pp. 732-736
    • Soucy, T.A.1    Smith, P.G.2    Milhollen, M.A.3
  • 69
    • 71549121697 scopus 로고    scopus 로고
    • A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6 - Dependent B cell lymphomas
    • Cerchietti LC, Lopes EC, Yang SN, et al: A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6 - dependent B cell lymphomas. Nat Med 15:1369-1376, 2009
    • (2009) Nat Med , vol.15 , pp. 1369-1376
    • Cerchietti, L.C.1    Lopes, E.C.2    Yang, S.N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.