Inhibition of the nuclear factor κB (NF-κB) pathway by tetracyclic kaurene diterpenes in macrophages: Specific effects on NF-κB-inducing kinase activity and on the coordinate activation of ERK and p38 MAPK

Journal of Biological Chemistry

Volumn 276, Issue 19, 2001, Pages 15854-15860

  Castrillo, Antonio ^a   De las Heras, Beatriz ^b   Hortelano, Sonsoles ^a   Rodríguez, Benjamín ^c   Villar, Angel ^b   Boscá, Lisardo ^a,d  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c CSIC Centro de Quimica Organica Lora Tamayo CENQUIOR   (Spain)

^d Instituto de Bioquimica   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

POLYSACCHARIDES; SYNTHESIS (CHEMICAL); TUMORS;

NUCLEAR FACTORS;

ENZYME INHIBITION;

DITERPENE; GIBBERELLIN; I KAPPA B KINASE; I KAPPA B KINASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; KAURENE DERIVATIVE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; NITRIC OXIDE SYNTHASE; NUCLEAR FACTOR KAPPA B INDUCING KINASE; PROTEIN KINASE; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR; UNCLASSIFIED DRUG; CD11B ANTIGEN; CD14 ANTIGEN; CHUK PROTEIN, MOUSE; IKBKB PROTEIN, MOUSE; IKBKE PROTEIN, MOUSE; KAURANE DERIVATIVE; KAURENE; MITOGEN ACTIVATED PROTEIN KINASE P38; NF KAPPA B KINASE; NF-KAPPA B KINASE; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME SPECIFICITY; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; KINETICS; METABOLISM; PHYSIOLOGY;

ANIMALIA;

ANIMALS; ANTIGENS, CD14; CELL LINE; DITERPENES; DITERPENES, KAURANE; I-KAPPA B KINASE; KINETICS; LIPOPOLYSACCHARIDES; MACROPHAGE-1 ANTIGEN; MACROPHAGES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES;

EID: 0035844182     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M100010200     Document Type: Article

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