Critical role of the death receptor pathway in the antitumoral effects induced by hispanolone derivatives

Oncogene

Volumn 32, Issue 2, 2013, Pages 259-268

  Traves P G ^a   Lopez Fontal R ^b   Cuadrado, I ^c   Luque, A ^d   Bosca L ^a   De Las Heras, B ^c   Hortelano, S ^e  

^a INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

^b CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^d HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^e INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

apoptosis; caspase 8; death receptors; hispanolone derivatives; TRAIL

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; DEATH RECEPTOR; DITERPENOID; FAS LIGAND; GALEOPSIN; HISPANOLONE DERIVATIVE; NEUTRALIZING ANTIBODY; PROTEIN BID; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; TUMOR NECROSIS FACTOR ALPHA RECEPTOR 2; TUMOR NECROSIS FACTOR RECEPTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOLUMINESCENCE; CANCER INHIBITION; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; ENZYME INHIBITION; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TUMOR CELL LINE; TUMOR XENOGRAFT;

ANIMALS; ANTIBODIES, NEUTRALIZING; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CASPASE 3; CASPASE 8; CASPASE 9; CELL LINE, TUMOR; DITERPENES; ENZYME ACTIVATION; FAS LIGAND PROTEIN; GENE EXPRESSION PROFILING; HUMANS; JURKAT CELLS; MACROPHAGES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED C57BL; MITOCHONDRIA; RECEPTORS, DEATH DOMAIN; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN;

EID: 84872174988     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.23     Document Type: Article

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