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Volumn 54, Issue 1, 2013, Pages 5-13

Decreased body fat, elevated plasma transforming growth factor-β levels, and impaired BMP4-like signaling in biglycan-deficient mice

Author keywords

Adiposity; BMP4 like signaling; Kidney histology; Ldlr knockout mice; Liver histology; Proteoglycans; TGF 1

Indexed keywords

BIGLYCAN; BONE MORPHOGENETIC PROTEIN 4; CHOLESTEROL; FIBRONECTIN; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; MESSENGER RNA; SMAD1 PROTEIN; SMAD3 PROTEIN; SMAD5 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRIACYLGLYCEROL;

EID: 84872163823     PISSN: 03008207     EISSN: 16078438     Source Type: Journal    
DOI: 10.3109/03008207.2012.715700     Document Type: Article
Times cited : (10)

References (59)
  • 1
    • 0141429078 scopus 로고    scopus 로고
    • Biglycan knockout mice: New models for musculoskeletal diseases
    • DOI 10.1023/A:1025336114352
    • Young, M.F., Bi, Y., Ameye, L., and Chen, X.D. (2002). Biglycan knockout mice: New models for musculoskeletal diseases. Glycoconj. J. 19(4-5):257-262. (Pubitemid 37174553)
    • (2002) Glycoconjugate Journal , vol.19 , Issue.4-5 , pp. 257-262
    • Young, M.F.1    Bi, Y.2    Ameye, L.3    Chen, X.-D.4
  • 3
    • 33745616078 scopus 로고    scopus 로고
    • Defective glycosylation of decorin and biglycan, altered collagen structure, and abnormal phenotype of the skin fibroblasts of an Ehlers-Danlos syndrome patient carrying the novel Arg270Cys substitution in galactosyltransferase I (β4GalT-7)
    • DOI 10.1007/s00109-006-0046-4
    • Seidler, D.G., Faiyaz-Ul-Haque, M., Hansen, U., Yip, G.W., Zaidi, S.H., Teebi, A.S., Kiesel, L., and Gotte, M. (2006). Defective glycosylation of decorin and biglycan, altered collagen structure, and abnormal phenotype of the skin fibroblasts of an Ehlers-Danlos syndrome patient carrying the novel Arg270Cys substitution in galactosyltransferase I (beta4GalT-7). J. Mol. Med. 84(7):583-594. (Pubitemid 43992850)
    • (2006) Journal of Molecular Medicine , vol.84 , Issue.7 , pp. 583-594
    • Seidler, D.G.1    Faiyaz-Ul-Haque, M.2    Hansen, U.3    Yip, G.W.4    Zaidi, S.H.E.5    Teebi, A.S.6    Kiesel, L.7    Gotte, M.8
  • 5
    • 0031031465 scopus 로고    scopus 로고
    • Selective expression and processing of biglycan during migration of bovine aortic endothelial cells: The role of endogenous basic fibroblast growth factor
    • DOI 10.1074/jbc.272.1.318
    • Kinsella, M.G., Tsoi, C.K., Jarvelainen, H.T., and Wight, T.N. (1997). Selective expression and processing of biglycan during migration of bovine aortic endothelial cells. The role of endogenous basic fibroblast growth factor. J. Biol. Chem. 272(1):318-325. Epub 1997/01/03. (Pubitemid 27021161)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.1 , pp. 318-325
    • Kinsella, M.G.1    Tsoi, C.K.2    Jarvelainen, H.T.3    Wight, T.N.4
  • 6
    • 17844384592 scopus 로고    scopus 로고
    • Biglycan is a new extracellular component of the Chordin-BMP4 signaling pathway
    • DOI 10.1038/sj.emboj.7600615
