-
1
-
-
2942582913
-
Survival of resting mature b lymphocytes depends on bcr signaling via the igalpha/beta heterodimer
-
Kraus M, Alimzhanov MB, Rajewsky N, Rajewsky K. Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer. Cell. 2004;117:787-800.
-
(2004)
Cell.
, vol.117
, pp. 787-800
-
-
Kraus, M.1
Alimzhanov, M.B.2
Rajewsky, N.3
Rajewsky, K.4
-
2
-
-
0342711256
-
In vivo ablation of surface immunoglobulin on mature b cells by inducible gene targeting results in rapid cell death
-
Lam KP, Kuhn R, Rajewsky K. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell. 1997;90:1073-83.
-
(1997)
Cell.
, vol.90
, pp. 1073-1083
-
-
Lam, K.P.1
Kuhn, R.2
Rajewsky, K.3
-
3
-
-
77951010885
-
Aggressive lymphomas
-
Lenz G, Staudt LM. Aggressive lymphomas. N Engl J Med. 2010; 362:1417-29.
-
(2010)
N Engl J Med.
, vol.362
, pp. 1417-1429
-
-
Lenz, G.1
Staudt, L.M.2
-
4
-
-
33646492861
-
Cutting edge: Constitutive b cell receptor signaling is critical for basal growth of b lymphoma
-
Gururajan M, Jennings CD, Bondada S. Cutting edge: constitutive B cell receptor signaling is critical for basal growth of B lymphoma. J Immunol. 2006;176:5715-9.
-
(2006)
J Immunol.
, vol.176
, pp. 5715-5719
-
-
Gururajan, M.1
Jennings, C.D.2
Bondada, S.3
-
5
-
-
41349110211
-
Syk-dependent tonic b-cell receptor signaling is a rational treatment target in diffuse large bcell lymphoma
-
Chen L, Monti S, Juszczynski P, et al. SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large Bcell lymphoma. Blood. 2008;111:2230-7.
-
(2008)
Blood.
, vol.111
, pp. 2230-227
-
-
Chen, L.1
Monti, S.2
Juszczynski, P.3
-
6
-
-
20144382754
-
Molecular profiling of diffuse large b-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response
-
Monti S, Savage KJ, Kutok JL, et al. Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response. Blood. 2005;105:1851-61.
-
(2005)
Blood.
, vol.105
, pp. 1851-1861
-
-
Monti, S.1
Savage, K.J.2
Kutok, J.L.3
-
7
-
-
33751198728
-
Protein tyrosine phosphatase receptor-type o truncated (ptprot) regulates syk phosphorylation, proximal b-cell-receptor signaling, and cellular proliferation
-
Chen L, Juszczynski P, Takeyama K, Aguiar RC, Shipp MA. Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell-receptor signaling, and cellular proliferation. Blood. 2006;108:3428-33.
-
(2006)
Blood.
, vol.108
, pp. 3428-3433
-
-
Chen, L.1
Juszczynski, P.2
Takeyama, K.3
Aguiar, R.C.4
Shipp, M.A.5
-
8
-
-
33751195937
-
Altered b-cell receptor signaling kinetics distinguish human follicular lymphoma b cells from tumor-infiltrating nonmalignant b cells
-
Irish JM, Czerwinski DK, Nolan GP, Levy R. Altered B-cell receptor signaling kinetics distinguish human follicular lymphoma B cells from tumor-infiltrating nonmalignant B cells. Blood. 2006;108:3135-42.
-
(2006)
Blood.
, vol.108
, pp. 3135-3142
-
-
Irish, J.M.1
Czerwinski, D.K.2
Nolan, G.P.3
Levy, R.4
-
9
-
-
33644851486
-
Genomic and expression profiling identifies the b-cell associated tyrosine kinase syk as a possible therapeutic target in mantle cell lymphoma
-
Rinaldi A, Kwee I, Taborelli M, et al. Genomic and expression profiling identifies the B-cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphoma. Br J Haematol. 2006;132:303-16.
-
(2006)
Br J Haematol.
, vol.132
, pp. 303-316
-
-
Rinaldi, A.1
Kwee, I.2
Taborelli, M.3
-
10
-
-
77951002653
-
Inhibition of syk with fostamatinib disodium has significant clinical activity in non-hodgkin lymphoma and chronic lymphocytic leukemia
-
This is the first publication revealing the promise of BCR targeting in B cell lymphomas.
-
Friedberg JW, Sharman J, Sweetenham J, et al. Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. Blood. ;115:2578-85. This is the first publication revealing the promise of BCR targeting in B cell lymphomas.
-
Blood
, vol.115
, pp. 2578-2585
-
-
Friedberg, J.W.1
Sharman, J.2
Sweetenham, J.3
-
11
-
-
0033945186
-
The role of bruton's tyrosine kinase in b-cell development and function: A genetic perspective
-
Satterthwaite AB, Witte O. The role of Bruton's tyrosine kinase in B-cell development and function: a genetic perspective. Immunol Rev. 2000;175:120-7.
-
(2000)
Immunol Rev.
, vol.175
, pp. 120-127
-
-
Satterthwaite, A.B.1
Witte, O.2
-
12
-
-
77955625479
-
The bruton tyrosine kinase inhibitor pci-32765 blocks b-cell activation and is efficacious in models of autoimmune disease and b-cell malignancy
-
Honigberg LA, Smith AM, Sirisawad M, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci USA. 2010;107:13075-80.
-
(2010)
Proc Natl Acad Sci USA.
