Chp, a homologue of the GTPase CDc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton

Current Biology

Volumn 8, Issue 20, 1998, Pages 1125-1129

  Aronheim, Ami ^a   Broder, Yehoshua C ^a   Cohen, Aviva ^a   Fritsch, Alexandra ^b   Belisle, Barbara ^b   Abo, Arie ^b  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b ONYX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CDNA LIBRARY; CLONE; CYTOSKELETON; ENZYME ACTIVATION; GUANOSINE TRIPHOSPHATASE; PROTEIN BINDING; PROTEIN KINASE; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TWO HYBRID SYSTEM;

EID: 0032497688     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0960-9822(98)70468-3     Document Type: Article

References (13)

1. Hall A: Rho GTPases and the actin cytoskeleton. Science 1998, 279:509-514.
2. Van Aelst L, D'Souza-Schorey C: Rho GTPases and signaling networks. Genes Dev 1997, 11:2295-2322.
3. Nobes CD, Hall A: Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 1995, 81:53-62.
4. Broder YC, Katz S, Aronheim A: The Ras recruitment system, a novel approach to the study of protein-protein interactions. Curr Biol 1998, 8:1121-1124.
5. Aronheim A, Zandi E, Hennemann H, Elledge S, Karin M: Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions. Mol Cell Biol 1997, 17:3094-3102.
6. Didsbury J, Weber RF, Bokoch GM, Evans T, Snyderman R: rac, a novel ras-related family of proteins that are botulinum toxin substrates. J Biol Chem 1989, 264:16378-163826.
7. Martin GA, Bollag G, McCormick F, Abo A: A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. EMBO J 1995, 14:1970-1978.
8. Bagrodia S, Derijard B, Davis RJ, Cerione RA: Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation. J Biol Chem 1995, 270:27995-27998.
9. Sells MA, Chernof J: Emerging from the Pak: the p21-activated protein kinase family. Trends Cell Biol 1997, 7:162-167.
10. Manser E, Huang HY, Loo TH, Chen XQ, Dong JM, Leung T, Lim L: Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes. Mol Cell Biol 1997, 17:1129-1143.
11. Marshall CJ: Ras effectors. Curr Opin Cell Biol 1996 8:197-204.
12. Minden A, Lin A, Claret FX, Abo A, Karin M: Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 1995, 81:1147-1157.
13. Coso OA, Chiariello M, Yu JC, Teramoto H, Crespo P, Xu N, et al.: The small GTP-binding proteins Rad and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 1995, 81:1137-1146.