    • Moreno, M., Munoz, R., Aroca, F., Labarca, M., Brandan, E., and Larrain, J. (2005). Biglycan is a new extracellular component of the Chordin-BMP4 signaling pathway. EMBO J. 24(7):1397-1405. (Pubitemid 40593060)
    • (2005) EMBO Journal , vol.24 , Issue.7 , pp. 1397-1405
    • Moreno, M.1    Munoz, R.2    Aroca, F.3    Labarca, M.4    Brandan, E.5    Larrain, J.6
  • 7
    • 2942706108 scopus 로고    scopus 로고
    • The small leucine-rich proteoglycan biglycan modulates BMP-4-induced osteoblast differentiation
    • DOI 10.1096/fj.03-0899com
    • Chen, X.D., Fisher, L.W., Robey, P.G., and Young, M.F. (2004). The small leucine-rich proteoglycan biglycan modulates BMP-4-induced osteoblast differentiation. FASEB J. 18(9):948-958. (Pubitemid 38787591)
    • (2004) FASEB Journal , vol.18 , Issue.9 , pp. 948-958
    • Chen, X.-D.1    Fisher, L.W.2    Robey, P.G.3    Young, M.F.4
  • 8
    • 79959743186 scopus 로고    scopus 로고
    • Regulation of pre-adipocyte proliferation and apoptosis by the small leucine-rich proteoglycans, biglycan and decorin
    • Ward, M., and Ajuwon, K.M. (2011). Regulation of pre-adipocyte proliferation and apoptosis by the small leucine-rich proteoglycans, biglycan and decorin. Cell Prolif. 44(4):343-351.
    • (2011) Cell Prolif. , vol.44 , Issue.4 , pp. 343-351
    • Ward, M.1    Ajuwon, K.M.2
  • 11
    • 0027984873 scopus 로고
    • Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor β
    • Hildebrand, A., Romaris, M., Rasmussen, L.M., Heinegard, D., Twardzik, D.R., Border, W.A., and Ruoslahti, E. (1994). Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta. Biochem. J. 302(Pt 2):527-534. (Pubitemid 24280108)
    • (1994) Biochemical Journal , vol.302 , Issue.2 , pp. 527-534
    • Hildebrand, A.1    Romaris, M.2    Rasmussen, M.3    Heinegard, D.4    Twardzik, D.R.5    Border, W.A.6    Ruoslahti, E.7
  • 12
    • 33747015300 scopus 로고    scopus 로고
    • Extracellular proteoglycans modify TGF-β bio-availability attenuating its signaling during skeletal muscle differentiation
    • DOI 10.1016/j.matbio.2006.04.004, PII S0945053X06000461
    • Droguett, R., Cabello-Verrugio, C., Riquelme, C., and Brandan, E. (2006). Extracellular proteoglycans modify TGF-beta bio-availability attenuating its signaling during skeletal muscle differentiation. Matrix Biol. 25(6):332-341. (Pubitemid 44202585)
    • (2006) Matrix Biology , vol.25 , Issue.6 , pp. 332-341
    • Droguett, R.1    Cabello-Verrugio, C.2    Riquelme, C.3    Brandan, E.4
  • 14
    • 0028109801 scopus 로고
    • Transforming growth factor β in tissue fibrosis
    • DOI 10.1056/NEJM199411103311907
    • Border, W.A., and Noble, N.A. (1994). Transforming growth factor beta in tissue fibrosis. N. Engl. J. Med. 331(19):1286-1292. (Pubitemid 24333194)
    • (1994) New England Journal of Medicine , vol.331 , Issue.19 , pp. 1286-1292
    • Border, W.A.1    Noble, N.A.2
  • 15
    • 0031454239 scopus 로고    scopus 로고
    • Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-β1 transgenic mice