, vol.107
, pp. 13075-13080
-
-
Honigberg, L.A.1
Smith, A.M.2
Sirisawad, M.3
-
13
-
-
79959404661
-
Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by pci-32765
-
Herman SE, Gordon AL, Hertlein E, et al. Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765. Blood. 2011;117:6287-96.
-
(2011)
Blood.
, vol.117
, pp. 6287-6296
-
-
Herman, S.E.1
Gordon, A.L.2
Hertlein, E.3
-
14
-
-
80053489817
-
The btk inhibitor pci-32765 is highly active and well tolerated in patients with relapsed/refractory b cell malignancies: Final results from a phase i study
-
Advani A, Sharman J, Smith SM. The Btk inhibitor PCI-32765 is highly active and well tolerated in patients with relapsed/refractory B cell malignancies: final results from a phase I study. Ann Oncol. 2011;22 (Suppl 4).
-
(2011)
Ann Oncol.
, Issue.SUPPL. 4
, pp. 22
-
-
Advani, A.1
Sharman, J.2
Smith, S.M.3
-
15
-
-
73849145729
-
Chronic active b-cell-receptor signalling in diffuse large b-cell lymphoma
-
Davis RE, Ngo VN, Lenz G, et al. Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature. 2010;463:88-92.
-
(2010)
Nature.
, vol.463
, pp. 88-92
-
-
Davis, R.E.1
Ngo, V.N.2
Lenz, G.3
-
16
-
-
84861345119
-
The bruton's tyrosine kinase (btk) inhibitor pci-32765 induces durable responses in relapsed refractory (r/r) chronic lymphocytic leukemia/small lymphocytic lymphoma (cll/sll): Follow up of a phase ib/ii study
-
Abstract 983. This abstract details the phase II experience with PCI 32765 in CLL
-
O'Brien S Burger JA, Blum KA, et al. The Bruton's tyrosine kinase (BTK) inhibitor PCI-32765 induces durable responses in relapsed refractory (R/R) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL): Follow up of a phase IB/II study. Blood. 2011; 118: Abstract 983. This abstract details the phase II experience with PCI 32765 in CLL.
-
(2011)
Blood.
, pp. 118
-
-
O'Brien, S.1
Burger, J.A.2
Blum, K.A.3
-
17
-
-
84860430028
-
The bruton's tyrosine kinase inhibitor pci-32765 is highly active as single-agent therapy in previously-treated mantle cell lymphoma (mcl): Preliminary results of a phase ii trial
-
Abstract 442. This abstract details the phase II experience with PCI 32765 in MCL
-
Wang L, Martin P, Blum KA, et al. The Bruton's Tyrosine Kinase Inhibitor PCI-32765 is Highly Active As Single-Agent Therapy in Previously-Treated Mantle Cell Lymphoma (MCL): Preliminary Results of a Phase II Trial. Blood. 2011;118: Abstract 442. This abstract details the phase II experience with PCI 32765 in MCL.
-
(2011)
Blood.
, pp. 118
-
-
Wang, L.1
Martin, P.2
Blum, K.A.3
-
18
-
-
78751553221
-
Cal-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of b-cell malignancies, inhibits pi3k signaling and cellular viability
-
Lannutti BJ, Meadows SA, Herman SE, et al. CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability. Blood. 2011;117:591-4.
-
(2011)
Blood.
, vol.117
, pp. 591-594
-
-
Lannutti, B.J.1
Meadows, S.A.2
Herman, S.E.3
-
19
-
-
79953655788
-
Cal-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase p110, demonstrates clinical activity and pharmacodynamic effects in patients with relapsed or refractory chronic lymphocytic leukemia
-
Abstract 55. This abstract details the phase I experience with CAL 101 in CLL
-
Furman RR, Byrd JC, Brown JR et al. CAL-101, An Isoform-Selective Inhibitor of Phosphatidylinositol 3-Kinase P110, Demonstrates Clinical Activity and Pharmacodynamic Effects In Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia. Blood. 2010; 116: Abstract 55. This abstract details the phase I experience with CAL 101 in CLL.
-
(2010)
Blood.
, pp. 116
-
-
Furman, R.R.1
Byrd, J.C.2
Brown, J.R.3
-
20
-
-
79958784935
-
Clinical safety and activity in a phase 1 study of cal-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase p110, in patients with relapsed or refractory non-hodgkin lymphoma
-
Abstract 1777. This abstract details the phase I experience with CAL 101 in NHL
-
Kahl BS, Byrd JC, Flinn IW, et al. Clinical Safety and Activity In a Phase 1 Study of CAL-101, An Isoform-Selective Inhibitor of Phosphatidylinositol 3-Kinase P110, In Patients with Relapsed or Refractory Non-Hodgkin Lymphoma. Blood. 2010; 116: Abstract 1777. This abstract details the phase I experience with CAL 101 in NHL.
-
(2010)
Blood.
, pp. 116
-
-
Kahl, B.S.1
Byrd, J.C.2
Flinn, I.W.3
-
21
-
-
84870814164
-
A phase 1 study of cal-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase p110, in combination with rituximab and/or bendamustine in patients with relapsed or refractory b-cell malignancies
-
Abstract 2699
-
De Vos S, MT S, IW F. A Phase 1 Study of CAL-101, An Isoform-Selective Inhibitor of Phosphatidylinositol 3-Kinase P110, In Combination with Rituximab and/or Bendamustine In Patients with Relapsed or Refractory B-Cell Malignancies. Blood. ;118:Abstract 2699.
-
Blood
, pp. 118
-
-
De Vos, S.1
Mt, S.2
Iw, F.3
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