    • Clouthier, D.E., Comerford, S.A., and Hammer, R.E. (1997). Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-beta1 transgenic mice. J. Clin. Invest. 100(11):2697-2713. (Pubitemid 28007537)
    • (1997) Journal of Clinical Investigation , vol.100 , Issue.11 , pp. 2697-2713
    • Clouthier, D.E.1    Comerford, S.A.2    Hammer, R.E.3
  • 16
    • 0038374866 scopus 로고    scopus 로고
    • Conditional tetracycline-regulated expression of TGF-β1 in liver of transgenic mice leads to reversible intermediary fibrosis
    • DOI 10.1053/jhep.2003.50196
    • Ueberham, E., Low, R., Ueberham, U., Schonig, K., Bujard, H., and Gebhardt, R. (2003). Conditional tetracycline-regulated expression of TGF-beta1 in liver of transgenic mice leads to reversible intermediary fibrosis. Hepatology 37(5):1067-1078. (Pubitemid 36538683)
    • (2003) Hepatology , vol.37 , Issue.5 , pp. 1067-1078
    • Ueberham, E.1    Low, R.2    Ueberham, U.3    Schonig, K.4    Bujard, H.5    Gebhardt, R.6
  • 17
    • 0034979153 scopus 로고    scopus 로고
    • Proteoglycans decorin and biglycan differentially modulate TGF-beta-mediated fibrotic responses in the lung
    • Kolb, M., Margetts, P.J., Sime, P.J., and Gauldie, J. (2001). Proteoglycans decorin and biglycan differentially modulate TGF-beta-mediated fibrotic responses in the lung. Am. J. Physiol. Lung Cell Mol. Physiol. 280(6): L1327-L1334.
    • (2001) Am. J. Physiol. Lung Cell Mol. Physiol , vol.280 , Issue.6
    • Kolb, M.1    Margetts, P.J.2    Sime, P.J.3    Gauldie, J.4
  • 21
    • 0036235834 scopus 로고    scopus 로고
    • Abnormal collagen fibrils in tendons of biglycan/fibromodulin-deficient mice lead to gait impairment, ectopic ossification, and osteoarthritis
    • DOI 10.1096/fj.01-0848com
    • Ameye, L., Aria, D., Jepsen, K., Oldberg, A., Xu, T., and Young, M.F. (2002). Abnormal collagen fibrils in tendons of biglycan/fibromodulindeficient mice lead to gait impairment, ectopic ossification, and osteoarthritis. FASEB J. 16(7):673-680. (Pubitemid 34465431)
    • (2002) FASEB Journal , vol.16 , Issue.7 , pp. 673-680
    • Ameye, L.1    Aria, D.2    Jepsen, K.3    Oldberg, A.K.E.4    Xu, T.5    Young, M.F.6
  • 24
    • 0036153106 scopus 로고    scopus 로고
    • Age-related osteoporosis in biglycan-deficient mice is related to defects in bone marrow stromal cells
    • Chen, X.D., Shi, S., Xu, T., Robey, P.G., and Young, M.F. (2002). Agerelated osteoporosis in biglycan-deficient mice is related to defects in bone marrow stromal cells. J. Bone. Miner. Res. 17(2):331-340. (Pubitemid 34087666)
    • (2002) Journal of Bone and Mineral Research , vol.17 , Issue.2 , pp. 331-340
    • Chen, X.-D.1    Shi, S.2    Xu, T.3    Robey, P.G.4    Young, M.F.5
  • 25
    • 67349129697 scopus 로고    scopus 로고
    • Hypercholesterolemia leads to elevated TGF-beta1 activity and T helper 3-dependent autoimmune responses in atherosclerotic mice
    • Zhou, X., Johnston, T.P., Johansson, D., Parini, P., Funa, K., Svensson, J., and Hansson, G.K. (2009). Hypercholesterolemia leads to elevated TGF-beta1 activity and T helper 3-dependent autoimmune responses in atherosclerotic mice. Atherosclerosis 204(2):381-387.
    • (2009) Atherosclerosis , vol.204 , Issue.2 , pp. 381-387
    • Zhou, X.1    Johnston, T.P.2    Johansson, D.3    Parini, P.4    Funa, K.5    Svensson, J.6    Hansson, G.K.7
  • 27
    • 42949151068 scopus 로고    scopus 로고
    • Angiotensin II increases vascular proteoglycan content preceding and contributing to atherosclerosis development
    • Huang, F., Thompson, J.C., Wilson, P.G., Aung, H.H., Rutledge, J.C., and Tannock, L.R. (2008). Angiotensin II increases vascular proteoglycan content preceding and contributing to atherosclerosis development. J. Lipid Res. 49(3):521-530.
    • (2008) J. Lipid Res , vol.49 , Issue.3 , pp. 521-530
    • Huang, F.1    Thompson, J.C.2    Wilson, P.G.3    Aung, H.H.4    Rutledge, J.C.5    Tannock, L.R.6
  • 28
    • 0023025366 scopus 로고
    • Transforming growth factor-β stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix
    • Ignotz, R.A., and Massague, J. (1986). Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J. Biol. Chem. 261(9):4337-4345. (Pubitemid 17198877)
    • (1986) Journal of Biological Chemistry , vol.261 , Issue.9 , pp. 4337-4345
    • Ignotz, R.A.1    Massague, J.2
  • 29
    • 0036913712 scopus 로고    scopus 로고
    • Transforming growth factor-β signal transduction and progressive renal disease
    • Cheng, J., and Grande, J.P. (2002). Transforming growth factor-beta signal transduction and progressive renal disease. Exp. Biol. Med. (Maywood) 227(11):943-956. (Pubitemid 36008302)
    • (2002) Experimental Biology and Medicine , vol.227 , Issue.11 , pp. 943-956
    • Cheng, J.1    Grande, J.P.2
  • 31
    • 0033538447 scopus 로고    scopus 로고
    • Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells
    • Hollnagel, A., Oehlmann, V., Heymer, J., Ruther, U., and Nordheim, A. (1999). Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells. J. Biol. Chem. 274(28):19838-19845.
    • (1999) J. Biol. Chem , vol.274 , Issue.28 , pp. 19838-19845
    • Hollnagel, A.1    Oehlmann, V.2    Heymer, J.3    Ruther, U.4    Nordheim, A.5
  • 32
    • 0037204990 scopus 로고    scopus 로고
    • Signal transduction by the TGFbeta superfamily
    • Attisano, L., and Wrana, J.L. (2002). Signal transduction by the TGFbeta superfamily. Science 296(5573):1646-1647.
    • (2002) Science , vol.296 , Issue.5573 , pp. 1646-1647
    • Attisano, L.1    Wrana, J.L.2
  • 33
    • 0024550294 scopus 로고
    • Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species
    • Fisher, L.W., Termine, J.D., and Young, M.F. (1989). Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species. J. Biol. Chem. 264(8):4571-4576. (Pubitemid 19081361)
    • (1989) Journal of Biological Chemistry , vol.264 , Issue.8 , pp. 4571-4576
    • Fisher, L.W.1    Termine, J.D.2    Young, M.F.3
  • 34
    • 0025353729 scopus 로고
    • Negative regulation of transforming growth factor-beta by the proteoglycan decorin
    • Yamaguchi, Y., Mann, D.M., and Ruoslahti, E. (1990). Negative regulation of transforming growth factor-beta by the proteoglycan decorin. Nature 346(6281):281-284.
    • (1990) Nature , vol.346 , Issue.6281 , pp. 281-284
    • Yamaguchi, Y.1    Mann, D.M.2    Ruoslahti, E.3
  • 35
    • 0026676859 scopus 로고
    • Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease
    • DOI 10.1038/360361a0
    • Border, W.A., Noble, N.A., Yamamoto, T., Harper, J.R., Yamaguchi, Y., Pierschbacher, M.D., and Ruoslahti, E. (1992). Natural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease. Nature 360(6402):361-364. (Pubitemid 23000677)
    • (1992) Nature , vol.360 , Issue.6402 , pp. 361-364
    • Border, W.A.1    Noble, N.A.2    Yamamoto, T.3    Harper, J.R.4    Yamaguchi, Y.5    Pierschbacher, M.D.6    Ruoslahti, E.7
  • 36
    • 0030709198 scopus 로고    scopus 로고
    • Antifibrotic effect of decorin in a bleomycin hamster model of lung fibrosis
    • DOI 10.1016/S0006-2952(97)00343-2, PII S0006295297003432
    • Giri, S.N., Hyde, D.M., Braun, R.K., Gaarde, W., Harper, J.R., and Pierschbacher, M.D. (1997). Antifibrotic effect of decorin in a bleomycin hamster model of lung fibrosis. Biochem. Pharmacol. 54(11): 1205-1216. (Pubitemid 27497247)
    • (1997) Biochemical Pharmacology , vol.54 , Issue.11 , pp. 1205-1216
    • Giri, S.N.1    Hyde, D.M.2    Braun, R.K.3    Gaarde, W.4    Harper, J.R.5    Pierschbacher, M.D.6
  • 37
    • 0034737608 scopus 로고    scopus 로고
    • Local expression of bovine decorin by cell-mediated gene transfer reduces neointimal formation after balloon injury in rats
    • Fischer, J.W., Kinsella, M.G., Clowes, M.M., Lara, S., Clowes, A.W., and Wight, T.N. (2000). Local expression of bovine decorin by cell-mediated gene transfer reduces neointimal formation after balloon injury in rats. Circ. Res. 86(6):676-683. (Pubitemid 30208436)
    • (2000) Circulation Research , vol.86 , Issue.6 , pp. 676-683
    • Fischer, J.W.1    Kinsella, M.G.2    Clowes, M.M.3    Lara, S.4    Clowes, A.W.5    Wight, T.N.6
  • 38
    • 79955775556 scopus 로고    scopus 로고
    • Deficiency of biglycan causes cardiac fibroblasts to differentiate into a myofibroblast phenotype
    • Melchior-Becker, A., Dai, G., Ding, Z., Schafer, L., Schrader, J., Young, M.F., and Fischer, J.W. (2011). Deficiency of biglycan causes cardiac fibroblasts to differentiate into a myofibroblast phenotype. J. Biol. Chem. 286(19): 17365-17375.
    • (2011) J. Biol. Chem. , vol.286 , Issue.19 , pp. 17365-17375
    • Melchior-Becker, A.1    Dai, G.2    Ding, Z.3    Schafer, L.4    Schrader, J.5    Young, M.F.6    Fischer, J.W.7
  • 39
    • 0038322020 scopus 로고    scopus 로고
    • Transforming growth factor-β inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function
    • DOI 10.1074/jbc.M212259200
    • Choy, L., and Derynck, R. (2003). Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function. J. Biol. Chem. 278(11):9609-9619. (Pubitemid 36800456)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.11 , pp. 9609-9619
    • Choy, L.1    Derynck, R.2
  • 40
    • 0025807001 scopus 로고
    • Differentiation of 3T3-L1 preadipocytes with 3-isobutyl-1-methylxanthine and dexamethasone stimulates cell-associated and soluble chondroitin 4-sulfate proteoglycans
    • Calvo, J.C., Rodbard, D., Katki, A., Chernick, S., and Yanagishita, M. (1991). Differentiation of 3T3-L1 preadipocytes with 3-isobutyl-1-methylxanthine and dexamethasone stimulates cell-associated and soluble chondroitin 4-sulfate proteoglycans. J. Biol. Chem. 266(17): 11237-11244. (Pubitemid 21906938)
    • (1991) Journal of Biological Chemistry , vol.266 , Issue.17 , pp. 11237-11244
    • Calvo, J.C.1    Rodbard, D.2    Katki, A.3    Chernick, S.4    Yanagishita, M.5
  • 41
    • 0027309374 scopus 로고
    • The response of rat liver perisinusoidal lipocytes to polypeptide growth regulator changes with their transdifferentiation into myofibroblast-like cells in culture
    • DOI 10.1016/S0168-8278(05)80008-X
    • Bachem, M.G., Meyer, D., Schafer, W., Riess, U., Melchior, R., Sell, K.M., and Gressner, A.M. (1993). The response of rat liver perisinusoidal lipocytes to polypeptide growth regulator changes with their transdifferentiation into myofibroblast-like cells in culture. J. Hepatol. 18 (1):40-52. (Pubitemid 23166350)
    • (1993) Journal of Hepatology , vol.18 , Issue.1 , pp. 40-52
    • Bachem, M.G.1    Meyer, D.2    Schafer, W.3    Riess, U.4    Melchior, R.5    Sell, K.-M.6    Gressner, A.M.7
  • 43
    • 77951689700 scopus 로고    scopus 로고
    • Soluble factors from ASCs effectively direct control of chondrogenic fate
    • Kim, B.S., Kang, K.S., and Kang, S.K. (2010). Soluble factors from ASCs effectively direct control of chondrogenic fate. Cell Prolif. 43(3):249-261.
    • (2010) Cell Prolif. , vol.43 , Issue.3 , pp. 249-261
    • Kim, B.S.1    Kang, K.S.2    Kang, S.K.3
  • 45
    • 84860889134 scopus 로고    scopus 로고
    • Acute inflammation plays a limited role in the regulation of adipose tissue COL1A1 protein abundance
    • Adapala, V.J., Adedokun, S.A., Considine, R.V., and Ajuwon, K.M. (2012). Acute inflammation plays a limited role in the regulation of adipose tissue COL1A1 protein abundance. J. Nutr. Biochem. 23(6): 567-572.
    • (2012) J. Nutr. Biochem. , vol.23 , Issue.6 , pp. 567-572
    • Adapala, V.J.1    Adedokun, S.A.2    Considine, R.V.3    Ajuwon, K.M.4
  • 48
    • 0036117417 scopus 로고    scopus 로고
    • Low density lipoproteins and mitogenic signal transduction processes: Role in the pathogenesis of renal disease
    • Kamanna, V.S. (2002). Low density lipoproteins and mitogenic signal transduction processes: Role in the pathogenesis of renal disease. Histol. Histopathol. 17(2):497-505. (Pubitemid 34411209)
    • (2002) Histology and Histopathology , vol.17 , Issue.2 , pp. 497-505
    • Kamanna, V.S.1
  • 49
    • 0031973666 scopus 로고    scopus 로고
    • Hyperlipidemia and kidney disease: Concepts derived from histopathology and cell biology of the glomerulus
    • Kamanna, V.S., Roh, D.D., and Kirschenbaum, M.A. (1998). Hyperlipidemia and kidney disease: Concepts derived from histopathology and cell biology of the glomerulus. Histol. Histopathol. 13(1): 169-179. (Pubitemid 28044610)
    • (1998) Histology and Histopathology , vol.13 , Issue.1 , pp. 169-179
    • Kamanna, V.S.1
  • 50
    • 1342344698 scopus 로고    scopus 로고
    • Cellular Lipid Metabolism and the Role of Lipids in Progressive Renal Disease
    • DOI 10.1159/000075925
    • Abrass, C.K. (2004). Cellular lipid metabolism and the role of lipids in progressive renal disease. Am. J. Nephrol. 24(1):46-53. (Pubitemid 38258276)
    • (2004) American Journal of Nephrology , vol.24 , Issue.1 , pp. 46-53
    • Abrass, C.K.1
  • 51
    • 33645663734 scopus 로고    scopus 로고
    • Bone morphogenetic protein 4 mediates bile duct ligation induced liver fibrosis through activation of Smad1 and ERK1/2 in rat hepatic stellate cells
    • Fan, J., Shen, H., Sun, Y., Li, P., Burczynski, F., Namaka, M., and Gong, Y. (2006). Bone morphogenetic protein 4 mediates bile duct ligation induced liver fibrosis through activation of Smad1 and ERK1/2 in rat hepatic stellate cells. J. Cell. Physiol. 207(2):499-505.
    • (2006) J. Cell. Physiol , vol.207 , Issue.2 , pp. 499-505
    • Fan, J.1    Shen, H.2    Sun, Y.3    Li, P.4    Burczynski, F.5    Namaka, M.6    Gong, Y.7
  • 53
    • 69149091047 scopus 로고    scopus 로고
    • BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage
    • Huang, H., Song, T.J., Li, X., Hu, L., He, Q., Liu, M., Lane, M.D., and Tang, Q.Q. (2009). BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. Proc. Natl. Acad. Sci. USA. 106(31):12670-12675.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , Issue.31 , pp. 12670-12675
    • Huang, H.1    Song, T.J.2    Li, X.3    Hu, L.4    He, Q.5    Liu, M.6    Lane, M.D.7    Tang, Q.Q.8
  • 54
    • 84855414794 scopus 로고    scopus 로고
    • Ablation of the transcriptional regulator Id1 enhances energy expenditure, increases insulin sensitivity, and protects against age and diet induced insulin resistance, and hepatosteatosis
    • Satyanarayana, A., Klarmann, K.D., Gavrilova, O., and Keller, J.R. (2012). Ablation of the transcriptional regulator Id1 enhances energy expenditure, increases insulin sensitivity, and protects against age and diet induced insulin resistance, and hepatosteatosis. FASEB J. 26 (1):309-323.
    • (2012) FASEB J. , vol.26 , Issue.1 , pp. 309-323
    • Satyanarayana, A.1    Klarmann, K.D.2    Gavrilova, O.3    Keller, J.R.4
  • 55
    • 70450275813 scopus 로고    scopus 로고
    • ID2 (inhibitor of DNA binding 2) is a rhythmically expressed transcriptional repressor required for circadian clock output in mouse liver
    • Hou, T.Y., Ward, S.M., Murad, J.M., Watson, N.P., Israel, M.A., and Duffield, G.E. (2009). ID2 (inhibitor of DNA binding 2) is a rhythmically expressed transcriptional repressor required for circadian clock output in mouse liver. J. Biol. Chem. 284(46):31735-31745.
    • (2009) J. Biol. Chem , vol.284 , Issue.46 , pp. 31735-31745
    • Hou, T.Y.1    Ward, S.M.2    Murad, J.M.3    Watson, N.P.4    Israel, M.A.5    Duffield, G.E.6
  • 56
    • 80053430193 scopus 로고    scopus 로고
    • Inhibition of Id1 augments insulin secretion and protects against high-fat diet-induced glucose intolerance
    • Akerfeldt, M.C., and Laybutt, D.R. (2011). Inhibition of Id1 augments insulin secretion and protects against high-fat diet-induced glucose intolerance. Diabetes 60(10):2506-2514.
    • (2011) Diabetes , vol.60 , Issue.10 , pp. 2506-2514
    • Akerfeldt, M.C.1    Laybutt, D.R.2
  • 59
    • 0035469891 scopus 로고    scopus 로고
    • Localized reduction of atherosclerosis in von Willebrand factor-deficient mice
    • Methia, N., Andre, P., Denis, C.V., Economopoulos, M., and Wagner, D.D. (2001). Localized reduction of atherosclerosis in von Willebrand factor-deficient mice. Blood 98(5):1424-1428.
    • (2001) Blood , vol.98 , Issue.5 , pp. 1424-1428
    • Methia, N.1    Andre, P.2    Denis, C.V.3    Economopoulos, M.4    Wagner, D.D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.